Bone marrow failure and myelofibrosis in a case of PVP storage disease.

Abstract:

:"PVP storage disease" is a disorder occurring in patients who have received high molecular weight polyvinylpyrrolidone (PVP), which cannot be excreted from the body. These large polymers deposit in the histiocytes and cause proliferation and infiltration of histiocytes in the reticuloendothelial system. There was usually no significant damage to these organs except that prolonged administration might cause bone destruction, skin lesions, arthritis, and polyneuropathy. We describe a patient who had received a large amount of PVP-containing solution for years. Severe bone marrow failure with extensive infiltration of bone marrow by foamy histiocytes occurred later. In addition, she suffered from multiple pathological fractures with spinal cord compression and arthritis of bilateral knee joints.

journal_name

Am J Hematol

authors

Dunn P,Kuo T,Shih LY,Wang PN,Sun CF,Chang MJ

doi

10.1002/(sici)1096-8652(199801)57:1<68::aid-ajh12>

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

68-71

issue

1

eissn

0361-8609

issn

1096-8652

pii

10.1002/(SICI)1096-8652(199801)57:1<68::AID-AJH12>

journal_volume

57

pub_type

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