Prolonged half-life of argatroban in patients with renal dysfunction and antiphospholipid antibody syndrome being treated for heparin-induced thrombocytopenia.

abstract：:The incidence of multiple myeloma (MM) is known to be variable according to ethnicity. However, the differences in clinical characteristics between ethnic groups are not well-defined. In Asian countries, although the incidence of MM has been lower than that of Western countries, there is growing evidence that MM is in...

journal_title：American journal of hematology

authors： Kim K,Lee JH,Kim JS,Min CK,Yoon SS,Shimizu K,Chou T,Kosugi H,Suzuki K,Chen W,Hou J,Lu J,Huang XJ,Huang SY,Chng WJ,Tan D,Teoh G,Chim CS,Nawarawong W,Siritanaratkul N,Durie BG

更新日期：2014-07-01 00:00:00

abstract：:Forty-two patients with chronic lymphocytic leukemia (CLL) were studied for morphology of lymphocytes by light and electron microscopy (EM), in vitro responses of lymphocytes to a battery of physical and chemical agents, overall clinical status, immunologic status, course, and response to therapy. CLL lymphocytes coul...

journal_title：American journal of hematology

authors： Knospe WH,Gregory SA,Trobaugh FE Jr,Stedronsky JA,Schrek R

更新日期：1977-01-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:Solid-phase enzyme immunoassays using recombinant gag and env proteins were developed to study humoral immune responses to HIV infection in a cohort of 105 hemophiliac patients. Thirteen patients with ARC or AIDS and 92 asymptomatic patients were studied. A cross-sectional study showed a wide range of antibody respons...

journal_title：American journal of hematology

authors： Kinney JS,Conway JH,Hilgartner MW,Clayman B,Mayur K,Yolken RH,Viscidi RP

更新日期：1991-01-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised patients usually with malignant diseases. We report here a Japanese female with follicular lymphoma who subsequently developed PML. In addition to JCV, human her...

journal_title：American journal of hematology

authors： Daibata M,Hatakeyama N,Kamioka M,Nemoto Y,Hiroi M,Miyoshi I,Taguchi H

更新日期：2001-07-01 00:00:00

abstract：:ASXL1 and SRSF2 mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi-institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients with ASXL1mut SRSF2mut AML and compared o...

journal_title：American journal of hematology

authors： Richardson DR,Swoboda DM,Moore DT,Johnson SM,Chan O,Galeotti J,Esparza S,Hussaini MO,Van Deventer H,Foster MC,Coombs CC,Montgomery ND,Sallman DA,Zeidner JF

更新日期：2021-01-27 00:00:00

abstract：:Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biolog...

journal_title：American journal of hematology

authors： Roos-Weil D,Nguyen-Khac F,Bernard OA

更新日期：2016-05-01 00:00:00

abstract：:Quinine-induced immune thrombocytopenia with hemolytic uremic syndrome (HUS) is a recently defined clinical entity. In this paper we have attempted to characterize the natural history and laboratory abnormalities typical of quinine-induced immune thrombocytopenia associated with hemolytic uremic syndrome in nine patie...

journal_title：American journal of hematology

authors： Gottschall JL,Neahring B,McFarland JG,Wu GG,Weitekamp LA,Aster RH

更新日期：1994-12-01 00:00:00

abstract：:Neutrophils that bear receptors for the Fc portion of immunoglobulin G have been demonstrated to be more active in assays of adherence, aggregation, and chemotaxis compared to Fc receptor-negative cells. We examined the relationship of neutrophil Fc receptor activity and cell-cell adherence or aggregation induced by p...

journal_title：American journal of hematology

authors： Spagnuolo PJ,Fain M,Bass SN

更新日期：1987-11-01 00:00:00

abstract：:In this study, we further established the role of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-alpha (IFN-alpha) as regulators of proliferation of acute myeloid leukemia (AML) cells. AML cells from 8 of 15 patients incorporated high levels of 3H-thymidin...

journal_title：American journal of hematology

authors： Carter A,Silvian-Draxler I,Tatarsky I

更新日期：1992-08-01 00:00:00

abstract：:Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM2 has been mapped to this chromosome, we examined the possible association of MDM2 in the pathogenesis of CLL. A rearrangement of the MDM2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Sout...

journal_title：American journal of hematology

authors： Huang YQ,Raphael B,Buchbinder A,Li JJ,Zhang WG,Friedman-Kien AE

更新日期：1994-10-01 00:00:00

abstract：:The Sicilian type of (delta beta) (0)-thalassemia characterized by a approximately 13 kb deletion, was present in a Turkish boy who is a homozygote and in his heterozygous parents who are first cousins. The father with approximately 21% Hb F had five alpha-globin genes (alpha alpha/alpha alpha alpha) and the mother wi...

journal_title：American journal of hematology

authors： Oner C,Gurgey A,Altay C,Kutlar F,Huisman TH

更新日期：1990-07-01 00:00:00

abstract：:We investigated the rare case of a patient with IgGlambda multiple myeloma for whom both prothrombin time and APTT were significantly prolonged. The IgG inhibited coagulation reactions upstream from prothrombin when coagulation was initiated by mRVVT, but not by FXa, as indicated by a chromogenic substrate for FXa. Th...

journal_title：American journal of hematology

authors： Takamiya O,Machida S,Okuda M,Nojima J,Koreeda C,Kubara K

更新日期：2004-01-01 00:00:00

abstract：:It has been suggested that alterations of cell cycle genes probably contribute to the pathogenesis of endemic Burkitt's lymphoma (BL) in addition to c-MYC translocation. Mutations disrupting the normal nuclear localization signal of the retinoblastoma-related gene Rb2/p130 have been documented in BL cell lines and pri...

journal_title：American journal of hematology

authors： Klumb CE,Magluta EP,Rezende LM,Apa AG,Alonso JF,Maia RC

更新日期：2007-03-01 00:00:00

abstract：:Current information about clinical significance of IDH mutations in myelodysplastic syndromes (MDS), their association with other genetic alterations and the stability during disease progression is limited. In this study, IDH mutations were identified in 4.6% of 477 patients with MDS based on the FAB classification an...

journal_title：American journal of hematology

authors： Lin CC,Hou HA,Chou WC,Kuo YY,Liu CY,Chen CY,Lai YJ,Tseng MH,Huang CF,Chiang YC,Lee FY,Liu MC,Liu CW,Tang JL,Yao M,Huang SY,Ko BS,Wu SJ,Tsay W,Chen YC,Tien HF

更新日期：2014-02-01 00:00:00

abstract：:A common side effect of opioids is nausea and vomiting; however, the incidence in hospitalized patients receiving opioids for acute pain is unknown. We performed a retrospective study in adult patients with sickle cell disease admitted for an acute pain crisis during a six-month period to evaluate the incidence of nau...

journal_title：American journal of hematology

authors： Shord SS,Chew L,Villano J

更新日期：2008-03-01 00:00:00

abstract：:Chuvash polycythemia results from a homozygous 598C>T mutation in exon 3 of the von Hippel-Lindau (VHL) gene. This disrupts the normoxia pathway for degrading hypoxia inducible factor (HIF)-1alpha and HIF-2alpha causing altered expression of HIF-1 and HIF-2 inducible genes. As hypoxia induces expression of pro-inflamm...

journal_title：American journal of hematology

authors： Niu X,Miasnikova GY,Sergueeva AI,Polyakova LA,Okhotin DJ,Tuktanov NV,Nouraie M,Ammosova T,Nekhai S,Gordeuk VR

更新日期：2009-02-01 00:00:00

abstract：:One of the more intriguing aspects of the spleen is the protection against certain bacterial infections afforded by its unique vascular and immune function. There have been extensive clinical surveys which indicate an incidence of overwhelming postsplenectomy infection (OPSI) above that of the disease for which the sp...

journal_title：American journal of hematology

authors： Krivit W

更新日期：1977-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and is associated with a favorable prognosis. While previous studies have evaluated NPM1 in a binary fashion, we recently demonstrated a significant independent negative prognostic effect of hig...

journal_title：American journal of hematology

authors： Patel SS,Pinkus GS,Ritterhouse LL,Segal JP,Dal Cin P,Restrepo T,Harris MH,Stone RM,Hasserjian RP,Weinberg OK

更新日期：2019-08-01 00:00:00

abstract：:Patients presenting with Hodgkin's disease (HD) may show lung involvement characterized by contiguous spread from ipsilateral hilar lymph nodes. Lung consolidation or noncontiguous pulmonary involvement makes an alternative diagnosis more likely. This report describes a patient with HD in whom concurrent pulmonary bla...

journal_title：American journal of hematology

authors： Winquist EW,Walmsley SL,Berinstein NL

更新日期：1993-06-01 00:00:00

abstract：:Variation in bleeding in the perioperative period is a complex and multifactorial event associated with immediate and delayed consequences for the patient and health care resources. Little is known about the complex genetic influences on perioperative bleeding. With the discovery of multiple variations in the human ge...

journal_title：American journal of hematology

authors： Muehlschlegel JD,Body SC

更新日期：2008-09-01 00:00:00

abstract：:Nongastric marginal zone B-cell lymphoma (NG-MZL) is a relatively uncommon indolent lymphoma. From 1990 to 2005, a total of 247 patients with histologically confirmed NG-MZL were analyzed. Ann Arbor stage I/II disease was present in 78% (167 out of 215). One hundred eighty-six patients out of two hundred eight were ca...

journal_title：American journal of hematology

authors： Oh SY,Ryoo BY,Kim WS,Park YH,Kim K,Kim HJ,Kwon JM,Lee J,Ko YH,Ahn YC,Oh SJ,Lee SI,Kim HJ,Kwon HC,Bang SM,Kim JH,Park J,Lee SS,Kim HY,Park K

更新日期：2007-06-01 00:00:00

abstract：:Drug metabolizing genes are involved in the detoxification of chemical carcinogens. Polymorphisms in drug-metabolizing genes affect the risk of some forms of cancer. We analyzed six polymorphisms to evaluate their association with risk for non-Hodgkin lymphoma (NHL), and to examine whether smoking modifies these assoc...

journal_title：American journal of hematology

authors： Kim HN,Kim NY,Yu L,Kim YK,Lee IK,Yang DH,Lee JJ,Shin MH,Park KS,Choi JS,Kim HJ

更新日期：2009-12-01 00:00:00

abstract：:Withdrawal: Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective. The above article, published online on 20 August 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, t...

journal_title：American journal of hematology

authors： Cordeiro Mitchell CN,Pradhan A,Singh B,Naik RP,Baker VL,Lanzkron SM,Christianson MS,Pecker LH

更新日期：2020-08-20 00:00:00

abstract：:Patients with MM are at an increased risk for life-threatening bacterial infections, primarily by organisms that require opsonization for interaction with granulocytes. In the present study we used a neutrophil chemiluminescence (CL) assay of opsonization to explore the opsonic activity of MM-Ig for zymosan particles....

journal_title：American journal of hematology

authors： Cheson BD

更新日期：1981-12-01 00:00:00

abstract：:The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. We analyzed the association of pretreatment FLC with event-free survival (EFS) and overall su...

journal_title：American journal of hematology

authors： Thompson CA,Maurer MJ,Cerhan JR,Katzmann JA,Ansell SM,Habermann TM,Macon WR,Weiner GJ,Link BK,Witzig TE

更新日期：2011-12-01 00:00:00

abstract：:The risk of graft-rejection after allogeneic hematopoietic cell transplantation using conventional cyclophosphamide-based conditioning is increased in patients with bone marrow failure syndromes (BMFS) who are heavily transfused and often HLA-alloimmunized. Fifty-six patients with BMFS underwent fludarabine-based redu...

journal_title：American journal of hematology

authors： Pantin J,Tian X,Shah AA,Kurlander R,Ramos C,Cook L,Khuu H,Stroncek D,Leitman S,Barrett J,Donohue T,Young NS,Geller N,Childs RW

更新日期：2013-10-01 00:00:00

abstract：:Granulysin is a newly identified CTL/NK cell-related cytotoxic protein, which is secreted in both constitutive and Ca-dependent manner. To evaluate its significance in stem-cell transplantation (SCT), serum granulysin was measured by newly established ELISA method in 26 patients undergoing SCT (21 allogeneic and 5 aut...

journal_title：American journal of hematology

authors： Nagasawa M,Isoda T,Itoh S,Kajiwara M,Morio T,Shimizu N,Ogawa K,Nagata K,Nakamura M,Mizutani S

更新日期：2006-05-01 00:00:00

abstract：:In order to assess the functional property of neonatal polymorphonuclear leukocytes (PMNs), we studied their chemoattractant-stimulated superoxide anion (O2-) production using a soluble chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) as a PMN stimulus. O2- production by neonatal PMNs was increased: ...

journal_title：American journal of hematology

authors： Yamazaki M,Matsuoka T,Yasui K,Komiyama A,Akabane T

更新日期：1988-03-01 00:00:00

abstract：:The objective of this case-matched study was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma. Data from 72 patients treated at the New York Presbyterian Hospital-Cornel...

journal_title：American journal of hematology

authors： Gay F,Rajkumar SV,Coleman M,Kumar S,Mark T,Dispenzieri A,Pearse R,Gertz MA,Leonard J,Lacy MQ,Chen-Kiang S,Roy V,Jayabalan DS,Lust JA,Witzig TE,Fonseca R,Kyle RA,Greipp PR,Stewart AK,Niesvizky R

更新日期：2010-09-01 00:00:00