Abstract:
:Extramedullary meningeal hematopoiesis (EMH) represents an uncommon finding after stem-cell transplantation. We describe the case of an allogeneic bone marrow transplantation (BMT) recipient who developed EMH 1 month after radiation myelitis had been diagnosed. A 39-year-old man with multiple myeloma underwent matched unrelated BMT following a myeloablative conditioning regimen of cyclophosphamide and total-body irradiation (200 cGyx6). This was followed by delivery of 40 Gy of involved-field radiation to an extramedullary plasmacytoma compressing the spinal cord. Although transplantation went extremely well, the patient developed radiation myelitis 7 months after transplantation, and EMH ensued 1 month later. Because the patient was not in a disease state known to cause EMH, it is tempting to speculate that radiation-related neural injuries might cause donor cells to migrate to the central nervous system.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Sakai M,Ohashi K,Kobayashi T,Yamashita T,Akiyama H,Nemoto T,Kishida S,Kamata N,Sakamaki Hdoi
10.1002/ajh.20341keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
291-3issue
4eissn
0361-8609issn
1096-8652journal_volume
79pub_type
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