Abstract:
:Thrombocytopenia developing in the course of chemotherapy for malignant disease is usually attributed to drug-induced marrow suppression and/or marrow replacement by tumor. We describe two patients who developed severe thrombocytopenia and hemorrhagic symptoms while being treated with oxaliplatin, 5-fluorouracil, and leukovorin for metastatic colon cancer in whom platelet destruction appears to have been caused by oxaliplatin-dependent antibodies specific for the platelet glycoprotein IIb/IIIa complex (alpha(IIb)/beta(3) integrin). Drug-induced immune thrombocytopenia (DITP) should be considered in patients who experience a sudden, isolated drop in platelet levels while being treated with chemotherapeutic agents, especially when adequate numbers of megakaryocytes are present in the bone marrow.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Curtis BR,Kaliszewski J,Marques MB,Saif MW,Nabelle L,Blank J,McFarland JG,Aster RHdoi
10.1002/ajh.20516keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
193-8issue
3eissn
0361-8609issn
1096-8652journal_volume
81pub_type
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