Exclusion of the stomatin, alpha-adducin and beta-adducin loci in a large kindred with dehydrated hereditary stomatocytosis.

abstract：:Clinical management of lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) has changed considerably over recent years, reflected in the use of new therapeutic agents (purine analogs, monoclonal antibodies, thalidomide- and bortezomib-based therapies). No population-based studies and few randomized tria...

journal_title：American journal of hematology

authors： Kristinsson SY,Eloranta S,Dickman PW,Andersson TM,Turesson I,Landgren O,Björkholm M

更新日期：2013-01-01 00:00:00

abstract：:We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

journal_title：American journal of hematology

authors： Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

更新日期：2000-01-01 00:00:00

abstract：:Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIF...

journal_title：American journal of hematology

authors： Andersen CL,Siersma VD,Hasselbalch HC,Lindegaard H,Vestergaard H,Felding P,de Fine Olivarius N,Bjerrum OW

更新日期：2013-10-01 00:00:00

abstract：:Quinine-induced immune thrombocytopenia with hemolytic uremic syndrome (HUS) is a recently defined clinical entity. In this paper we have attempted to characterize the natural history and laboratory abnormalities typical of quinine-induced immune thrombocytopenia associated with hemolytic uremic syndrome in nine patie...

journal_title：American journal of hematology

authors： Gottschall JL,Neahring B,McFarland JG,Wu GG,Weitekamp LA,Aster RH

更新日期：1994-12-01 00:00:00

abstract：:Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies di...

journal_title：American journal of hematology

authors： Finan RR,Tamim H,Ameen G,Sharida HE,Rashid M,Almawi WY

更新日期：2002-12-01 00:00:00

abstract：:We report on the association of Hb Dunn (alpha 6[A4]Asp----Asn) and Hb O-Arab (beta 121 [GH4]Glu----Lys) in a healthy Moroccan man. Hb Dunn had the same electrophoretic properties as Hb G-Philadelphia, but its percentage was lower. Its identification was based on sequence determination of the alpha T1 peptide. Bgl II ...

journal_title：American journal of hematology

authors： Baklouti F,Francina A,Dorléac E,Baudin-Chich V,Gombaud-Saintonge G,Plauchu H,Wajcman H,Delaunay J,Godet J

更新日期：1988-04-01 00:00:00

abstract：:Extensive extralymphatic Hodgkin disease developed in a young man with common variable immunodeficiency manifested by hypogammaglobulinemia, recurrent sinopulmonary infections, and multiple autoimmune phenomena. Both humoral and cell-mediated immune dysfunction were present prior to treatment. After two cycles of chem...

journal_title：American journal of hematology

authors： Fesus SM,Hagemeister FB,Manning J

更新日期：1989-10-01 00:00:00

abstract：:Genetic modifiers contribute to phenotypic variability in patients with sickle cell anemia (SCA). The influence of the bilirubin UDP-glucuronosyltransferase (UGT) 1A1 (TA)(n)TAA promoter polymorphism on bilirubin levels and gallbladder disease in SCA was examined using prospectively collected data from the Cooperative...

journal_title：American journal of hematology

authors： Carpenter SL,Lieff S,Howard TA,Eggleston B,Ware RE

更新日期：2008-10-01 00:00:00

abstract：:There is a high prevalence of thalassemia in the Taiwan area. Prenatal diagnosis of severe forms of thalassemia is important for the prevention of this disease. We performed prenatal diagnosis in 167 cases, of which 59 cases were diagnosed by chorionic villi biopsy, 91 cases by amniotic fluid analysis, and 17 cases by...

journal_title：American journal of hematology

authors： Liu TC,Lin SF,Yang TY,Lee JP,Chen TP,Chang JG

更新日期：1997-06-01 00:00:00

abstract：:Secondary leukaemia following treatment of M3 acute promyelocytic leukaemia (APL) is a rare event. We describe a patient in remission following chemotherapy for APL who relapsed with M2 acute non-lymphoblastic leukaemia (ANLL). The original t(15;17) (q22;q21) chromosome translocation was lost and replaced by a clone c...

journal_title：American journal of hematology

authors： Hatzis T,Standen GR,Howell RT,Savill C,Wagstaff M,Scott GL

更新日期：1995-01-01 00:00:00

abstract：:Hb Saint Nazaire [beta 103 (G5) Phe-->Ile] was found in four apparently unrelated French families. The five patients carrying this hemoglobin have been detected because of a moderate erythrocytosis. The structural abnormality of Hb Saint Nazaire concerns the same residue as in Hb Heathrow [beta 103 (G5) Phe-->Leu). A ...

journal_title：American journal of hematology

authors： Wajcman H,Kister J,M'Rad A,Promé D,Milpied N,Rapp MJ,Harousseau JL,Riou J,Bardakdjian J,Galacteros F

更新日期：1993-09-01 00:00:00

abstract：:Cytotoxic agents like Hydroxyurea, Busulfan and Interferon-alpha are to date the most commonly used therapeutic approaches in Essential Thrombocythemia (ET). However, few data on the efficacy and safety of these agents in the long-term are currently available. We report a retrospective analysis of the long-term outcom...

journal_title：American journal of hematology

authors： Palandri F,Catani L,Testoni N,Ottaviani E,Polverelli N,Fiacchini M,De Vivo A,Salmi F,Lucchesi A,Baccarani M,Vianelli N

更新日期：2009-04-01 00:00:00

abstract：:Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell facto...

journal_title：American journal of hematology

authors： Pullarkat VA,Pullarkat ST,Calverley DC,Brynes RK

更新日期：2000-12-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 14. At day 5 marrow ...

journal_title：American journal of hematology

authors： Dale DC,Liles WC,Llewellyn C,Price TH

更新日期：1998-01-01 00:00:00

abstract：:In this study, we further established the role of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-alpha (IFN-alpha) as regulators of proliferation of acute myeloid leukemia (AML) cells. AML cells from 8 of 15 patients incorporated high levels of 3H-thymidin...

journal_title：American journal of hematology

authors： Carter A,Silvian-Draxler I,Tatarsky I

更新日期：1992-08-01 00:00:00

abstract：:We report the long-term follow-up results of a phase II trial of thalidomide for early-stage multiple myeloma (MM). Patients were eligible if they had smoldering multiple myeloma (SMM) or indolent MM without the need for immediate therapy. Thalidomide was initiated at a dose of 200 mg/day and adjusted as tolerated. Di...

journal_title：American journal of hematology

authors： Detweiler-Short K,Hayman S,Gertz MA,Lacy MQ,Dispenzieri A,Kumar S,Zeldenrust SR,Russell SJ,Lust JA,Kyle RA,Greipp PR,Witzig TE,Vincent Rajkumar S

更新日期：2010-10-01 00:00:00

abstract：:A single-tube osmotic fragility test has been proposed for thalassemia screening with a range of different concentrations of saline having been employed. We have compared the sensitivity and specificity of 0.32%, 0.34%, and 0.36% buffered saline, and on the basis of our findings, recommend the use of 0.36% saline. Thi...

journal_title：American journal of hematology

authors： Chow J,Phelan L,Bain BJ

更新日期：2005-07-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative option for primary hemophagocytic lymphohistiocytosis (HLH), a rare disease of infants and young children, characterized by recurrent fever, hepatosplenomegaly, and cytopenia. We report a case of successful engraftment and stable fu...

journal_title：American journal of hematology

authors： Cesaro S,Gazzola MV,Marson P,Calore E,Caenazzo L,Destro R,De Silvestro G,Varotto S,Pillon M,Zanesco L,Messina C

更新日期：2003-02-01 00:00:00

abstract：:Chronic transfusion therapy is the treatment of choice for preventing stroke recurrence in children with sickle cell disease (SCD). The majority of children affected by this devastating complication live in the developing world where access to regular blood transfusions may be impractical. Since 2000, in the absence o...

journal_title：American journal of hematology

authors： Ali SB,Moosang M,King L,Knight-Madden J,Reid M

更新日期：2011-10-01 00:00:00

abstract：:The incidence of multiple myeloma (MM) is known to be variable according to ethnicity. However, the differences in clinical characteristics between ethnic groups are not well-defined. In Asian countries, although the incidence of MM has been lower than that of Western countries, there is growing evidence that MM is in...

journal_title：American journal of hematology

authors： Kim K,Lee JH,Kim JS,Min CK,Yoon SS,Shimizu K,Chou T,Kosugi H,Suzuki K,Chen W,Hou J,Lu J,Huang XJ,Huang SY,Chng WJ,Tan D,Teoh G,Chim CS,Nawarawong W,Siritanaratkul N,Durie BG

更新日期：2014-07-01 00:00:00

abstract：:The incidence of drug-induced neutropenia has not changed in the western hemisphere over the last 30 years. Yet, the drug panorama has changed considerably. This implies that host factors may play an intriguing role for this idiosyncratic reaction. The knowledge as to mechanisms for the reaction has advanced with emer...

journal_title：American journal of hematology

authors： Tesfa D,Keisu M,Palmblad J

更新日期：2009-07-01 00:00:00

abstract：:A preclinical study demonstrated anti-proliferative and apoptotic effect of propranolol on multiple myeloma (MM) cell. Clinical studies suggested that beta-blocker (BB) might impact the prognosis of breast, prostate, colorectal, ovarian, lung, and skin cancer. This retrospective study evaluated the effect of BB in MM ...

journal_title：American journal of hematology

authors： Hwa YL,Shi Q,Kumar SK,Lacy MQ,Gertz MA,Kapoor P,Buadi FK,Leung N,Dingli D,Go RS,Hayman SR,Gonsalves WI,Russell S,Lust JA,Lin Y,Rajkumar SV,Dispenzieri A

更新日期：2017-01-01 00:00:00

abstract：:In order to study the influence of oxidized low-density lipoprotein (Ox-LDL) on platelet functional morphology at an early activation stage, washed human blood platelets were stimulated by 100 micrograms/ml Ox-LDL at 37 degrees C. The settling and spreading process of stimulated and unstimulated platelets on Formvar-c...

journal_title：American journal of hematology

authors： Zhao B,Rickert CH,Filler TJ,Liu B,Verhallen PF,Dierichs R

更新日期：1995-07-01 00:00:00

abstract：:Anemia is a major cause of morbidity and mortality among patients with sickle cell anemia. In this study, 108 episodes of severe anemia were prospectively evaluated in 108 patients with hemoglobin SS disease attending the pediatric sickle cell clinic of the University of Nigeria Teaching Hospital, Enugu, Nigeria. Youn...

journal_title：American journal of hematology

authors： Juwah AI,Nlemadim A,Kaine W

更新日期：2003-03-01 00:00:00

abstract：:We evaluated T-lymphocyte functions in the peripheral blood of a patient with B-cell chronic lymphocytic leukemia after transformation to large cell lymphoma (Richter's syndrome). A subpopulation of E-rosette adherent cells were found with T-lymphocytic surface markers (OKT3+/8+/4+), monocytic characteristics (latex i...

journal_title：American journal of hematology

authors： Lahat N,Aghai E,Quitt M,Nir E,Froom P

更新日期：1985-11-01 00:00:00

abstract：:We studied the calmodulin-like activity (CaM) level in hemolyzed samples of whole blood after determining the percentage and absolute number of reticulocytes present. Twenty-six samples from 25 people with a range of reticulocyte counts were studied. CaM levels correlated with the percentage (r = 0.63, P less than .01...

journal_title：American journal of hematology

authors： Warth JA,Brewer GJ,Gnegy ME,Treisman G,Near K

更新日期：1983-09-01 00:00:00

abstract：:Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

journal_title：American journal of hematology

authors： Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

更新日期：1986-06-01 00:00:00

abstract：:Iron studies were compared in 434 patients from 80 hemochromatosis families classified as putative homozygotes, heterozygotes, and normal by HLA typing. There were 28 of 255 (11%) heterozygotes with an elevated serum ferritin and 22 of 255 (8.6%) with an elevated transferrin saturation. Serum ferritin (140 +/- 10.2 mi...

journal_title：American journal of hematology

authors： Adams PC

更新日期：1994-02-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised patients usually with malignant diseases. We report here a Japanese female with follicular lymphoma who subsequently developed PML. In addition to JCV, human her...

journal_title：American journal of hematology

authors： Daibata M,Hatakeyama N,Kamioka M,Nemoto Y,Hiroi M,Miyoshi I,Taguchi H

更新日期：2001-07-01 00:00:00

abstract：:The acute sickle cell painful episode is the most common cause of hospitalization of patients with sickle cell anemia. Its detailed clinical features and peri-discharge features are not well known. In order to determine the actual pattern of hospital admissions of patients with SS and the causes of frequent hospital r...

journal_title：American journal of hematology

authors： Ballas SK,Lusardi M

更新日期：2005-05-01 00:00:00