Lenalidomide in multiple myeloma: Current status and future potential.

abstract：:Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in patients undergoing treatment for acute leukemia (AL). Antifungal prophylactic strategies are associated with significant toxicities and cost. We performed a retrospective study of the incidence and risk factors for IFD among patients n...

journal_title：American journal of hematology

authors： Hammond SP,Marty FM,Bryar JM,DeAngelo DJ,Baden LR

更新日期：2010-09-01 00:00:00

abstract：:Flow cytometry (FCM) is an adjunct study to routine analysis of cerebrospinal fluid (CSF) to investigate for involvement by a hematologic malignancy. However, in our experience, FCM only infrequently detects abnormalities in CSF. To help optimize resources without forfeiting clinically important data, we sought to det...

journal_title：American journal of hematology

authors： Kovach AE,DeLelys ME,Kelliher AS,Dillon LJ,Hasserjian RP,Ferry JA,Preffer FI,Sohani AR

更新日期：2014-10-01 00:00:00

abstract：:Endothelin-1 (Et-1) is a vasoconstrictor produced by endothelial and vascular smooth muscle cells in response to hypoxia, which induces hypertrophy in cultured cardiac myocytes. We measured plasma Et-1 levels and left ventricular dimensions in 13 patients with sickle cell anemia (SCD) and in 12 African-American contro...

journal_title：American journal of hematology

authors： Werdehoff SG,Moore RB,Hoff CJ,Fillingim E,Hackman AM

更新日期：1998-07-01 00:00:00

abstract：:The expression of a human erythroid cell surface antigen recognized by monoclonal antibody (mAB) HAE9 has been studied on peripheral blood reticulocytes by one- and two-color flow cytometry. Total reticulocyte count was determined using Thiazole Orange (TO) and flow cytometry. In normal individuals, 4.56% of reticuloc...

journal_title：American journal of hematology

authors： Mechetner EB,Sedmak DD,Barth RF

更新日期：1991-09-01 00:00:00

abstract：:The pharmacokinetics of factor VIII were studied in a series of 20 hemophilia-A patients undergoing surgery. Regardless of the type of operation, elimination of factor VIII was shown to be increased only in ten cases (50%) during the post-operative period. In this subgroup of patients, factor VIII half-life, measured ...

journal_title：American journal of hematology

authors： Longo G,Messori A,Morfini M,Baudo F,Ciavarella N,Cinotti S,Filimberti E,Giustarini G,Molinari AC,Ferrini PR

更新日期：1989-03-01 00:00:00

abstract：:Vascular complications, including pulmonary hypertension (PH), have been reported to occur following splenectomy for various disorders,including hereditary spherocytosis (HS). We performed a prospective cross-sectional study of 36 adults with HS (78% with prior splenectomy)utilizing echocardiography to estimate tricus...

journal_title：American journal of hematology

authors： Crary SE,Ramaciotti C,Buchanan GR

更新日期：2011-12-01 00:00:00

abstract：:Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare form of Hodgkin lymphoma that typically presents as early stage, indolent disease in young adult males. The relationship between NLPHL and DLBCL is incompletely understood, and there remains a paucity of data with regard the incidence and management of ...

journal_title：American journal of hematology

authors： Eyre TA,Gatter K,Collins GP,Hall GW,Watson C,Hatton CS

更新日期：2015-06-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:Everolimus is an oral antineoplastic agent that targets the raptor mammalian target of rapamycin (mTORC1). The phosphatidylinositol 3-kinase/mTOR signal transduction pathway has been demonstrated to be activated in tumor samples from patients with Hodgkin lymphoma (HL). The goal of this trial was to learn the antitumo...

journal_title：American journal of hematology

authors： Johnston PB,Inwards DJ,Colgan JP,Laplant BR,Kabat BF,Habermann TM,Micallef IN,Porrata LF,Ansell SM,Reeder CB,Roy V,Witzig TE

更新日期：2010-05-01 00:00:00

abstract：:To clarify the presentation and course of patients with chronic lymphocytic leukemia (CLL) and amyloidosis. Mayo databases were interrogated for patients who carried a diagnosis of amyloidosis and CLL evaluated at Mayo Clinic, Rochester from January 1974 to October 2012. Charts were abstracted and data analyzed. Of th...

journal_title：American journal of hematology

authors： Kourelis TV,Gertz M,Zent C,Lacy M,Kyle R,Kapoor P,Zeldenrust S,Buadi F,Witzig T,Hayman S,Lust J,Russell S,Lin Y,Rajkumar VS,Kumar S,Leung N,Dingli D,Dispenzieri A

更新日期：2013-05-01 00:00:00

abstract：:Clinical trials in hemostasis and thrombosis (HT) are needed to guide medical practice and future research. Providing public support for trials that could have the greatest impact on clinical care has been a major challenge. The National Heart, Lung and Blood Institute (NHLBI) convened a State-of-the-Science meeting i...

journal_title：American journal of hematology

authors： Cines DB,Blajchman MA,High KA,Bussel JB,State-of-the Science Symposium Hemostasis-Thrombosis Committee.

更新日期：2012-02-01 00:00:00

abstract：:Immunologic studies were performed on mononuclear cells from ten chronically transfused children with sickle cell disease, and the results were compared with those from five other groups: 21 sickle cell patients who were not receiving regular transfusions, 6 chronically transfused children with other forms of refracto...

journal_title：American journal of hematology

authors： Wang W,Herrod H,Presbury G,Wilimas J

更新日期：1985-09-01 00:00:00

abstract：:The human spleen normally retains about one-third of the body's platelets in an exchangeable pool which can be released into the circulation by alpha-adrenergic stimulation. Some previous investigators concluded that the splenic platelet population was enriched in a subpopulation of large, young, dense platelets (mega...

journal_title：American journal of hematology

authors： Chamberlain KG,Tong M,Penington DG

更新日期：1990-07-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) has a wide range of presentations after hematopoietic stem-cell transplantation (HSCT). We retrospectively studied the risk factors and outcomes of patients with early (≤day 100) and late (>day 100) TA-TMA. Among the 1451 HSCT recipients, early TA-TMA occurred ...

journal_title：American journal of hematology

authors： Heybeli C,Sridharan M,Alkhateeb HB,Villasboas Bisneto JC,Buadi FK,Chen D,Dingli D,Dispenzieri A,Gertz MA,Go RS,Hashmi SK,Hayman SR,Hogan WJ,Inwards DJ,Kenderian SS,Kumar SK,Litzow MR,Porrata LF,Lacy MQ,Micallef IN,

更新日期：2020-07-02 00:00:00

abstract：:A new density system for the separation of human red blood cells by density-gradient centrifugation is described. The gradient medium is made with colloidal silica particles coated with polyvinylpyrrolidone suspended in aqueous solution of meglamine diatrizoate. By this method, more than 10 red-cell fractions can be s...

journal_title：American journal of hematology

authors： Vettore L,De Matteis MC,Zampini P

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of intravenous immunoglobulin (IVIG), in comparison with plasma exchange (PE), in the treatment of patients with thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). DESIGN:Prospective, nonrandomized comparative study. SETTING:Hematology department in a general hos...

journal_title：American journal of hematology

authors： Finazzi G,Bellavita P,Falanga A,Viero P,Barbui T

更新日期：1992-11-01 00:00:00

abstract：:Patients presenting with Hodgkin's disease (HD) may show lung involvement characterized by contiguous spread from ipsilateral hilar lymph nodes. Lung consolidation or noncontiguous pulmonary involvement makes an alternative diagnosis more likely. This report describes a patient with HD in whom concurrent pulmonary bla...

journal_title：American journal of hematology

authors： Winquist EW,Walmsley SL,Berinstein NL

更新日期：1993-06-01 00:00:00

abstract：:Liquid culture of the mononuclear fraction of the blood of marmosets without any added stimulator resulted in the appearance of megakaryocytes. These cells could not be identified by light microscopy or by indirect immunofluorescence using antiplatelet antiserum. Ultrastructural identification was made using platelet ...

journal_title：American journal of hematology

authors： Burstein SA,Breton-Gorius J,Harker LA

更新日期：1980-01-01 00:00:00

abstract：:Six patients and their parents from five different families with Hb H have been evaluated clinically and hematologically. Previous studies using restriction endonuclease mapping technique indicated that alpha-thalassemia determinants in these cases are heterogeneous. Only one of the five cases have the usual genotype ...

journal_title：American journal of hematology

authors： Altay C,Gurgey A,Tuncbilek E

更新日期：1980-01-01 00:00:00

abstract：:Patients with MM are at an increased risk for life-threatening bacterial infections, primarily by organisms that require opsonization for interaction with granulocytes. In the present study we used a neutrophil chemiluminescence (CL) assay of opsonization to explore the opsonic activity of MM-Ig for zymosan particles....

journal_title：American journal of hematology

authors： Cheson BD

更新日期：1981-12-01 00:00:00

abstract：:A family is described in which venous thromboembolic disease is associated with reduced plasma protein C activity and normal levels of protein C antigen. Immunoelectrophoretic analysis of protein C antigen gave an abnormal pattern in all affected members, suggesting that the disorder is related to the presence of a st...

journal_title：American journal of hematology

authors： Conlan MG,Bridges A,Williams E,Marlar R

更新日期：1988-12-01 00:00:00

abstract：:The aim of our study was to assess the cytokine profile of sickle cell disease (SCD) patients in steady state and in vaso-occlusive crisis (VOC). VOC has a complex nature, involving interactions between sickle red blood cells (RBC), the endothelium, and leucocytes. Endothelial damage due to recurrent adhesion of sickl...

journal_title：American journal of hematology

authors： Pathare A,Al Kindi S,Alnaqdy AA,Daar S,Knox-Macaulay H,Dennison D

更新日期：2004-12-01 00:00:00

abstract：:We report a family with a dominantly transmitted syndrome resembling Fanconi's anemia and spanning two generations. This syndrome was characterized by an ill-defined hematologic stem cell disorder, immune dysfunction, poor dentition, hyperpigmented skin, warts, and multiple second trimester spontaneous abortions and i...

journal_title：American journal of hematology

authors： Alter CL,Levine PH,Bennett J,Kessler C,Rick M,Washburn RG,Gallin JI,Miller RW,Auerbach AD

更新日期：1989-12-01 00:00:00

abstract：:Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biolog...

journal_title：American journal of hematology

authors： Roos-Weil D,Nguyen-Khac F,Bernard OA

更新日期：2016-05-01 00:00:00

abstract：:Although numerous publications have described the chromosome abnormalities in B-cell non-Hodgkin lymphoma and their significance, sparse literature exists pertaining to the chromosome abnormalities in T-cell lymphoma. We did cytogenetic analyses in 21 cases of peripheral T-cell lymphoma (PTCL). Chromosomally abnormal ...

journal_title：American journal of hematology

authors： Inwards DJ,Habermann TM,Banks PM,Colgan JP,Dewald GW

更新日期：1990-10-01 00:00:00

abstract：:Lenalidomide and azacitidine are active in MDS patients, and may complement each other by targeting the bone marrow microenvironment and the malignant clone. A recent Phase I trial testing the lenalidomide and azacitidine combination yielded encouraging results; however, lenalidomide’s contribution was unclear. In thi...

journal_title：American journal of hematology

authors： Sekeres MA,O'Keefe C,List AF,Paulic K,Afable M 2nd,Englehaupt R,Maciejewski JP

更新日期：2011-01-01 00:00:00

abstract：:In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk Myelodysplastic Syndromes (MDS) patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytoge...

journal_title：American journal of hematology

authors： Papageorgiou SG,Vasilatou D,Kontos CK,Kotsianidis I,Symeonidis A,Galanopoulos AG,Hatzimichael E,Megalakaki A,Poulakidas E,Diamantopoulos P,Vassilakopoulos TP,Zikos P,Papadaki H,Mparmparousi D,Bouronikou E,Panayiotidis P,V

更新日期：2018-07-01 00:00:00

abstract：:A 50-year-old woman with muscular fatigue and monoclonal gammopathy of unknown significance was shown to have high levels of antibodies against the acetylcholine receptor of the skeletal muscle endplate. The specific antibody activity was exclusively associated with the monoclonal component. There were no objective si...

journal_title：American journal of hematology

authors： Ahlberg RE,Lefvert AK

更新日期：1988-09-01 00:00:00

abstract：:Conventional treatment of mantle cell lymphoma (MCL) yields modest responses and short remissions. We report 30 hematopoietic stem cell transplants (HSCT) for MCL: 13 autologous, 10 allogeneic myeloablative, and 7 nonablative. After a median 1.2 years from diagnosis (range 0.5 to 4.7) and a median of 2 pre-HSCT chemot...

journal_title：American journal of hematology

authors： Laudi N,Arora M,Burns L,McGlave P,Miller J,Bohac G,Rogers T,Barker J,Coad J,Weisdorf D

更新日期：2006-07-01 00:00:00

abstract：:Among a cohort of 142 patients with Hodgkin disease (HD), pathologic stages (PS) IA through IVB, 84 remained in complete remission (CR) at least 3 years after the completion of initial protocol therapy. Eight of these patients subsequently developed a recurrence of HD and were defined as having a late relapse. The dis...

journal_title：American journal of hematology

authors： Kanofsky JR,Golomb HM,Vardiman JE,Sweet DL,Ultmann JE

更新日期：1981-01-01 00:00:00