Abstract:
:If a translocation is followed by loss of one of the two derivative chromosomes, the result is an unbalanced translocation, showing monosomy for the segments making up the lost derivative. We have found that in most unbalanced translocations, a third event takes place: a morphologically normal copy of one of the two translocation participants is added to the karyotype. This creates a complex abnormal karyotype with monosomy, disomy, and trisomy for different segments of the translocation participants. We have examined 82 unbalanced translocations from 77 patients, 73 of whom had a myeloid hemopoietic malignancy. Acquisition of a normal copy of a translocation participant was found in 49 translocations. Twenty-five of these showed trisomy for 1q. In 16 of the 25 1q-trisomic cases the translocation was t(1;7)(q10;p10) (trisomy for 1q and monosomy for 7q). Patients with trisomy for 1q were younger than the remaining patients. Whereas those with t(1;7))(q10;p10) showed brief survivals, those with trisomy 1q but monosomy for regions other than 7q survived longer than the remaining patients. We conclude that most unbalanced translocations involve a partial trisomy, that 1q is trisomic far more frequently than any other segment, and that partial trisomy is associated with patient age and survival.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Pedersen B,Nørgaard JM,Pedersen BB,Clausen N,Rasmussen IH,Thorling Kdoi
10.1002/1096-8652(200007)64:3<161::aid-ajh4>3.0.cokeywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
161-9issue
3eissn
0361-8609issn
1096-8652pii
10.1002/1096-8652(200007)64:3<161::AID-AJH4>3.0.COjournal_volume
64pub_type
杂志文章abstract::A significant anemia develops in Buffalo rats bearing the Morris hepatoma 7777. By indiceal measurements the red blood cells (RBCs) appear to be microcytic and hypochromic. Ferrokinetic studies demonstrate a decreased uptake of iron in the bone marrow and an increased incorporation of iron in the spleens of the tumor-...
journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:1998-03-01 00:00:00
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:American journal of hematology
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更新日期:1988-09-01 00:00:00
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journal_title:American journal of hematology
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更新日期:2000-03-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00
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journal_title:American journal of hematology
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更新日期:1995-06-01 00:00:00
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journal_title:American journal of hematology
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doi:10.1002/(sici)1096-8652(199803)57:3<253::aid-ajh14
更新日期:1998-03-01 00:00:00
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更新日期:2000-01-01 00:00:00
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2013-01-01 00:00:00
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journal_title:American journal of hematology
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更新日期:1999-04-01 00:00:00
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更新日期:1988-05-01 00:00:00