Danazol relieves refractory pruritus associated with myeloproliferative disorders and other diseases.

Abstract:

:Severe pruritus is frequently associated with myeloproliferative and other systemic illnesses, and often fails to respond to conventional measures. We used danazol (Danocrine), a synthetic attenuated androgen, in the treatment of severe pruritus refractory to conventional therapy. Eight patients had myeloproliferative disorders (MPD), seven had autoimmune disorders, and seven had skin diseases. Danazol at 400-800 mg/day was administered, and previous medications were tapered off. When itching was controlled with danazol alone, the dosage was reduced or discontinued, and resumed if itching recurred. Clinical responses were graded, and side effects were monitored. Overall, in 12 of 22 patients refractory to other measures, itching was controlled with danazol alone. In 10 patients itching returned when danazol was discontinued or dosage was continued for up to 5 years in responders. No serious side effects were observed. Our experience indicates that danazol is a good alternative for patients with severe pruritus associated with myeloproliferative and other systemic disorders.

journal_name

Am J Hematol

authors

Kolodny L,Horstman LL,Sevin BU,Brown H,Ahn YS

doi

10.1002/(SICI)1096-8652(199602)51:2<112::AID-AJH3>

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

112-6

issue

2

eissn

0361-8609

issn

1096-8652

pii

10.1002/(SICI)1096-8652(199602)51:2<112::AID-AJH3>

journal_volume

51

pub_type

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