Intensive short-term chemotherapy regimen induces high remission rate (over 90%) and event-free survival both in children and adult patients with advanced sporadic Burkitt lymphoma/leukemia.

abstract：OBJECTIVE:To assess the efficacy of intravenous immunoglobulin (IVIG), in comparison with plasma exchange (PE), in the treatment of patients with thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). DESIGN:Prospective, nonrandomized comparative study. SETTING:Hematology department in a general hos...

journal_title：American journal of hematology

authors： Finazzi G,Bellavita P,Falanga A,Viero P,Barbui T

更新日期：1992-11-01 00:00:00

abstract：:In thalassemia, fetal hemoglobin (HbF) augmentation with hydroxycarbamide (also known as hydroxyurea) is not always successful. The expected parallel effects on red cell (RBC) membrane deformability, cell hydration, and membrane phospholipid organization, all important for extending RBC life span and increasing Hb, ha...

journal_title：American journal of hematology

authors： Singer ST,Vichinsky EP,Larkin S,Olivieri N,Sweeters N,Kuypers FA,E\/beta Thalassemia Study Group.

更新日期：2008-11-01 00:00:00

abstract：:Several parameters may predict disease severity and overall survival in chronic lymphocytic leukemia (CLL). The purpose of our study of 190 CLL patients was to compare immunoglobulin heavy chain variable region (IgV(H)) mutation status, cytogenetic abnormalities, and leukemia cell CD38 and Zap-70 to older, traditional...

journal_title：American journal of hematology

authors： Weinberg JB,Volkheimer AD,Chen Y,Beasley BE,Jiang N,Lanasa MC,Friedman D,Vaccaro G,Rehder CW,Decastro CM,Rizzieri DA,Diehl LF,Gockerman JP,Moore JO,Goodman BK,Levesque MC

更新日期：2007-12-01 00:00:00

abstract：:Plasma cell dyscrasias are a group of clinically and biochemically diverse disorders of unknown etiology, characterized by the disproportionate proliferation of one or more clones of B cells, and the presence of a structurally and electrophoretically homogeneous (monoclonal) immunoglobulin or polypeptide subunit in se...

journal_title：American journal of hematology

authors： Kapoor P,Singh E,Radhakrishnan P,Mehta P

更新日期：2006-12-01 00:00:00

abstract：:Solid-phase enzyme immunoassays using recombinant gag and env proteins were developed to study humoral immune responses to HIV infection in a cohort of 105 hemophiliac patients. Thirteen patients with ARC or AIDS and 92 asymptomatic patients were studied. A cross-sectional study showed a wide range of antibody respons...

journal_title：American journal of hematology

authors： Kinney JS,Conway JH,Hilgartner MW,Clayman B,Mayur K,Yolken RH,Viscidi RP

更新日期：1991-01-01 00:00:00

abstract：:Increasing dose intensity (DI) of chemotherapy for patients with aggressive non-Hodgkin lymphoma (NHL) may improve outcomes at the cost of increased toxicity. This issue was addressed in a randomized trial aiming to double the DI of myelosuppressive drugs. Between 1994 and 1999, 250 patients with previously untreated ...

journal_title：American journal of hematology

authors： Hertzberg M,Matthews JP,Stone JM,Dubosq MC,Grigg A,Ellis D,Benson W,Browett P,Horvath N,Januszewicz H,Abdi E,Green M,Bonaventura A,Marlton P,Cannell P,Wolf M,ALLG.

更新日期：2014-05-01 00:00:00

abstract：:The pharmacokinetics of factor VIII were studied in a series of 20 hemophilia-A patients undergoing surgery. Regardless of the type of operation, elimination of factor VIII was shown to be increased only in ten cases (50%) during the post-operative period. In this subgroup of patients, factor VIII half-life, measured ...

journal_title：American journal of hematology

authors： Longo G,Messori A,Morfini M,Baudo F,Ciavarella N,Cinotti S,Filimberti E,Giustarini G,Molinari AC,Ferrini PR

更新日期：1989-03-01 00:00:00

abstract：:Corticosteroids are essential and one of the mainstays in the treatment of acute lymphoblastic leukemia (ALL). In vitro assays show that dexamethasone(DXM) is five to six times more cytotoxic to leukemic lymphoblasts than prednisolone (PDN) [1], and the use of DXM as an alternative drug for PDN is an important issue i...

journal_title：American journal of hematology

authors： Zheng C,Liu X,Wu J,Cai X,Zhu W,Sun Z

更新日期：2010-10-01 00:00:00

abstract：:Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimisti...

journal_title：American journal of hematology

authors： Chaturvedi S,DeBaun MR

更新日期：2016-01-01 00:00:00

abstract：:Patients initially diagnosed with type 1 von Willebrand disease (VWD) have been reclassified as type 2 after a more exhaustive analysis in several studies. Our study's objectives were (1) to reanalyze patients that were previously diagnosed as type 1 to achieve a more accurate diagnosis and (2) to compare the von Will...

journal_title：American journal of hematology

authors： Penas N,Pérez-Rodríguez A,Torea JH,Lourés E,Noya MS,López-Fernández MF,Batlle J

更新日期：2005-11-01 00:00:00

abstract：:We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, elect...

journal_title：American journal of hematology

authors： Leebeek FW,Knot EA,Ten Cate JW,Traas DW

更新日期：1989-01-01 00:00:00

abstract：:A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

journal_title：American journal of hematology

authors： Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

更新日期：1983-02-01 00:00:00

abstract：:We molecularly characterized sixty-seven cases of Hb H disease by the polymerase chain reaction. The strategy depends on amplifying the alpha-thalassemia-1 (alpha-thal-1) gene by primers flanking the breakpoint and sequence differences of the 3' end of the alpha-globin gene and the nonhomologous elements I, II, and II...

journal_title：American journal of hematology

authors： Liu TC,Chiou SS,Lin SF,Chen TP,Tseng WP,Chen PH,Chang JG

更新日期：1994-04-01 00:00:00

abstract：:Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement. The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia. Hematopoietic growth factors serum levels were measured by ELISA technique in forty-eight...

journal_title：American journal of hematology

authors： Marta RF,Enria D,Molinas FC

更新日期：2000-05-01 00:00:00

abstract：:We evaluated possible prognostic factors just before salvage therapy with vincristine, doxorubicin, and dexamethasone (VAD) for 36 patients with refractory multiple myeloma. The median duration from diagnosis to the first VAD salvage was 14 months (range 2-76 months). Among parameters that have been shown to be associ...

journal_title：American journal of hematology

authors： Suguro M,Kanda Y,Yamamoto R,Chizuka A,Hamaki T,Matsuyama T,Takezako N,Miwa A,Togawa A

更新日期：2000-10-01 00:00:00

abstract：:Monoclonal B-cell lymphocytosis (MBL) with normal lymphocyte counts is associated with decreased numbers of normal circulating B-cell subsets.Little is known about the distribution of normal lymphoid cells and their subsets in the peripheral blood (PB) of subjects with monoclonal B-cell lymphocytosis (MBL). In our stu...

journal_title：American journal of hematology

authors： Hauswirth AW,Almeida J,Nieto WG,Teodosio C,Rodriguez-Caballero A,Romero A,López A,Fernandez-Navarro P,Vega T,Perez-Andres M,Valent P,Jäger U,Orfao A,Primary Health Care Group of Salamanca for Study of MBL.

更新日期：2012-07-01 00:00:00

abstract：:We report the clinical, molecular, and immunohistological findings of 20 Chinese patients with mantle cell lymphoma diagnosed over a 10-year period. The disease affected mainly elderly patients (median age, 65.5 years) with a male predominance (M/F, 3/1). Eighty percent presented with advanced stage III/IV disease but...

journal_title：American journal of hematology

authors： Chim CS,Chan AC,Choo CK,Kwong YL,Lie AK,Liang R

更新日期：1998-12-01 00:00:00

abstract：:A 10-month-old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymp...

journal_title：American journal of hematology

authors： Yamamoto M,Nakagawa M,Ichimura N,Ohtsuki F,Ohtsuka Y,Tsujino Y,Tanaka A,Kamiya T,Wada H

更新日期：1996-07-01 00:00:00

abstract：:This study concerned the gamma chain composition of Hb F and the haplotypes of 44 patients with beta-thalassemia major or intermedia and many of their relatives. Seventeen patients came from Northern (Turkish) Cyprus, 12 from the Istanbul area, and 15 from Macedonia and Bulgaria. Analysis of the A gamma T-G gamma-A ga...

journal_title：American journal of hematology

authors： Aksoy M,Kutlar A,Efremov GD,Nikolov N,Petkov G,Reese AL,Harano T,Chen SS,Huisman TH

更新日期：1985-09-01 00:00:00

abstract：:A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

journal_title：American journal of hematology

authors： Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

更新日期：1999-02-01 00:00:00

abstract：:We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to...

journal_title：American journal of hematology

authors： Viprakasit V,Kankirawatana S,Akarasereenont P,Durongpisitkul K,Chotewuttakorn S,Tanphaichitr VS

更新日期：2002-07-01 00:00:00

abstract：:Aragon et al [4] reported that rat erythrocytes can be cross-linked and permeabilized without significant inactivation or alterations of several enzymes in the glycolytic pathway. If this is the case, in situ kinetic analysis of the red cell enzymes in normal human red cells and abnormal red cells associated with hemo...

journal_title：American journal of hematology

authors： Ikawa M,Yoshida A

更新日期：1982-08-01 00:00:00

abstract：:The main treatment for many patients with Myelodysplastic Syndromes (MDS) remains red cell transfusion to attenuate the symptoms of chronic anemia. Fatigue can reduce a patient's health related quality of life (HRQoL), but there is little understanding of the optimal use of transfusions to improve this. A systematic r...

journal_title：American journal of hematology

authors： Pinchon DJ,Stanworth SJ,Dorée C,Brunskill S,Norfolk DR

更新日期：2009-10-01 00:00:00

abstract：:Primary iron overload encompasses a variety of genetic iron overload syndromes, dominated in frequency by HFE-related, or Type 1 hemochromatosis, for which French diagnostic and therapeutic guidelines have been recently proposed. Differential diagnosis of Type 1 hemochromatosis can be made from both clinical data and ...

journal_title：American journal of hematology

authors： Brissot P

更新日期：2007-12-01 00:00:00

abstract：:The efficacy of the three common intra- and extragenic polymorphic sites of the factor VIII and IX genes has been examined in the Indian population, with an aim to develop a strategy that would be accurate and informative, yet economical. The approach for hemophilia A carrier detection includes tests for BclI, XbaI, a...

journal_title：American journal of hematology

authors： Shetty S,Ghosh K,Pathare A,Colah R,Badakare S,Mohanty D

更新日期：1997-04-01 00:00:00

abstract：:all-trans-Retinoic acid (ATRA) induces complete remission in majority of patients with acute promyelocytic leukemia (APL). However, accelerated metabolism of ATRA that is induced by chronic daily administration of oral ATRA has been implicated as one of the mechanisms leading to a reduced sensitivity or resistance to ...

journal_title：American journal of hematology

authors： Ozpolat B,Mehta K,Tari AM,Lopez-Berestein G

更新日期：2002-05-01 00:00:00

abstract：:Sickle cell (SS) disease is a complex of various genetic conditions. In some, homozygosity for the beta S gene may be present alone or in combination with the heterozygous or homozygous alpha-thalassemia-2 condition. Such combinations might ameliorate the clinical and hematological condition of the patient. The same m...

journal_title：American journal of hematology

authors： Huisman TH

更新日期：1979-01-01 00:00:00

abstract：:Heparin-associated thrombocytopenia with thrombosis (HATT) is fatal in 29% and leads to limb amputation in another 21% of patients. Patients with arterial thrombosis do worse than do those with venous thrombosis alone. Heparin-associated thrombocytopenia is mediated through IgG or IgM immunoglobulin fractions and is b...

journal_title：American journal of hematology

authors： Nand S,Robinson JA

更新日期：1988-07-01 00:00:00

abstract：:Quinine-induced immune thrombocytopenia with hemolytic uremic syndrome (HUS) is a recently defined clinical entity. In this paper we have attempted to characterize the natural history and laboratory abnormalities typical of quinine-induced immune thrombocytopenia associated with hemolytic uremic syndrome in nine patie...

journal_title：American journal of hematology

authors： Gottschall JL,Neahring B,McFarland JG,Wu GG,Weitekamp LA,Aster RH

更新日期：1994-12-01 00:00:00

abstract：:The Muir-Torre syndrome (MTS) is defined as the concurrent or sequential discovery of at least one sebaceous gland tumor and a minimum of one internal malignancy. A man with Hodgkin's lymphoma who subsequently developed an ocular sebaceous carcinoma in situ is described and the world literature of patients with the MT...

journal_title：American journal of hematology

authors： Cohen PR

更新日期：1992-05-01 00:00:00