Effects of humic acid on the viability and coagulant properties of human umbilical vein endothelial cells.

abstract：:Transferrin-iron uptake by peripheral blood monocytes was studied in vitro to test the hypothesis that the relative paucity of mononuclear phagocyte iron loading in hereditary hemochromatosis results from a defect in uptake of iron from transferrin. Monocytes from nine control subjects and 17 patients with hemochromat...

journal_title：American journal of hematology

authors： Sizemore DJ,Bassett ML

更新日期：1984-05-01 00:00:00

abstract：:Six patients, five with acute myeloid leukemia (AML) and one with a myelodysplastic syndrome (MDS), were found to have monosomy 7 by conventional cytogenetics at diagnosis. Repetitive DNA sequences from the heterochromatic region of human chromosomes 1 and 7 were used as probes for in situ hybridization experiments on...

journal_title：American journal of hematology

authors： Kolluri RV,Manuelidis L,Cremer T,Sait S,Gezer S,Raza A

更新日期：1990-02-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a unique type of lymphoma with a prognosis intermediate between indolent and aggressive types. The purpose of this study was to study blood cytokine levels in newly diagnosed and relapsed MCL patients with respect to patterns of abnormalities and relationship to the MCL International Prog...

journal_title：American journal of hematology

authors： Sonbol MB,Maurer MJ,Stenson MJ,Allmer C,LaPlant BR,Weiner GJ,Macon WR,Cerhan JR,Witzig TE,Gupta M

更新日期：2014-12-01 00:00:00

abstract：:The purpose of the study was to determine if UDP-glucuronosyltransferase (UGT) 2B7 allelic variants encoding for UGT2B7, primary enzyme responsible for morphine glucuronidation contribute to the variability in the hepatic clearance of morphine in sickle cell disease (SCD). Twenty-four hour PK study of morphine and UGT...

journal_title：American journal of hematology

authors： Darbari DS,van Schaik RH,Capparelli EV,Rana S,McCarter R,van den Anker J

更新日期：2008-03-01 00:00:00

abstract：:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare form of Hodgkin lymphoma that typically presents as early stage, indolent disease in young adult males. The relationship between NLPHL and DLBCL is incompletely understood, and there remains a paucity of data with regard the incidence and management of ...

journal_title：American journal of hematology

authors： Eyre TA,Gatter K,Collins GP,Hall GW,Watson C,Hatton CS

更新日期：2015-06-01 00:00:00

abstract：:Hairy cell leukemia is a chronic lymphoproliferative disorder characterized clinically by splenomegaly and cytopenias. Spontaneous remissions are rare and splenectomy is often performed when the blood counts worsen and cause symptoms. Three of our patients with hairy cell leukemia developed recurrent pancytopenia and ...

journal_title：American journal of hematology

authors： Keefer MJ,Weber MJ,Bottomley SS,Solanki DL,Hosty TA

更新日期：1987-07-01 00:00:00

abstract：:Imatinib mesylate radically changed the natural history of chronic myeloid leukemia (CML). The recent availability of alternative tyrosine kinase inhibitors (TKIs) renders the clinical management of CML more complex. In this article, we summarize our long-term single institution experience. From 2003 to 2012, 102 pati...

journal_title：American journal of hematology

authors： Viganò I,Di Giacomo N,Bozzani S,Antolini L,Piazza R,Gambacorti Passerini C

更新日期：2014-10-01 00:00:00

abstract：:Over 300,000 infants are born annually with sickle cell anemia (SCA) in sub-Saharan Africa, and >50% die young from infection or anemia, usually without diagnosis of SCA. Early identification by newborn screening (NBS), followed by simple interventions dramatically reduced the mortality of SCA in the United States, bu...

journal_title：American journal of hematology

authors： McGann PT,Ferris MG,Ramamurthy U,Santos B,de Oliveira V,Bernardino L,Ware RE

更新日期：2013-12-01 00:00:00

abstract：:During the 5-year period from 1981 to 1985, we have observed 8 cases of acquired immunodeficiency syndrome (AIDS) among our 85 patients with hemophilia A. Thus, the prevalence of AIDS with hemophilia A is 9.4% in our patient population. By utilizing stored serum or plasma samples dating back to 1978, antibody against ...

journal_title：American journal of hematology

authors： Kim HC,Nahum K,Raska K Jr,Gocke DJ,Kosmin M,Karp GI,Saidi P

更新日期：1987-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and is associated with a favorable prognosis. While previous studies have evaluated NPM1 in a binary fashion, we recently demonstrated a significant independent negative prognostic effect of hig...

journal_title：American journal of hematology

authors： Patel SS,Pinkus GS,Ritterhouse LL,Segal JP,Dal Cin P,Restrepo T,Harris MH,Stone RM,Hasserjian RP,Weinberg OK

更新日期：2019-08-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) may convert to a diffuse large cell lymphoma (Richter's syndrome) over time. In occasional cases of Richter's transformation, Epstein-Barr virus (EBV) has been identified in the lymphoma cells. To evaluate the association of EBV infection with Richter's syndrome, the biopsy specimens...

journal_title：American journal of hematology

authors： Ansell SM,Li CY,Lloyd RV,Phyliky RL

更新日期：1999-02-01 00:00:00

abstract：:As the number of anticoagulant drugs increases and new ones are brought to market, the utility of the routine screening coagulation tests of today--namely the prothrombin time and activated partial thromboplastin time--will be significantly reduced in many clinical situations. Although the new anticoagulants are desig...

journal_title：American journal of hematology

authors： Gehrie E,Laposata M

更新日期：2012-02-01 00:00:00

abstract：:While systemic plasma endothelin-1 (ET-1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET-1, NO, and cell-free hemoglobin, during the course of periodic vaso-occlusive episodes remain un...

journal_title：American journal of hematology

authors： Ergul S,Brunson CY,Hutchinson J,Tawfik A,Kutlar A,Webb RC,Ergul A

更新日期：2004-07-01 00:00:00

abstract：:If a translocation is followed by loss of one of the two derivative chromosomes, the result is an unbalanced translocation, showing monosomy for the segments making up the lost derivative. We have found that in most unbalanced translocations, a third event takes place: a morphologically normal copy of one of the two t...

journal_title：American journal of hematology

authors： Pedersen B,Nørgaard JM,Pedersen BB,Clausen N,Rasmussen IH,Thorling K

更新日期：2000-07-01 00:00:00

abstract：:"PVP storage disease" is a disorder occurring in patients who have received high molecular weight polyvinylpyrrolidone (PVP), which cannot be excreted from the body. These large polymers deposit in the histiocytes and cause proliferation and infiltration of histiocytes in the reticuloendothelial system. There was usua...

journal_title：American journal of hematology

authors： Dunn P,Kuo T,Shih LY,Wang PN,Sun CF,Chang MJ

更新日期：1998-01-01 00:00:00

abstract：:Acute leukemias of ambiguous lineage (ALAL) comprise acute undifferentiated leukemias (AUL) and mixed-phenotype acute leukemias (MPAL). In the revised fourth edition of the World Health Organization (WHO) classification provided further refinements to the diagnostic criteria for ALAL. Molecular characterization of MPA...

journal_title：American journal of hematology

authors： Patel SS,Weinberg OK

更新日期：2020-06-01 00:00:00

abstract：:Patients initially diagnosed with type 1 von Willebrand disease (VWD) have been reclassified as type 2 after a more exhaustive analysis in several studies. Our study's objectives were (1) to reanalyze patients that were previously diagnosed as type 1 to achieve a more accurate diagnosis and (2) to compare the von Will...

journal_title：American journal of hematology

authors： Penas N,Pérez-Rodríguez A,Torea JH,Lourés E,Noya MS,López-Fernández MF,Batlle J

更新日期：2005-11-01 00:00:00

abstract：:A 68-year-old previously well woman developed sudden onset of limb gangrene in association with liver dysfunction. An immediately acting inhibitor to factor V with some of the features of lupus anticoagulant was demonstrated. The patient required limb amputation within 2 weeks and activity of the anticoagulant seemed ...

journal_title：American journal of hematology

authors： Kapur A,Kelsey PR,Isaacs PE

更新日期：1993-04-01 00:00:00

abstract：:Red cell ferritin was evaluated in 101 individuals with heterozygous beta-thalassemia to determine its clinical utility as an index for iron deficiency or overload in these subjects. The mean red cell ferritin for the total population was elevated threefold and showed a significant correlation with transferrin saturat...

journal_title：American journal of hematology

authors： Van der Weyden MB,Fong H,Hallam LJ,Harrison C

更新日期：1989-04-01 00:00:00

abstract：:Human theta (theta 1)-globin gene represents a member of the alpha-like globin gene family residing on chromosome 16. theta 1-Specific transcripts have been detected so far only in erythroid tissues and in erythroleukemia K562 cells. To investigate systematically its inducible expression and developmental specificity,...

journal_title：American journal of hematology

authors： Mamalaki A,Anagnou NP,Moschonas NK

更新日期：1990-12-01 00:00:00

abstract：:Clofarabine has shown activity and tolerability in older patients with acute myeloid leukemia (AML). We investigated the safety and tolerability of an oral formulation of clofarabine for consolidation therapy of patients aged 60 and older with AML. In this phase I study, twenty-two patients older than 60 years with AM...

journal_title：American journal of hematology

authors： Jacoby MA,Martin MG,Uy GL,Westervelt P,Dipersio JF,Cashen A,Stockerl-Goldstein K,Vij R,Luo J,Reineck T,Bernabe N,Abboud CN

更新日期：2014-05-01 00:00:00

abstract：:Chimeric antigen receptors (CARs) can be introduced into T-cells redirecting them to target specific tumor antigens. CAR-modified T cells targeting CD19 have shown remarkable activity against CD19+ malignancies including B cell acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymph...

journal_title：American journal of hematology

authors： Frey NV,Porter DL

更新日期：2016-01-01 00:00:00

abstract：:We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

journal_title：American journal of hematology

authors： Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

更新日期：2000-01-01 00:00:00

abstract：OVERVIEW:Evidence suggests that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment r...

journal_title：American journal of hematology

authors： Estey EH

更新日期：2014-11-01 00:00:00

abstract：:Among 47 patients with thrombotic thrombocytopenic purpura (TTP), 8 patients were diagnosed to have postoperative-TTP. Two patients underwent vascular surgery, 5 patients coronary artery bypass grafts, and 1 patient resection of myocardial sarcoma. Prior to surgery, all patients except one had normal hemograms and pla...

journal_title：American journal of hematology

authors： Chang JC,Shipstone A,Llenado-Lee MA

更新日期：1996-09-01 00:00:00

abstract：:Gamma inferferon (gamma IFN), alpha tumor necrosis factor (alpha TNF), and interleukin 6 (IL-60) are cytokines produced by a wide variety of cells, including T lymphocytes and NK cells. These cytokines affect B-cell proliferation and differentiation into immunoglobulin secreting cells. In addition, gamma IFN and alpha...

journal_title：American journal of hematology

authors： Garcia-Suarez J,Prieto A,Reyes E,Manzano L,Arribalzaga K,Alvarez-Mon M

更新日期：1995-08-01 00:00:00

abstract：:Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies di...

journal_title：American journal of hematology

authors： Finan RR,Tamim H,Ameen G,Sharida HE,Rashid M,Almawi WY

更新日期：2002-12-01 00:00:00

abstract：:A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

journal_title：American journal of hematology

authors： Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

更新日期：1983-02-01 00:00:00

abstract：:We have developed a murine monoclonal antibody (mAb) specific for the delta chain of hemoglobin (Hb) A2 that does not cross-react with alpha, beta, or gamma chains. The mAb reacted with Hb P-Nilotic (beta delta hybrid), but not with Hb Lepore-Boston (delta beta hybrid), indicating an epitope consisting of positions 11...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1991-11-01 00:00:00

abstract：:We report a case of T-cell chronic lymphoproliferative disorder (CLPD) that shows neither features of T-cell prolymphocytic leukemia nor disease progression for more than 34 months. Flow cytometric analyses of the lymphocytes revealed high expression of CD4 and CD25. Up-regulation of Foxp3, a master regulatory gene fo...

journal_title：American journal of hematology

authors： Kikuchi T,Katayama Y,Kubonishi S,Watanabe T,Watanabe Y,Matsuoka K,Maeda Y,Namba N,Masunari T,Nasu R,Ikeda K,Tanimoto M

更新日期：2006-09-01 00:00:00