Danazol relieves refractory pruritus associated with myeloproliferative disorders and other diseases.

abstract：:Clinical trials in hemostasis and thrombosis (HT) are needed to guide medical practice and future research. Providing public support for trials that could have the greatest impact on clinical care has been a major challenge. The National Heart, Lung and Blood Institute (NHLBI) convened a State-of-the-Science meeting i...

journal_title：American journal of hematology

authors： Cines DB,Blajchman MA,High KA,Bussel JB,State-of-the Science Symposium Hemostasis-Thrombosis Committee.

更新日期：2012-02-01 00:00:00

abstract：:all-trans-Retinoic acid (ATRA) induces complete remission in majority of patients with acute promyelocytic leukemia (APL). However, accelerated metabolism of ATRA that is induced by chronic daily administration of oral ATRA has been implicated as one of the mechanisms leading to a reduced sensitivity or resistance to ...

journal_title：American journal of hematology

authors： Ozpolat B,Mehta K,Tari AM,Lopez-Berestein G

更新日期：2002-05-01 00:00:00

abstract：:Decreased von Willebrand factor (VWF)-cleaving protease activity (<5%) has been implicated in patients with congenital thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (Upshaw-Schulman syndrome) and associated with mutations within the ADAMTS13 gene. In this report, we describe longitudinal studies in a p...

journal_title：American journal of hematology

authors： Snider CE,Moore JC,Warkentin TE,Finch CN,Hayward CP,Kelton JG

更新日期：2004-12-01 00:00:00

abstract：:A 25-year-old African-American man with sickle cell-beta(+)-thalassemia presented with acute asthma of 2 days' duration. The asthma was well controlled by 48 hr, and parenteral medications were changed to oral bronchodilators and steroids. Sixty hours after presentation, he developed pain similar to that of sickle cel...

journal_title：American journal of hematology

authors： Johnson K,Stastny JF,Rucknagel DL

更新日期：1994-08-01 00:00:00

abstract：:The effect of alcohol on inorganic and organic iron absorption was studied in 70 subjects, using a whole-body counter technique. The mean iron absorption of a test dose was 24.44%, while in the presence of whisky, absorption fell to 9.73% (P less than 0.0001). Absorption of a test dose in the presence of whisky withou...

journal_title：American journal of hematology

authors： Celada A,Rudolf H,Donath A

更新日期：1978-01-01 00:00:00

abstract：:The incidence of drug-induced neutropenia has not changed in the western hemisphere over the last 30 years. Yet, the drug panorama has changed considerably. This implies that host factors may play an intriguing role for this idiosyncratic reaction. The knowledge as to mechanisms for the reaction has advanced with emer...

journal_title：American journal of hematology

authors： Tesfa D,Keisu M,Palmblad J

更新日期：2009-07-01 00:00:00

abstract：:Long-term survival following chemotherapy or autologous bone marrow transplantation in adults with relapsed/refractory non-Hodgkin's lymphoma was evaluated. English language articles published from January 1, 1988 to September 1, 1993 were obtained from a broad-based MEDLINE search retrieving 3,854 citations regarding...

journal_title：American journal of hematology

authors： Meehan KR,Pritchard RS,Leichter JW,Littenberg B,Welch HG

更新日期：1995-10-01 00:00:00

abstract：:Levels of many coagulation factors are low in the healthy infant and even lower in the asphyxiated premature infant. We investigated whether a brief exposure to asphyxia at the time of birth causes the activation and consumption of coagulation factors. Following delivery by caesarean section, premature lambs were asph...

journal_title：American journal of hematology

authors： Andrew M,O'Brodovich H,Mitchell L

更新日期：1988-07-01 00:00:00

abstract：:Zoledronic acid (ZOL), an intravenous bisphosphonate, has been shown to reduce and delay the incidence of skeletal-related events (SREs) in multiple myeloma (MM) patients with bone disease. A retrospective claims-based analysis was conducted that used two distinct US managed care databases to examine the relationship ...

journal_title：American journal of hematology

authors： Henk HJ,Teitelbaum A,Perez JR,Kaura S

更新日期：2012-05-01 00:00:00

abstract：:In HIV-positive patients with non-Hodgkin lymphoma (NHL), no benefit of adding rituximab to chemotherapy was seen in a randomized controlled trial (RCT). We performed a meta-analysis of prospective studies to ascertain outcomes in HIV-positive NHL patients treated with chemotherapy (chemo) versus rituximab and chemo (...

journal_title：American journal of hematology

authors： Castillo JJ,Echenique IA

更新日期：2012-03-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a Kunitz-type proteinase inhibitor that has a crucial role in haemostasis and is primarily synthesized in the vascular endothelium. We investigated plasma total TFPI, antiphospholipid antibodies, and some other coagulation and fibrinolytic system parameters in 30 patients with...

journal_title：American journal of hematology

authors： Akarsu M,Demirkan F,Ozsan GH,Onen F,Yüksel F,Ozkan S,Undar B

更新日期：2001-12-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML), a demyelinating infectious disease caused by JC virus (JCV), occurs almost exclusively in immunocompromised patients usually with malignant diseases. We report here a Japanese female with follicular lymphoma who subsequently developed PML. In addition to JCV, human her...

journal_title：American journal of hematology

authors： Daibata M,Hatakeyama N,Kamioka M,Nemoto Y,Hiroi M,Miyoshi I,Taguchi H

更新日期：2001-07-01 00:00:00

abstract：:The second generation BCR/ABL kinase inhibitor nilotinib is increasingly used for the treatment of imatinib-resistant chronic myeloid leukemia (CML). So far, nilotinib is considered a well-tolerated drug with little if any side effects, although an increase in the fasting glucose level has been reported. We examined a...

journal_title：American journal of hematology

authors： Aichberger KJ,Herndlhofer S,Schernthaner GH,Schillinger M,Mitterbauer-Hohendanner G,Sillaber C,Valent P

更新日期：2011-07-01 00:00:00

abstract：:Thromboembolic complications following splenectomy for hematologic diseases occur in up to 10% of patients and may range from portal vein thrombosis (PVT) to pulmonary embolism (PE) and deep vein thrombosis (DVT). Up to now there exist no recommendations for the duration and intensity of prophylactic anticoagulation, ...

journal_title：American journal of hematology

authors： Mohren M,Markmann I,Dworschak U,Franke A,Maas C,Mewes S,Weiss G,Jentsch-Ullrich K

更新日期：2004-06-01 00:00:00

abstract：:A patient with congenital protein-C deficiency was treated with stanozolol for 8 weeks to increase circulating levels of protein C. A rise in protein C was achieved, accompanied by an increase in factor II, factor X, antithrombin III, and protein S; but at the 8th week the patient suffered a transient ischemia attack....

journal_title：American journal of hematology

authors： De Stefano V,Leone G,Teofili L,Ferrelli R,Pollari G,Antonini V,Bizzi B

更新日期：1988-10-01 00:00:00

abstract：:A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

journal_title：American journal of hematology

authors： Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

更新日期：1999-02-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is a rare inherited telomeropathy most frequently caused by mutations in a number of genes all thought to be involved in telomere maintenance. The main causes of mortality in DC are bone marrow failure as well as malignancies including leukemias and solid tumors. The clinical picture includ...

journal_title：American journal of hematology

authors： Perdigones N,Perin JC,Schiano I,Nicholas P,Biegel JA,Mason PJ,Babushok DV,Bessler M

更新日期：2016-12-01 00:00:00

abstract：:A 1750 base pair cDNA to human terminal deoxynucleotidyl transferase (TdT) has been cloned. This cDNA detects a dominant 2200 base pair messenger RNA species in normal and leukemic cells synthesizing the enzyme. A quantitative dot blot assay was utilized to survey a number of clinical samples from patients with TdT po...

journal_title：American journal of hematology

authors： Wolf SC,Steinherz PG,Landau NR,Silverstone AE

更新日期：1987-07-01 00:00:00

abstract：:Unprecedented advances in our understanding of the pathobiology, prognostication, and therapeutic options in mantle cell lymphoma (MCL) have taken place in the last few years. Heterogeneity in the clinical course of MCL-indolent vs aggressive-is further delineated by a correlation with the mutational status of the var...

journal_title：American journal of hematology

authors： Jain P,Wang M

更新日期：2019-06-01 00:00:00

abstract：:Primary iron overload encompasses a variety of genetic iron overload syndromes, dominated in frequency by HFE-related, or Type 1 hemochromatosis, for which French diagnostic and therapeutic guidelines have been recently proposed. Differential diagnosis of Type 1 hemochromatosis can be made from both clinical data and ...

journal_title：American journal of hematology

authors： Brissot P

更新日期：2007-12-01 00:00:00

abstract：:Ten patients developing lymphomas after disease modifying anti-rheumatic drugs (DMARD) (methotrexate, n = 3, mean cumulative dose = 3.4 g; cyclophosphamide, n = 2, mean dose = 70 g; azathioprine, n = 6, mean dose = 243 g) were investigated. Methotrexate-related lymphomas were Epstein-Barr virus (EBV)-positive, had inf...

journal_title：American journal of hematology

authors： Au WY,Ma ES,Choy C,Chung LP,Fung TK,Liang R,Kwong YL

更新日期：2006-01-01 00:00:00

abstract：:A single point mutation of the factor V (FV) gene, leading to the substitution Arg506Gln in the FV molecule (FV-Leiden) and hence resistance to its breakdown by activated protein C (APC), is the most prevalent risk factor for venous thrombosis in the Caucasians. A ratio determined by activated partial thromboplastin t...

journal_title：American journal of hematology

authors： Ts'ao C,Neofotistos D,Oropeza M,Vahabinejad S,Finn WG

更新日期：1997-03-01 00:00:00

abstract：:Heparin-induced thrombocytopenia is a rare but severe complication of heparin therapy that can result in severe venous or arterial thromboembolic events and whose treatment remains partially unanswered. Recombinant hirudin is potentially effective as an antithrombotic treatment in the management of heparin-induced thr...

journal_title：American journal of hematology

authors： Schiele F,Vuillemenot A,Kramarz P,Kieffer Y,Anguenot T,Bernard Y,Bassand JP

更新日期：1995-09-01 00:00:00

abstract：:We report a case of a patient who developed a fatal adult respiratory distress syndrome (ARDS) during treatment with rh granulocyte-macrophage colony stimulating factor (rhGM-CSF) (250 mcg/m2/day s.c.) and low-dose cytosine-arabinoside (Ara-C) (20 mg/m2/day s.c.). Several mechanisms which might explain the lung tissue...

journal_title：American journal of hematology

authors： Verhoef G,Boogaerts M

更新日期：1991-04-01 00:00:00

abstract：:Follicular lymphoma (FL) frequently transforms into the more aggressive diffuse large B cell lymphoma (DLBCL-tr), but no protein biomarkers have been identified for predictive or early diagnosis. Gene expression analyses have identified genes changing on transformation but have failed to be reproducible in different s...

journal_title：American journal of hematology

authors： Andréasson U,Dictor M,Jerkeman M,Berglund M,Sundström C,Linderoth J,Rosenquist R,Borrebaeck CA,Ek S

更新日期：2009-12-01 00:00:00

abstract：:Vascular complications, including pulmonary hypertension (PH), have been reported to occur following splenectomy for various disorders,including hereditary spherocytosis (HS). We performed a prospective cross-sectional study of 36 adults with HS (78% with prior splenectomy)utilizing echocardiography to estimate tricus...

journal_title：American journal of hematology

authors： Crary SE,Ramaciotti C,Buchanan GR

更新日期：2011-12-01 00:00:00

abstract：:Epstein-Barr virus (EBV) occasionally infects T and NK cells and causes EBV-infected T/NK-cell lymphoproliferative disease (LPD), which comprises chronic active EBV infection, EBV-associated hemophagocytic syndrome, mosquito allergy, hydroa vacciniforme, aggressive NK-cell leukemia, and NK/T-cell lymphoma. The diagnos...

journal_title：American journal of hematology

authors： Sawada A,Sato E,Koyama M,Higuchi B,Kusuki S,Kim JY,Takeshita Y,Sakata A,Sakata N,Okamura T,Yasui M,Inoue M,Kawa K

更新日期：2006-08-01 00:00:00

abstract：:This study demonstrates the quantitative characteristics of the first patient-reported outcome (PRO) tool developed for patients with nontransfusion-dependent β-thalassemia (NTDT), the NTDT-PRO© . A multicenter validation study was performed over 24 weeks, involving 48 patients from Italy, Lebanon, Greece, and Thailan...

journal_title：American journal of hematology

authors： Taher A,Cappellini MD,Viprakasit V,Sutcharitchan P,Mahmoud D,Laadem A,Khan A,Gwaltney C,Harding G,Attie K,Zhang X,Zou J,Pariseau J,Henry Hu X,Kattamis A

更新日期：2019-02-01 00:00:00

abstract：:The effect of the synthetic vasopressin derivative 1-desamino-8D-arginine vasopressin (DDAVP = desmopressin) on bleeding time was studied in three patients with Hermansky Pudlak syndrome. A good response was observed in this type of storage pool disease. DDAVP might be useful in managing the bleeding disorder found in...

journal_title：American journal of hematology

authors： Wijermans PW,van Dorp DB

更新日期：1989-03-01 00:00:00

abstract：:We report the case of a 64-year-old woman with plasma cytoid lymphoma of the ileum and gastric wall. Serum protein electrophoresis and immunoelectrophoresis showed a triclonal IgG kappa, IgA kappa, and IgM kappa gammopathy. Biopsy of the tumor revealed three different cell types, which were stained with antibodies spe...

journal_title：American journal of hematology

authors： Murata T,Fujita H,Harano H,Hukawa M,Kanamori H,Matsuzaki M,Mohri H,Kudoh J,Shimizu N,Okubo T

更新日期：1993-02-01 00:00:00