Langerhans cell histiocytosis: lack of a viral etiology.

Abstract:

:Langerhans cell histiocytosis (LCH) is an enigmatic histiocytic proliferative disorder of unknown etiology that affects children primarily. We have investigated the possibility that viruses are etiological or that they have a "triggering effect" in LCH. Sensitive in situ hybridization and polymerase chain reaction (PCR) techniques were used in 56 cases of LCH. We sought and failed to find evidence of genomes for adenovirus, cytomegalovirus, Epstein-Barr virus, herpes simplex virus, human herpesvirus type 6, human immunodeficiency virus, human T-cell leukemia virus types I and II, and parvovirus. Although some probes hybridized to tissues from several cases, PCR failed to confirm the presence of viral genome in any. We conclude that there is no evidence that these viruses are associated with LCH.

journal_name

Am J Hematol

authors

McClain K,Jin H,Gresik V,Favara B

doi

10.1002/ajh.2830470104

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

16-20

issue

1

eissn

0361-8609

issn

1096-8652

journal_volume

47

pub_type

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