Abstract:
:Pentosan polysulfate is a low-molecular-weight sulfated polysaccharide used as an antithrombotic drug. We present two patients who developed thrombocytopenia and venous thrombosis during treatment with pentosan polysulfate. The relationship between pentosan polysulfate and thrombocytopenia is supported by platelet aggregation and serotonin release tests. In the light of the literature and our two cases, it appears that pentosan polysulfate alone as standard heparin and low-molecular-weight heparin can induce thrombocytopenia and thrombosis. Platelet counts should therefore be periodically monitored during pentosan polysulfate treatment. In the case of pentosan polysulfate-induced thrombocytopenia, it seems that heparin or low-molecular-weight heparin should not be instituted during the acute phase even if platelet aggregation studies are negative, because of their low sensitivity. After remission of thrombocytopenia, whether or not glycosaminoglycans can be reinstituted, at least temporarily, after antibody had disappeared is still an open question.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Tardy-Poncet B,Tardy B,Grelac F,Reynaud J,Mismetti P,Bertrand JC,Guyotat Ddoi
10.1002/ajh.2830450312subject
Has Abstractpub_date
1994-03-01 00:00:00pages
252-7issue
3eissn
0361-8609issn
1096-8652journal_volume
45pub_type
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章,评审
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journal_title:American journal of hematology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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journal_title:American journal of hematology
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