Abstract:
:A 25-year-old African-American man with sickle cell-beta(+)-thalassemia presented with acute asthma of 2 days' duration. The asthma was well controlled by 48 hr, and parenteral medications were changed to oral bronchodilators and steroids. Sixty hours after presentation, he developed pain similar to that of sickle cell vaso-occlusion, for which he received small amounts of analgesics. He died approximately 84 hours after presentation. Autopsy showed extensive marrow necrosis and massive fat embolism. This is the first reported case of fat embolism syndrome associated with this genotype, the mildest of the clinically significant sickle cell hemoglobinopathies. The relationship between these etiologic factors and indications for transfusions are discussed.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Johnson K,Stastny JF,Rucknagel DLdoi
10.1002/ajh.2830460418subject
Has Abstractpub_date
1994-08-01 00:00:00pages
354-7issue
4eissn
0361-8609issn
1096-8652journal_volume
46pub_type
杂志文章abstract::Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the poly...
journal_title:American journal of hematology
pub_type: 临床试验,杂志文章
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更新日期:2019-07-01 00:00:00
abstract::Epstein-Barr virus (EBV) occasionally infects T and NK cells and causes EBV-infected T/NK-cell lymphoproliferative disease (LPD), which comprises chronic active EBV infection, EBV-associated hemophagocytic syndrome, mosquito allergy, hydroa vacciniforme, aggressive NK-cell leukemia, and NK/T-cell lymphoma. The diagnos...
journal_title:American journal of hematology
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更新日期:2006-08-01 00:00:00
abstract::The main treatment for many patients with Myelodysplastic Syndromes (MDS) remains red cell transfusion to attenuate the symptoms of chronic anemia. Fatigue can reduce a patient's health related quality of life (HRQoL), but there is little understanding of the optimal use of transfusions to improve this. A systematic r...
journal_title:American journal of hematology
pub_type: 杂志文章,评审
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abstract::Acquired pure megakaryocytic aplasia is a rare disorder defined by severe thrombocytopenia with no other hematologic abnormalities and absent, or severely decreased marrow megakaryocytes. The etiology may be immune suppression of megakaryocyte development. Two patients are described who both responded rapidly to a com...
journal_title:American journal of hematology
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更新日期:1999-10-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is a unique type of lymphoma with a prognosis intermediate between indolent and aggressive types. The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International Prog...
journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
abstract::A modified protein-bound cobalamin absorption test was used to study dietary cobalamin absorption in healthy adults of different age groups and patients with isolated low serum concentrations of cobalamin. Dietary cobalamin absorption was significantly reduced in healthy adults aged 55-75 years compared with young adu...
journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.2830390202
更新日期:1992-02-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.20558
更新日期:2006-07-01 00:00:00
abstract::Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitution...
journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
abstract::Withdrawal: Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective. The above article, published online on 20 August 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, t...
journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.25974
更新日期:2020-08-20 00:00:00
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journal_title:American journal of hematology
pub_type:
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8652(199610)53:2<133::AID-AJH13
更新日期:1996-10-01 00:00:00
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journal_title:American journal of hematology
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更新日期:2007-12-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.2830450210
更新日期:1994-02-01 00:00:00
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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abstract::Various in vitro studies and clinical observations suggest that Fanconi's anemia (FA) patients are unable to detoxify adequately superoxide anions (O2-) released by activated phagocytes. Recent studies have shown that certain lymphokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) ...
journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of hematology
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更新日期:1982-06-01 00:00:00
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journal_title:American journal of hematology
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更新日期:2006-03-01 00:00:00