Abstract:
:Serum lactic dehydrogenase (LDH) levels are mildly elevated in beta-thalassemia major due to ineffective erythropoiesis. We reviewed the charts of 15 consecutive thalassemic children who underwent allogeneic, T-cell-depleted bone marrow transplantation (BMT) in our department during the last 3 years. Eleven patients had successful engraftment and are alive and well without evidence of disease, according to physical examinations, blood counts, and polymerase chain reaction (PCR) tests, with a median follow-up of 2 years. Two patients died due to transplantation-related complications, and two rejected the graft and received their backup autologous marrow. The LDH levels in the transplanted patients gradually decreased from an average of 952 +/- 155 IU/L 10 days pre-transplant (N = 300-620) to 426 +/- 56 IU/L at the day of transplantation, and stayed at approximately the same level post-transplant (489 +/- 55 IU/L). By contrast, the LDH levels reverted to the pre-transplant value in those patients who rejected their marrow. The significance of this clinical observation for the pathophysiologic mechanism of intramedullary hemolysis and ineffective erythropoiesis in beta-thalassemia major is discussed.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Toren A,Or R,Kapelushnik J,Chividalli G,Aku M,Slavin S,Nagler Adoi
10.1002/(SICI)1096-8652(199602)51:2<166::AID-AJH13subject
Has Abstractpub_date
1996-02-01 00:00:00pages
166-7issue
2eissn
0361-8609issn
1096-8652pii
10.1002/(SICI)1096-8652(199602)51:2<166::AID-AJH13journal_volume
51pub_type
杂志文章abstract::The clinical development of lenalidomide (Revlimid™), then pomalidomide (Actimid™) as members of immunomodulatory drugs (IMiDs) for the treatment of multiple myeloma (MM), exemplifies how insight into disease biology can lead to design of effective therapeutic agents. Increased experience and understanding of IMiD's d...
journal_title:American journal of hematology
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pub_type: 杂志文章
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.26102
更新日期:2021-01-21 00:00:00
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/ajh.2830480405
更新日期:1995-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.2830490315
更新日期:1995-07-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.23912
更新日期:2015-03-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章,评审
doi:10.1002/ajh.25071
更新日期:2018-05-01 00:00:00
abstract::Familial Pseudohyperkalemia (FP) is a dominant red cell trait characterized by increased serum [K(+)] in whole blood stored at or below room temperature, without additional hematological abnormalities. Functional gene mapping and sequencing analysis of the candidate genes within the 2q35-q36 critical interval identifi...
journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.23357
更新日期:2013-01-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:1981-12-01 00:00:00
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-10-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:1989-02-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.2830380321
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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更新日期:1976-01-01 00:00:00