Normalization of serum lactic dehydrogenase in beta-thalassemia patients following bone marrow transplantation.

Abstract:

:Serum lactic dehydrogenase (LDH) levels are mildly elevated in beta-thalassemia major due to ineffective erythropoiesis. We reviewed the charts of 15 consecutive thalassemic children who underwent allogeneic, T-cell-depleted bone marrow transplantation (BMT) in our department during the last 3 years. Eleven patients had successful engraftment and are alive and well without evidence of disease, according to physical examinations, blood counts, and polymerase chain reaction (PCR) tests, with a median follow-up of 2 years. Two patients died due to transplantation-related complications, and two rejected the graft and received their backup autologous marrow. The LDH levels in the transplanted patients gradually decreased from an average of 952 +/- 155 IU/L 10 days pre-transplant (N = 300-620) to 426 +/- 56 IU/L at the day of transplantation, and stayed at approximately the same level post-transplant (489 +/- 55 IU/L). By contrast, the LDH levels reverted to the pre-transplant value in those patients who rejected their marrow. The significance of this clinical observation for the pathophysiologic mechanism of intramedullary hemolysis and ineffective erythropoiesis in beta-thalassemia major is discussed.

journal_name

Am J Hematol

authors

Toren A,Or R,Kapelushnik J,Chividalli G,Aku M,Slavin S,Nagler A

doi

10.1002/(SICI)1096-8652(199602)51:2<166::AID-AJH13

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

166-7

issue

2

eissn

0361-8609

issn

1096-8652

pii

10.1002/(SICI)1096-8652(199602)51:2<166::AID-AJH13

journal_volume

51

pub_type

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