Danazol relieves refractory pruritus associated with myeloproliferative disorders and other diseases.


:Severe pruritus is frequently associated with myeloproliferative and other systemic illnesses, and often fails to respond to conventional measures. We used danazol (Danocrine), a synthetic attenuated androgen, in the treatment of severe pruritus refractory to conventional therapy. Eight patients had myeloproliferative disorders (MPD), seven had autoimmune disorders, and seven had skin diseases. Danazol at 400-800 mg/day was administered, and previous medications were tapered off. When itching was controlled with danazol alone, the dosage was reduced or discontinued, and resumed if itching recurred. Clinical responses were graded, and side effects were monitored. Overall, in 12 of 22 patients refractory to other measures, itching was controlled with danazol alone. In 10 patients itching returned when danazol was discontinued or dosage was continued for up to 5 years in responders. No serious side effects were observed. Our experience indicates that danazol is a good alternative for patients with severe pruritus associated with myeloproliferative and other systemic disorders.


Am J Hematol


Kolodny L,Horstman LL,Sevin BU,Brown H,Ahn YS




Has Abstract


1996-02-01 00:00:00














  • Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange.

    abstract::We report the case of an immunocompetent woman who developed disseminated intravascular coagulation (DIC) due to acute cytomegalovirus (CMV) infection and was successfully treated with plasma exchange. Extensive investigations revealed no other cause for her DIC, and she did not have any recurrence after more than 1 y...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Niewold TB,Bundrick JB

    更新日期:2006-06-01 00:00:00

  • Proliferation of abnormal bone marrow histiocytes, an undesired effect of granulocyte macrophage-colony-stimulating factor therapy in a patient with Hurler's syndrome undergoing bone marrow transplantation.

    abstract::Granulocyte macrophage-colony-stimulating factor (GM-CSF) has shown promise as a means of alleviating leukopenia associated with a wide variety of disorders. It is currently undergoing evaluation as an adjunct to bone marrow transplantation but its use in patients with metabolic disorders, such as Hurler's syndrome (H...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lang E,Cibull ML,Gallicchio VS,Henslee-Downey PJ,Davey DD,Messino MJ,Harder EJ

    更新日期:1992-12-01 00:00:00

  • Hemostatic effects of low-dose protamine following cardiopulmonary bypass.

    abstract::Twenty-eight patients undergoing cardiac surgery were prospectively studied and were assigned to two groups. The patients received 0.8- (Group L) or 2.0-fold (Group H) dose of protamine for the neutralization after cardiopulmonary bypass (CPB) which was determined by Hepcon HMS(R) assay system in which the reagent cha...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miyashita T,Nakajima T,Hayashi Y,Kuro M

    更新日期:2000-06-01 00:00:00

  • Successful engraftment and stable full donor chimerism after myeloablation with thiotepa, fludarabine, and melphalan and CD34-selected peripheral allogeneic stem cell transplantation in hemophagocytic lymphohistiocytosis.

    abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative option for primary hemophagocytic lymphohistiocytosis (HLH), a rare disease of infants and young children, characterized by recurrent fever, hepatosplenomegaly, and cytopenia. We report a case of successful engraftment and stable fu...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Cesaro S,Gazzola MV,Marson P,Calore E,Caenazzo L,Destro R,De Silvestro G,Varotto S,Pillon M,Zanesco L,Messina C

    更新日期:2003-02-01 00:00:00

  • Prenatal and molecular diagnosis of hemophilia B.

    abstract::Prenatal diagnosis was carried out on a woman who had previously given birth to a son with a spontaneous mutation of C-->T transition at nt 31133 of the factor IX (F.IX) gene. The diagnosis was performed on chorionic villi sampling by the method of amplification-created restriction site (ACRS). It revealed a female fe...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Young JH,Wang JC,Gau JP,Hu HT

    更新日期:1996-08-01 00:00:00

  • Utility and prognostic value of 18 F-FDG positron emission tomography-computed tomography scans in patients with newly diagnosed multiple myeloma.

    abstract::Positron emission tomography-computed tomography (PET-CT) can identify bony lesions, assess disease burden, and detect extramedullary disease (EMD) in patients with multiple myeloma. We retrospectively reviewed records of patients who underwent PET-CT within 60 days of a new diagnosis (before therapy commenced) to ide...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Aljama MA,Sidiqi MH,Buadi FK,Lacy MQ,Gertz MA,Dispenzieri A,Dingli D,Muchtar E,Fonder AL,Hayman SR,Hobbs MA,Gonsalves WI,Warsame RM,Kourelis T,Hwa YL,Kapoor P,Kyle RA,Leung N,Go RS,Rajkumar SV,Kumar SK

    更新日期:2018-12-01 00:00:00

  • The prognostic value of monosomal karyotype (MK) in higher-risk patients with myelodysplastic syndromes treated with 5-Azacitidine: A retrospective analysis of the Hellenic (Greek) Myelodysplastic syndromes Study Group.

    abstract::In this study, we investigated the incidence and prognostic impact of monosomal karyotype (MK) in 405 higher-risk Myelodysplastic Syndromes (MDS) patients treated with 5-AZA. The MK was present in 66 out of 405 (16.3%) patients, most of whom had complex karyotype (CK). MK was strongly associated with CK and the cytoge...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Papageorgiou SG,Vasilatou D,Kontos CK,Kotsianidis I,Symeonidis A,Galanopoulos AG,Hatzimichael E,Megalakaki A,Poulakidas E,Diamantopoulos P,Vassilakopoulos TP,Zikos P,Papadaki H,Mparmparousi D,Bouronikou E,Panayiotidis P,V

    更新日期:2018-07-01 00:00:00

  • Febrile transfusion reaction following initial transfusion in a man with immunoblastic lymphadenopathy and granulocyte autoantibodies.

    abstract::A 69-year-old man with immunoblastic lymphadenopathy and autoimmune hemolytic anemia who had no previous exposure to blood products developed a severe febrile nonhemolytic transfusion reaction following the initial infusion of packed red blood cells. The reaction recurred with transfusion of packed red blood cells, bu...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Barnes HM,Poon MC,Huang ST,Conrad ME,Lin J,McGowan EI

    更新日期:1983-02-01 00:00:00

  • Intravenous immunoglobulin therapy results in post-infusional hyperproteinemia, increased serum viscosity, and pseudohyponatremia.

    abstract::Intravenous immunoglobulin (IVIG) therapy is associated with rare reports of thromboembolic events and severe hyponatremia. We hypothesized that IVIG therapy may result in hyperproteinemia, increased serum viscosity, and pseudohyponatremia. We conducted a prospective observational study to evaluate the incidence of hy...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Steinberger BA,Ford SM,Coleman TA

    更新日期:2003-06-01 00:00:00

  • Nationwide survey on the use of horse antithymocyte globulins (ATGAM) in patients with acquired aplastic anemia: A report on behalf of the French Reference Center for Aplastic Anemia.

    abstract::Antithymocyte globulins (ATG) plus cyclosporine (CSA) is the gold standard immunosuppressive treatment (IST) for patients with aplastic anemia. A prospective randomized trial showed in 2011 that hATG was superior to rabbit ATG for first-line treatment of severe AA. The French Health Agency (ANSM) permitted a patient-n...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Peffault de Latour R,Tabrizi R,Marcais A,Leblanc T,Lamy T,Mohty M,Tavitian S,Jubert C,Pasquet M,Galambrun C,Nguyen S,Cahn JY,Braun T,Deconinck E,Bay JO,Sicre de Fontbrune F,Barraco F,Socié G

    更新日期:2018-05-01 00:00:00

  • Post-transfusion purpura associated with alloimmunization against the platelet-specific antigen, Baka.

    abstract::Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-PlA1 antibody could not...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Keimowitz RM,Collins J,Davis K,Aster RH

    更新日期:1986-01-01 00:00:00

  • Chronic lymphocytic leukemia: Time to go past genomics?

    abstract::Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biolog...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Roos-Weil D,Nguyen-Khac F,Bernard OA

    更新日期:2016-05-01 00:00:00

  • Developmental and inducible patterns of human theta 1-globin gene expression in embryonic/fetal and adult erythroid cells.

    abstract::Human theta (theta 1)-globin gene represents a member of the alpha-like globin gene family residing on chromosome 16. theta 1-Specific transcripts have been detected so far only in erythroid tissues and in erythroleukemia K562 cells. To investigate systematically its inducible expression and developmental specificity,...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Mamalaki A,Anagnou NP,Moschonas NK

    更新日期:1990-12-01 00:00:00

  • Idiopathic immune-mediated acquired von Willebrand's disease in a patient with angiodysplasia: demonstration of an unusual inhibitor causing a functional defect and rapid clearance of von Willebrand factor.

    abstract::A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

    更新日期:1999-02-01 00:00:00

  • Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.

    abstract::The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,...

    journal_title:American journal of hematology

    pub_type: 信件


    authors: Li Y,Zheng T,Kilfoy BA,Lan Q,Holford T,Han X,Zhao P,Dai M,Leaderer B,Rothman N,Zhang Y

    更新日期:2010-03-01 00:00:00

  • A phase III randomized trial of high-dose CEOP + filgrastim versus standard-dose CEOP in patients with non-Hodgkin lymphoma: 10-year follow-up data: Australasian Leukaemia and Lymphoma Group (ALLG) NHL07 trial.

    abstract::Increasing dose intensity (DI) of chemotherapy for patients with aggressive non-Hodgkin lymphoma (NHL) may improve outcomes at the cost of increased toxicity. This issue was addressed in a randomized trial aiming to double the DI of myelosuppressive drugs. Between 1994 and 1999, 250 patients with previously untreated ...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hertzberg M,Matthews JP,Stone JM,Dubosq MC,Grigg A,Ellis D,Benson W,Browett P,Horvath N,Januszewicz H,Abdi E,Green M,Bonaventura A,Marlton P,Cannell P,Wolf M,ALLG.

    更新日期:2014-05-01 00:00:00

  • ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.

    abstract::ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibili...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Canaani J,Savani BN,Labopin M,Michallet M,Craddock C,Socié G,Volin L,Maertens JA,Crawley C,Blaise D,Ljungman PT,Cornelissen J,Russell N,Baron F,Gorin N,Esteve J,Ciceri F,Schmid C,Giebel S,Mohty M,Nagler A

    更新日期:2017-08-01 00:00:00

  • A prospective newborn screening and treatment program for sickle cell anemia in Luanda, Angola.

    abstract::Over 300,000 infants are born annually with sickle cell anemia (SCA) in sub-Saharan Africa, and >50% die young from infection or anemia, usually without diagnosis of SCA. Early identification by newborn screening (NBS), followed by simple interventions dramatically reduced the mortality of SCA in the United States, bu...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: McGann PT,Ferris MG,Ramamurthy U,Santos B,de Oliveira V,Bernardino L,Ware RE

    更新日期:2013-12-01 00:00:00

  • Diagnostic utility of cerebrospinal fluid flow cytometry in patients with and without prior hematologic malignancy.

    abstract::Flow cytometry (FCM) is an adjunct study to routine analysis of cerebrospinal fluid (CSF) to investigate for involvement by a hematologic malignancy. However, in our experience, FCM only infrequently detects abnormalities in CSF. To help optimize resources without forfeiting clinically important data, we sought to det...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kovach AE,DeLelys ME,Kelliher AS,Dillon LJ,Hasserjian RP,Ferry JA,Preffer FI,Sohani AR

    更新日期:2014-10-01 00:00:00

  • The transferrin receptor system is not involved in the pathogenesis of hematological disorders with 3q inversion.

    abstract::To clarify the idea that an alteration of the transferrin receptor (TF-R) gene, localized to 3q26, may be of pathogenetic significance in hematological disorders with 3q anomaly, we studied the TF-R systems of erythroblasts from both functional and genetic aspects. The patient described here had refractory anemia with...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Abe Y,Muta K,Yufu Y,Takahira H,Nishimura J,Nawata H

    更新日期:1990-03-01 00:00:00

  • Outcomes and management strategies for graft failure after umbilical cord blood transplantation.

    abstract::Graft failure is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Graft failure is more prevalent after umbilical cord blood transplantation (UCBT) compared with conventional adult stem cell sources. We identified 21 consecutive patients who experienced graft failure aft...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Singh H,Nikiforow S,Li S,Ballen KK,Spitzer TR,Soiffer R,Antin JH,Cutler C,Chen YB

    更新日期:2014-12-01 00:00:00

  • UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease.

    abstract::The purpose of the study was to determine if UDP-glucuronosyltransferase (UGT) 2B7 allelic variants encoding for UGT2B7, primary enzyme responsible for morphine glucuronidation contribute to the variability in the hepatic clearance of morphine in sickle cell disease (SCD). Twenty-four hour PK study of morphine and UGT...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Darbari DS,van Schaik RH,Capparelli EV,Rana S,McCarter R,van den Anker J

    更新日期:2008-03-01 00:00:00

  • The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome.

    abstract::Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) that shows overlap with classical Hodgkin lymphoma (CHL) and a favorable prognosis compared to mediastinal gray-zone lymphoma (MGZL). We performed immunohistochemistry on initial diagnostic specimens of 49 c...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Bledsoe JR,Redd RA,Hasserjian RP,Soumerai JD,Nishino HT,Boyer DF,Ferry JA,Zukerberg LR,Harris NL,Abramson JS,Sohani AR

    更新日期:2016-10-01 00:00:00

  • Inhibition of the activation of hageman factor (factor XII) by eosinophils and eosinophilic constituents.

    abstract::Several syndromes characterized by striking eosinophilia may be complicated by thrombosis. The experiments described indicate that, paradoxically, eosinophils and certain of their constituents inhibit the activation of Hageman factor (HF, factor XII). In earlier studies, suspensions of mixed types of granulocytes, oth...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ratnoff OD,Gleich GJ,Shurin SB,Kazura J,Everson B,Embury P

    更新日期:1993-01-01 00:00:00

  • Clonal hematopoiesis in patients with dyskeratosis congenita.

    abstract::Dyskeratosis congenita (DC) is a rare inherited telomeropathy most frequently caused by mutations in a number of genes all thought to be involved in telomere maintenance. The main causes of mortality in DC are bone marrow failure as well as malignancies including leukemias and solid tumors. The clinical picture includ...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Perdigones N,Perin JC,Schiano I,Nicholas P,Biegel JA,Mason PJ,Babushok DV,Bessler M

    更新日期:2016-12-01 00:00:00

  • A rapid paper-based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease.

    abstract::Quantification of sickle hemoglobin (HbS) in patients with sickle cell disease (SCD) undergoing hydroxyurea or chronic transfusion therapy is essential to monitoring the effectiveness of these therapies. The clinical monitoring of %HbS using conventional laboratory methods is limited by high per-test costs and long tu...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Piety NZ,Yang X,Lezzar D,George A,Shevkoplyas SS

    更新日期:2015-06-01 00:00:00

  • Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population.

    abstract::Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies di...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Finan RR,Tamim H,Ameen G,Sharida HE,Rashid M,Almawi WY

    更新日期:2002-12-01 00:00:00

  • Evolution of sickle cell disease from a life-threatening disease of children to a chronic disease of adults: The last 40 years.

    abstract::Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimisti...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Chaturvedi S,DeBaun MR

    更新日期:2016-01-01 00:00:00

  • Immunologic thrombocytopenic purpura as presenting symptom of hepatitis C infection.

    abstract::We report on 3 female patients with immunologic thrombocytopenic purpura (ITP) for whom diagnostic procedures evidenced a chronic Hepatitis C virus (HCV) infection. In 2 cases, a transfusion performed more than 10 years ago represented the probable way of contamination. One patient received a course of steroids, which...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Bauduer F,Marty F,Larrouy M,Ducout L

    更新日期:1998-04-01 00:00:00

  • Acute promyelocytic leukaemia (M3): relapse with acute myeloblastic leukaemia (M2) and dic(5;17) (q11;p11).

    abstract::Secondary leukaemia following treatment of M3 acute promyelocytic leukaemia (APL) is a rare event. We describe a patient in remission following chemotherapy for APL who relapsed with M2 acute non-lymphoblastic leukaemia (ANLL). The original t(15;17) (q22;q21) chromosome translocation was lost and replaced by a clone c...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Hatzis T,Standen GR,Howell RT,Savill C,Wagstaff M,Scott GL

    更新日期:1995-01-01 00:00:00