Abstract:
:Granulysin is a newly identified CTL/NK cell-related cytotoxic protein, which is secreted in both constitutive and Ca-dependent manner. To evaluate its significance in stem-cell transplantation (SCT), serum granulysin was measured by newly established ELISA method in 26 patients undergoing SCT (21 allogeneic and 5 autologous). In the allogeneic SCT, granulysin was transiently increased in 3 weeks, which was not observed in autologous SCT. In acute GVHD, serum granulysin was markedly increased and correlated with the severity of GVHD. Elevation of granulysin was not necessarily associated with increase of sIL2R or IFN-gamma. In vitro, allospecific T cells released granulysin in an allo-specific manner, and it was correlated with allo-specific cytotoxic activity. These results indicate that increased release of granulysin presents alloreactivity and serum granulysin is useful as a marker of GVHD in SCT.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Nagasawa M,Isoda T,Itoh S,Kajiwara M,Morio T,Shimizu N,Ogawa K,Nagata K,Nakamura M,Mizutani Sdoi
10.1002/ajh.20570subject
Has Abstractpub_date
2006-05-01 00:00:00pages
340-8issue
5eissn
0361-8609issn
1096-8652journal_volume
81pub_type
杂志文章abstract::We studied the calmodulin-like activity (CaM) level in hemolyzed samples of whole blood after determining the percentage and absolute number of reticulocytes present. Twenty-six samples from 25 people with a range of reticulocyte counts were studied. CaM levels correlated with the percentage (r = 0.63, P less than .01...
journal_title:American journal of hematology
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