Monoclonal antibodies in the management of acute leukemia.

abstract：:A case of a leukemic transformation following a 27-year history of idiopathic myelofibrosis (IMF) is presented. The patient had two chromosomal abnormalities: a deletion of chromosome 13, del 13(q12q14), and a deletion of chromosome 11, del 11(q14q23). This patient's final diagnosis was acute micromegakaryocytic leuke...

journal_title：American journal of hematology

authors： Toubai T,Tanaka J,Higa T,Ota S,Ibata M,Shono Y,Mashiko S,Miura Y,Umehara S,Kahata K,Toyoshima N,Morioka M,Asaka M,Kasai M,Imamura M

更新日期：2005-01-01 00:00:00

abstract：:To clarify the idea that an alteration of the transferrin receptor (TF-R) gene, localized to 3q26, may be of pathogenetic significance in hematological disorders with 3q anomaly, we studied the TF-R systems of erythroblasts from both functional and genetic aspects. The patient described here had refractory anemia with...

journal_title：American journal of hematology

authors： Abe Y,Muta K,Yufu Y,Takahira H,Nishimura J,Nawata H

更新日期：1990-03-01 00:00:00

abstract：:Hypereosinophilic syndrome (HES) is a rare disorder that can manifest in various organ systems. We report the case of a 54-year-old woman with a remote history of seizure disorder who presented with early signs of right-sided heart failure. Laboratory studies showed significant eosinophilia (8 x 10(9) l(-1)). Computed...

journal_title：American journal of hematology

authors： Chao BH,Cline-Parhamovich K,Grizzard JD,Smith TJ

更新日期：2007-10-01 00:00:00

abstract：:Iron deposition in combination with inflammatory and immunogenetic factors is involved in the pathophysiology of cardiac dysfunction in β-thalassemia major. We investigated the mechanical and endocrine function of the left atrium and ventricle to identify early signs of dysfunction. We studied 90 patients (mean age: 2...

journal_title：American journal of hematology

authors： Kostopoulou AG,Tsiapras DP,Chaidaroglou AS,De Giannis DE,Farmakis D,Kremastinos DT

更新日期：2014-01-01 00:00:00

abstract：:We report a case of a patient who developed a fatal adult respiratory distress syndrome (ARDS) during treatment with rh granulocyte-macrophage colony stimulating factor (rhGM-CSF) (250 mcg/m2/day s.c.) and low-dose cytosine-arabinoside (Ara-C) (20 mg/m2/day s.c.). Several mechanisms which might explain the lung tissue...

journal_title：American journal of hematology

authors： Verhoef G,Boogaerts M

更新日期：1991-04-01 00:00:00

abstract：:Vascular complications are the main cause of morbidity in diabetes mellitus. To evaluate lipoprotein and hemostatic parameters and their relationship with clinically detectable microangiopathy, we studied 58 insulin-dependent diabetes mellitus patients and 60 controls matched for age, sex, and body mass index. Thirtee...

journal_title：American journal of hematology

authors： Reverter JL,Reverter JC,Tàssies D,Rius F,Monteagudo J,Rubiés-Prat J,Escolar G,Ordinas A,Sanmarti A

更新日期：1997-10-01 00:00:00

abstract：:We report the long-term follow-up results of a phase II trial of thalidomide for early-stage multiple myeloma (MM). Patients were eligible if they had smoldering multiple myeloma (SMM) or indolent MM without the need for immediate therapy. Thalidomide was initiated at a dose of 200 mg/day and adjusted as tolerated. Di...

journal_title：American journal of hematology

authors： Detweiler-Short K,Hayman S,Gertz MA,Lacy MQ,Dispenzieri A,Kumar S,Zeldenrust SR,Russell SJ,Lust JA,Kyle RA,Greipp PR,Witzig TE,Vincent Rajkumar S

更新日期：2010-10-01 00:00:00

abstract：:A patient with congenital protein-C deficiency was treated with stanozolol for 8 weeks to increase circulating levels of protein C. A rise in protein C was achieved, accompanied by an increase in factor II, factor X, antithrombin III, and protein S; but at the 8th week the patient suffered a transient ischemia attack....

journal_title：American journal of hematology

authors： De Stefano V,Leone G,Teofili L,Ferrelli R,Pollari G,Antonini V,Bizzi B

更新日期：1988-10-01 00:00:00

abstract：:The efficacy of the three common intra- and extragenic polymorphic sites of the factor VIII and IX genes has been examined in the Indian population, with an aim to develop a strategy that would be accurate and informative, yet economical. The approach for hemophilia A carrier detection includes tests for BclI, XbaI, a...

journal_title：American journal of hematology

authors： Shetty S,Ghosh K,Pathare A,Colah R,Badakare S,Mohanty D

更新日期：1997-04-01 00:00:00

abstract：:A 64-year-old woman with mild bilateral parotid gland swelling and bilateral lower extremity purpura was admitted for evaluation of xerostomia and pancytopenia. The patient had an increased erythrocyte sedimentation rate, pancytopenia, and positive tests for antibodies to nuclear antigen, SS-A, and SS-B. Impaired cell...

journal_title：American journal of hematology

authors： Seki T,Kiyosawa K,Monno S,Imai Y,Furukawa K,Kumazawa S,Ota M,Saito H,Furuta S,Nakahata T

更新日期：1993-07-01 00:00:00

abstract：:Solid-phase enzyme immunoassays using recombinant gag and env proteins were developed to study humoral immune responses to HIV infection in a cohort of 105 hemophiliac patients. Thirteen patients with ARC or AIDS and 92 asymptomatic patients were studied. A cross-sectional study showed a wide range of antibody respons...

journal_title：American journal of hematology

authors： Kinney JS,Conway JH,Hilgartner MW,Clayman B,Mayur K,Yolken RH,Viscidi RP

更新日期：1991-01-01 00:00:00

abstract：:Indolent non-hodgkin lymphomas (iNHL) are a rare cause of monoclonal immunoglobulin deposits-related glomerulopathy (mIgGN). In patients with iNHL-related mIgGN, whether treatment should include either single or a combination of drug(s) to target the malignant clone and renal inflammation remains elusive. In this retr...

journal_title：American journal of hematology

authors： Perry M,Delarche A,Ribes D,Vergez F,Guilbeau-Frugier C,Laurent C,Huart A,Tavitian S,El Hachem H,Oberic L,Chauveau D,Michallet AS,Ysebaert L,Faguer S

更新日期：2014-10-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

journal_title：American journal of hematology

authors： Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

更新日期：2004-08-01 00:00:00

abstract：:A 25-year-old African-American man with sickle cell-beta(+)-thalassemia presented with acute asthma of 2 days' duration. The asthma was well controlled by 48 hr, and parenteral medications were changed to oral bronchodilators and steroids. Sixty hours after presentation, he developed pain similar to that of sickle cel...

journal_title：American journal of hematology

authors： Johnson K,Stastny JF,Rucknagel DL

更新日期：1994-08-01 00:00:00

abstract：:The activation pathways for the generation of enzymes involved in blood clotting, clot lysis, complement activation, and kinin generation are briefly reviewed. The interrelationship of the four systems is illustrated by the multiple functions of four key enzymes: Factor XIIa, kallikrein, plasmin, and C1 esterase. The ...

journal_title：American journal of hematology

authors： Murano G

更新日期：1978-01-01 00:00:00

abstract：:Platelet-rich plasma were treated with increasing concentrations of vitamin E (alpha-tocopherol). Washed platelets were exposed to oxidized low density lipoprotein (LDL) and examined by aggregometry and electron microscopy. The treatment of washed platelets by oxidized LDL induced morphological signs of activation lik...

journal_title：American journal of hematology

authors： Szuwart T,Dierichs RB,Zhao B

更新日期：1999-03-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patie...

journal_title：American journal of hematology

authors： Feins S,Kong W,Williams EF,Milone MC,Fraietta JA

更新日期：2019-05-01 00:00:00

abstract：:Venous thromboembolism (VTE) recurs frequently. Greater height is associated with increased risk of incident VTE, but it is unclear whether height is related to risk of VTE recurrence. Recurrent VTE is associated with substantial morbidity and mortality, thus identifying individuals at greatest risk of experiencing a ...

journal_title：American journal of hematology

authors： Lutsey PL,Folsom AR

更新日期：2012-07-01 00:00:00

abstract：:A specialized serum ferritin assay has been developed for the detection of iron deficiency in epidemiologic studies. An enzyme immunoassay (EIA) was employed to eliminate the need for radioisotopes. The problem of low sensitivity inherent with the EIA for serum ferritin was eliminated by the use of monoclonal immunolo...

journal_title：American journal of hematology

authors： Flowers CA,Kuizon M,Beard JL,Skikne BS,Covell AM,Cook JD

更新日期：1986-10-01 00:00:00

abstract：:The molecular basis of triosephosphate isomerase (TPI) deficiency was studied in 3 patients from three separate families. In all 3 patients, genomic DNA directly sequenced after amplification by the polymerase chain reaction exhibited the point mutation TPI315C amino acid 104 Glu-->Asp. Although other mutations known ...

journal_title：American journal of hematology

authors： Schneider A,Westwood B,Yim C,Prchal J,Berkow R,Labotka R,Warrier R,Beutler E

更新日期：1995-12-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised patients usually with malignant diseases. We report here a Japanese female with follicular lymphoma who subsequently developed PML. In addition to JCV, human her...

journal_title：American journal of hematology

authors： Daibata M,Hatakeyama N,Kamioka M,Nemoto Y,Hiroi M,Miyoshi I,Taguchi H

更新日期：2001-07-01 00:00:00

abstract：:The objective of this case-matched study was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma. Data from 72 patients treated at the New York Presbyterian Hospital-Cornel...

journal_title：American journal of hematology

authors： Gay F,Rajkumar SV,Coleman M,Kumar S,Mark T,Dispenzieri A,Pearse R,Gertz MA,Leonard J,Lacy MQ,Chen-Kiang S,Roy V,Jayabalan DS,Lust JA,Witzig TE,Fonseca R,Kyle RA,Greipp PR,Stewart AK,Niesvizky R

更新日期：2010-09-01 00:00:00

abstract：:Because of a possible hazard from the use of radioisotopes to determine iron absorption by infants, the use of stable isotopes for this purpose has much appeal. We have applied the method of inductively coupled plasma mass spectrometry (ICP/MS) to determine the mass ratio, 58Fe/57Fe, in blood before and after oral adm...

journal_title：American journal of hematology

authors： Janghorbani M,Ting BT,Fomon SJ

更新日期：1986-03-01 00:00:00

abstract：:Acute Myeloid Leukemia (AML) and myelodysplasia (MDS) with chromosome 3q abnormalities have a dismal outcome either untreated or with conventional treatments. Azacitidine (AZA) is now considered as the standard of care in high-risk MDS and oligoblastic AML patients. The objective of this study was to evaluate the impa...

journal_title：American journal of hematology

authors： Wanquet A,Prebet T,Berthon C,Sebert M,Roux C,Kulasekararaj A,Micol JB,Esterni B,Itzykson R,Thepot S,Recher C,Delaunay J,Dreyfus F,Mufti G,Fenaux P,Vey N

更新日期：2015-10-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a Kunitz-type proteinase inhibitor that has a crucial role in haemostasis and is primarily synthesized in the vascular endothelium. We investigated plasma total TFPI, antiphospholipid antibodies, and some other coagulation and fibrinolytic system parameters in 30 patients with...

journal_title：American journal of hematology

authors： Akarsu M,Demirkan F,Ozsan GH,Onen F,Yüksel F,Ozkan S,Undar B

更新日期：2001-12-01 00:00:00

abstract：:We describe a newly detected alpha-thalassemia-2 (alpha-thal-2) deletion characterized by a small -2.7-kb deletion involving the alpha 1 globin gene. This deletion has thus far been observed in only one Chinese subject with Hb H disease. ...

journal_title：American journal of hematology

authors： Zhao JB,Zhao L,Fei YJ,Liu JC,Huisman TH

更新日期：1991-11-01 00:00:00

abstract：:We prospectively treated 46 patients with favorable myelodysplastic syndrome classified as refractory anemia (RA), refractory cytopenia (RC), or refractory anemia with ringed sideroblasts (RARS). These patients received one of two schedules of 13-Cis-Retinoic Acid (low dose 80 mg daily for 6 months vs. high dose 200 m...

journal_title：American journal of hematology

authors： Letendre L,Levitt R,Pierre RV,Schroeder G,Krook JA,Mailliard JE,Morton RF,Tschetter LK

更新日期：1995-04-01 00:00:00

abstract：:Although standard clinical prognostic factors predict outcome in diffuse large B-cell lymphoma (DLBCL), predicting the outcome of patients might be further refined using biological factors. We tested whether serum cytokines could provide prognostic information in DLBCL patients. Thirty cytokines were measured in pretr...

journal_title：American journal of hematology

authors： Ansell SM,Maurer MJ,Ziesmer SC,Slager SL,Habermann TM,Link BK,Witzig TE,Macon WR,Dogan A,Cerhan JR,Novak AJ

更新日期：2012-09-01 00:00:00

abstract：:We analyzed the genetic defects of 21 unrelated patients with venous thrombosis in whom hereditary protein C deficiency was diagnosed. Eleven mutations were detected in 18 families, while no mutation was detectable in the other three families. Among these mutations, a common genetic mutation of protein C (PROC) gene r...

journal_title：American journal of hematology

authors： Tsay W,Shen MC

更新日期：2004-05-01 00:00:00

abstract：:The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

journal_title：American journal of hematology

authors： Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

更新日期：2001-09-01 00:00:00