Increased levels of tissue factor pathway inhibitor may reflect disease activity and play a role in thrombotic tendency in Behçet's disease.

abstract：:A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

journal_title：American journal of hematology

authors： Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

更新日期：1999-02-01 00:00:00

abstract：:In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk Myelodysplastic Syndromes (MDS) patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytoge...

journal_title：American journal of hematology

authors： Papageorgiou SG,Vasilatou D,Kontos CK,Kotsianidis I,Symeonidis A,Galanopoulos AG,Hatzimichael E,Megalakaki A,Poulakidas E,Diamantopoulos P,Vassilakopoulos TP,Zikos P,Papadaki H,Mparmparousi D,Bouronikou E,Panayiotidis P,V

更新日期：2018-07-01 00:00:00

abstract：:Clofarabine has shown activity and tolerability in older patients with acute myeloid leukemia (AML). We investigated the safety and tolerability of an oral formulation of clofarabine for consolidation therapy of patients aged 60 and older with AML. In this phase I study, twenty-two patients older than 60 years with AM...

journal_title：American journal of hematology

authors： Jacoby MA,Martin MG,Uy GL,Westervelt P,Dipersio JF,Cashen A,Stockerl-Goldstein K,Vij R,Luo J,Reineck T,Bernabe N,Abboud CN

更新日期：2014-05-01 00:00:00

abstract：:Over 300,000 infants are born annually with sickle cell anemia (SCA) in sub-Saharan Africa, and >50% die young from infection or anemia, usually without diagnosis of SCA. Early identification by newborn screening (NBS), followed by simple interventions dramatically reduced the mortality of SCA in the United States, bu...

journal_title：American journal of hematology

authors： McGann PT,Ferris MG,Ramamurthy U,Santos B,de Oliveira V,Bernardino L,Ware RE

更新日期：2013-12-01 00:00:00

abstract：:Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

journal_title：American journal of hematology

authors： Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

更新日期：1986-06-01 00:00:00

abstract：:Ten previously untreated elderly patients with hypocellular acute leukemia received a low dose of cytosine arabinoside (Ara-C), 10 mg/m2 injected subcutaneously every 12 hours for 14-28 days. Six patients achieved a complete remission (CR) for periods ranging for 6-23 months (median 8.5 months) and the others had a pa...

journal_title：American journal of hematology

authors： Kanamori H,Maruta A,Miyashita H,Harano H,Fukawa H,Matsuzaki M,Motomura S,Mohri H,Kodama F,Okubo T

更新日期：1992-01-01 00:00:00

abstract：:Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F-cells. Fetal hemoglobin (Hb F) inhibits the polymerization events of sickle hemoglobin (Hb S), thereby ameliorating the clinical symptoms of sickle cell disease. Ribonucleotide reductase inhibitors (RRIs) ...

journal_title：American journal of hematology

authors： Iyamu WE,Adunyah SE,Fasold H,Horiuchi K,Elford HL,Asakura T,Turner EA

更新日期：2000-04-01 00:00:00

abstract：:Chronic transfusion therapy is the treatment of choice for preventing stroke recurrence in children with sickle cell disease (SCD). The majority of children affected by this devastating complication live in the developing world where access to regular blood transfusions may be impractical. Since 2000, in the absence o...

journal_title：American journal of hematology

authors： Ali SB,Moosang M,King L,Knight-Madden J,Reid M

更新日期：2011-10-01 00:00:00

abstract：:Intensive induction chemotherapy using anthracycline and cytarabine backbone is considered the most effective upfront therapy in physically fit older patients with acute myeloid leukemia (AML). However, outcomes of the standard induction in elderly AML are inferior to those observed in younger patients, and they are s...

journal_title：American journal of hematology

authors： Pluta A,Robak T,Wrzesien-Kus A,Katarzyna Budziszewska B,Sulek K,Wawrzyniak E,Czemerska M,Zwolinska M,Golos A,Holowiecka-Goral A,Kyrcz-Krzemien S,Piszcz J,Kloczko J,Mordak-Domagala M,Lange A,Razny M,Madry K,Wiktor-Jedrze

更新日期：2017-04-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is considered to be a pleuripotential stem cell disorder with the capacity to differentiate into myeloid, erythroid, megakaryocytic, and lymphoid cell lines. Consequently, blast crisis (BC) involving each of the above lineages has been well described. Among lymphoblastic crises, differen...

journal_title：American journal of hematology

authors： Advani SH,Malhotra H,Kadam PR,Iyer RS,Nanjangud G,Balsara B,Saikia T,Gopal R,Nair CN

更新日期：1991-02-01 00:00:00

abstract：:We have generated a murine hybridoma that secretes a monoclonal antibody (mAb) that is highly specific for hemoglobin C (HbC) [alpha 2 beta 2 6(A3)Glu----Lys] and shows no cross reactivity with HbA, HbA2, HbF, HbS, HbE, or Hb O-Arab. Using this antibody, we developed a simple and rapid enzyme linked immunosorbent assa...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1990-03-01 00:00:00

abstract：:We report a case of a patient who developed a fatal adult respiratory distress syndrome (ARDS) during treatment with rh granulocyte-macrophage colony stimulating factor (rhGM-CSF) (250 mcg/m2/day s.c.) and low-dose cytosine-arabinoside (Ara-C) (20 mg/m2/day s.c.). Several mechanisms which might explain the lung tissue...

journal_title：American journal of hematology

authors： Verhoef G,Boogaerts M

更新日期：1991-04-01 00:00:00

abstract：:A 13-year-old boy presented with progressive bilateral lower limb weakness due to exradural granulocytic sarcoma of the spine. After surgical decompression and radiotherapy, he remained in complete remission 6 years after initial diagnosis. The possible reasons for the favorable outcome of this unique case are discuss...

journal_title：American journal of hematology

authors： Chan JK,Lau WH,Saw D

更新日期：1986-08-01 00:00:00

abstract：:In patients with light-chain myeloma or primary AL-amyloidosis, 24-hr light-chain excretion in the urine is considered an essential marker of the tumor mass. However, 24-hr urine collection and analysis may be cumbersome and prone to inaccuracy. Recently, a sensitive immunonephelometric assay for immunoglobulin free l...

journal_title：American journal of hematology

authors： Alyanakian MA,Abbas A,Delarue R,Arnulf B,Aucouturier P

更新日期：2004-04-01 00:00:00

abstract：:Polycythemia vera (PCV) and multiple myeloma are both clonal disorders of hematopoietic stem cells. The simultaneous occurrence of these diseases in an individual patient is rare. A case of synchronous PCV and smoldering myeloma is presented and the literature is reviewed. The issues of clinical importance in this unu...

journal_title：American journal of hematology

authors： Fink L,Bauer F,Perry JJ

更新日期：1993-11-01 00:00:00

abstract：:The risk of graft-rejection after allogeneic hematopoietic cell transplantation using conventional cyclophosphamide-based conditioning is increased in patients with bone marrow failure syndromes (BMFS) who are heavily transfused and often HLA-alloimmunized. Fifty-six patients with BMFS underwent fludarabine-based redu...

journal_title：American journal of hematology

authors： Pantin J,Tian X,Shah AA,Kurlander R,Ramos C,Cook L,Khuu H,Stroncek D,Leitman S,Barrett J,Donohue T,Young NS,Geller N,Childs RW

更新日期：2013-10-01 00:00:00

abstract：:We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to...

journal_title：American journal of hematology

authors： Viprakasit V,Kankirawatana S,Akarasereenont P,Durongpisitkul K,Chotewuttakorn S,Tanphaichitr VS

更新日期：2002-07-01 00:00:00

abstract：:We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and imm...

journal_title：American journal of hematology

authors： Lust JA,Banks PM,Hooper WC,Paya CV,Kueck BD,Hanson GA,Ritch PS,Woloschak GE

更新日期：1989-07-01 00:00:00

abstract：:Splenic lymphoma with villous lymphocytes (SLVL) is a relatively new entity with only a few reports published. We report seven cases of SLVL with detailed clinicopathologic and comprehensive immunophenotypic studies to further characterize this lymphoma, which is frequently confused with hairy cell leukemia and other ...

journal_title：American journal of hematology

authors： Sun T,Susin M,Brody J,Dittmar K,Teichberg S,Weiner R,Lin JH,Felber N

更新日期：1994-01-01 00:00:00

abstract：:Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete p...

journal_title：American journal of hematology

authors： Rosner F,Hirshaut Y,Grünwald HW,Deutsch S

更新日期：1978-01-01 00:00:00

abstract：:The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

journal_title：American journal of hematology

authors： Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

更新日期：2001-09-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rarely complicated by chylothorax: we present a 93-year-old woman with CLL who developed recurrent pleural effusions that were ultimately found to be chylous in nature. Despite eight repeated thoracenteses, she continued to experience re-accumulation of fluid, and therefore, video...

journal_title：American journal of hematology

authors： Doerr CH,Staats BA,Markovic SN

更新日期：2002-07-01 00:00:00

abstract：DISEASE OVERVIEW:Approximately one-fourth of primary cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCD...

journal_title：American journal of hematology

authors： Hristov AC,Tejasvi T,Wilcox RA

更新日期：2020-08-20 00:00:00

abstract：:We have studied telomere length in the bone marrow cells or the granulocyte and lymphocyte cell fractions of 54 patients with myelodysplastic syndromes (MDS) by Southern blot hybridization using the (TTAGGG)4 probe. The average telomere length expressed as the peak telomere repeat array (TRA) in the peripheral blood, ...

journal_title：American journal of hematology

authors： Boultwood J,Fidler C,Kusec R,Rack K,Elliott PJ,Atoyebi O,Chapman R,Oscier DG,Wainscoat JS

更新日期：1997-12-01 00:00:00

abstract：:The improved microchromatographic procedure for the detection of Hb-S and/or Hb-C in cord blood at birth (Schroeder et al.: J. Lab Clin Med 86:528-532, 1975) as well as a modification thereof may also be used for the quantitative determination of Hb-F in the presence of Hb-S and/or Hb-C. However, Hb-A interferes and m...

journal_title：American journal of hematology

authors： Schroeder WA,Evans L,Grussing L,Abraham EC,Huisman TH,Lam H,Shelton JB

更新日期：1976-01-01 00:00:00

abstract：:The role of reduced-intensity conditioning (RIC) in adult acute lymphoblastic leukemia (ALL) remains unclear because of the small sample size, short follow-up duration, various regimens for conditioning and graft-versus-host disease (GVHD) prophylaxis, and the heterogeneity of selection criteria for transplantation. W...

journal_title：American journal of hematology

authors： Eom KS,Shin SH,Yoon JH,Yahng SA,Lee SE,Cho BS,Kim YJ,Kim HJ,Min CK,Kim DW,Lee JW,Min WS,Park CW,Lee S

更新日期：2013-08-01 00:00:00

abstract：:The role of peripheral platelet destruction as a reversible etiology of thrombocytopenia in chronic lymphocytic leukemia (CLL) was evaluated in nine patients with CLL and refractory thrombocytopenia who underwent splenectomy. The patients' ages ranged from 54 to 74 years. Progressive thrombocytopenia refractory to ant...

journal_title：American journal of hematology

authors： Merl SA,Theodorakis ME,Goldberg J,Gottlieb AJ

更新日期：1983-11-01 00:00:00

abstract：:CD7 antigen, a T-cell lineage associated antigen, is expressed in a minority of patients with acute myeloid leukemia (AML). The biologic and clinical significance of this finding is not clearly established. In this retrospective study of patients with de novo acute myeloid leukemia, we have identified CD7 expression a...

journal_title：American journal of hematology

authors： Saxena A,Sheridan DP,Card RT,McPeek AM,Mewdell CC,Skinnider LF

更新日期：1998-08-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

journal_title：American journal of hematology

authors： Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

更新日期：2004-08-01 00:00:00

abstract：:A 25-year-old African-American man with sickle cell-beta(+)-thalassemia presented with acute asthma of 2 days' duration. The asthma was well controlled by 48 hr, and parenteral medications were changed to oral bronchodilators and steroids. Sixty hours after presentation, he developed pain similar to that of sickle cel...

journal_title：American journal of hematology

authors： Johnson K,Stastny JF,Rucknagel DL

更新日期：1994-08-01 00:00:00