Normalization of serum lactic dehydrogenase in beta-thalassemia patients following bone marrow transplantation.


:Serum lactic dehydrogenase (LDH) levels are mildly elevated in beta-thalassemia major due to ineffective erythropoiesis. We reviewed the charts of 15 consecutive thalassemic children who underwent allogeneic, T-cell-depleted bone marrow transplantation (BMT) in our department during the last 3 years. Eleven patients had successful engraftment and are alive and well without evidence of disease, according to physical examinations, blood counts, and polymerase chain reaction (PCR) tests, with a median follow-up of 2 years. Two patients died due to transplantation-related complications, and two rejected the graft and received their backup autologous marrow. The LDH levels in the transplanted patients gradually decreased from an average of 952 +/- 155 IU/L 10 days pre-transplant (N = 300-620) to 426 +/- 56 IU/L at the day of transplantation, and stayed at approximately the same level post-transplant (489 +/- 55 IU/L). By contrast, the LDH levels reverted to the pre-transplant value in those patients who rejected their marrow. The significance of this clinical observation for the pathophysiologic mechanism of intramedullary hemolysis and ineffective erythropoiesis in beta-thalassemia major is discussed.


Am J Hematol


Toren A,Or R,Kapelushnik J,Chividalli G,Aku M,Slavin S,Nagler A




Has Abstract


1996-02-01 00:00:00














  • Impact of aberrant DNA methylation patterns including CYP1B1 methylation in adolescents and young adults with acute lymphocytic leukemia.

    abstract::Aberrant promoter DNA methylation is a well-described mechanism of leukemogenesis within hematologic malignancies, including acute lymphoblastic leukemia (ALL). However, the importance of methylation patterns among the adolescent and young adult (AYA) ALL population has not been well established. DNA methylation of 18...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: DiNardo CD,Gharibyan V,Yang H,Wei Y,Pierce S,Kantarjian HM,Garcia-Manero G,Rytting M

    更新日期:2013-09-01 00:00:00

  • Functional analysis of the marginating pool of human polymorphonuclear leukocytes.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Berkow RL,Dodson RW

    更新日期:1987-01-01 00:00:00

  • History and implications of the neutrophil glycoprotein deficiencies.

    abstract::This review focuses on the initial clinical descriptions and subsequent investigation of the syndrome of recurrent infections associated with neutrophil membrane glycoprotein deficiencies. Characterization of the missing group of three glycoprotein heterodimers and their role in adhesion-related neutrophil function is...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Styrt B

    更新日期:1989-08-01 00:00:00

  • Prospective validation of a risk score based on biological markers for predicting progression free survival in Binet stage A chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study.

    abstract::A risk score based on three biological features (CD38, ZAP-70, and IGHV mutational status) was previously developed to predict progression-free survival (PFS) in untreated Binet A CLL patients. Here we perform a score validation analysis in a prospective and independent cohort of patients. Biological markers (CD38, ZA...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Gentile M,Cutrona G,Mosca L,Matis S,Fabris S,Lionetti M,Ilariucci F,Zupo S,Musolino C,Levato L,Molica S,Di Raimondo F,Vincelli I,Di Rienzo N,Pesce EA,Angrilli F,Federico M,Neri A,Ferrarini M,Morabito F

    更新日期:2014-07-01 00:00:00

  • Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

    abstract::Two patients underwent allogeneic hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia. Chronic graft-versus-host disease (GVHD) developed, with persistent symptomatic oral lesions. At 2 and 6 years post-HSCT, both patients developed squamous cell carcinoma (SCC) of the tongue in areas previously ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Szeto CH,Shek TW,Lie AK,Au WY,Yuen AP,Kwong YL

    更新日期:2004-10-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Abe Y,Muta K,Yufu Y,Takahira H,Nishimura J,Nawata H

    更新日期:1990-03-01 00:00:00

  • Hemosiderosis with diabetes mellitus in untransfused Hemoglobin H disease.

    abstract::A 37-year-old untransfused, non-drinking man with Hemoglobin H-CS disease presented with insulin-dependent diabetes mellitus, markedly elevated serum ferritin level, and marked iron deposition in hepatocytes. He did not carry either of the two common mutations of the HLA-H gene for hereditary hemochromatosis, namely, ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Chim CS,Chan V,Todd D

    更新日期:1998-02-01 00:00:00

  • Outcomes of inpatients with and without sickle cell disease after high-volume surgical procedures.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Dinan MA,Chou CH,Hammill BG,Graham FL,Schulman KA,Telen MJ,Reed SD

    更新日期:2009-11-01 00:00:00

  • Inpatient management of sickle cell pain: a 'snapshot' of current practice.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Miller ST,Kim HY,Weiner D,Wager CG,Gallagher D,Styles L,Dampier CD,Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN).

    更新日期:2012-03-01 00:00:00

  • Phenotypic variability of Filipino beta(o)-thalassemia/HbE patients in Indonesia.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Setianingsih I,Williamson R,Daud D,Harahap A,Marzuki S,Forrest S

    更新日期:1999-09-01 00:00:00

  • Serum antibodies to distinct epitopes of the tissue-type plasminogen activator (t-PA) in patients with systemic lupus erythematosus.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ruiz-Arguelles A,Angles-Cano E,Perez-Romano B,Ruiz-Arguelles GJ,Deleze M,Alarcon-Segovia D,Gaussem P

    更新日期:1995-06-01 00:00:00

  • Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Sanfilippo KM,Luo S,Wang TF,Fiala M,Schoen M,Wildes TM,Mikhael J,Kuderer NM,Calverley DC,Keller J,Thomas T,Carson KR,Gage BF

    更新日期:2019-11-01 00:00:00

  • Juvenile features in adult-type chronic granulocytic leukemia.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Gay JC,Dessypris EN,Roloff JS,Lukens JN

    更新日期:1984-01-01 00:00:00

  • Quantitative microchromatographic determination of hemoglobin F in patients with hemoglobins S and/or C.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Schroeder WA,Evans L,Grussing L,Abraham EC,Huisman TH,Lam H,Shelton JB

    更新日期:1976-01-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Davoren A,Aster RH

    更新日期:2006-01-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Janowska-Wieczorek A,Andrews EJ,Khaliq A,Pilarski LM

    更新日期:1987-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Morabito F,Bringhen S,Larocca A,Wijermans P,Victoria Mateos M,Gimsing P,Mazzone C,Gottardi D,Omedè P,Zweegman S,José Lahuerta J,Zambello R,Musto P,Magarotto V,Schaafsma M,Oriol A,Juliusson G,Cerrato C,Catalano L,Gen

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    journal_title:American journal of hematology

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    authors: Zhao B,Rickert CH,Filler TJ,Liu B,Verhallen PF,Dierichs R

    更新日期:1995-07-01 00:00:00

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    journal_title:American journal of hematology

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    authors: Adams PC

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    journal_title:American journal of hematology

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    authors: Suguro M,Kanda Y,Yamamoto R,Chizuka A,Hamaki T,Matsuyama T,Takezako N,Miwa A,Togawa A

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Mazzolari E,Forino C,Razza A,Porta F,Villa A,Notarangelo LD

    更新日期:2009-08-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Celada A,Rudolf H,Donath A

    更新日期:1978-01-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Eng B,Patterson M,Borys S,Chui DH,Waye JS

    更新日期:2000-01-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Wolberg AS,Kon RH,Monroe DM,Hoffman M

    更新日期:2000-09-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Bizzaro N

    更新日期:1992-04-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Yam P,Petz LD,Spath P

    更新日期:1982-06-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Kostopoulou AG,Tsiapras DP,Chaidaroglou AS,De Giannis DE,Farmakis D,Kremastinos DT

    更新日期:2014-01-01 00:00:00