Modulation of monocyte Mo2 surface antigen expression by exposure to respiratory syncytial virus.

Abstract:

:The Mo2 antibody recognizes a monocyte-specific cell surface antigen of unknown function. Upward modulation of Mo2 surface epitope density was demonstrated in response to 72-hr culture of monocytes with respiratory syncytial virus (RSV), but this was not seen after culture with phytohemagglutinin or other respiratory viruses. Monoclonal antibody probes for RSV proteins were used to demonstrate probable replication of RSV proteins in peripheral blood monocytes and pulmonary alveolar macrophages. These data provide possible clues to the biologic role of the Mo2 antigen.

journal_name

Am J Hematol

authors

Baumann MA,Paul CC,Stokes C,Bernstein JM

doi

10.1002/ajh.2830250314

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

337-40

issue

3

eissn

0361-8609

issn

1096-8652

journal_volume

25

pub_type

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