Abstract:
:Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy, and thus investigation of the underlying disease is necessary. We describe a patient with prolonged fever, HPS, and chromosomal abnormalities in the bone marrow who underwent thorough evaluation for the cause of his symptoms. A final diagnosis of acute lymphoblastic leukemia (ALL) was established in a fourth, repeated bone marrow biopsy performed more than 2 months after the first presenting symptom appeared. This unusual case demonstrates the importance of cytogenetic abnormalities found in cases of HPS and the importance of repeated testing when an underlying disease is suspected.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel Odoi
10.1002/ajh.20123keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
364-7issue
4eissn
0361-8609issn
1096-8652journal_volume
76pub_type
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:2015-08-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:American journal of hematology
pub_type:
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更新日期:2012-02-01 00:00:00
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pub_type: 临床试验,信件
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pub_type: 临床试验,杂志文章
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abstract::Antithrombin III (AT III) was isolated by two procedures using polyethylene glycol-400 (PEG) precipitation as the first stage. The PEG supernatant (PEG-sup) was applied to a heparin-affinity chromatographic system and AT III-heparin cofactor (AT III-HCF) was isolated. The PEG precipitate (PEG-ppt) was separated by a S...
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更新日期:1983-08-01 00:00:00