Myelodysplastic syndrome treatment with danazol and cis-retinoic acid.

abstract：:Therapy of Hodgkin lymphoma (HL) is designed to prolong survival and minimize toxicity. A total of 124 patients with newly diagnosed HL and adverse prognostic factors were prospectively studied between July, 1999 and August, 2005. Patients with early unfavorable and advanced disease were eligible for the study. Patien...

journal_title：American journal of hematology

authors： Dann EJ,Blumenfeld Z,Bar-Shalom R,Avivi I,Ben-Shachar M,Goor O,Libster D,Gaitini D,Rowe JM,Epelbaum R

更新日期：2012-01-01 00:00:00

abstract：:In this study, we examined differences in inpatient costs, length of stay, and in-hospital mortality between hospitalizations for patients with and without sickle cell disease (SCD) undergoing high-volume surgical procedures. We used Clinical Classification Software (CCS) codes to identify discharges in the 2002-2005 ...

journal_title：American journal of hematology

authors： Dinan MA,Chou CH,Hammill BG,Graham FL,Schulman KA,Telen MJ,Reed SD

更新日期：2009-11-01 00:00:00

abstract：:High-density lipoprotein (HDL) of 100-400 micrograms/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1-5 microM). Highly concentrated HDL (1,200 micrograms/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist-induced p...

journal_title：American journal of hematology

authors： Pfennig O,Zhao B,Frye S,Dierichs R

更新日期：1995-12-01 00:00:00

abstract：:Positron emission tomography-computed tomography (PET-CT) can identify bony lesions, assess disease burden, and detect extramedullary disease (EMD) in patients with multiple myeloma. We retrospectively reviewed records of patients who underwent PET-CT within 60 days of a new diagnosis (before therapy commenced) to ide...

journal_title：American journal of hematology

authors： Aljama MA,Sidiqi MH,Buadi FK,Lacy MQ,Gertz MA,Dispenzieri A,Dingli D,Muchtar E,Fonder AL,Hayman SR,Hobbs MA,Gonsalves WI,Warsame RM,Kourelis T,Hwa YL,Kapoor P,Kyle RA,Leung N,Go RS,Rajkumar SV,Kumar SK

更新日期：2018-12-01 00:00:00

abstract：:Defects in stomatin, alpha-adducin, and beta-adducin have been implicated in erythrocyte disorders of cation permeability. We performed linkage analysis of the genetic loci for these proteins in a large kindred with xerocytosis (dehydrated hereditary stomatocytosis). Using polymerase chain reaction-based genotyping te...

journal_title：American journal of hematology

authors： Innes DS,Sinard JH,Gilligan DM,Snyder LM,Gallagher PG,Morrow JS

更新日期：1999-01-01 00:00:00

abstract：:Flow cytometry (FCM) is an adjunct study to routine analysis of cerebrospinal fluid (CSF) to investigate for involvement by a hematologic malignancy. However, in our experience, FCM only infrequently detects abnormalities in CSF. To help optimize resources without forfeiting clinically important data, we sought to det...

journal_title：American journal of hematology

authors： Kovach AE,DeLelys ME,Kelliher AS,Dillon LJ,Hasserjian RP,Ferry JA,Preffer FI,Sohani AR

更新日期：2014-10-01 00:00:00

abstract：:Our objectives were to measure and compare plasminogen activator inhibitor levels (PAI-1) in primary adult thrombotic thrombocytopenic purpura (TTP) and in secondary TTP associated with bone marrow transplantation (BMT)-TTP. PAI-1 antigen levels were measured by an enzyme linked immunosorbent assay on platelet poor pl...

journal_title：American journal of hematology

authors： Anthony MT,Zeigler ZR,Lister J,Raymond JM,Shadduck RK,Kramer RE,Gryn JF,Rintels PB,Besa EC,George JN,Silver B,Joyce R,Bodensteiner D

更新日期：1998-09-01 00:00:00

abstract：:Anthracyclines have contributed to a marked increase in survival in different types of cancer [1,2]. Unfortunately, they are associated with dose-dependent cardiotoxicity and heart failure (HF) [3–8]. Change to a weekly dosage schedule with slow infusions has been tested, a strategy that requires more frequent hospita...

journal_title：American journal of hematology

authors： Georgakopoulos P,Roussou P,Matsakas E,Karavidas A,Anagnostopoulos N,Marinakis T,Galanopoulos A,Georgiakodis F,Zimeras S,Kyriakidis M,Ahimastos A

更新日期：2010-11-01 00:00:00

abstract：:Chimeric antigen receptors (CARs) can be introduced into T-cells redirecting them to target specific tumor antigens. CAR-modified T cells targeting CD19 have shown remarkable activity against CD19+ malignancies including B cell acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymph...

journal_title：American journal of hematology

authors： Frey NV,Porter DL

更新日期：2016-01-01 00:00:00

abstract：:A quantitative bioassay for serum erythropoietin in anemic patients was established with erythroid colony-forming technique using methyl cellulose. Fetal mouse liver contains many erythropoietin-dependent erythroid colony-forming cells (CFU-E) with the concentration as well as sensitivity to erythropoietin being the h...

journal_title：American journal of hematology

authors： Okamoto T,Kanamaru A,Hara H,Nagai K

更新日期：1982-04-01 00:00:00

abstract：DISEASE OVERVIEW:Chronic neutrophilic leukemia (CNL) is a rare, often aggressive myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis, bone marrow granulocyte hyperplasia, and frequent hepatosplenomegaly. The seminal discovery of oncogenic driver mutations in colony-stimulating facto...

journal_title：American journal of hematology

authors： Szuber N,Elliott M,Tefferi A

更新日期：2020-02-01 00:00:00

abstract：:A case of leukemia cutis (LC) of monocytic lineage in a patient with myelodysplastic syndrome (MDS) is presented. Cutaneous infiltrates were recognized concurrent with diagnosis of refractory anemia (RA) with monocytosis. Skin infiltrates subsequently spontaneously regressed although MDS progressed with increasing mon...

journal_title：American journal of hematology

authors： Yavorkovsky LL,Zain J,Wu CD,Trivelli L,Cook P

更新日期：2001-02-01 00:00:00

abstract：:A case of a leukemic transformation following a 27-year history of idiopathic myelofibrosis (IMF) is presented. The patient had two chromosomal abnormalities: a deletion of chromosome 13, del 13(q12q14), and a deletion of chromosome 11, del 11(q14q23). This patient's final diagnosis was acute micromegakaryocytic leuke...

journal_title：American journal of hematology

authors： Toubai T,Tanaka J,Higa T,Ota S,Ibata M,Shono Y,Mashiko S,Miura Y,Umehara S,Kahata K,Toyoshima N,Morioka M,Asaka M,Kasai M,Imamura M

更新日期：2005-01-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) therapy is associated with rare reports of thromboembolic events and severe hyponatremia. We hypothesized that IVIG therapy may result in hyperproteinemia, increased serum viscosity, and pseudohyponatremia. We conducted a prospective observational study to evaluate the incidence of hy...

journal_title：American journal of hematology

authors： Steinberger BA,Ford SM,Coleman TA

更新日期：2003-06-01 00:00:00

abstract：:Variation in bleeding in the perioperative period is a complex and multifactorial event associated with immediate and delayed consequences for the patient and health care resources. Little is known about the complex genetic influences on perioperative bleeding. With the discovery of multiple variations in the human ge...

journal_title：American journal of hematology

authors： Muehlschlegel JD,Body SC

更新日期：2008-09-01 00:00:00

abstract：:Some evidence has shown that platelet crossmatching is useful in multitransfused patients with hypoplastic bone marrows who are refractory to platelet therapy through alloimmunization. Several immunoglobulin binding assays other than enzyme-linked immunospecific assay (ELISA) have been studied previously. We performed...

journal_title：American journal of hematology

authors： Brubaker DB,Duke JC,Romine M

更新日期：1987-04-01 00:00:00

abstract：:Cobalamin (vitamin B12) deficiency is a common cause of megaloblastic anemia in Western populations. Laboratory evaluation of megaloblastic anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in the clinical laboratory with competit...

journal_title：American journal of hematology

authors： Oberley MJ,Yang DT

更新日期：2013-06-01 00:00:00

abstract：:A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expres...

journal_title：American journal of hematology

authors： Yasukawa M,Arai J,Kakimoto M,Sakai I,Kohno H,Fujita S

更新日期：2001-01-01 00:00:00

abstract：:The Mo2 antibody recognizes a monocyte-specific cell surface antigen of unknown function. Upward modulation of Mo2 surface epitope density was demonstrated in response to 72-hr culture of monocytes with respiratory syncytial virus (RSV), but this was not seen after culture with phytohemagglutinin or other respiratory ...

journal_title：American journal of hematology

authors： Baumann MA,Paul CC,Stokes C,Bernstein JM

更新日期：1987-07-01 00:00:00

abstract：:National AIDS surveillance suggests that approximately 3.5% of all hemophilic patients in the United States have developed AIDS as of February 1988; however, the cumulative incidence of AIDS among seropositive patients at individual hemophilia treatment centers (HTCs) has been reported to be as high as 12%. The purpos...

journal_title：American journal of hematology

authors： Stehr-Green JK,Jason JM,Evatt BL

更新日期：1989-11-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rarely complicated by chylothorax: we present a 93-year-old woman with CLL who developed recurrent pleural effusions that were ultimately found to be chylous in nature. Despite eight repeated thoracenteses, she continued to experience re-accumulation of fluid, and therefore, video...

journal_title：American journal of hematology

authors： Doerr CH,Staats BA,Markovic SN

更新日期：2002-07-01 00:00:00

abstract：:Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimisti...

journal_title：American journal of hematology

authors： Chaturvedi S,DeBaun MR

更新日期：2016-01-01 00:00:00

abstract：:A case of a patient presenting with idiopathic concurrent erythrocytic and megakaryocytic aplasia is reported. The patient's response to immunosuppressive therapy and her bone marrow pathology clearly suggest an immune mechanism. Based on the lack of suppression of erythroid colony growth, several mechanisms are postu...

journal_title：American journal of hematology

authors： Canavan BF,Huhn RD,Kim HC,Kosmin M,Sheay W,Saidi P

更新日期：1996-01-01 00:00:00

abstract：:A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymp...

journal_title：American journal of hematology

authors： Yamamoto M,Nakagawa M,Ichimura N,Ohtsuki F,Ohtsuka Y,Tsujino Y,Tanaka A,Kamiya T,Wada H

更新日期：1996-07-01 00:00:00

abstract：:The purpose of the study was to analyze clinical and/or autopsy findings at the time of death among adults with sickle cell disease (SCD) at Howard University in Washington, DC over a 25-year period. A single physician recorded circumstances of death among 141 adult SCD patients he treated and knew well from 1976 to 2...

journal_title：American journal of hematology

authors： Darbari DS,Kple-Faget P,Kwagyan J,Rana S,Gordeuk VR,Castro O

更新日期：2006-11-01 00:00:00

abstract：:Immunomodulatory drugs (IMiDs) are a cornerstone in the treatment of multiple myeloma (MM), but specific markers to predict outcome are still missing. Recent work pointed to a prognostic role for IMiD target genes (e.g. CRBN). Moreover, indirect activity of IMiDs on immune cells correlated with outcome, raising the po...

journal_title：American journal of hematology

authors： Bolomsky A,Hübl W,Spada S,Müldür E,Schlangen K,Heintel D,Rocci A,Weißmann A,Fritz V,Willheim M,Zojer N,Palumbo A,Ludwig H

更新日期：2017-03-01 00:00:00

abstract：:Aberrant promoter DNA methylation is a well-described mechanism of leukemogenesis within hematologic malignancies, including acute lymphoblastic leukemia (ALL). However, the importance of methylation patterns among the adolescent and young adult (AYA) ALL population has not been well established. DNA methylation of 18...

journal_title：American journal of hematology

authors： DiNardo CD,Gharibyan V,Yang H,Wei Y,Pierce S,Kantarjian HM,Garcia-Manero G,Rytting M

更新日期：2013-09-01 00:00:00

abstract：:Febrile neutropenia (FN) is a frequent complication of cancer chemotherapy, which causes death in 4-21% of patients and worsens the quality of life of patients. As a simple and accurate way of identifying patients who are at risk of FN, a lymphocyte count on post-chemotherapy day 5 was suggested. To confirm the feasib...

journal_title：American journal of hematology

authors： Choi CW,Sung HJ,Park KH,Yoon SY,Kim SJ,Oh SC,Seo JH,Kim BS,Shin SW,Kim YH,Kim JS

更新日期：2003-08-01 00:00:00

abstract：:Prenatal diagnosis was carried out on a woman who had previously given birth to a son with a spontaneous mutation of C-->T transition at nt 31133 of the factor IX (F.IX) gene. The diagnosis was performed on chorionic villi sampling by the method of amplification-created restriction site (ACRS). It revealed a female fe...

journal_title：American journal of hematology

authors： Young JH,Wang JC,Gau JP,Hu HT

更新日期：1996-08-01 00:00:00

abstract：:A 1750 base pair cDNA to human terminal deoxynucleotidyl transferase (TdT) has been cloned. This cDNA detects a dominant 2200 base pair messenger RNA species in normal and leukemic cells synthesizing the enzyme. A quantitative dot blot assay was utilized to survey a number of clinical samples from patients with TdT po...

journal_title：American journal of hematology

authors： Wolf SC,Steinherz PG,Landau NR,Silverstone AE

更新日期：1987-07-01 00:00:00