Management of cancer-associated thrombotic microangiopathy: what is the right approach?

abstract：:Clopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel-induced platelet inhibition and published literature correlates suboptimal clopidogrel response to ad...

journal_title：American journal of hematology

authors： Smock KJ,Saunders PJ,Rodgers GM,Johari V

更新日期：2011-12-01 00:00:00

abstract：:A rare beta-thalassemia mutation at the splicing junction [namely, G-->C in intervening sequence (IVS) I-1] was found in a Japanese family. The proband and his mother were heterozygous for the mutation. Analysis of mRNA extracted from the reticulocyte-rich fraction obtained from the proband's mother revealed that the ...

journal_title：American journal of hematology

authors： Fujihara N,Tozuka M,Ueno I,Yamauchi K,Nakagoshi R,Ishikawa S,Hirota M,Okumura N,Ishii E,Katsuyama T

更新日期：2003-01-01 00:00:00

abstract：:During 1971-1988, 194 adults with de novo acute myeloid leukemia (AML) received initial therapy at the University of Minnesota with an anthracycline-based regimen. Seventy-two of the 194 required further chemotherapy and received a second cycle of the same or similar therapy; 63 of these 72 were evaluable. For each ma...

journal_title：American journal of hematology

authors： Hammerschmidt DE,Crea MT

更新日期：1994-11-01 00:00:00

abstract：:Selective labeling of phagocytes in human blood can be achieved by incubation of unseparated, heparinized blood with 99mTc-sulfur colloid. We have developed a method for quantitation of granulocyte chemotaxis using granulocytes labeled by this technique. The method was found to be more accurate and less tedious to per...

journal_title：American journal of hematology

authors： English D,McPherson TA

更新日期：1977-01-01 00:00:00

abstract：:We describe a newly detected alpha-thalassemia-2 (alpha-thal-2) deletion characterized by a small -2.7-kb deletion involving the alpha 1 globin gene. This deletion has thus far been observed in only one Chinese subject with Hb H disease. ...

journal_title：American journal of hematology

authors： Zhao JB,Zhao L,Fei YJ,Liu JC,Huisman TH

更新日期：1991-11-01 00:00:00

abstract：:In order to study the influence of oxidized low-density lipoprotein (Ox-LDL) on platelet functional morphology at an early activation stage, washed human blood platelets were stimulated by 100 micrograms/ml Ox-LDL at 37 degrees C. The settling and spreading process of stimulated and unstimulated platelets on Formvar-c...

journal_title：American journal of hematology

authors： Zhao B,Rickert CH,Filler TJ,Liu B,Verhallen PF,Dierichs R

更新日期：1995-07-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

journal_title：American journal of hematology

authors： Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

更新日期：2004-08-01 00:00:00

abstract：:Acquired pure megakaryocytic aplasia is a rare disorder defined by severe thrombocytopenia with no other hematologic abnormalities and absent, or severely decreased marrow megakaryocytes. The etiology may be immune suppression of megakaryocyte development. Two patients are described who both responded rapidly to a com...

journal_title：American journal of hematology

authors： Leach JW,Hussein KK,George JN

更新日期：1999-10-01 00:00:00

abstract：:Although numerous publications have described the chromosome abnormalities in B-cell non-Hodgkin lymphoma and their significance, sparse literature exists pertaining to the chromosome abnormalities in T-cell lymphoma. We did cytogenetic analyses in 21 cases of peripheral T-cell lymphoma (PTCL). Chromosomally abnormal ...

journal_title：American journal of hematology

authors： Inwards DJ,Habermann TM,Banks PM,Colgan JP,Dewald GW

更新日期：1990-10-01 00:00:00

abstract：:Indolent non-hodgkin lymphomas (iNHL) are a rare cause of monoclonal immunoglobulin deposits-related glomerulopathy (mIgGN). In patients with iNHL-related mIgGN, whether treatment should include either single or a combination of drug(s) to target the malignant clone and renal inflammation remains elusive. In this retr...

journal_title：American journal of hematology

authors： Perry M,Delarche A,Ribes D,Vergez F,Guilbeau-Frugier C,Laurent C,Huart A,Tavitian S,El Hachem H,Oberic L,Chauveau D,Michallet AS,Ysebaert L,Faguer S

更新日期：2014-10-01 00:00:00

abstract：:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare form of Hodgkin lymphoma that typically presents as early stage, indolent disease in young adult males. The relationship between NLPHL and DLBCL is incompletely understood, and there remains a paucity of data with regard the incidence and management of ...

journal_title：American journal of hematology

authors： Eyre TA,Gatter K,Collins GP,Hall GW,Watson C,Hatton CS

更新日期：2015-06-01 00:00:00

abstract：:Phosphatidylinositol-3-kinase (PI3K) signaling plays a crucial role in oncogene-mediated tumor growth and proliferation. Buparlisib (BKM120) is an oral pan-class I PI3K inhibitor. This phase I study was conducted to determine the dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of BKM120 in patients (pts)...

journal_title：American journal of hematology

authors： Ragon BK,Kantarjian H,Jabbour E,Ravandi F,Cortes J,Borthakur G,DeBose L,Zeng Z,Schneider H,Pemmaraju N,Garcia-Manero G,Kornblau S,Wierda W,Burger J,DiNardo CD,Andreeff M,Konopleva M,Daver N

更新日期：2017-01-01 00:00:00

abstract：:A patient with chronic myelogenous leukemia (CML) had a Philadelphia chromosome (Ph') [t(9q+;22q-)] in all cells and trisomy C in 13% of cells (later determined to be trisomy 8) at the time of diagnosis. After 21 months of intermittent treatment with busulfan, the acute phase developed with the appearance of an additi...

journal_title：American journal of hematology

authors： Stern R,Sorenson J,Wurster-Hill DH,Cornwell GG 3rd,McIntyre OR

更新日期：1979-01-01 00:00:00

abstract：:Variable survival outcomes are seen following treatment for aggressive non-Hodgkin lymphoma (NHL). This study examined whether outcomes for aggressive B-cell NHL are associated with single nucleotide polymorphisms (SNPs) in oxidative stress-related genes, which can alter drug metabolism and immune responses. Genotypes...

journal_title：American journal of hematology

authors： Gustafson HL,Yao S,Goldman BH,Lee K,Spier CM,LeBlanc ML,Rimsza LM,Cerhan JR,Habermann TM,Link BK,Maurer MJ,Slager SL,Persky DO,Miller TP,Fisher RI,Ambrosone CB,Briehl MM

更新日期：2014-06-01 00:00:00

abstract：:Defects in stomatin, alpha-adducin, and beta-adducin have been implicated in erythrocyte disorders of cation permeability. We performed linkage analysis of the genetic loci for these proteins in a large kindred with xerocytosis (dehydrated hereditary stomatocytosis). Using polymerase chain reaction-based genotyping te...

journal_title：American journal of hematology

authors： Innes DS,Sinard JH,Gilligan DM,Snyder LM,Gallagher PG,Morrow JS

更新日期：1999-01-01 00:00:00

abstract：:The -117(G-->A)A gamma hereditary persistence of fetal hemoglobin (Greek HPFH) and beta zero 39-thal mutations are rather frequent in Sardinia so that their interaction is to be expected. Characterization of eight compound heterozygotes for these defects indicated that HPFH was linked to haplotype VII and beta zero 39...

journal_title：American journal of hematology

authors： Pistidda P,Frogheri L,Oggiano L,Guiso L,Manca L,Dore F,Masala B,Gilman JG,Longinotti M

更新日期：1995-08-01 00:00:00

abstract：:Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the differential diagnosis of hemolytic anemias, especially if the patient has a concomitant lymphoproliferative disorder, autoimmune disease, or viral or mycoplasmal infecti...

journal_title：American journal of hematology

authors： Gehrs BC,Friedberg RC

更新日期：2002-04-01 00:00:00

abstract：:We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and imm...

journal_title：American journal of hematology

authors： Lust JA,Banks PM,Hooper WC,Paya CV,Kueck BD,Hanson GA,Ritch PS,Woloschak GE

更新日期：1989-07-01 00:00:00

abstract：:If a translocation is followed by loss of one of the two derivative chromosomes, the result is an unbalanced translocation, showing monosomy for the segments making up the lost derivative. We have found that in most unbalanced translocations, a third event takes place: a morphologically normal copy of one of the two t...

journal_title：American journal of hematology

authors： Pedersen B,Nørgaard JM,Pedersen BB,Clausen N,Rasmussen IH,Thorling K

更新日期：2000-07-01 00:00:00

abstract：:To clarify the idea that an alteration of the transferrin receptor (TF-R) gene, localized to 3q26, may be of pathogenetic significance in hematological disorders with 3q anomaly, we studied the TF-R systems of erythroblasts from both functional and genetic aspects. The patient described here had refractory anemia with...

journal_title：American journal of hematology

authors： Abe Y,Muta K,Yufu Y,Takahira H,Nishimura J,Nawata H

更新日期：1990-03-01 00:00:00

abstract：:Autoimmune hemolytic anemia is thought to be mediated via auto-antibodies produced by lymphoid B cells. This may be an idiopathic process or secondary to an underlying infection or lymphoproliferative disorder. Conventional treatment comprises immunosuppression with corticosteroids and, in some cases, splenectomy. A p...

journal_title：American journal of hematology

authors： Ramanathan S,Koutts J,Hertzberg MS

更新日期：2005-02-01 00:00:00

abstract：:New treatments have transformed multiple myeloma into a chronic disease. Hence, optimal management of treatment and disease-related complications remains a critical component of survivorship care. Survivorship care model in cancers requiring a fixed-duration therapy may not be applicable to myeloma, since patients are...

journal_title：American journal of hematology

authors： Chakraborty R,Majhail NS

更新日期：2020-06-01 00:00:00

abstract：:Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-PlA1 antibody could not...

journal_title：American journal of hematology

authors： Keimowitz RM,Collins J,Davis K,Aster RH

更新日期：1986-01-01 00:00:00

abstract：:Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies di...

journal_title：American journal of hematology

authors： Finan RR,Tamim H,Ameen G,Sharida HE,Rashid M,Almawi WY

更新日期：2002-12-01 00:00:00

abstract：:The arachidonic acid metabolites produced by human peripheral blood monocytes were studied to determine which metabolites could have a role in thrombogenesis. Monocytes were found to be free of platelets by scanning electron microscopy and by measurement of 12-HETE. Human peripheral blood monocytes produce thromboxane...

journal_title：American journal of hematology

authors： Jones CM,Hall ER,Hester JP,Wu KK

更新日期：1989-07-01 00:00:00

abstract：DISEASE OVERVIEW:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional disease features include bone marrow stromal reaction including reticulin fibrosis, abnorm...

journal_title：American journal of hematology

authors： Tefferi A

更新日期：2018-12-01 00:00:00

abstract：:We have investigated whether the quantitative flow cytometry is an useful tool to better characterize B-cell chronic lymphoproliferative disorders (CLDs). Peripheral blood samples from 104 patients with leukemic B-cell disorders and 20 healthy donors were analyzed. Directly phycoerythrin-conjugated CD19, CD20, CD22, C...

journal_title：American journal of hematology

authors： D'Arena G,Musto P,Cascavilla N,Dell'Olio M,Di Renzo N,Carotenuto M

更新日期：2000-08-01 00:00:00

abstract：:Argatroban is a direct thrombin inhibitor approved for the treatment of heparin-induced thrombocytopenia (HIT) type II. Argatroban is predominantly metabolized in the liver. It is widely believed that no dosage adjustment is required in patients with renal insufficiency, making it a preferred agent in patients on rena...

journal_title：American journal of hematology

authors： Athar U,Husain J,Hudson J,Lynch J,Gajra A

更新日期：2008-03-01 00:00:00

abstract：:We report on 3 female patients with immunologic thrombocytopenic purpura (ITP) for whom diagnostic procedures evidenced a chronic Hepatitis C virus (HCV) infection. In 2 cases, a transfusion performed more than 10 years ago represented the probable way of contamination. One patient received a course of steroids, which...

journal_title：American journal of hematology

authors： Bauduer F,Marty F,Larrouy M,Ducout L

更新日期：1998-04-01 00:00:00

abstract：:Recent literature has demonstrated concern over the risk of Pneumocystis jirovecii pneumonia (PJP) when administering rituximab with combination chemotherapy such as in R-CHOP; however, the exact risk and potential need for prophylaxis is unknown. We sought to determine the incidence of PJP infection following R-CHOP ...

journal_title：American journal of hematology

authors： Barreto JN,Ice LL,Thompson CA,Tosh PK,Osmon DR,Dierkhising RA,Plevak MF,Limper AH

更新日期：2016-11-01 00:00:00