High-density lipoprotein fails to inhibit serotonin-induced activation of blood platelets.

Abstract:

:High-density lipoprotein (HDL) of 100-400 micrograms/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1-5 microM). Highly concentrated HDL (1,200 micrograms/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist-induced platelet activation.

journal_name

Am J Hematol

authors

Pfennig O,Zhao B,Frye S,Dierichs R

doi

10.1002/ajh.2830500417

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

307-9

issue

4

eissn

0361-8609

issn

1096-8652

journal_volume

50

pub_type

杂志文章
  • Splenectomy for thrombocytopenia in chronic lymphocytic leukemia.

    abstract::The role of peripheral platelet destruction as a reversible etiology of thrombocytopenia in chronic lymphocytic leukemia (CLL) was evaluated in nine patients with CLL and refractory thrombocytopenia who underwent splenectomy. The patients' ages ranged from 54 to 74 years. Progressive thrombocytopenia refractory to ant...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830150306

    authors: Merl SA,Theodorakis ME,Goldberg J,Gottlieb AJ

    更新日期:1983-11-01 00:00:00

  • A 10-year experience with treatment of high and standard risk Hodgkin disease: six cycles of tailored BEACOPP, with interim scintigraphy, are effective and female fertility is preserved.

    abstract::Therapy of Hodgkin lymphoma (HL) is designed to prolong survival and minimize toxicity. A total of 124 patients with newly diagnosed HL and adverse prognostic factors were prospectively studied between July, 1999 and August, 2005. Patients with early unfavorable and advanced disease were eligible for the study. Patien...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.22187

    authors: Dann EJ,Blumenfeld Z,Bar-Shalom R,Avivi I,Ben-Shachar M,Goor O,Libster D,Gaitini D,Rowe JM,Epelbaum R

    更新日期:2012-01-01 00:00:00

  • Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

    abstract::How often elevated serum ferritin in primary-care patients reflects increased iron stores (normally 0.8 g in men, 0.4 g in women) is not known. The Hereditary Hemochromatosis and Iron Overload Screening (HEIRS) study screened 101,168 primary-care participants (44% Caucasians, 27% African-Americans, 14% Asians/Pacific ...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ajh.21179

    authors: Gordeuk VR,Reboussin DM,McLaren CE,Barton JC,Acton RT,McLaren GD,Harris EL,Reiss JA,Adams PC,Speechley M,Phatak PD,Sholinsky P,Eckfeldt JH,Chen WP,Passmore L,Dawkins FW

    更新日期:2008-08-01 00:00:00

  • Pilot study of ascorbic acid for the treatment of refractory immune thrombocytopenic purpura.

    abstract::The treatment of corticosteroid- and/or splenectomy-refractory immune thrombocytopenic purpura (ITP) includes vinca alkaloids, immunosuppressives, Danazol, intravenous gammaglobulin, and alpha-interferon. However, these treatments have often been associated with toxic side effects. Brox et al. (Br J Haematol 70:341-34...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830430110

    authors: Jubelirer SJ

    更新日期:1993-05-01 00:00:00

  • Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 14. At day 5 marrow ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199801)57:1<7::aid-ajh2>3.

    authors: Dale DC,Liles WC,Llewellyn C,Price TH

    更新日期:1998-01-01 00:00:00

  • T-cell non-Hodgkin lymphoma in human immunodeficiency virus-1-infected individuals.

    abstract::We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and imm...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830310307

    authors: Lust JA,Banks PM,Hooper WC,Paya CV,Kueck BD,Hanson GA,Ritch PS,Woloschak GE

    更新日期:1989-07-01 00:00:00

  • Phenotypic variability of Filipino beta(o)-thalassemia/HbE patients in Indonesia.

    abstract::Three Indonesian patients with identical genotypes, each compound heterozygotes for Filipino beta(o)-thalassemia/HbE, expressed different clinical severities. One patient has mild disease and is transfusion independent, while the other two are severely affected and transfusion dependent. The size of the Filipino beta(...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199909)62:1<7::aid-ajh2>3.

    authors: Setianingsih I,Williamson R,Daud D,Harahap A,Marzuki S,Forrest S

    更新日期:1999-09-01 00:00:00

  • Corticosteroids and rituximab as adjunctive treatments for thrombotic thrombocytopenic purpura.

    abstract::Although treatment with plasma exchange increased the survival of patients with thrombotic thrombocytopenia purpura to 80% in the 1980s, no further increase of survival occurred over the next 20 years. However, more consistent use of adjuvant treatment with corticosteroids and rituximab in recent years has begun to fu...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.23126

    authors: George JN

    更新日期:2012-05-01 00:00:00

  • Two-year evaluation of clinical and laboratory variables of immune function in 117 hemophiliacs seropositive or seronegative for HIV-1.

    abstract::Fifty-nine HIV-1 antibody positive and 58 antibody negative hemophiliacs were evaluated over a 2 year study period to gain insight into the natural history and prognosis of HIV-1 disease in members of this risk group. Mean CD4 (Leu 3+) cell counts calculated at 6 month intervals decreased gradually in seropositive pat...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830320406

    authors: Teitel JM,Freedman JJ,Garvey MB,Kardish M

    更新日期:1989-12-01 00:00:00

  • Molecular basis and hematological characterization of Hb H disease in southeast Asia.

    abstract::We molecularly characterized sixty-seven cases of Hb H disease by the polymerase chain reaction. The strategy depends on amplifying the alpha-thalassemia-1 (alpha-thal-1) gene by primers flanking the breakpoint and sequence differences of the 3' end of the alpha-globin gene and the nonhomologous elements I, II, and II...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830450405

    authors: Liu TC,Chiou SS,Lin SF,Chen TP,Tseng WP,Chen PH,Chang JG

    更新日期:1994-04-01 00:00:00

  • Reversible posterior leukoencephalopathy syndrome after repeat intermediate-dose cytarabine chemotherapy in a patient with acute myeloid leukemia.

    abstract::A 56-year-old man was admitted to our hospital with leukocytosis, anemia, and thrombocytopenia. Acute monoblastic leukemia was diagnosed. Two subsequent courses of consolidation chemotherapy consisted of conventional doses of cytarabine and intermediate-dose cytarabine. Intermediate-dose cytarabine was infused intrave...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.20772

    authors: Saito B,Nakamaki T,Nakashima H,Usui T,Hattori N,Kawakami K,Tomoyasu S

    更新日期:2007-04-01 00:00:00

  • Sustained remissions and low rate of BCR-ABL resistance mutations with imatinib treatment chronic myelogenous leukemia in patients treated in late chronic phase: a 5-year follow up.

    abstract::The introduction of Imatinib (IM) has significantly altered the treatment for CML, although only limited follow-up results are available. As failure of Interferon-alpha had been associated with poor prognosis and results of IM-treatment in this patient group may allow earlier estimation of long-term benefits for early...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21055

    authors: Hess G,Meyer RG,Schuch B,Bechthold K,El-Kholy I,Huber C

    更新日期:2008-03-01 00:00:00

  • Tumor necrosis factor-alpha overproduction in Fanconi's anemia.

    abstract::Various in vitro studies and clinical observations suggest that Fanconi's anemia (FA) patients are unable to detoxify adequately superoxide anions (O2-) released by activated phagocytes. Recent studies have shown that certain lymphokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830420211

    authors: Schultz JC,Shahidi NT

    更新日期:1993-02-01 00:00:00

  • Hematological evaluation of patients with various combinations of alpha-thalassemia.

    abstract::Six patients and their parents from five different families with Hb H have been evaluated clinically and hematologically. Previous studies using restriction endonuclease mapping technique indicated that alpha-thalassemia determinants in these cases are heterogeneous. Only one of the five cases have the usual genotype ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830090304

    authors: Altay C,Gurgey A,Tuncbilek E

    更新日期:1980-01-01 00:00:00

  • Some studies with a monoclonal antibody directed against human fibrinogen.

    abstract::Some properties of a monoclonal antibody generated against the fibrinogen component of a factor VIII preparation were investigated. The antibody bound with equal affinity in solid phase radioimmunoassays to fibrinogens isolated from both normal patients and patients with von Willebrand disease. It reacted in a sensiti...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830180202

    authors: Francis SE,Joshua DE,Exner T,Kronenberg H

    更新日期:1985-02-01 00:00:00

  • Human thymus antigen: characterization and its expression on human leukemias.

    abstract::Specific anti-human thymus xenoantiserum (ATS) was utilized for characterizing a human thymus antigen (HTA) preferentially expressed on human thymocytes. Binding of ATS with different cell types was studied by immunofluorescence and immunoperoxidase techniques, as well as by radioimmunoprecipitation (RIP) followed by ...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830100206

    authors: Fujimoto J,Ishii Y,Koshiba H,Matsuura A,Ogasawara M,Uede T,Kikuchi K

    更新日期:1981-01-01 00:00:00

  • Thrombomodulin and induced tissue factor expression on monocytes as markers of diabetic microangiopathy: a prospective study on hemostasis and lipoproteins in insulin-dependent diabetes mellitus.

    abstract::Vascular complications are the main cause of morbidity in diabetes mellitus. To evaluate lipoprotein and hemostatic parameters and their relationship with clinically detectable microangiopathy, we studied 58 insulin-dependent diabetes mellitus patients and 60 controls matched for age, sex, and body mass index. Thirtee...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199710)56:2<93::aid-ajh4>3

    authors: Reverter JL,Reverter JC,Tàssies D,Rius F,Monteagudo J,Rubiés-Prat J,Escolar G,Ordinas A,Sanmarti A

    更新日期:1997-10-01 00:00:00

  • Feasibility, toxicity, and activity of LNH84-derived chemotherapy in the management of aggressive lymphomas.

    abstract::The results of chemotherapy remain unsatisfactory for many patients with advanced lymphomas. Both standard and more aggressive chemotherapy regimens might have their respective role in the management of theses diseases. We have tested the feasibility and assessed the toxicity and activity of a LNH84-derived chemothera...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1096-8652(199707)55:4<199::aid-ajh6>

    authors: Laurencet FM,Zulian GB,Bauer J,Mermillod B,Iten PA,Alberto P

    更新日期:1997-08-01 00:00:00

  • An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer.

    abstract::Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patie...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1002/ajh.25418

    authors: Feins S,Kong W,Williams EF,Milone MC,Fraietta JA

    更新日期:2019-05-01 00:00:00

  • The effect of acute and chronic leukapheresis on the natural killer (NK) cell function of normal human volunteers.

    abstract::Twenty-two normal volunteers had approximately eight, 2-hr-long leukapheresis procedures over a 2-year period and their natural killer (NK) cell function was prospectively measured. The NK activity of the preprocedure peripheral blood (pre-PB) was found to correlate well with the NK activity of the inital leukocytes r...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830220203

    authors: Stevenson HC,Beman JS,Crisp B,Coggin D,Kanapa DJ,Miller P,Herberman RB,Maluish AE

    更新日期:1986-06-01 00:00:00

  • Induction of cytotoxic T lymphocytes by dendritic cells pulsed with murine leukemic cell RNA.

    abstract::Peptide-pulsed dendritic cells can stimulate T cells showing specific cytotoxicity in chronic myelogenous leukemia. We tried to induce a specific cytotoxic T-cell response stimulated by RNA-pulsed dendritic cells in acute myelogenous leukemia. The total RNA of WEHI-3BD+, a myelomonocytic leukemia cell line derived fro...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.10471

    authors: Jung CW,Kwon JH,Seol JG,Park WH,Hyun JM,Kim ES,Kim ST,Lee SJ,Kim BK,Lee YY

    更新日期:2004-03-01 00:00:00

  • Hydroxycarbamide-induced changes in E/beta thalassemia red blood cells.

    abstract::In thalassemia, fetal hemoglobin (HbF) augmentation with hydroxycarbamide (also known as hydroxyurea) is not always successful. The expected parallel effects on red cell (RBC) membrane deformability, cell hydration, and membrane phospholipid organization, all important for extending RBC life span and increasing Hb, ha...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.21266

    authors: Singer ST,Vichinsky EP,Larkin S,Olivieri N,Sweeters N,Kuypers FA,E\/beta Thalassemia Study Group.

    更新日期:2008-11-01 00:00:00

  • Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma.

    abstract::The serum free light chain (FLC) assay quantitates free immunoglobulin kappa and lambda light chains, which has prognostic value in plasma cell dyscrasias. However, there is limited data on serum FLC in lymphoid malignancies. We analyzed the association of pretreatment FLC with event-free survival (EFS) and overall su...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ajh.22168

    authors: Thompson CA,Maurer MJ,Cerhan JR,Katzmann JA,Ansell SM,Habermann TM,Macon WR,Weiner GJ,Link BK,Witzig TE

    更新日期:2011-12-01 00:00:00

  • Chronic lymphocytic leukemia: correlation of clinical course and therapeutic response with in vitro testing and morphology of lymphocytes.

    abstract::Forty-two patients with chronic lymphocytic leukemia (CLL) were studied for morphology of lymphocytes by light and electron microscopy (EM), in vitro responses of lymphocytes to a battery of physical and chemical agents, overall clinical status, immunologic status, course, and response to therapy. CLL lymphocytes coul...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830020110

    authors: Knospe WH,Gregory SA,Trobaugh FE Jr,Stedronsky JA,Schrek R

    更新日期:1977-01-01 00:00:00

  • Exclusion of the stomatin, alpha-adducin and beta-adducin loci in a large kindred with dehydrated hereditary stomatocytosis.

    abstract::Defects in stomatin, alpha-adducin, and beta-adducin have been implicated in erythrocyte disorders of cation permeability. We performed linkage analysis of the genetic loci for these proteins in a large kindred with xerocytosis (dehydrated hereditary stomatocytosis). Using polymerase chain reaction-based genotyping te...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-8652(199901)60:1<72::aid-ajh13>

    authors: Innes DS,Sinard JH,Gilligan DM,Snyder LM,Gallagher PG,Morrow JS

    更新日期:1999-01-01 00:00:00

  • CD7, CD34-positive stem cell leukemia arising in agnogenic myeloid metaplasia.

    abstract::Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder arising from a single hematopoietic cell. Approximately 5% of reported cases of AMM have terminated in leukemic crisis; however, the precise characteristics of the leukemic cells have rarely been reported. We report a case of AMM that occurred...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830440111

    authors: Tasaka T,Nagai M,Murao S,Yamaguchi M,Kitanaka A,Sasaki K,Murata M,Tanaka T,Kuwabara H,Ikeda K

    更新日期:1993-09-01 00:00:00

  • Genomic Characteristics and Prognostic Significance of Co-mutated ASXL1/SRSF2 Acute Myeloid Leukemia.

    abstract::ASXL1 and SRSF2 mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi-institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients with ASXL1mut SRSF2mut AML and compared o...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.26110

    authors: Richardson DR,Swoboda DM,Moore DT,Johnson SM,Chan O,Galeotti J,Esparza S,Hussaini MO,Van Deventer H,Foster MC,Coombs CC,Montgomery ND,Sallman DA,Zeidner JF

    更新日期:2021-01-27 00:00:00

  • Chromosomes and causation of human cancer and leukemia: XXVIII. Value of detailed chromosome studies on large numbers of cells in CML.

    abstract::Comparison of the chromosome findings obtained on routine examination (10-50 cells) of the marrows from patients with Ph1-positive CML with those based on a large number (110-500 cells) of metaphases in six of these patients, in whom appropriate material was available, revealed the presence of small percentages of ane...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.2830030202

    authors: Sonta SI,Sandberg AA

    更新日期:1977-01-01 00:00:00

  • Risk of diffuse large B-cell lymphoma after solid organ transplantation in the United States.

    abstract::Non-Hodgkin lymphoma arising in the context of immunosuppression is an important adverse outcome after solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed subtype of post-transplantation non-Hodgkin lymphoma, but few studies of transplant recipients have examined subtype-s...

    journal_title:American journal of hematology

    pub_type: 杂志文章

    doi:10.1002/ajh.23726

    authors: Gibson TM,Engels EA,Clarke CA,Lynch CF,Weisenburger DD,Morton LM

    更新日期:2014-07-01 00:00:00

  • Gentle yet effective treatment for elderly patients with refractory or relapsing multiple myeloma.

    abstract::Fourteen patients, aged 65-85 years, with refractory (11) or relapsing (3) multiple myeloma were treated with a "protracted-sequential" protocol comprising vincristine 1-2 mg or vindesine 3 mg/M(2) (max. 5 mg) IVI over 4 hr on D1, prednisolone 40-50 mg PO D1-14, and melphalan 2-4 mg PO or cyclophosphamide 50-100 mg PO...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1002/1096-8652(200009)65:1<81::aid-ajh15>3.0.co

    authors: Manoharan A

    更新日期:2000-09-01 00:00:00