Detection of relapse in non-Hodgkin's lymphoma: role of routine follow-up studies.

Abstract:

:Complete remission can be achieved in 60-80% of adults with diffuse aggressive non-Hodgkin's lymphoma. However, 20-40% of them will subsequently relapse. Nevertheless, formal follow-up guidelines for recurrence detection have never been advocated. We analyzed the pattern of relapse in 30 patients with intermediate- and high-grade non-Hodgkin's lymphoma and the value of intensive protocol for relapse detection. This protocol includes frequent follow-up visits, complete blood count, and serum LDH tests along with annual chest, abdominal, and pelvic CT scans. The median duration of complete remission was 12 months. Twenty-five relapses (83%) were suspected after an interim history and/or physical examination, whereas only 5 relapses (17%) were detected by routine radiographic or laboratory follow-up studies. The majority of relapses (19/30) were detected in sites that included the sites of prior disease. For the first 12 months of complete remission, the estimated cumulative save in charge for a follow-up strategy, based on regular visits in the hematology clinic and performing laboratory and radiologic studies as clinically indicated, is 44% of the cost of a routine intensive evaluation. A reliable and cost-effective follow-up method for non-Hodgkin's lymphoma patients in complete remission should include frequent history and physical examination. Complementary studies should be performed according to clinical indications.

journal_name

Am J Hematol

authors

Elis A,Blickstein D,Klein O,Eliav-Ronen R,Manor Y,Lishner M

doi

10.1002/ajh.10017

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

41-4

issue

1

eissn

0361-8609

issn

1096-8652

pii

10.1002/ajh.10017

journal_volume

69

pub_type

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