Disturbance of plasma and platelet thrombospondin levels in sickle cell disease.

abstract：:Fifty-nine HIV-1 antibody positive and 58 antibody negative hemophiliacs were evaluated over a 2 year study period to gain insight into the natural history and prognosis of HIV-1 disease in members of this risk group. Mean CD4 (Leu 3+) cell counts calculated at 6 month intervals decreased gradually in seropositive pat...

journal_title：American journal of hematology

authors： Teitel JM,Freedman JJ,Garvey MB,Kardish M

更新日期：1989-12-01 00:00:00

abstract：:Immunologic studies were performed on mononuclear cells from ten chronically transfused children with sickle cell disease, and the results were compared with those from five other groups: 21 sickle cell patients who were not receiving regular transfusions, 6 chronically transfused children with other forms of refracto...

journal_title：American journal of hematology

authors： Wang W,Herrod H,Presbury G,Wilimas J

更新日期：1985-09-01 00:00:00

abstract：:A 74-year old woman with Ph1-negative chronic myelogenous leukemia (CML) and heterozygous for glucose-6-phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that P...

journal_title：American journal of hematology

authors： Kaye FJ,Najfeld V,Singer J,Cuttner J,Fialkow PJ

更新日期：1984-07-01 00:00:00

abstract：:A single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified products of immunoglobulin (Ig) heavy chain rearrangements can be used to analyze B cell clonalities and clonal identities of B cells from different samples. However, the usefulness of the PCR-SSCP analysis is not fu...

journal_title：American journal of hematology

authors： Shiokawa S,Nishimura J,Uike N,Saburi Y,Suehiro T,Yamamoto K

更新日期：1999-10-01 00:00:00

abstract：:A 17-year-old male with bilineal hybrid acute leukemia is described. Two-color flow cytometric analysis of blast surface phenotype revealed that there were two groups of blasts which showed either CD 10+ CD 19+ CD 13- CD 33- or CD 10- CD 19- CD 13+ CD 33+, but not both. He developed a complete remission by treatment w...

journal_title：American journal of hematology

authors： Jinnai I,Kusumoto S,Shiomi Z,Bessho M,Saitoh M,Hirashima K,Minamihisamatsu M,Kamiyama T,Takase K

更新日期：1990-10-01 00:00:00

abstract：:National AIDS surveillance suggests that approximately 3.5% of all hemophilic patients in the United States have developed AIDS as of February 1988; however, the cumulative incidence of AIDS among seropositive patients at individual hemophilia treatment centers (HTCs) has been reported to be as high as 12%. The purpos...

journal_title：American journal of hematology

authors： Stehr-Green JK,Jason JM,Evatt BL

更新日期：1989-11-01 00:00:00

abstract：:A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

journal_title：American journal of hematology

authors： Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

更新日期：1983-02-01 00:00:00

abstract：:The role of leukapheresis was explored in the management of anaemia and thrombocytopenia complicating the accumulation of lymphoid cells in patients with chronic lymphocytic leukaemia and lymphoma. The aim of this study was to determine the efficiency of this procedure in correcting these complicating features and to ...

journal_title：American journal of hematology

authors： Cooper IA,Ding JC,Adams PB,Quinn MA,Brettell M

更新日期：1979-01-01 00:00:00

abstract：:Nucleotide sequence analysis of the 5' beta-globin gene flanking region has been carried out for numerous homozygous beta-thalassemia patients with different mutations and of various ethnic backgrounds. Four different rearrangements were found associated with numerous beta-thalassemia mutations. The (AT)X(T)Y repeat m...

journal_title：American journal of hematology

authors： Dimovski AJ,Adekile AD,Divoky V,Baysal E,Huisman TH

更新日期：1994-01-01 00:00:00

abstract：:Comparison of the chromosome findings obtained on routine examination (10-50 cells) of the marrows from patients with Ph1-positive CML with those based on a large number (110-500 cells) of metaphases in six of these patients, in whom appropriate material was available, revealed the presence of small percentages of ane...

journal_title：American journal of hematology

authors： Sonta SI,Sandberg AA

更新日期：1977-01-01 00:00:00

abstract：:Alpha-hemoglobin stabilizing protein (AHSP) is a potential modifier of beta-thalassemia by virtue of its ability to detoxify excess free alpha-globin. However, examination of patients with beta-thalassemia from a few geographic regions failed to identify obvious AHSP mutations. We extended these studies by analyzing A...

journal_title：American journal of hematology

authors： dos Santos CO,Zhou S,Secolin R,Wang X,Cunha AF,Higgs DR,Kwiatkowski JL,Thein SL,Gallagher PG,Costa FF,Weiss MJ

更新日期：2008-02-01 00:00:00

abstract：:We have investigated whether the quantitative flow cytometry is an useful tool to better characterize B-cell chronic lymphoproliferative disorders (CLDs). Peripheral blood samples from 104 patients with leukemic B-cell disorders and 20 healthy donors were analyzed. Directly phycoerythrin-conjugated CD19, CD20, CD22, C...

journal_title：American journal of hematology

authors： D'Arena G,Musto P,Cascavilla N,Dell'Olio M,Di Renzo N,Carotenuto M

更新日期：2000-08-01 00:00:00

abstract：:We have developed a rapid approach to detect the two most common alpha-thalassemia-2 (alpha-thal-2) determinants by the polymerase chain reaction (PCR) technique, which takes a few hours to complete. Specific oligonucleotides selectively amplify appropriate segments of the chromosome with the deletion and the normal c...

journal_title：American journal of hematology

authors： Baysal E,Huisman TH

更新日期：1994-07-01 00:00:00

abstract：:Newly identified iron binding proteins isolated from rat duodenal homogenates permit better understanding of iron absorption. Mucins bind iron at acid pH to keep iron soluble and available for absorption at the more alkaline pH of the duodenum; this explains iron deficiency following prolonged achlorhydria. Integrin (...

journal_title：American journal of hematology

authors： Conrad ME,Umbreit JN

更新日期：1993-01-01 00:00:00

abstract：:To clarify the presentation and course of patients with chronic lymphocytic leukemia (CLL) and amyloidosis. Mayo databases were interrogated for patients who carried a diagnosis of amyloidosis and CLL evaluated at Mayo Clinic, Rochester from January 1974 to October 2012. Charts were abstracted and data analyzed. Of th...

journal_title：American journal of hematology

authors： Kourelis TV,Gertz M,Zent C,Lacy M,Kyle R,Kapoor P,Zeldenrust S,Buadi F,Witzig T,Hayman S,Lust J,Russell S,Lin Y,Rajkumar VS,Kumar S,Leung N,Dingli D,Dispenzieri A

更新日期：2013-05-01 00:00:00

abstract：:Arsenic trioxide (As(2)O(3)) has been found effective in the treatment in the treatment of acute promyelocytic leukemia (APML). Most studies with As(2)O(3) involve patients with APML who have relapsed following standard therapy. Between January 1998 and July 2000, 14 patients were recruited for an ongoing trial of As(...

journal_title：American journal of hematology

authors： Mathews V,Balasubramanian P,Shaji RV,George B,Chandy M,Srivastava A

更新日期：2002-08-01 00:00:00

abstract：:Extensive extralymphatic Hodgkin disease developed in a young man with common variable immunodeficiency manifested by hypogammaglobulinemia, recurrent sinopulmonary infections, and multiple autoimmune phenomena. Both humoral and cell-mediated immune dysfunction were present prior to treatment. After two cycles of chem...

journal_title：American journal of hematology

authors： Fesus SM,Hagemeister FB,Manning J

更新日期：1989-10-01 00:00:00

abstract：:In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk Myelodysplastic Syndromes (MDS) patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytoge...

journal_title：American journal of hematology

authors： Papageorgiou SG,Vasilatou D,Kontos CK,Kotsianidis I,Symeonidis A,Galanopoulos AG,Hatzimichael E,Megalakaki A,Poulakidas E,Diamantopoulos P,Vassilakopoulos TP,Zikos P,Papadaki H,Mparmparousi D,Bouronikou E,Panayiotidis P,V

更新日期：2018-07-01 00:00:00

abstract：:In a phase II trial, we evaluated chlorambucil and rituximab (CLB-R) as first-line induction treatment with or without R as maintenance for elderly chronic lymphocytic leukemia (CLL) patients. Treatment consisted of eight 28-day cycles of CLB (8 mg/m(2) /day, days 1-7) and R (day 1 of cycle 3, 375 mg/m(2) ; cycles 4-8...

journal_title：American journal of hematology

authors： Foà R,Del Giudice I,Cuneo A,Del Poeta G,Ciolli S,Di Raimondo F,Lauria F,Cencini E,Rigolin GM,Cortelezzi A,Nobile F,Callea V,Brugiatelli M,Massaia M,Molica S,Trentin L,Rizzi R,Specchia G,Di Serio F,Orsucci L,Ambros

更新日期：2014-05-01 00:00:00

abstract：:Sickle cell (SS) disease is a complex of various genetic conditions. In some, homozygosity for the beta S gene may be present alone or in combination with the heterozygous or homozygous alpha-thalassemia-2 condition. Such combinations might ameliorate the clinical and hematological condition of the patient. The same m...

journal_title：American journal of hematology

authors： Huisman TH

更新日期：1979-01-01 00:00:00

abstract：:Evaluation of pharmacologic agents that stimulate fetal hemoglobin production has been done mainly in baboons and macaques. We investigated whether results in transgenic mice can predict the stimulation of fetal hemoglobin in primates, by testing gamma globin induction in response to a new ribonucleotide reductase inh...

journal_title：American journal of hematology

authors： Pace BS,Elford HL,Stamatoyannopoulos G

更新日期：1994-02-01 00:00:00

abstract：:Single agents have demonstrated activity in relapsed and refractory (R/R) peripheral T-cell lymphoma (PTCL). Their benefit relative to combination chemotherapy remains undefined. Patients with histologically confirmed PTCL were enrolled in the Comprehensive Oncology Measures for Peripheral T-cell Lymphoma Treatment (C...

journal_title：American journal of hematology

authors： Stuver RN,Khan N,Schwartz M,Acosta M,Federico M,Gisselbrecht C,Horwitz SM,Lansigan F,Pinter-Brown LC,Pro B,Shustov AR,Foss FM,Jain S

更新日期：2019-06-01 00:00:00

abstract：:Acquired α-thalassemia myelodysplastic syndrome (MDS) (ATMDS) is an acquired syndrome characterized by a somatic point mutation or splicing defect in the ATRX gene in patients with myeloid disorders, primarily MDS. In a large MDS patient series, the incidence of ATMDS was below 0.5%. But no large series has yet assess...

journal_title：American journal of hematology

authors： Herbaux C,Duployez N,Badens C,Poret N,Gardin C,Decamp M,Eclache V,Daliphard S,Murati A,Cony-Makhoul P,Cheze S,Beve B,Lacoste C,Prebet T,Hunault-Berger M,Maloisel F,Renneville A,Figeac M,Stamatoullas-Bastard A,Bastar

更新日期：2015-08-01 00:00:00

abstract：:The FAB classification of myelodysplastic syndromes (MDS) has been useful in predicting prognosis; however, additional methods are required to detect patients at high risk for early conversion to acute nonlymphoblastic leukemia (ANLL). Using a panel of monoclonal antibodies to myelomonocytic surface antigens (MMSA) an...

journal_title：American journal of hematology

authors： Mittelman M,Karcher DS,Kammerman LA,Lessin LS

更新日期：1993-07-01 00:00:00

abstract：:A preclinical study demonstrated anti-proliferative and apoptotic effect of propranolol on multiple myeloma (MM) cell. Clinical studies suggested that beta-blocker (BB) might impact the prognosis of breast, prostate, colorectal, ovarian, lung, and skin cancer. This retrospective study evaluated the effect of BB in MM ...

journal_title：American journal of hematology

authors： Hwa YL,Shi Q,Kumar SK,Lacy MQ,Gertz MA,Kapoor P,Buadi FK,Leung N,Dingli D,Go RS,Hayman SR,Gonsalves WI,Russell S,Lust JA,Lin Y,Rajkumar SV,Dispenzieri A

更新日期：2017-01-01 00:00:00

abstract：:We measured the plasma level of fibrinogen in 560 patients with disseminated intravascular coagulation (DIC) and evaluated its relationship with outcome and with other hemostatic markers. Forty-seven percent of patients had >200 mg/dL of plasma fibrinogen and 24% had <100 mg/dl of plasma fibrinogen, suggesting that pl...

journal_title：American journal of hematology

authors： Wada H,Mori Y,Okabayashi K,Gabazza EC,Kushiya F,Watanabe M,Nishikawa M,Shiku H,Nobori T

更新日期：2003-01-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recru...

journal_title：American journal of hematology

authors： Cui L,Li ZG,Chai YH,Yu J,Gao J,Zhu XF,Jin RM,Shi XD,Zhang LP,Gao YJ,Zhang RD,Zheng HY,Hu SY,Cui YH,Zhu YP,Zou Y,Ng MHL,Xiao Y,Li JH,Zhang YH,He HL,Xian Y,Wang TY,Li CK,Wu MY,Chinese Children Leukemia Gro

更新日期：2018-07-01 00:00:00

abstract：:The levels of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), lactic dehydrogenase (LDH), and LDH isoenzyme patterns (LD1 to LD5) have been measured in lymphocyte extract from 28 patients with B-chronic lymphocytic leukemia (B-CLL). The activities of ADA, PNP, and LDH have been correlated with two mo...

journal_title：American journal of hematology

authors： Vives Corrons JL,Rozman C,Pujades MA,Colomer D,Perez Vila E,Anegon I,Gallart T,Vives Puiggrós J,Viñolas N,Montserrat E

更新日期：1988-03-01 00:00:00

abstract：:Substantial evidence exists indicating T cell abnormalities in chronic lymphocytic leukemia (CLL). There is also evidence that the T cell is an important source of burst promoting activity (BPA) for the peripheral blood (PB) erythroid burst forming unit (BFU-e). We studied the BPA of T cells and response of BFU-e in n...

journal_title：American journal of hematology

authors： Socinski MA,Ershler WB

更新日期：1984-02-01 00:00:00

abstract：:We present a case of acquired von Willebrand syndrome (AVWS) due to a monoclonal gammopathy of undetermined significance. Initially this case was diagnosed as congenital von Willebrand disease (VWD); however, re-examination of the medical history rendered a congenital bleeding disorder unlikely. A normal plasma von Wi...

journal_title：American journal of hematology

authors： Eikenboom JC,Tjernberg P,Van Marion V,Heering KJ

更新日期：2007-01-01 00:00:00