Synthesis of the minor fetal hemoglobin Fic in colonies of erythropoietic precursors isolated from human umbilical cord blood.

Abstract:

:The biosynthesis of the minor hemoglobin FIc, which contains acetylated gamma chains, and the major hemoglobin Fo was studied during erythroid cell differentiation and maturation in cultures of erythroid precursors isolated from five human umbilical cord blood samples. A gradual decrease in the synthesis of Hb FIc was observed during the maturation of the erythroid cells when cultured from 7 to 15 days. The synthesis of Hb Fo did not show a consistent change; however, the relative synthesis of Hb FIc was the highest in the 7-day-old colonies and decreased at day 15 to levels observed in the reticulocytes. The addition of sodium butyrate, which is known to promote histone acetylation, significantly increased the synthesis of Hb FIc in 7-day-old colonies.

journal_name

Am J Hematol

authors

Abraham EC,Reese AL,Stallings M,Abraham A,Garbutt GJ,Huisman TH

doi

10.1002/ajh.2830120302

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

207-13

issue

3

eissn

0361-8609

issn

1096-8652

journal_volume

12

pub_type

杂志文章
  • Rituximab in combination with chemotherapy versus chemotherapy alone in HIV-associated non-Hodgkin lymphoma: a pooled analysis of 15 prospective studies.

    abstract::In HIV-positive patients with non-Hodgkin lymphoma (NHL), no benefit of adding rituximab to chemotherapy was seen in a randomized controlled trial (RCT). We performed a meta-analysis of prospective studies to ascertain outcomes in HIV-positive NHL patients treated with chemotherapy (chemo) versus rituximab and chemo (...

    journal_title:American journal of hematology

    pub_type: 杂志文章,meta分析

    doi:10.1002/ajh.22275

    authors: Castillo JJ,Echenique IA

    更新日期:2012-03-01 00:00:00

  • Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs.

    abstract::Ten patients developing lymphomas after disease modifying anti-rheumatic drugs (DMARD) (methotrexate, n = 3, mean cumulative dose = 3.4 g; cyclophosphamide, n = 2, mean dose = 70 g; azathioprine, n = 6, mean dose = 243 g) were investigated. Methotrexate-related lymphomas were Epstein-Barr virus (EBV)-positive, had inf...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20508

    authors: Au WY,Ma ES,Choy C,Chung LP,Fung TK,Liang R,Kwong YL

    更新日期:2006-01-01 00:00:00

  • The effect of acute and chronic leukapheresis on the natural killer (NK) cell function of normal human volunteers.

    abstract::Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830220203

    authors: Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

    更新日期:1986-06-01 00:00:00

  • Familial type II protein C deficiency associated with warfarin-induced skin necrosis and bilateral adrenal hemorrhage.

    abstract::A family is described in which venous thromboembolic disease is associated with reduced plasma protein C activity and normal levels of protein C antigen. Immunoelectrophoretic analysis of protein C antigen gave an abnormal pattern in all affected members, suggesting that the disorder is related to the presence of a st...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830290410

    authors: Conlan MG,Bridges A,Williams E,Marlar R

    更新日期:1988-12-01 00:00:00

  • A rapid paper-based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease.

    abstract::Quantification of sickle hemoglobin (HbS) in patients with sickle cell disease (SCD) undergoing hydroxyurea or chronic transfusion therapy is essential to monitoring the effectiveness of these therapies. The clinical monitoring of %HbS using conventional laboratory methods is limited by high per-test costs and long tu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23980

    authors: Piety NZ,Yang X,Lezzar D,George A,Shevkoplyas SS

    更新日期:2015-06-01 00:00:00

  • Sequential administration of cyclophosphamide and granulocyte-colony stimulating factor relieves impaired myeloid maturation in Felty's syndrome.

    abstract::A patient with Felty's syndrome (FS) and persistent profound neutropenia developed recurrent infections and sepsis syndrome. No impairment of granulocyte-macrophage colony development was observed in vitro. Marrow morphology revealed an absence of mature neutrophil forms despite administration of granulocyte-colony st...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830430415

    authors: Pixley JS,Yoneda KY,Manalo PB

    更新日期:1993-08-01 00:00:00

  • Calmodulin level in whole blood correlates with the percentage of reticulocytes.

    abstract::We studied the calmodulin-like activity (CaM) level in hemolyzed samples of whole blood after determining the percentage and absolute number of reticulocytes present. Twenty-six samples from 25 people with a range of reticulocyte counts were studied. CaM levels correlated with the percentage (r = 0.63, P less than .01...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830150207

    authors: Warth JA,Brewer GJ,Gnegy ME,Treisman G,Near K

    更新日期:1983-09-01 00:00:00

  • Evaluation of single-tube osmotic fragility as a screening test for thalassemia.

    abstract::A single-tube osmotic fragility test has been proposed for thalassemia screening with a range of different concentrations of saline having been employed. We have compared the sensitivity and specificity of 0.32%, 0.34%, and 0.36% buffered saline, and on the basis of our findings, recommend the use of 0.36% saline. Thi...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20387

    authors: Chow J,Phelan L,Bain BJ

    更新日期:2005-07-01 00:00:00

  • Low incidence of pneumocystis pneumonia utilizing PCR-based diagnosis in patients with B-cell lymphoma receiving rituximab-containing combination chemotherapy.

    abstract::Recent literature has demonstrated concern over the risk of Pneumocystis jirovecii pneumonia (PJP) when administering rituximab with combination chemotherapy such as in R-CHOP; however, the exact risk and potential need for prophylaxis is unknown. We sought to determine the incidence of PJP infection following R-CHOP ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.24499

    authors: Barreto JN,Ice LL,Thompson CA,Tosh PK,Osmon DR,Dierkhising RA,Plevak MF,Limper AH

    更新日期:2016-11-01 00:00:00

  • Hodgkin lymphoma: 2012 update on diagnosis, risk-stratification, and management.

    abstract:DISEASE OVERVIEW:Hodgkin lymphoma (HL) is an uncommon B-cell lymphoid malignancy affecting 9,000 new patients annually and representing approximately 11% of all lymphomas in the United States. DIAGNOSIS:HL is composed of two distinct disease entities; the more commonly diagnosed classical HL and the rare nodular lymph...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.23348

    authors: Ansell SM

    更新日期:2012-12-01 00:00:00

  • Neutropenia in the age of genetic testing: Advances and challenges.

    abstract::Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expa...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.25374

    authors: Furutani E,Newburger PE,Shimamura A

    更新日期:2019-03-01 00:00:00

  • Risk factors for infections in myelofibrosis: role of disease status and treatment. A multicenter study of 507 patients.

    abstract::Although infectious complications represent a relevant cause of morbidity and mortality in patients with myelofibrosis (MF), little is known about their incidence, outcome and risk factors. We retrospectively evaluated a cohort of 507 MF patients, diagnosed between 1980 and 2014 in five Italian hematology centers, to ...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ajh.24572

    authors: Polverelli N,Breccia M,Benevolo G,Martino B,Tieghi A,Latagliata R,Sabattini E,Riminucci M,Godio L,Catani L,Nicolosi M,Perricone M,Sollazzo D,Colafigli G,Campana A,Merli F,Vitolo U,Alimena G,Martinelli G,Lewis RE,V

    更新日期:2017-01-01 00:00:00

  • Erythrocyte incorporation of ingested stable isotope of iron (58Fe).

    abstract::Because of a possible hazard from the use of radioisotopes to determine iron absorption by infants, the use of stable isotopes for this purpose has much appeal. We have applied the method of inductively coupled plasma mass spectrometry (ICP/MS) to determine the mass ratio, 58Fe/57Fe, in blood before and after oral adm...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830210307

    authors: Janghorbani M,Ting BT,Fomon SJ

    更新日期:1986-03-01 00:00:00

  • Clinical utility of closure times using the platelet function analyzer-100/200.

    abstract::The "platelet function analyzer" (PFA)-100 was first introduced to us in 1995. Since then, the instrument has appeared in over 50 reviews and almost 1000 publications. Recently, the PFA-100 has been "upgraded" to the PFA-200, which has transformed the user interface and electronic management, but retained the fundamen...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.24620

    authors: Favaloro EJ

    更新日期:2017-04-01 00:00:00

  • Intravenous immunoglobulin therapy results in post-infusional hyperproteinemia, increased serum viscosity, and pseudohyponatremia.

    abstract::Intravenous immunoglobulin (IVIG) therapy is associated with rare reports of thromboembolic events and severe hyponatremia. We hypothesized that IVIG therapy may result in hyperproteinemia, increased serum viscosity, and pseudohyponatremia. We conducted a prospective observational study to evaluate the incidence of hy...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10325

    authors: Steinberger BA,Ford SM,Coleman TA

    更新日期:2003-06-01 00:00:00

  • T-cell non-Hodgkin lymphoma in human immunodeficiency virus-1-infected individuals.

    abstract::We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and imm...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830310307

    authors: Lust JA,Banks PM,Hooper WC,Paya CV,Kueck BD,Hanson GA,Ritch PS,Woloschak GE

    更新日期:1989-07-01 00:00:00

  • Intensive management of high-utilizing adults with sickle cell disease lowers admissions.

    abstract::A minority of super-utilizing adults with sickle cell disease (SCD) account for a disproportionate number of emergency department (ED) and hospital admissions. We performed a retrospective cohort study comparing the rate of admission before and after the opening of a clinic for adults with SCD. Unique to this clinic w...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23912

    authors: Koch KL,Karafin MS,Simpson P,Field JJ

    更新日期:2015-03-01 00:00:00

  • Risk of diffuse large B-cell lymphoma after solid organ transplantation in the United States.

    abstract::Non-Hodgkin lymphoma arising in the context of immunosuppression is an important adverse outcome after solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed subtype of post-transplantation non-Hodgkin lymphoma, but few studies of transplant recipients have examined subtype-s...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23726

    authors: Gibson TM,Engels EA,Clarke CA,Lynch CF,Weisenburger DD,Morton LM

    更新日期:2014-07-01 00:00:00

  • Asymptomatic association of hemoglobin Dunn (alpha 6[A4]Asp----Asn) and hemoglobin O-Arab (beta 121[GH4]Glu----Lys) in a Moroccan man.

    abstract::We report on the association of Hb Dunn (alpha 6[A4]Asp----Asn) and Hb O-Arab (beta 121 [GH4]Glu----Lys) in a healthy Moroccan man. Hb Dunn had the same electrophoretic properties as Hb G-Philadelphia, but its percentage was lower. Its identification was based on sequence determination of the alpha T1 peptide. Bgl II ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830270405

    authors: Baklouti F,Francina A,Dorléac E,Baudin-Chich V,Gombaud-Saintonge G,Plauchu H,Wajcman H,Delaunay J,Godet J

    更新日期:1988-04-01 00:00:00

  • Retinoblastoma-related geneRb2/p130 are rarely mutated in Burkitt's lymphoma from Brazil.

    abstract::It has been suggested that alterations of cell cycle genes probably contribute to the pathogenesis of endemic Burkitt's lymphoma (BL) in addition to c-MYC translocation. Mutations disrupting the normal nuclear localization signal of the retinoblastoma-related gene Rb2/p130 have been documented in BL cell lines and pri...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20749

    authors: Klumb CE,Magluta EP,Rezende LM,Apa AG,Alonso JF,Maia RC

    更新日期:2007-03-01 00:00:00

  • Febrile transfusion reaction following initial transfusion in a man with immunoblastic lymphadenopathy and granulocyte autoantibodies.

    abstract::A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830140112

    authors: Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

    更新日期:1983-02-01 00:00:00

  • Reversible posterior leukoencephalopathy syndrome after repeat intermediate-dose cytarabine chemotherapy in a patient with acute myeloid leukemia.

    abstract::A 56-year-old man was admitted to our hospital with leukocytosis, anemia, and thrombocytopenia. Acute monoblastic leukemia was diagnosed. Two subsequent courses of consolidation chemotherapy consisted of conventional doses of cytarabine and intermediate-dose cytarabine. Intermediate-dose cytarabine was infused intrave...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20772

    authors: Saito B,Nakamaki T,Nakashima H,Usui T,Hattori N,Kawakami K,Tomoyasu S

    更新日期:2007-04-01 00:00:00

  • Elevated soluble IL-2Rα, IL-8, and MIP-1β levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) is a unique type of lymphoma with a prognosis intermediate between indolent and aggressive types. The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International Prog...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23838

    authors: Sonbol MB,Maurer MJ,Stenson MJ,Allmer C,LaPlant BR,Weiner GJ,Macon WR,Cerhan JR,Witzig TE,Gupta M

    更新日期:2014-12-01 00:00:00

  • Transient ischemic attack in a patient with congenital protein-C deficiency during treatment with stanozolol.

    abstract::A patient with congenital protein-C deficiency was treated with stanozolol for 8 weeks to increase circulating levels of protein C. A rise in protein C was achieved, accompanied by an increase in factor II, factor X, antithrombin III, and protein S; but at the 8th week the patient suffered a transient ischemia attack....

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830290211

    authors: De Stefano V,Leone G,Teofili L,Ferrelli R,Pollari G,Antonini V,Bizzi B

    更新日期:1988-10-01 00:00:00

  • Changes in hemostatic and fibrinolytic proteins in patients receiving L-asparaginase therapy.

    abstract::Hemostatic changes were evaluated in ten patients with acute lymphoblastic leukemia and lymphoma who received chemotherapy with L-asparaginase, vincristine, and prednisolone for 1 week. Following treatment, prothrombin time and activated partial thromboplastin time were significantly prolonged, while a marked decrease...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830320105

    authors: Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Ito K,Matsuda T

    更新日期:1989-09-01 00:00:00

  • Safety and efficacy results of switch from imiglucerase to velaglucerase alfa treatment in patients with type 1 Gaucher disease.

    abstract::Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9-71 years) clinically stable on ERT with imiglucerase, safely switched to a compa...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ajh.24007

    authors: Elstein D,Mehta A,Hughes DA,Giraldo P,Charrow J,Smith L,Shankar SP,Hangartner TN,Kunes Y,Wang N,Crombez E,Zimran A

    更新日期:2015-07-01 00:00:00

  • Report of a factor VIII inhibitor in a patient with autoimmune lymphoproliferative syndrome.

    abstract::The occurrence of factor VIII inhibitors in non-hemophilic patients is a rare event with a potentially lethal outcome. Despite its infrequent occurrence, the association of this inhibitor with multiple autoimmune diseases is well recognized. We report the case of a patient with the recently described autoimmune lympho...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/1096-8652(200007)64:3<214::aid-ajh14>3.0.c

    authors: Fang BS,Sneller MC,Straus SE,Frenkel L,Dale JK,Rick ME

    更新日期:2000-07-01 00:00:00

  • Phenotypic variability of Filipino beta(o)-thalassemia/HbE patients in Indonesia.

    abstract::Three Indonesian patients with identical genotypes, each compound heterozygotes for Filipino beta(o)-thalassemia/HbE, expressed different clinical severities. One patient has mild disease and is transfusion independent, while the other two are severely affected and transfusion dependent. The size of the Filipino beta(...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199909)62:1<7::aid-ajh2>3.

    authors: Setianingsih I,Williamson R,Daud D,Harahap A,Marzuki S,Forrest S

    更新日期:1999-09-01 00:00:00

  • Prognostic value of minimal residual disease and polyclonal plasma cells in myeloma patients achieving a complete response to therapy.

    abstract::Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the poly...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ajh.25481

    authors: Tschautscher MA,Jevremovic D,Rajkumar V,Dispenzieri A,Lacy MQ,Gertz MA,Buadi FK,Dingli D,Hwa YL,Fonder AL,Hobbs MA,Hayman SR,Zeldenrust SR,Lust JA,Russell SJ,Leung N,Kapoor P,Go RS,Lin Y,Gonsalves WI,Kourelis T,

    更新日期:2019-07-01 00:00:00

  • A novel alpha-thalassemia-2 (-2.7-kb) observed in a Chinese patient with Hb H disease.

    abstract::We describe a newly detected alpha-thalassemia-2 (alpha-thal-2) deletion characterized by a small -2.7-kb deletion involving the alpha 1 globin gene. This deletion has thus far been observed in only one Chinese subject with Hb H disease. ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830380321

    authors: Zhao JB,Zhao L,Fei YJ,Liu JC,Huisman TH

    更新日期:1991-11-01 00:00:00