Abstract:
:A patient with chronic myelogenous leukemia (CML) had a Philadelphia chromosome (Ph') [t(9q+;22q-)] in all cells and trisomy C in 13% of cells (later determined to be trisomy 8) at the time of diagnosis. After 21 months of intermittent treatment with busulfan, the acute phase developed with the appearance of an additional abnormality (trisomy ? 19). During a complete remission and reconversion to the chronic phase, trisomies 8 and ? 19 DISAPPEARed, although the Ph' remained. Following a period of marked thrombocytosis, a second relapse occurred with the reappearance of both marker chromosomes.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Stern R,Sorenson J,Wurster-Hill DH,Cornwell GG 3rd,McIntyre ORdoi
10.1002/ajh.2830060208subject
Has Abstractpub_date
1979-01-01 00:00:00pages
155-61issue
2eissn
0361-8609issn
1096-8652journal_volume
6pub_type
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