Abstract:
:Severe pruritus is frequently associated with myeloproliferative and other systemic illnesses, and often fails to respond to conventional measures. We used danazol (Danocrine), a synthetic attenuated androgen, in the treatment of severe pruritus refractory to conventional therapy. Eight patients had myeloproliferative disorders (MPD), seven had autoimmune disorders, and seven had skin diseases. Danazol at 400-800 mg/day was administered, and previous medications were tapered off. When itching was controlled with danazol alone, the dosage was reduced or discontinued, and resumed if itching recurred. Clinical responses were graded, and side effects were monitored. Overall, in 12 of 22 patients refractory to other measures, itching was controlled with danazol alone. In 10 patients itching returned when danazol was discontinued or dosage was continued for up to 5 years in responders. No serious side effects were observed. Our experience indicates that danazol is a good alternative for patients with severe pruritus associated with myeloproliferative and other systemic disorders.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Kolodny L,Horstman LL,Sevin BU,Brown H,Ahn YSdoi
10.1002/(SICI)1096-8652(199602)51:2<112::AID-AJH3>subject
Has Abstractpub_date
1996-02-01 00:00:00pages
112-6issue
2eissn
0361-8609issn
1096-8652pii
10.1002/(SICI)1096-8652(199602)51:2<112::AID-AJH3>journal_volume
51pub_type
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