Normalization of serum lactic dehydrogenase in beta-thalassemia patients following bone marrow transplantation.


:Serum lactic dehydrogenase (LDH) levels are mildly elevated in beta-thalassemia major due to ineffective erythropoiesis. We reviewed the charts of 15 consecutive thalassemic children who underwent allogeneic, T-cell-depleted bone marrow transplantation (BMT) in our department during the last 3 years. Eleven patients had successful engraftment and are alive and well without evidence of disease, according to physical examinations, blood counts, and polymerase chain reaction (PCR) tests, with a median follow-up of 2 years. Two patients died due to transplantation-related complications, and two rejected the graft and received their backup autologous marrow. The LDH levels in the transplanted patients gradually decreased from an average of 952 +/- 155 IU/L 10 days pre-transplant (N = 300-620) to 426 +/- 56 IU/L at the day of transplantation, and stayed at approximately the same level post-transplant (489 +/- 55 IU/L). By contrast, the LDH levels reverted to the pre-transplant value in those patients who rejected their marrow. The significance of this clinical observation for the pathophysiologic mechanism of intramedullary hemolysis and ineffective erythropoiesis in beta-thalassemia major is discussed.


Am J Hematol


Toren A,Or R,Kapelushnik J,Chividalli G,Aku M,Slavin S,Nagler A




Has Abstract


1996-02-01 00:00:00














  • Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin.

    abstract::Thrombocytopenia developing in the course of chemotherapy for malignant disease is usually attributed to drug-induced marrow suppression and/or marrow replacement by tumor. We describe two patients who developed severe thrombocytopenia and hemorrhagic symptoms while being treated with oxaliplatin, 5-fluorouracil, and ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Curtis BR,Kaliszewski J,Marques MB,Saif MW,Nabelle L,Blank J,McFarland JG,Aster RH

    更新日期:2006-03-01 00:00:00

  • High-density lipoprotein fails to inhibit serotonin-induced activation of blood platelets.

    abstract::High-density lipoprotein (HDL) of 100-400 micrograms/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1-5 microM). Highly concentrated HDL (1,200 micrograms/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist-induced p...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Pfennig O,Zhao B,Frye S,Dierichs R

    更新日期:1995-12-01 00:00:00

  • Retrospective review of the management of elective surgery with desmopressin and clotting factor concentrates in patients with von Willebrand disease.

    abstract::Limited data are available regarding optimal treatment with desmopressin (DDAVP) or intermediate-purity FVIII concentrates rich in VWF (CFCs) in patients with von Willebrand disease (VWD) who undergo planned surgery. We undertook a retrospective review over 10 years (1988-1997) and identified 27 patients treated with ...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Nitu-Whalley IC,Griffioen A,Harrington C,Lee CA

    更新日期:2001-04-01 00:00:00

  • IDH mutations are closely associated with mutations of DNMT3A, ASXL1 and SRSF2 in patients with myelodysplastic syndromes and are stable during disease evolution.

    abstract::Current information about clinical significance of IDH mutations in myelodysplastic syndromes (MDS), their association with other genetic alterations and the stability during disease progression is limited. In this study, IDH mutations were identified in 4.6% of 477 patients with MDS based on the FAB classification an...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lin CC,Hou HA,Chou WC,Kuo YY,Liu CY,Chen CY,Lai YJ,Tseng MH,Huang CF,Chiang YC,Lee FY,Liu MC,Liu CW,Tang JL,Yao M,Huang SY,Ko BS,Wu SJ,Tsay W,Chen YC,Tien HF

    更新日期:2014-02-01 00:00:00

  • NK-cell repertoire is feasible for diagnosing Epstein-Barr virus-infected NK-cell lymphoproliferative disease and evaluating the treatment effect.

    abstract::Epstein-Barr virus (EBV) occasionally infects T and NK cells and causes EBV-infected T/NK-cell lymphoproliferative disease (LPD), which comprises chronic active EBV infection, EBV-associated hemophagocytic syndrome, mosquito allergy, hydroa vacciniforme, aggressive NK-cell leukemia, and NK/T-cell lymphoma. The diagnos...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Sawada A,Sato E,Koyama M,Higuchi B,Kusuki S,Kim JY,Takeshita Y,Sakata A,Sakata N,Okamura T,Yasui M,Inoue M,Kawa K

    更新日期:2006-08-01 00:00:00

  • Myelodysplastic syndrome treatment with danazol and cis-retinoic acid.

    abstract::We prospectively treated 46 patients with favorable myelodysplastic syndrome classified as refractory anemia (RA), refractory cytopenia (RC), or refractory anemia with ringed sideroblasts (RARS). These patients received one of two schedules of 13-Cis-Retinoic Acid (low dose 80 mg daily for 6 months vs. high dose 200 m...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Letendre L,Levitt R,Pierre RV,Schroeder G,Krook JA,Mailliard JE,Morton RF,Tschetter LK

    更新日期:1995-04-01 00:00:00

  • Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism.

    abstract::Mutations in the calreticulin gene (CALR) were recently identified in approximately 70-80% of patients with JAK2-V617F-negative essential thrombocytosis and primary myelofibrosis. All frameshift mutations generate a recurring novel C-terminus. Here we provide evidence that mutant calreticulin does not accumulate effic...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Garbati MR,Welgan CA,Landefeld SH,Newell LF,Agarwal A,Dunlap JB,Chourasia TK,Lee H,Elferich J,Traer E,Rattray R,Cascio MJ,Press RD,Bagby GC,Tyner JW,Druker BJ,Dao KH

    更新日期:2016-02-01 00:00:00

  • Subcutaneous versus intravenous granulocyte colony stimulating factor for the treatment of neutropenia in hospitalized hemato-oncological patients: randomized controlled trial.

    abstract::Intravenous (IV) granulocyte colony stimulating factor (G-CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato-oncological patients receiving chemotherapy. To compare IV vs. SC G-CSF administration, we conducted a randomized, open-label trial. We included inpatients rece...

    journal_title:American journal of hematology

    pub_type: 杂志文章,随机对照试验


    authors: Paul M,Ram R,Kugler E,Farbman L,Peck A,Leibovici L,Lahav M,Yeshurun M,Shpilberg O,Herscovici C,Wolach O,Itchaki G,Bar-Natan M,Vidal L,Gafter-Gvili A,Raanani P

    更新日期:2014-03-01 00:00:00

  • Plasminogen activator inhibitor (PAI-1) antigen levels in primary TTP and secondary TTP post-bone marrow transplantation.

    abstract::Our objectives were to measure and compare plasminogen activator inhibitor levels (PAI-1) in primary adult thrombotic thrombocytopenic purpura (TTP) and in secondary TTP associated with bone marrow transplantation (BMT)-TTP. PAI-1 antigen levels were measured by an enzyme linked immunosorbent assay on platelet poor pl...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Anthony MT,Zeigler ZR,Lister J,Raymond JM,Shadduck RK,Kramer RE,Gryn JF,Rintels PB,Besa EC,George JN,Silver B,Joyce R,Bodensteiner D

    更新日期:1998-09-01 00:00:00

  • Effects of humic acid on the viability and coagulant properties of human umbilical vein endothelial cells.

    abstract::We have previously shown that humic acid (well-water humic acid, HA, and synthetic humic acid, SHA) enhances cell surface expression of tissue factor (TF). Here we report that incubation of human umbilical vein endothelial cells (HUVEC) for 2 hr with HA or SHA cause a rapid rise in TF mRNA levels, as shown by Northern...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Yang HL,Chiu HC,Lu FJ

    更新日期:1996-03-01 00:00:00

  • Changes in hemostatic and fibrinolytic proteins in patients receiving L-asparaginase therapy.

    abstract::Hemostatic changes were evaluated in ten patients with acute lymphoblastic leukemia and lymphoma who received chemotherapy with L-asparaginase, vincristine, and prednisolone for 1 week. Following treatment, prothrombin time and activated partial thromboplastin time were significantly prolonged, while a marked decrease...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Ito K,Matsuda T

    更新日期:1989-09-01 00:00:00

  • A 10-year experience with treatment of high and standard risk Hodgkin disease: six cycles of tailored BEACOPP, with interim scintigraphy, are effective and female fertility is preserved.

    abstract::Therapy of Hodgkin lymphoma (HL) is designed to prolong survival and minimize toxicity. A total of 124 patients with newly diagnosed HL and adverse prognostic factors were prospectively studied between July, 1999 and August, 2005. Patients with early unfavorable and advanced disease were eligible for the study. Patien...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Dann EJ,Blumenfeld Z,Bar-Shalom R,Avivi I,Ben-Shachar M,Goor O,Libster D,Gaitini D,Rowe JM,Epelbaum R

    更新日期:2012-01-01 00:00:00

  • Laparoscopic splenectomies for idiopathic thrombocytopenic purpura: experience of sixty cases.

    abstract::We performed a laparoscopic splenectomy (LS) in 60 patients (age 9-83, 45 females) with idiopathic thrombocytopenic purpura (ITP) who did not achieve sustained remission on steroid therapy. Using a modified procedure, the mean duration of LS was 78 min (range 25-240 min) and surgery was associated with only 5% major a...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Szold A,Schwartz J,Abu-Abeid S,Bulvik S,Eldor A

    更新日期:2000-01-01 00:00:00

  • High Ia (HLA-DR) and low CD11b (Mo1) expression may predict early conversion to leukemia in myelodysplastic syndromes.

    abstract::The FAB classification of myelodysplastic syndromes (MDS) has been useful in predicting prognosis; however, additional methods are required to detect patients at high risk for early conversion to acute nonlymphoblastic leukemia (ANLL). Using a panel of monoclonal antibodies to myelomonocytic surface antigens (MMSA) an...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Mittelman M,Karcher DS,Kammerman LA,Lessin LS

    更新日期:1993-07-01 00:00:00

  • Bortezomib, melphalan, prednisone (VMP) versus melphalan, prednisone, thalidomide (MPT) in elderly newly diagnosed multiple myeloma patients: A retrospective case-matched study.

    abstract::Novel agents in combination with melphalan and prednisone (MP) significantly improved progression-free survival (PFS) and overall survival (OS) in multiple myeloma (MM). Randomized trials comparing MP plus bortezomib (VMP) versus MP plus thalidomide (MPT) are lacking. Nine hundred and fifty-six elderly (>65 years) new...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Morabito F,Bringhen S,Larocca A,Wijermans P,Victoria Mateos M,Gimsing P,Mazzone C,Gottardi D,Omedè P,Zweegman S,José Lahuerta J,Zambello R,Musto P,Magarotto V,Schaafsma M,Oriol A,Juliusson G,Cerrato C,Catalano L,Gen

    更新日期:2014-04-01 00:00:00

  • A subpopulation of suppressor cells in Richter's syndrome with both monocytic and T-lymphocytic characteristics.

    abstract::We evaluated T-lymphocyte functions in the peripheral blood of a patient with B-cell chronic lymphocytic leukemia after transformation to large cell lymphoma (Richter's syndrome). A subpopulation of E-rosette adherent cells were found with T-lymphocytic surface markers (OKT3+/8+/4+), monocytic characteristics (latex i...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lahat N,Aghai E,Quitt M,Nir E,Froom P

    更新日期:1985-11-01 00:00:00

  • Modified APC-resistance test: variable ratios with respect to source of factor V-deficient plasma.

    abstract::A single point mutation of the factor V (FV) gene, leading to the substitution Arg506Gln in the FV molecule (FV-Leiden) and hence resistance to its breakdown by activated protein C (APC), is the most prevalent risk factor for venous thrombosis in the Caucasians. A ratio determined by activated partial thromboplastin t...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ts'ao C,Neofotistos D,Oropeza M,Vahabinejad S,Finn WG

    更新日期:1997-03-01 00:00:00

  • Erythrocyte pyruvate kinase deficiency: a kinetic method for differentiation between heterozygosity and compound-heterozygosity.

    abstract::The goal of the present study was to search for criteria that allow one to distinguish between normal individuals and heterozygotes as well as compound heterozygotes for pyruvate kinase (PK) deficiency. As the residual activity of PK with heterozygotes was between 35% and 110% of the normal activity, it was necessary ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lakomek M,Winkler H,Linne S,Schröter W

    更新日期:1989-08-01 00:00:00

  • Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia.

    abstract::Hemophagocytic syndrome (HPS) is an unusual acute syndrome presenting with fever, hepatosplenomegaly, and cytopenias. The hallmark of HPS is the accumulation of activated macrophages that engulf hematopoietic cells in the reticuloendothelial system. Most cases of HPS in adults are secondary to infection or malignancy,...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Goldschmidt N,Gural A,Kornberg A,Spectre G,Shopen A,Paltiel O

    更新日期:2004-08-01 00:00:00

  • Triosephosphate isomerase deficiency: repetitive occurrence of point mutation in amino acid 104 in multiple apparently unrelated families.

    abstract::The molecular basis of triosephosphate isomerase (TPI) deficiency was studied in 3 patients from three separate families. In all 3 patients, genomic DNA directly sequenced after amplification by the polymerase chain reaction exhibited the point mutation TPI315C amino acid 104 Glu-->Asp. Although other mutations known ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Schneider A,Westwood B,Yim C,Prchal J,Berkow R,Labotka R,Warrier R,Beutler E

    更新日期:1995-12-01 00:00:00

  • IKAROS expression in distinct bone marrow cell populations as a candidate biomarker for outcome with lenalidomide-dexamethasone therapy in multiple myeloma.

    abstract::Immunomodulatory drugs (IMiDs) are a cornerstone in the treatment of multiple myeloma (MM), but specific markers to predict outcome are still missing. Recent work pointed to a prognostic role for IMiD target genes (e.g. CRBN). Moreover, indirect activity of IMiDs on immune cells correlated with outcome, raising the po...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Bolomsky A,Hübl W,Spada S,Müldür E,Schlangen K,Heintel D,Rocci A,Weißmann A,Fritz V,Willheim M,Zojer N,Palumbo A,Ludwig H

    更新日期:2017-03-01 00:00:00

  • Pure red cell aplasia with thymona: evidence of T-cell clonal disorder.

    abstract::Pure red cell aplasia (PRCA) sometimes accompanies thymoma. Herein, we report a PRCA patient with thymoma with a clonal disorder of T cells. A 55-year-old man presented with anemia and anterior mediastinum tumor. The laboratory study revealed hemoglobin 8.2 g/dl; leukocytes 15.8 x 10(9)/L with 76.5% neutrophils, 20.0%...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Masuda M,Arai Y,Okamura T,Mizoguchi H

    更新日期:1997-04-01 00:00:00

  • Platelet glycoprotein Ia 807C/T (Phe224) and 873G/A (Thr246) dimorphisms in Turkey.

    abstract::At sites of vascular injury, the platelet collagen receptor Glycoprotein Ia/IIa (GPIa/IIa) acts as an important mediator of platelet adhesion to fibrillar collagens. Two silent polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene have been implicated in increased risk of developing thrombosis and myocardi...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Komurcu E,Erginel-Unaltuna N

    更新日期:2002-01-01 00:00:00

  • Predictive value of enzyme-linked immunoassay platelet crossmatching for transfusion of platelet concentrates to alloimmunized recipients.

    abstract::Some evidence has shown that platelet crossmatching is useful in multitransfused patients with hypoplastic bone marrows who are refractory to platelet therapy through alloimmunization. Several immunoglobulin binding assays other than enzyme-linked immunospecific assay (ELISA) have been studied previously. We performed...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Brubaker DB,Duke JC,Romine M

    更新日期:1987-04-01 00:00:00

  • High plasma fibrinogen level is associated with poor clinical outcome in DIC patients.

    abstract::We measured the plasma level of fibrinogen in 560 patients with disseminated intravascular coagulation (DIC) and evaluated its relationship with outcome and with other hemostatic markers. Forty-seven percent of patients had >200 mg/dL of plasma fibrinogen and 24% had <100 mg/dl of plasma fibrinogen, suggesting that pl...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Wada H,Mori Y,Okabayashi K,Gabazza EC,Kushiya F,Watanabe M,Nishikawa M,Shiku H,Nobori T

    更新日期:2003-01-01 00:00:00

  • Detection of relapse in non-Hodgkin's lymphoma: role of routine follow-up studies.

    abstract::Complete remission can be achieved in 60-80% of adults with diffuse aggressive non-Hodgkin's lymphoma. However, 20-40% of them will subsequently relapse. Nevertheless, formal follow-up guidelines for recurrence detection have never been advocated. We analyzed the pattern of relapse in 30 patients with intermediate- an...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Elis A,Blickstein D,Klein O,Eliav-Ronen R,Manor Y,Lishner M

    更新日期:2002-01-01 00:00:00

  • T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, Sjögren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia.

    abstract::We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

    更新日期:2002-02-01 00:00:00

  • CD34 expression is associated with poor clinical outcome in patients with acute promyelocytic leukemia.

    abstract::This study investigated the clinical characteristics and prognostic relevance of CD34 expression in 47 patients with acute promyelocytic leukemia (APL), showing t(15;17) or PML/RARalpha. Ten (21.3%) of the APL patients were CD34(+). CD34 expression was associated with hypogranular morphology (P = 0.002) and hyperleuko...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lee JJ,Cho D,Chung IJ,Cho SH,Park KS,Park MR,Ryang DW,Kim HJ

    更新日期:2003-07-01 00:00:00

  • Coincidental polycythemia vera and multiple myeloma: case report and review.

    abstract::Polycythemia vera (PCV) and multiple myeloma are both clonal disorders of hematopoietic stem cells. The simultaneous occurrence of these diseases in an individual patient is rare. A case of synchronous PCV and smoldering myeloma is presented and the literature is reviewed. The issues of clinical importance in this unu...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Fink L,Bauer F,Perry JJ

    更新日期:1993-11-01 00:00:00

  • Study of fibrinolytic parameters in different types of polycythemia.

    abstract::Polycythemia vera (PV) is a myeloproliferative disorder characterized by thrombotic and, less often, bleeding complications. Many mechanisms have been advanced to explain the occurrence of these complications, none of them satisfactory. We examined a cohort of 27 patients with PV, secondary erythrocytosis, and essenti...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lugassy G,Filin I

    更新日期:1999-03-01 00:00:00