Abstract:
:In 2010, the Food and Drug Administration (FDA) added a black box warning to anti-D immune globulin (Rho(D) immune globulin, anti-D) for immune thrombocytopenia (ITP) to warn of the complications related to severe hemolysis. The objective of this retrospective medical record review was to examine recent trends in anti-D use to treat ITP and rates of adverse events in a single large pediatric hematology program. Over a 7-year period, 176 (35%) of 502 ITP patients at our center received anti-D. Anti-D was the second most commonly prescribed drug for ITP from 2003 to 2010 overall and was given first most frequently (41%). Sixty-four percent of patients responded to anti-D, but 36% had adverse effects, including five patients requiring hospitalization. From 2003 to 2010, the use of anti-D as an initial therapy for ITP significantly decreased (P < 0.001). This trend preceded the 2010 FDA black box warning. In our experience, anti-D was associated with a significant number of adverse effects when used as a treatment for ITP, although none were life-threatening. Despite recent guidelines suggesting anti-D therapy for initial treatment for ITP, anti-D therapy for ITP has significantly decreased over the past 7 years.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Long M,Kalish LA,Neufeld EJ,Grace RFdoi
10.1002/ajh.22261subject
Has Abstractpub_date
2012-03-01 00:00:00pages
315-7issue
3eissn
0361-8609issn
1096-8652journal_volume
87pub_type
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.24252
更新日期:2016-02-01 00:00:00
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更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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abstract::An 18-year-old girl with a preoperative platelet count of 216,000/cmm received 3 units of stored plasma at the time of surgery. Within 6 hours her platelet count had fallen to 5,000/mm3 and hemorrhagic manifestations appeared. One of the plasma donors was found to be P1A1 negative with an anti P1A1 antibody. The recip...
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/ajh.1161
更新日期:2001-10-01 00:00:00
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1096-8652(199707)55:4<199::aid-ajh6>
更新日期:1997-08-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章,实务指引
doi:10.1002/ajh.21269
更新日期:2008-11-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2015-06-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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更新日期:2010-10-01 00:00:00