Abstract:
:One of the more intriguing aspects of the spleen is the protection against certain bacterial infections afforded by its unique vascular and immune function. There have been extensive clinical surveys which indicate an incidence of overwhelming postsplenectomy infection (OPSI) above that of the disease for which the splenectomy was done. In the absence of the spleen, either congenital or subsequent to surgical removal, this overwhelming sepsis has a 50% case fatality rate. The most common infective organism has been Diplococcus (tstreptococcus) pneumoniae (D. pneumoniae). Intensive investigations indicated loss of phagocytic function of the spleen, depression of serum IgM levels, a possible suppression of the lymphocyte responsiveness, and changes in opsonin-alternative complement system as potential causes of OPSI. Preventive measures against OPSI include trials of prophylactic Phenoxymethyl Penicillin (penicillin) and pneumococcal vaccine.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Krivit Wdoi
10.1002/ajh.2830020210subject
Has Abstractpub_date
1977-01-01 00:00:00pages
193-201issue
2eissn
0361-8609issn
1096-8652journal_volume
2pub_type
杂志文章abstract::We present a case of chronic tonsillitis in a patient with chronic lymphocytic leukemia. Despite empiric radiation and antibiotic therapy, the patient's sore throat and tonsillar enlargement persisted. Excisional biopsy of the involved tonsil revealed the presence of Cryptococcus neoformans. Blood cultures also yielde...
journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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pub_type: 临床试验,信件
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journal_title:American journal of hematology
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更新日期:1994-02-01 00:00:00
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
pub_type: 杂志文章,多中心研究
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