Quantitative microchromatographic determination of hemoglobin F in patients with hemoglobins S and/or C.

abstract：:The main treatment for many patients with Myelodysplastic Syndromes (MDS) remains red cell transfusion to attenuate the symptoms of chronic anemia. Fatigue can reduce a patient's health related quality of life (HRQoL), but there is little understanding of the optimal use of transfusions to improve this. A systematic r...

journal_title：American journal of hematology

authors： Pinchon DJ,Stanworth SJ,Dorée C,Brunskill S,Norfolk DR

更新日期：2009-10-01 00:00:00

abstract：:The biosynthesis of the minor hemoglobin FIc, which contains acetylated gamma chains, and the major hemoglobin Fo was studied during erythroid cell differentiation and maturation in cultures of erythroid precursors isolated from five human umbilical cord blood samples. A gradual decrease in the synthesis of Hb FIc was...

journal_title：American journal of hematology

authors： Abraham EC,Reese AL,Stallings M,Abraham A,Garbutt GJ,Huisman TH

更新日期：1982-05-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

journal_title：American journal of hematology

authors： Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

更新日期：2004-08-01 00:00:00

abstract：:FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been i...

journal_title：American journal of hematology

authors： Rohmer J,Couteau-Chardon A,Trichereau J,Panel K,Gesquiere C,Ben Abdelali R,Bidet A,Bladé JS,Cayuela JM,Cony-Makhoul P,Cottin V,Delabesse E,Ebbo M,Fain O,Flandrin P,Galicier L,Godon C,Grardel N,Guffroy A,Hamidou M,

更新日期：2020-11-01 00:00:00

abstract：:A 49-year-old Caucasian woman presented with features suggestive of thrombotic microangiopathy (TMA). She did not respond to treatment with repeated plasma exchange and corticosteroids. A bone marrow biopsy revealed presence of metastatic carcinoma. A limited autopsy revealed presence of breast cancer with rib metasta...

journal_title：American journal of hematology

authors： Werner TL,Agarwal N,Carney HM,Rodgers GM

更新日期：2007-04-01 00:00:00

abstract：:Withdrawal: Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective. The above article, published online on 20 August 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, t...

journal_title：American journal of hematology

authors： Cordeiro Mitchell CN,Pradhan A,Singh B,Naik RP,Baker VL,Lanzkron SM,Christianson MS,Pecker LH

更新日期：2020-08-20 00:00:00

abstract：:We report the clinical, molecular, and immunohistological findings of 20 Chinese patients with mantle cell lymphoma diagnosed over a 10-year period. The disease affected mainly elderly patients (median age, 65.5 years) with a male predominance (M/F, 3/1). Eighty percent presented with advanced stage III/IV disease but...

journal_title：American journal of hematology

authors： Chim CS,Chan AC,Choo CK,Kwong YL,Lie AK,Liang R

更新日期：1998-12-01 00:00:00

abstract：:With the emerging success of treating CD19 expressing B cell malignancies with ex vivo modified, autologous T cells that express CD19-directed chimeric antigen receptors (CAR), there is intense interest in expanding this evolving technology to develop effective modalities to treat other malignancies including solid tu...

journal_title：American journal of hematology

authors： Perera LP,Zhang M,Nakagawa M,Petrus MN,Maeda M,Kadin ME,Waldmann TA,Perera PY

更新日期：2017-09-01 00:00:00

abstract：:Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the poly...

journal_title：American journal of hematology

authors： Tschautscher MA,Jevremovic D,Rajkumar V,Dispenzieri A,Lacy MQ,Gertz MA,Buadi FK,Dingli D,Hwa YL,Fonder AL,Hobbs MA,Hayman SR,Zeldenrust SR,Lust JA,Russell SJ,Leung N,Kapoor P,Go RS,Lin Y,Gonsalves WI,Kourelis T,

更新日期：2019-07-01 00:00:00

abstract：:Over 300,000 infants are born annually with sickle cell anemia (SCA) in sub-Saharan Africa, and >50% die young from infection or anemia, usually without diagnosis of SCA. Early identification by newborn screening (NBS), followed by simple interventions dramatically reduced the mortality of SCA in the United States, bu...

journal_title：American journal of hematology

authors： McGann PT,Ferris MG,Ramamurthy U,Santos B,de Oliveira V,Bernardino L,Ware RE

更新日期：2013-12-01 00:00:00

abstract：:The arachidonic acid metabolites produced by human peripheral blood monocytes were studied to determine which metabolites could have a role in thrombogenesis. Monocytes were found to be free of platelets by scanning electron microscopy and by measurement of 12-HETE. Human peripheral blood monocytes produce thromboxane...

journal_title：American journal of hematology

authors： Jones CM,Hall ER,Hester JP,Wu KK

更新日期：1989-07-01 00:00:00

abstract：:Various in vitro studies and clinical observations suggest that Fanconi's anemia (FA) patients are unable to detoxify adequately superoxide anions (O2-) released by activated phagocytes. Recent studies have shown that certain lymphokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) ...

journal_title：American journal of hematology

authors： Schultz JC,Shahidi NT

更新日期：1993-02-01 00:00:00

abstract：:The Sickle Cell Disease Clinical Research Network (SCDCRN) designed the PROACTIVE Feasibility Study (ClinicalTrials.gov NCT00951808) to determine whether elevated serum levels of secretory phospholipase A2 (sPLA2) during hospitalization for pain would permit preemptive therapy of sickle cell acute chest syndrome (ACS)...

journal_title：American journal of hematology

authors： Miller ST,Kim HY,Weiner D,Wager CG,Gallagher D,Styles L,Dampier CD,Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN).

更新日期：2012-03-01 00:00:00

abstract：:Chuvash polycythemia results from a homozygous 598C>T mutation in exon 3 of the von Hippel-Lindau (VHL) gene. This disrupts the normoxia pathway for degrading hypoxia inducible factor (HIF)-1alpha and HIF-2alpha causing altered expression of HIF-1 and HIF-2 inducible genes. As hypoxia induces expression of pro-inflamm...

journal_title：American journal of hematology

authors： Niu X,Miasnikova GY,Sergueeva AI,Polyakova LA,Okhotin DJ,Tuktanov NV,Nouraie M,Ammosova T,Nekhai S,Gordeuk VR

更新日期：2009-02-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is an enigmatic histiocytic proliferative disorder of unknown etiology that affects children primarily. We have investigated the possibility that viruses are etiological or that they have a "triggering effect" in LCH. Sensitive in situ hybridization and polymerase chain reaction (PC...

journal_title：American journal of hematology

authors： McClain K,Jin H,Gresik V,Favara B

更新日期：1994-09-01 00:00:00

abstract：:Idiopathic thrombocytopenic purpura is an autoimmune disease which involves opsonization of platelets by autoantibodies directed against different surface glycoproteins, leading to their premature destruction by the reticuloendothelial system. Management of patients with refractory ITP is difficult. Recent studies hav...

journal_title：American journal of hematology

authors： Braendstrup P,Bjerrum OW,Nielsen OJ,Jensen BA,Clausen NT,Hansen PB,Andersen I,Schmidt K,Andersen TM,Peterslund NA,Birgens HS,Plesner T,Pedersen BB,Hasselbalch HC

更新日期：2005-04-01 00:00:00

abstract：:An elderly patient with evidence of atherosclerosis and uremic bleeding diathesis developed two foci of cerebral thrombosis immediately after an infusion of desmopressin (DDAVP). Because large molecular weight multimers of von Willebrand factor (vWF) have been demonstrated to cause platelet aggregation under condition...

journal_title：American journal of hematology

authors： Byrnes JJ,Larcada A,Moake JL

更新日期：1988-05-01 00:00:00

abstract：:Congenital malformations of the inferior vena cava (IVC) are uncommon and may be associated with an increased risk of venous thrombosis. We report the case of a man with congenital absence of the IVC and remote history of deep venous thrombosis who now presents with severe abdominal wall superficial thrombophlebitis. ...

journal_title：American journal of hematology

authors： Evanchuk DM,Von Gehr A,Zehnder JL

更新日期：2008-03-01 00:00:00

abstract：:Thrombospondin (TSP), a large protein found in platelet alpha-granules (as TSP-1), mediates adhesion of sickle reticulocytes to cultured vascular endothelium. To further explore the physiologic relevance of this observation, we have measured plasma TSP levels and platelet TSP-1 content in subjects with sickle cell dis...

journal_title：American journal of hematology

authors： Browne PV,Mosher DF,Steinberg MH,Hebbel RP

更新日期：1996-04-01 00:00:00

abstract：:Heparin-associated thrombocytopenia with thrombosis (HATT) is fatal in 29% and leads to limb amputation in another 21% of patients. Patients with arterial thrombosis do worse than do those with venous thrombosis alone. Heparin-associated thrombocytopenia is mediated through IgG or IgM immunoglobulin fractions and is b...

journal_title：American journal of hematology

authors： Nand S,Robinson JA

更新日期：1988-07-01 00:00:00

abstract：DISEASE OVERVIEW:Hodgkin lymphoma (HL) is an uncommon B-cell lymphoid malignancy affecting 9,000 new patients annually and representing approximately 11% of all lymphomas in the United States. DIAGNOSIS:HL is composed of two distinct disease entities; the more commonly diagnosed classical HL and the rare nodular lymph...

journal_title：American journal of hematology

authors： Ansell SM

更新日期：2012-12-01 00:00:00

abstract：:In a phase II trial, we evaluated chlorambucil and rituximab (CLB-R) as first-line induction treatment with or without R as maintenance for elderly chronic lymphocytic leukemia (CLL) patients. Treatment consisted of eight 28-day cycles of CLB (8 mg/m(2) /day, days 1-7) and R (day 1 of cycle 3, 375 mg/m(2) ; cycles 4-8...

journal_title：American journal of hematology

authors： Foà R,Del Giudice I,Cuneo A,Del Poeta G,Ciolli S,Di Raimondo F,Lauria F,Cencini E,Rigolin GM,Cortelezzi A,Nobile F,Callea V,Brugiatelli M,Massaia M,Molica S,Trentin L,Rizzi R,Specchia G,Di Serio F,Orsucci L,Ambros

更新日期：2014-05-01 00:00:00

abstract：:The acute sickle cell painful episode is the most common cause of hospitalization of patients with sickle cell anemia. Its detailed clinical features and peri-discharge features are not well known. In order to determine the actual pattern of hospital admissions of patients with SS and the causes of frequent hospital r...

journal_title：American journal of hematology

authors： Ballas SK,Lusardi M

更新日期：2005-05-01 00:00:00

abstract：:We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of ...

journal_title：American journal of hematology

authors： Sinisalo M,Hietaharju A,Sauranen J,Wirta O

更新日期：2004-05-01 00:00:00

abstract：:Central nervous system (CNS) thrombotic events are a well-known complication of acute lymphoblastic leukemia (ALL) induction therapy, especially with treatments including l-asparaginase (l-ASP). Data on risk factors and clinical evolution is still lacking in adult patients. We report on the clinical evolution of 22 CN...

journal_title：American journal of hematology

authors： Couturier MA,Huguet F,Chevallier P,Suarez F,Thomas X,Escoffre-Barbe M,Cacheux V,Pignon JM,Bonmati C,Sanhes L,Bories P,Daguindau E,Dorvaux V,Reman O,Frayfer J,Orvain C,Lhéritier V,Ifrah N,Dombret H,Hunault-Berger M,

更新日期：2015-11-01 00:00:00

abstract：:A discordance between p53 protein overexpression and the presence of mutations in the gene has been observed in many types of tumors, including human lymphomas. To probe this finding, we have studied a large series of 94 lymphomas of different pathologic types and histologic differentiation. Analyzing exons 5-9, we ha...

journal_title：American journal of hematology

authors： Martinez-Delgado B,Robledo M,Arranz E,Infantes F,Echezarreta G,Marcos B,Sanz C,Rivas C,Benitez J

更新日期：1997-05-01 00:00:00

abstract：:The FAB classification of myelodysplastic syndromes (MDS) has been useful in predicting prognosis; however, additional methods are required to detect patients at high risk for early conversion to acute nonlymphoblastic leukemia (ANLL). Using a panel of monoclonal antibodies to myelomonocytic surface antigens (MMSA) an...

journal_title：American journal of hematology

authors： Mittelman M,Karcher DS,Kammerman LA,Lessin LS

更新日期：1993-07-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of therapy. For patien...

journal_title：American journal of hematology

authors： Harrington WJ Sr,Kolodny L,Horstman LL,Jy W,Ahn YS

更新日期：1997-02-01 00:00:00

abstract：:The role of leukapheresis was explored in the management of anaemia and thrombocytopenia complicating the accumulation of lymphoid cells in patients with chronic lymphocytic leukaemia and lymphoma. The aim of this study was to determine the efficiency of this procedure in correcting these complicating features and to ...

journal_title：American journal of hematology

authors： Cooper IA,Ding JC,Adams PB,Quinn MA,Brettell M

更新日期：1979-01-01 00:00:00

abstract：:Despite substantial progress in the treatment of AML, a proportion of patients do not achieve first complete remission (1(st) CR) with the induction chemotherapy, and, among patients achieving it, a majority is expected to relapse within three years. As allogeneic hematopoietic stem cell transplantation has been estab...

journal_title：American journal of hematology

authors： Dauguet N,Récher C,Demur C,Fournié JJ,Poupot M,Poupot R

更新日期：2011-02-01 00:00:00