Molecular basis and hematological characterization of Hb H disease in southeast Asia.

abstract：:Regulatory T-cells (Tregs) are increased in chronic lymphocytic leukemia(CLL) and correlates with clinical and biological features of active/progressive disease. However, little is known about their ability to predict the time to first treatment (TFT). We evaluated 75 patients with Rai stage 0 CLL, in whom the absolut...

journal_title：American journal of hematology

authors： D'Arena G,D'Auria F,Simeon V,Laurenti L,Deaglio S,Mansueto G,Del Principe MI,Statuto T,Pietrantuono G,Guariglia R,Innocenti I,Martorelli MC,Villani O,De Feo V,Del Poeta G,Musto P

更新日期：2012-06-01 00:00:00

abstract：:To clarify the presentation and course of patients with chronic lymphocytic leukemia (CLL) and amyloidosis. Mayo databases were interrogated for patients who carried a diagnosis of amyloidosis and CLL evaluated at Mayo Clinic, Rochester from January 1974 to October 2012. Charts were abstracted and data analyzed. Of th...

journal_title：American journal of hematology

authors： Kourelis TV,Gertz M,Zent C,Lacy M,Kyle R,Kapoor P,Zeldenrust S,Buadi F,Witzig T,Hayman S,Lust J,Russell S,Lin Y,Rajkumar VS,Kumar S,Leung N,Dingli D,Dispenzieri A

更新日期：2013-05-01 00:00:00

abstract：:Because of a possible hazard from the use of radioisotopes to determine iron absorption by infants, the use of stable isotopes for this purpose has much appeal. We have applied the method of inductively coupled plasma mass spectrometry (ICP/MS) to determine the mass ratio, 58Fe/57Fe, in blood before and after oral adm...

journal_title：American journal of hematology

authors： Janghorbani M,Ting BT,Fomon SJ

更新日期：1986-03-01 00:00:00

abstract：:Reduced intensity conditioning (RIC) regimens are widely used in allogeneic stem cell transplantation (SCT). In this study, we retrospectively investigated the clinical outcomes of RIC with fludarabine (Flu; 180 mg/m(2)), intravenous busulfan (BU; 6.4 mg/kg) or oral BU (8 mg/kg), and low-dose total body irradiation (T...

journal_title：American journal of hematology

authors： Takahata M,Hashino S,Okada K,Onozawa M,Kahata K,Sugita J,Shigematsu A,Kondo T,Yamamoto S,Endo T,Nishio M,Ito YM,Tanaka J,Koike T,Asaka M,Imamura M

更新日期：2010-04-01 00:00:00

abstract：:Autoantibody production following allogeneic stem-cell transplantation is common and is often ascribed to the immune dysregulation associated with graft-versus-host disease. Recent data suggests that donor-memory B cells can be reactivated on exposure to antigen and result in antibody production in the recipient ident...

journal_title：American journal of hematology

authors： Ritchie DS,Sainani A,D'Souza A,Grigg AP

更新日期：2005-08-01 00:00:00

abstract：:Corticosteroids are essential and one of the mainstays in the treatment of acute lymphoblastic leukemia (ALL). In vitro assays show that dexamethasone(DXM) is five to six times more cytotoxic to leukemic lymphoblasts than prednisolone (PDN) [1], and the use of DXM as an alternative drug for PDN is an important issue i...

journal_title：American journal of hematology

authors： Zheng C,Liu X,Wu J,Cai X,Zhu W,Sun Z

更新日期：2010-10-01 00:00:00

abstract：:The main treatment for many patients with Myelodysplastic Syndromes (MDS) remains red cell transfusion to attenuate the symptoms of chronic anemia. Fatigue can reduce a patient's health related quality of life (HRQoL), but there is little understanding of the optimal use of transfusions to improve this. A systematic r...

journal_title：American journal of hematology

authors： Pinchon DJ,Stanworth SJ,Dorée C,Brunskill S,Norfolk DR

更新日期：2009-10-01 00:00:00

abstract：:This report describes the bone marrow findings in four patients whose marrow was involved by anaplastic large-cell Ki-1 lymphoma, an uncommon event in this type of lymphoma. In the marrow aspirate smears, the involvement was subtle, and was in the form of isolated large cells with irregular nuclear configuration, coar...

journal_title：American journal of hematology

authors： Wong KF,Chan JK,Ng CS,Chu YC,Lam PW,Yuen HL

更新日期：1991-06-01 00:00:00

abstract：:In the current study, we investigated C/EBPA gene mutations and promoter hypermethylation in a series of 53 patients with CN-AML. In addition, we also analyzed two other frequent mutations (FLT3/ITD and NPM1) in these patients and correlated them with C/EBPA gene alterations. 13/53 patients were FLT3/ITD+/NPM1-, 11/53...

journal_title：American journal of hematology

authors： Lu Y,Chen W,Chen W,Stein A,Weiss LM,Huang Q

更新日期：2010-06-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:Acquired α-thalassemia myelodysplastic syndrome (MDS) (ATMDS) is an acquired syndrome characterized by a somatic point mutation or splicing defect in the ATRX gene in patients with myeloid disorders, primarily MDS. In a large MDS patient series, the incidence of ATMDS was below 0.5%. But no large series has yet assess...

journal_title：American journal of hematology

authors： Herbaux C,Duployez N,Badens C,Poret N,Gardin C,Decamp M,Eclache V,Daliphard S,Murati A,Cony-Makhoul P,Cheze S,Beve B,Lacoste C,Prebet T,Hunault-Berger M,Maloisel F,Renneville A,Figeac M,Stamatoullas-Bastard A,Bastar

更新日期：2015-08-01 00:00:00

abstract：:To monitor successful engraftment after bone marrow transplantation, we performed Southern hybridization analysis or dot blot analysis of DNA in a set of sex-mismatched cases using a Y-chromosome-specific DNA probe (pHY10). This method was extremely sensitive and rapid for checking which cells contain the Y-chromosome...

journal_title：American journal of hematology

authors： Morisaki H,Morisaki T,Nakahori Y,Ogura H,Kanno H,Tani K,Kodo H,Fujii H,Asano S,Miwa S

更新日期：1988-01-01 00:00:00

abstract：DISEASE OVERVIEW:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional disease features include bone marrow stromal reaction including reticulin fibrosis, abnorm...

journal_title：American journal of hematology

authors： Tefferi A

更新日期：2018-12-01 00:00:00

abstract：:Newly identified iron binding proteins isolated from rat duodenal homogenates permit better understanding of iron absorption. Mucins bind iron at acid pH to keep iron soluble and available for absorption at the more alkaline pH of the duodenum; this explains iron deficiency following prolonged achlorhydria. Integrin (...

journal_title：American journal of hematology

authors： Conrad ME,Umbreit JN

更新日期：1993-01-01 00:00:00

abstract：:The "platelet function analyzer" (PFA)-100 was first introduced to us in 1995. Since then, the instrument has appeared in over 50 reviews and almost 1000 publications. Recently, the PFA-100 has been "upgraded" to the PFA-200, which has transformed the user interface and electronic management, but retained the fundamen...

journal_title：American journal of hematology

authors： Favaloro EJ

更新日期：2017-04-01 00:00:00

abstract：:Human theta (theta 1)-globin gene represents a member of the alpha-like globin gene family residing on chromosome 16. theta 1-Specific transcripts have been detected so far only in erythroid tissues and in erythroleukemia K562 cells. To investigate systematically its inducible expression and developmental specificity,...

journal_title：American journal of hematology

authors： Mamalaki A,Anagnou NP,Moschonas NK

更新日期：1990-12-01 00:00:00

abstract：:This study was designed to explore the value of markers of bone turnover, macrophage inflammatory protein-1alpha (MIP-1alpha), and osteopontin (OPN) in the diagnosis of myeloma bone disease. Twenty-five patients with newly diagnosed and untreated multiple myeloma (MM), and 22 age-, sex-, and bone mineral density-match...

journal_title：American journal of hematology

authors： Dizdar O,Barista I,Kalyoncu U,Karadag O,Hascelik G,Cila A,Pinar A,Celik I,Kars A,Tekuzman G

更新日期：2007-03-01 00:00:00

abstract：:We studied 15 patients with essential thrombocythemia (ET) before treatment and after normalization of platelet count by anagrelide. Significantly increased plasma levels of PDGF, TGFbeta, and bFGF were found. Patients with mild reticulin fibrosis in bone marrow had higher PDGF levels. During treatment, plasma TGFbeta...

journal_title：American journal of hematology

authors： Lev PR,Marta RF,Vassallu P,Molinas FC

更新日期：2002-06-01 00:00:00

abstract：:Splenectomy is a time-honoured well established approach for patients with steroid-resistant immune thrombocytopenia (ITP). However, due to the more recent availability of therapeutic options alternative to splenectomy, such as rituximab and agonists of the thrombopoietin-receptor, the choice of second-line therapy is...

journal_title：American journal of hematology

authors： Palandri F,Polverelli N,Catani L,Sollazzo D,Romano M,Levorato M,Vianelli N

更新日期：2014-11-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a Kunitz-type proteinase inhibitor that has a crucial role in haemostasis and is primarily synthesized in the vascular endothelium. We investigated plasma total TFPI, antiphospholipid antibodies, and some other coagulation and fibrinolytic system parameters in 30 patients with...

journal_title：American journal of hematology

authors： Akarsu M,Demirkan F,Ozsan GH,Onen F,Yüksel F,Ozkan S,Undar B

更新日期：2001-12-01 00:00:00

abstract：:In a phase II trial, we evaluated chlorambucil and rituximab (CLB-R) as first-line induction treatment with or without R as maintenance for elderly chronic lymphocytic leukemia (CLL) patients. Treatment consisted of eight 28-day cycles of CLB (8 mg/m(2) /day, days 1-7) and R (day 1 of cycle 3, 375 mg/m(2) ; cycles 4-8...

journal_title：American journal of hematology

authors： Foà R,Del Giudice I,Cuneo A,Del Poeta G,Ciolli S,Di Raimondo F,Lauria F,Cencini E,Rigolin GM,Cortelezzi A,Nobile F,Callea V,Brugiatelli M,Massaia M,Molica S,Trentin L,Rizzi R,Specchia G,Di Serio F,Orsucci L,Ambros

更新日期：2014-05-01 00:00:00

abstract：:Follicular lymphoma (FL) frequently transforms into the more aggressive diffuse large B cell lymphoma (DLBCL-tr), but no protein biomarkers have been identified for predictive or early diagnosis. Gene expression analyses have identified genes changing on transformation but have failed to be reproducible in different s...

journal_title：American journal of hematology

authors： Andréasson U,Dictor M,Jerkeman M,Berglund M,Sundström C,Linderoth J,Rosenquist R,Borrebaeck CA,Ek S

更新日期：2009-12-01 00:00:00

abstract：:A single-strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified products of immunoglobulin (Ig) heavy chain rearrangements can be used to analyze B cell clonalities and clonal identities of B cells from different samples. However, the usefulness of the PCR-SSCP analysis is not fu...

journal_title：American journal of hematology

authors： Shiokawa S,Nishimura J,Uike N,Saburi Y,Suehiro T,Yamamoto K

更新日期：1999-10-01 00:00:00

abstract：:Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the var...

journal_title：American journal of hematology

authors： Jain P,Wang M

更新日期：2019-06-01 00:00:00

abstract：:A single-tube osmotic fragility test has been proposed for thalassemia screening with a range of different concentrations of saline having been employed. We have compared the sensitivity and specificity of 0.32%, 0.34%, and 0.36% buffered saline, and on the basis of our findings, recommend the use of 0.36% saline. Thi...

journal_title：American journal of hematology

authors： Chow J,Phelan L,Bain BJ

更新日期：2005-07-01 00:00:00

abstract：:A family is described in which venous thromboembolic disease is associated with reduced plasma protein C activity and normal levels of protein C antigen. Immunoelectrophoretic analysis of protein C antigen gave an abnormal pattern in all affected members, suggesting that the disorder is related to the presence of a st...

journal_title：American journal of hematology

authors： Conlan MG,Bridges A,Williams E,Marlar R

更新日期：1988-12-01 00:00:00

abstract：:Arsenic trioxide (As(2)O(3)) has been found effective in the treatment in the treatment of acute promyelocytic leukemia (APML). Most studies with As(2)O(3) involve patients with APML who have relapsed following standard therapy. Between January 1998 and July 2000, 14 patients were recruited for an ongoing trial of As(...

journal_title：American journal of hematology

authors： Mathews V,Balasubramanian P,Shaji RV,George B,Chandy M,Srivastava A

更新日期：2002-08-01 00:00:00

abstract：:The objective of this case-matched study was to compare the efficacy and toxicity of the addition of clarithromycin (Biaxin) to lenalidomide/low-dose dexamethasone (BiRd) vs. lenalidomide/low-dose dexamethasone (Rd) for newly diagnosed myeloma. Data from 72 patients treated at the New York Presbyterian Hospital-Cornel...

journal_title：American journal of hematology

authors： Gay F,Rajkumar SV,Coleman M,Kumar S,Mark T,Dispenzieri A,Pearse R,Gertz MA,Leonard J,Lacy MQ,Chen-Kiang S,Roy V,Jayabalan DS,Lust JA,Witzig TE,Fonseca R,Kyle RA,Greipp PR,Stewart AK,Niesvizky R

更新日期：2010-09-01 00:00:00

abstract：:A 25-year-old African-American man with sickle cell-beta(+)-thalassemia presented with acute asthma of 2 days' duration. The asthma was well controlled by 48 hr, and parenteral medications were changed to oral bronchodilators and steroids. Sixty hours after presentation, he developed pain similar to that of sickle cel...

journal_title：American journal of hematology

authors： Johnson K,Stastny JF,Rucknagel DL

更新日期：1994-08-01 00:00:00

abstract：:The effect of heparin on platelet aggregation was systematically examined on platelets in plasma (PRP), as well as on gel-filtered, washed, and formaldehyde-fixed platelets. Results indicate that, although heparin causes a mild potentiation of platelet aggregation in the PRP systems, a significant inhibitory activity ...

journal_title：American journal of hematology

authors： Saba HI,Saba SR,Morelli GA

更新日期：1984-10-01 00:00:00