Prognostic value of bone marrow angiogenesis in multiple myeloma: use of light microscopy as well as computerized image analyzer in the assessment of microvessel density and total vascular area in multiple myeloma and its correlation with various clinical

abstract：:Congenital malformations of the inferior vena cava (IVC) are uncommon and may be associated with an increased risk of venous thrombosis. We report the case of a man with congenital absence of the IVC and remote history of deep venous thrombosis who now presents with severe abdominal wall superficial thrombophlebitis. ...

journal_title：American journal of hematology

authors： Evanchuk DM,Von Gehr A,Zehnder JL

更新日期：2008-03-01 00:00:00

abstract：:The purpose of the study was to analyze clinical and/or autopsy findings at the time of death among adults with sickle cell disease (SCD) at Howard University in Washington, DC over a 25-year period. A single physician recorded circumstances of death among 141 adult SCD patients he treated and knew well from 1976 to 2...

journal_title：American journal of hematology

authors： Darbari DS,Kple-Faget P,Kwagyan J,Rana S,Gordeuk VR,Castro O

更新日期：2006-11-01 00:00:00

abstract：:Pentosan polysulfate is a low-molecular-weight sulfated polysaccharide used as an antithrombotic drug. We present two patients who developed thrombocytopenia and venous thrombosis during treatment with pentosan polysulfate. The relationship between pentosan polysulfate and thrombocytopenia is supported by platelet agg...

journal_title：American journal of hematology

authors： Tardy-Poncet B,Tardy B,Grelac F,Reynaud J,Mismetti P,Bertrand JC,Guyotat D

更新日期：1994-03-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of therapy. For patien...

journal_title：American journal of hematology

authors： Harrington WJ Sr,Kolodny L,Horstman LL,Jy W,Ahn YS

更新日期：1997-02-01 00:00:00

abstract：:A 71-year-old woman and her elder sister developed ligneous conjunctivitis after ocular surgery. Laboratory tests demonstrated that the proband and her sister had 6.6% and 8.1% of plasminogen activity, and 1.2 and 1.4 mg/dl of antigen, respectively. Thus, they were diagnosed as having severe type I plasminogen deficie...

journal_title：American journal of hematology

authors： Suzuki T,Ikewaki J,Iwata H,Ohashi Y,Ichinose A

更新日期：2009-06-01 00:00:00

abstract：:The treatment of corticosteroid- and/or splenectomy-refractory immune thrombocytopenic purpura (ITP) includes vinca alkaloids, immunosuppressives, Danazol, intravenous gammaglobulin, and alpha-interferon. However, these treatments have often been associated with toxic side effects. Brox et al. (Br J Haematol 70:341-34...

journal_title：American journal of hematology

authors： Jubelirer SJ

更新日期：1993-05-01 00:00:00

abstract：:Botrocetin, a protein isolated from the venom of the snake Bothrops jararaca, induces platelet aggregation/agglutination by von Willebrand factor (vWF) binding to the membrane glycoprotein (GP) Ib, an action resembling that of ristocetin. However, some differences in the interaction between vWF and platelet GPIb induc...

journal_title：American journal of hematology

authors： Nishio K,Fujimura Y,Niinomi K,Takahashi Y,Yoshioka A,Fukui H,Usami Y,Titani K,Ruggeri ZM,Zimmerman TS

更新日期：1990-04-01 00:00:00

abstract：:This report describes the bone marrow findings in four patients whose marrow was involved by anaplastic large-cell Ki-1 lymphoma, an uncommon event in this type of lymphoma. In the marrow aspirate smears, the involvement was subtle, and was in the form of isolated large cells with irregular nuclear configuration, coar...

journal_title：American journal of hematology

authors： Wong KF,Chan JK,Ng CS,Chu YC,Lam PW,Yuen HL

更新日期：1991-06-01 00:00:00

abstract：:Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and V...

journal_title：American journal of hematology

authors： Tang W,Cushman M,Green D,Rich SS,Lange LA,Yang Q,Tracy RP,Tofler GH,Basu S,Wilson JG,Keating BJ,Weng LC,Taylor HA,Jacobs DR Jr,Delaney JA,Palmer CD,Young T,Pankow JS,O'Donnell CJ,Smith NL,Reiner AP,Folsom AR

更新日期：2015-06-01 00:00:00

abstract：:We have developed a murine monoclonal antibody (mAb) specific for the delta chain of hemoglobin (Hb) A2 that does not cross-react with alpha, beta, or gamma chains. The mAb reacted with Hb P-Nilotic (beta delta hybrid), but not with Hb Lepore-Boston (delta beta hybrid), indicating an epitope consisting of positions 11...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1991-11-01 00:00:00

abstract：:Lentiviral modification combined with ex vivo erythroid differentiation was used to stably inhibit RhAG expression, a critical component of the Rh(rhesus) membrane complex defective in the Rh(null) syndrome. The cultured red cells generated recapitulate the major alterations of native Rh(null) cells regarding antigen ...

journal_title：American journal of hematology

authors： Cambot M,Mazurier C,Canoui-Poitrine F,Hebert N,Picot J,Clay D,Picard V,Ripoche P,Douay L,Dubart-Kupperschmitt A,Cartron JP

更新日期：2013-05-01 00:00:00

abstract：:Fourteen patients, aged 65-85 years, with refractory (11) or relapsing (3) multiple myeloma were treated with a "protracted-sequential" protocol comprising vincristine 1-2 mg or vindesine 3 mg/M(2) (max. 5 mg) IVI over 4 hr on D1, prednisolone 40-50 mg PO D1-14, and melphalan 2-4 mg PO or cyclophosphamide 50-100 mg PO...

journal_title：American journal of hematology

authors： Manoharan A

更新日期：2000-09-01 00:00:00

abstract：:Clofarabine has shown activity and tolerability in older patients with acute myeloid leukemia (AML). We investigated the safety and tolerability of an oral formulation of clofarabine for consolidation therapy of patients aged 60 and older with AML. In this phase I study, twenty-two patients older than 60 years with AM...

journal_title：American journal of hematology

authors： Jacoby MA,Martin MG,Uy GL,Westervelt P,Dipersio JF,Cashen A,Stockerl-Goldstein K,Vij R,Luo J,Reineck T,Bernabe N,Abboud CN

更新日期：2014-05-01 00:00:00

abstract：:This study concerned the gamma chain composition of Hb F and the haplotypes of 44 patients with beta-thalassemia major or intermedia and many of their relatives. Seventeen patients came from Northern (Turkish) Cyprus, 12 from the Istanbul area, and 15 from Macedonia and Bulgaria. Analysis of the A gamma T-G gamma-A ga...

journal_title：American journal of hematology

authors： Aksoy M,Kutlar A,Efremov GD,Nikolov N,Petkov G,Reese AL,Harano T,Chen SS,Huisman TH

更新日期：1985-09-01 00:00:00

abstract：:The presence of teardrop-shaped red cells in peripheral blood has traditionally been felt to reflect altered marrow architecture, namely myelofibrosis. We evaluated two patients with splenomegaly, moderately severe hemolytic anemia due to warm-reactive IgG anti-red cell autoantibody, and bone marrow erythroid hyperpla...

journal_title：American journal of hematology

authors： Farolino DL,Rustagi PK,Currie MS,Doeblin TD,Logue GL

更新日期：1986-04-01 00:00:00

abstract：:While systemic plasma endothelin-1 (ET-1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET-1, NO, and cell-free hemoglobin, during the course of periodic vaso-occlusive episodes remain un...

journal_title：American journal of hematology

authors： Ergul S,Brunson CY,Hutchinson J,Tawfik A,Kutlar A,Webb RC,Ergul A

更新日期：2004-07-01 00:00:00

abstract：:A 64-year-old woman with mild bilateral parotid gland swelling and bilateral lower extremity purpura was admitted for evaluation of xerostomia and pancytopenia. The patient had an increased erythrocyte sedimentation rate, pancytopenia, and positive tests for antibodies to nuclear antigen, SS-A, and SS-B. Impaired cell...

journal_title：American journal of hematology

authors： Seki T,Kiyosawa K,Monno S,Imai Y,Furukawa K,Kumazawa S,Ota M,Saito H,Furuta S,Nakahata T

更新日期：1993-07-01 00:00:00

abstract：:A case of red cell adenosine deaminase (ADA) overproduction associated with hereditary hemolytic anemia is reported here. This appears to be the second report. Proband is a 38-year-old Japanese male who had hemoglobin, 15.8 g/100 ml; reticulocyte count, 4.5%; serum indirect bilirubin, 4.9 mg/100 ml; 51Cr-labeled red c...

journal_title：American journal of hematology

authors： Miwa S,Fujii H,Matsumoto N,Nakatsuji T,Oda S,Asano H,Asano S

更新日期：1978-01-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an innate immunodeficiency with a genetic defect of the nicotinamide adenosine dinucleotide phosphate, reduced, oxidase components. This leads to decreased reactive oxygen species (ROS) production, which renders patients susceptible to life-threatening infections. Over the course...

journal_title：American journal of hematology

authors： Wolach B,Gavrieli R,de Boer M,van Leeuwen K,Berger-Achituv S,Stauber T,Ben Ari J,Rottem M,Schlesinger Y,Grisaru-Soen G,Abuzaitoun O,Marcus N,Zion Garty B,Broides A,Levy J,Stepansky P,Etzioni A,Somech R,Roos D

更新日期：2017-01-01 00:00:00

abstract：:We describe a 23-year-old retired military officer who was immunocompetent but diagnosed with hemophagocytic syndrome (HPS) by Plasmodium vivax infection. Initially, the patient was suspected to have toxic hepatitis related to heavy drinking. But abnormal hematologic findings required a further bone marrow examination...

journal_title：American journal of hematology

authors： Park TS,Oh SH,Choi JC,Kim HH,Chang CL,Son HC,Lee EY

更新日期：2003-10-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with isolated thrombocytopenia and hemorrhagic risk. While many children with ITP can be safely observed, treatments are often needed for various reasons, including to decrease bleeding, or to improve health related quality of life (HRQoL). There are a n...

journal_title：American journal of hematology

authors： Grace RF,Shimano KA,Bhat R,Neunert C,Bussel JB,Klaassen RJ,Lambert MP,Rothman JA,Breakey VR,Hege K,Bennett CM,Rose MJ,Haley KM,Buchanan GR,Geddis A,Lorenzana A,Jeng M,Pastore YD,Crary SE,Neier M,Neufeld EJ,Neu N

更新日期：2019-07-01 00:00:00

abstract：:Iron studies were compared in 434 patients from 80 hemochromatosis families classified as putative homozygotes, heterozygotes, and normal by HLA typing. There were 28 of 255 (11%) heterozygotes with an elevated serum ferritin and 22 of 255 (8.6%) with an elevated transferrin saturation. Serum ferritin (140 +/- 10.2 mi...

journal_title：American journal of hematology

authors： Adams PC

更新日期：1994-02-01 00:00:00

abstract：:The clinical features of patients with splenic marginal zone cell lymphoma (SMZCL) have rarely been reported. In the present study, immunological abnormalities, particularly hematological abnormalities, observed in SMZCL were described. Autoimmune hemolytic anemia, immune thrombocytopenia, and appearance of lupus anti...

journal_title：American journal of hematology

authors： Murakami H,Irisawa H,Saitoh T,Matsushima T,Tamura J,Sawamura M,Karasawa M,Hosomura Y,Kojima M

更新日期：1997-11-01 00:00:00

abstract：:Tumor cells of 14 cases of non-Hodgkin lymphomas and 2 cases of Hodgkin disease were tested for the presence of the transferrin receptor (CD71) by flow cytofluorimetry before 67gallium imaging. It appeared that expression of CD71 phenotype was closely related to the positivity of gallium scan before therapy. We feel t...

journal_title：American journal of hematology

authors： Feremans W,Bujan W,Neve P,Delville JP,Schandene L

更新日期：1991-03-01 00:00:00

abstract：:At sites of vascular injury, the platelet collagen receptor Glycoprotein Ia/IIa (GPIa/IIa) acts as an important mediator of platelet adhesion to fibrillar collagens. Two silent polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene have been implicated in increased risk of developing thrombosis and myocardi...

journal_title：American journal of hematology

authors： Komurcu E,Erginel-Unaltuna N

更新日期：2002-01-01 00:00:00

abstract：:Nongastric marginal zone B-cell lymphoma (NG-MZL) is a relatively uncommon indolent lymphoma. From 1990 to 2005, a total of 247 patients with histologically confirmed NG-MZL were analyzed. Ann Arbor stage I/II disease was present in 78% (167 out of 215). One hundred eighty-six patients out of two hundred eight were ca...

journal_title：American journal of hematology

authors： Oh SY,Ryoo BY,Kim WS,Park YH,Kim K,Kim HJ,Kwon JM,Lee J,Ko YH,Ahn YC,Oh SJ,Lee SI,Kim HJ,Kwon HC,Bang SM,Kim JH,Park J,Lee SS,Kim HY,Park K

更新日期：2007-06-01 00:00:00

abstract：:In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not appear to be statist...

journal_title：American journal of hematology

authors： Nand S,Stock W,Godwin J,Fisher SG

更新日期：1996-05-01 00:00:00

abstract：:How often elevated serum ferritin in primary-care patients reflects increased iron stores (normally 0.8 g in men, 0.4 g in women) is not known. The Hereditary Hemochromatosis and Iron Overload Screening (HEIRS) study screened 101,168 primary-care participants (44% Caucasians, 27% African-Americans, 14% Asians/Pacific ...

journal_title：American journal of hematology

authors： Gordeuk VR,Reboussin DM,McLaren CE,Barton JC,Acton RT,McLaren GD,Harris EL,Reiss JA,Adams PC,Speechley M,Phatak PD,Sholinsky P,Eckfeldt JH,Chen WP,Passmore L,Dawkins FW

更新日期：2008-08-01 00:00:00

abstract：:One of the more intriguing aspects of the spleen is the protection against certain bacterial infections afforded by its unique vascular and immune function. There have been extensive clinical surveys which indicate an incidence of overwhelming postsplenectomy infection (OPSI) above that of the disease for which the sp...

journal_title：American journal of hematology

authors： Krivit W

更新日期：1977-01-01 00:00:00

abstract：:The Sicilian type of (delta beta) (0)-thalassemia characterized by a approximately 13 kb deletion, was present in a Turkish boy who is a homozygote and in his heterozygous parents who are first cousins. The father with approximately 21% Hb F had five alpha-globin genes (alpha alpha/alpha alpha alpha) and the mother wi...

journal_title：American journal of hematology

authors： Oner C,Gurgey A,Altay C,Kutlar F,Huisman TH

更新日期：1990-07-01 00:00:00