Familial and metachronous malignant lymphoma: absence of constitutional p53 mutations.

abstract：:Despite the common practice of combining dexamethasone (Dex) with bortezomib (Bz) in patients with multiple myeloma (MM), until now there has been few prospective trials undertaken. We undertook a trial that recapitulated the original APEX study except that dexamethasone was incorporated from cycle 1. We also incorpor...

journal_title：American journal of hematology

authors： Harrison SJ,Quach H,Link E,Feng H,Dean J,Copeman M,Van De Velde H,Schwarer A,Baker B,Spencer A,Catalano J,Campbell P,Augustson B,Romeril K,Prince HM

更新日期：2015-05-01 00:00:00

abstract：:Seven normal human peripheral blood cell fractions (buffy coat, mononuclear cells, non-T, T, Fc-IgM receptor-depleted T-lymphocyte, Fc-IgG receptor-depleted T-lymphocyte, and autologous rosette-forming T-cell-depleted T-lymphocyte subpopulations) treated with phytohemagglutinin (PHA) were examined for the production o...

journal_title：American journal of hematology

authors： López-Karpovitch X,Padrós-Semorile MR,Rojas R,Martínez-Sánchez L

更新日期：1985-11-01 00:00:00

abstract：:The objective of this study is to establish a method to identify patients with primary immune thrombocytopenia (ITP) utilizing administrative data from diverse data sources that would be appropriate for epidemiologic studies of ITP, regardless of patients' age and source of health care. Medical records of the Oklahoma...

journal_title：American journal of hematology

authors： Terrell DR,Beebe LA,Vesely SK,Neas BR,Segal JB,George JN

更新日期：2012-09-01 00:00:00

abstract：:The effect of several iron chelators on iron uptake and release by mouse peritoneal macrophages has been investigated. The 1,2-dimethyl (L1) and 1-ethyl-2-methyl (L1NEt) derivatives of 3-hydroxypyrid-4-one markedly enhanced iron mobilisation from macrophages pulsed with 59Fe-transferrin-antitransferrin immune complexe...

journal_title：American journal of hematology

authors： Brock JH,Licéaga J,Arthur HM,Kontoghiorghes GJ

更新日期：1990-05-01 00:00:00

abstract：DISEASE OVERVIEW:The myelodysplastic syndromes (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic th...

journal_title：American journal of hematology

authors： Garcia-Manero G

更新日期：2015-09-01 00:00:00

abstract：:Protein S (ProS) is a physiological inhibitor of coagulation with an important function in the down-regulation of thrombin generation. ProS deficiency is a major risk factor for venous thrombosis. This study enrolled 40 ProS-deficient probands to investigate the molecular basis of hereditary ProS deficiency in Chinese...

journal_title：American journal of hematology

authors： Tang L,Jian XR,Hamasaki N,Guo T,Wang HF,Lu X,Wang QY,Hu Y

更新日期：2013-10-01 00:00:00

abstract：:Hypereosinophilic syndrome (HES) is a rare disorder that can manifest in various organ systems. We report the case of a 54-year-old woman with a remote history of seizure disorder who presented with early signs of right-sided heart failure. Laboratory studies showed significant eosinophilia (8 x 10(9) l(-1)). Computed...

journal_title：American journal of hematology

authors： Chao BH,Cline-Parhamovich K,Grizzard JD,Smith TJ

更新日期：2007-10-01 00:00:00

abstract：:The effect of short-chain aliphatic acids on [3H]deoxythymidine incorporation into DNA was studied in human mitogen-stimulated lymphocytes. Butyric acid at 1-2 mM level was strongly inhibitory; however, its hydroxy or amino derivatives were ineffective. Valeric and propionic acids were less inhibitory. Formic, acetic,...

journal_title：American journal of hematology

authors： Stolc V

更新日期：1982-09-01 00:00:00

abstract：:Follicular lymphoma (FL) frequently transforms into the more aggressive diffuse large B cell lymphoma (DLBCL-tr), but no protein biomarkers have been identified for predictive or early diagnosis. Gene expression analyses have identified genes changing on transformation but have failed to be reproducible in different s...

journal_title：American journal of hematology

authors： Andréasson U,Dictor M,Jerkeman M,Berglund M,Sundström C,Linderoth J,Rosenquist R,Borrebaeck CA,Ek S

更新日期：2009-12-01 00:00:00

abstract：:Cyclooxygenases (COX) are key enzymes in the conversion of arachidonic acid to prostaglandins. Several studies have shown a relation between angiogenesis and COX-2 expression. Elevated expression of cyclooxygenase-2 (COX-2), however, has not been reported in multiple myeloma (MM) in the literature. The aim of this stu...

journal_title：American journal of hematology

authors： Cetin M,Buyukberber S,Demir M,Sari I,Sari I,Deniz K,Eser B,Altuntas F,Camci C,Oztürk A,Turgut B,Vural O,Unal A

更新日期：2005-11-01 00:00:00

abstract：:A 63-year-old white man with myasthenia gravis and red cell aplasia was found to have hepatic iron overload. The differential diagnosis included hereditary hemochromatosis and secondary iron overload related to red cell aplasia. Family studies of siblings, including HLA typing, initially suggested a diagnosis of secon...

journal_title：American journal of hematology

authors： Adams PC

更新日期：1994-03-01 00:00:00

abstract：:The recent progress in sensitive KIT D816V mutation analysis suggests that mutation analysis of peripheral blood (PB) represents a promising diagnostic test in mastocytosis. However, there is a need for systematic assessment of the analytical sensitivity and specificity of the approach in order to establish its value ...

journal_title：American journal of hematology

authors： Kristensen T,Vestergaard H,Bindslev-Jensen C,Møller MB,Broesby-Olsen S,Mastocytosis Centre, Odense University Hospital (MastOUH).

更新日期：2014-05-01 00:00:00

abstract：:Children with sickle cell anemia (SCA) and a primary overt stroke are at high risk of recurrent (secondary) stroke. Chronic transfusion therapy dramatically reduces but does not eliminate this high risk, and inevitably results in transfusion-related hemosiderosis. We previously reported the use of hydroxyurea/phleboto...

journal_title：American journal of hematology

authors： Greenway A,Ware RE,Thornburg CD

更新日期：2011-04-01 00:00:00

abstract：:This study investigated the clinical characteristics and prognostic relevance of CD34 expression in 47 patients with acute promyelocytic leukemia (APL), showing t(15;17) or PML/RARalpha. Ten (21.3%) of the APL patients were CD34(+). CD34 expression was associated with hypogranular morphology (P = 0.002) and hyperleuko...

journal_title：American journal of hematology

authors： Lee JJ,Cho D,Chung IJ,Cho SH,Park KS,Park MR,Ryang DW,Kim HJ

更新日期：2003-07-01 00:00:00

abstract：:Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) that shows overlap with classical Hodgkin lymphoma (CHL) and a favorable prognosis compared to mediastinal gray-zone lymphoma (MGZL). We performed immunohistochemistry on initial diagnostic specimens of 49 c...

journal_title：American journal of hematology

authors： Bledsoe JR,Redd RA,Hasserjian RP,Soumerai JD,Nishino HT,Boyer DF,Ferry JA,Zukerberg LR,Harris NL,Abramson JS,Sohani AR

更新日期：2016-10-01 00:00:00

abstract：:Venous thromboembolism (VTE) is common but often unrecognized in medically ill patients. Over the past 5 years, three large-scale placebo-controlled trials enrolling a total of 5500 medically ill patients have highlighted the risk of VTE in this group. These trials have helped to define a specific at-risk patient prof...

journal_title：American journal of hematology

authors： Stinnett JM,Pendleton R,Skordos L,Wheeler M,Rodgers GM

更新日期：2005-03-01 00:00:00

abstract：:Little is known about the mechanisms explaining the wide variation in platelet counts (PLT) and other hematologic parameters in humans. We previously showed that the sex-based difference in hematocrit was associated with nucleotide variation in the erythropoietin receptor gene (EPOR). We sought to identify new polymor...

journal_title：American journal of hematology

authors： Zeng SM,Murray JC,Widness JA,Strauss RG,Yankowitz J

更新日期：2004-09-01 00:00:00

abstract：:We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, elect...

journal_title：American journal of hematology

authors： Leebeek FW,Knot EA,Ten Cate JW,Traas DW

更新日期：1989-01-01 00:00:00

abstract：:Between 1980 and 1988, 126 patients with leukemia were treated with piperazinedione and fractionated total body irradiation (TBI) followed by allogeneic bone marrow transplantation from HLA matched siblings. Sixty-one patients had acute myelogenous leukemia, 46 acute lymphoblastic leukemia, and 19 chronic myelogenous ...

journal_title：American journal of hematology

authors： Dimopoulos MA,Yau JC,Huan SD,Jagannath S,Spitzer G,Spinolo JA,Zagars GK,LeMaistre CF,Dicke KA,Zander AR

更新日期：1994-06-01 00:00:00

abstract：:This study concerned the gamma chain composition of Hb F and the haplotypes of 44 patients with beta-thalassemia major or intermedia and many of their relatives. Seventeen patients came from Northern (Turkish) Cyprus, 12 from the Istanbul area, and 15 from Macedonia and Bulgaria. Analysis of the A gamma T-G gamma-A ga...

journal_title：American journal of hematology

authors： Aksoy M,Kutlar A,Efremov GD,Nikolov N,Petkov G,Reese AL,Harano T,Chen SS,Huisman TH

更新日期：1985-09-01 00:00:00

abstract：:Familial Pseudohyperkalemia (FP) is a dominant red cell trait characterized by increased serum [K(+)] in whole blood stored at or below room temperature, without additional hematological abnormalities. Functional gene mapping and sequencing analysis of the candidate genes within the 2q35-q36 critical interval identifi...

journal_title：American journal of hematology

authors： Andolfo I,Alper SL,Delaunay J,Auriemma C,Russo R,Asci R,Esposito MR,Sharma AK,Shmukler BE,Brugnara C,De Franceschi L,Iolascon A

更新日期：2013-01-01 00:00:00

abstract：:Alpha-hemoglobin stabilizing protein (AHSP) is a potential modifier of beta-thalassemia by virtue of its ability to detoxify excess free alpha-globin. However, examination of patients with beta-thalassemia from a few geographic regions failed to identify obvious AHSP mutations. We extended these studies by analyzing A...

journal_title：American journal of hematology

authors： dos Santos CO,Zhou S,Secolin R,Wang X,Cunha AF,Higgs DR,Kwiatkowski JL,Thein SL,Gallagher PG,Costa FF,Weiss MJ

更新日期：2008-02-01 00:00:00

abstract：:We present a case of acquired von Willebrand syndrome (AVWS) due to a monoclonal gammopathy of undetermined significance. Initially this case was diagnosed as congenital von Willebrand disease (VWD); however, re-examination of the medical history rendered a congenital bleeding disorder unlikely. A normal plasma von Wi...

journal_title：American journal of hematology

authors： Eikenboom JC,Tjernberg P,Van Marion V,Heering KJ

更新日期：2007-01-01 00:00:00

abstract：:A 77-year-old man with relapsed non-Hodgkin's lymphoma, diffuse large B-cell type, was treated with naproxen, a nonsteroidal anti-inflammatory drug (NSAID), for paraneoplastic fever. A dramatic disappearance of not only the fever but also generalized lymphadenopathy was observed. Naproxen was continued, and he maintai...

journal_title：American journal of hematology

authors： Yoshinaga K,Teramura M,Iwabe K,Kobayashi S,Masuda M,Motoji T,Mizoguchi H

更新日期：2001-03-01 00:00:00

abstract：:In 2010, the Food and Drug Administration (FDA) added a black box warning to anti-D immune globulin (Rho(D) immune globulin, anti-D) for immune thrombocytopenia (ITP) to warn of the complications related to severe hemolysis. The objective of this retrospective medical record review was to examine recent trends in anti...

journal_title：American journal of hematology

authors： Long M,Kalish LA,Neufeld EJ,Grace RF

更新日期：2012-03-01 00:00:00

abstract：:Evidence suggest that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment related mo...

journal_title：American journal of hematology

authors： Estey E

更新日期：2016-08-01 00:00:00

abstract：:At sites of vascular injury, the platelet collagen receptor Glycoprotein Ia/IIa (GPIa/IIa) acts as an important mediator of platelet adhesion to fibrillar collagens. Two silent polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene have been implicated in increased risk of developing thrombosis and myocardi...

journal_title：American journal of hematology

authors： Komurcu E,Erginel-Unaltuna N

更新日期：2002-01-01 00:00:00

abstract：:The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

journal_title：American journal of hematology

authors： Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

更新日期：2001-09-01 00:00:00

abstract：:We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

journal_title：American journal of hematology

authors： Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

更新日期：2000-01-01 00:00:00

abstract：:We report the long-term follow-up results of a phase II trial of thalidomide for early-stage multiple myeloma (MM). Patients were eligible if they had smoldering multiple myeloma (SMM) or indolent MM without the need for immediate therapy. Thalidomide was initiated at a dose of 200 mg/day and adjusted as tolerated. Di...

journal_title：American journal of hematology

authors： Detweiler-Short K,Hayman S,Gertz MA,Lacy MQ,Dispenzieri A,Kumar S,Zeldenrust SR,Russell SJ,Lust JA,Kyle RA,Greipp PR,Witzig TE,Vincent Rajkumar S

更新日期：2010-10-01 00:00:00