Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival.

abstract：:We describe a 23-year-old retired military officer who was immunocompetent but diagnosed with hemophagocytic syndrome (HPS) by Plasmodium vivax infection. Initially, the patient was suspected to have toxic hepatitis related to heavy drinking. But abnormal hematologic findings required a further bone marrow examination...

journal_title：American journal of hematology

authors： Park TS,Oh SH,Choi JC,Kim HH,Chang CL,Son HC,Lee EY

更新日期：2003-10-01 00:00:00

abstract：:We have studied 91 patients with SS genotype, 44 children and 47 adults. Excluding the Cameroon and atypical haplotypes, the distribution in the children's sample exhibited 43% Benin, 38% Bantu, and 3% Senegal. In adults, the sample exhibited 46% Benin, 30% Bantu, and 9% Senegal (chi 2: 13.511, 2 df, P = 0.001). When ...

journal_title：American journal of hematology

authors： Muniz A,Corral L,Alaez C,Svarch E,Espinosa E,Carbonell N,di Leo R,Felicetti L,Nagel RL,Martinez G

更新日期：1995-06-01 00:00:00

abstract：:Recent literature has demonstrated concern over the risk of Pneumocystis jirovecii pneumonia (PJP) when administering rituximab with combination chemotherapy such as in R-CHOP; however, the exact risk and potential need for prophylaxis is unknown. We sought to determine the incidence of PJP infection following R-CHOP ...

journal_title：American journal of hematology

authors： Barreto JN,Ice LL,Thompson CA,Tosh PK,Osmon DR,Dierkhising RA,Plevak MF,Limper AH

更新日期：2016-11-01 00:00:00

abstract：:Imatinib mesylate radically changed the natural history of chronic myeloid leukemia (CML). The recent availability of alternative tyrosine kinase inhibitors (TKIs) renders the clinical management of CML more complex. In this article, we summarize our long-term single institution experience. From 2003 to 2012, 102 pati...

journal_title：American journal of hematology

authors： Viganò I,Di Giacomo N,Bozzani S,Antolini L,Piazza R,Gambacorti Passerini C

更新日期：2014-10-01 00:00:00

abstract：:The relationship between thrombocytopenia and the level of anticardiolipin antibodies (aCL) and/or the existence of lupus anticoagulant (LA) ware studied in 146 patients with systemic lupus erythematosus (SLE). These patients were divided into six groups: A, those LA positive with a high level of aCL (>10 U/ml) (10 ca...

journal_title：American journal of hematology

authors： Nojima J,Suehisa E,Kuratsune H,Machii T,Toku M,Tada H,Yamaguti K,Koike T,Kanakura Y,Kitani T,Amino N

更新日期：1998-05-01 00:00:00

abstract：:Duvelisib (IPI-145), an oral, dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ, was evaluated in a Phase 1 study in advanced hematologic malignancies, which included expansion cohorts in relapsed/refractory (RR) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and treatment-naïve (TN) CLL...

journal_title：American journal of hematology

authors： O'Brien S,Patel M,Kahl BS,Horwitz SM,Foss FM,Porcu P,Jones J,Burger J,Jain N,Allen K,Faia K,Douglas M,Stern HM,Sweeney J,Kelly P,Kelly V,Flinn I

更新日期：2018-11-01 00:00:00

abstract：:Defects in stomatin, alpha-adducin, and beta-adducin have been implicated in erythrocyte disorders of cation permeability. We performed linkage analysis of the genetic loci for these proteins in a large kindred with xerocytosis (dehydrated hereditary stomatocytosis). Using polymerase chain reaction-based genotyping te...

journal_title：American journal of hematology

authors： Innes DS,Sinard JH,Gilligan DM,Snyder LM,Gallagher PG,Morrow JS

更新日期：1999-01-01 00:00:00

abstract：:To investigate the mechanisms that modulate granulocyte-macrophage colony-stimulating activity (GM-CSA) and burst promoting activity (BPA) elaboration, we studied human peripheral blood-derived monocyte-macrophage (M0) and T-lymphocyte (TL) interaction. Coincubation of live M0 with autologous TL at a 1:3 ratio in the ...

journal_title：American journal of hematology

authors： Verma DS,Spitzer G,Beran M

更新日期：1982-06-01 00:00:00

abstract：:Thrombotic complications occur at high rates in hospitalized patients with COVID-19, yet the impact of intensive antithrombotic therapy on mortality is uncertain. We examined in-hospital mortality with intermediate- compared to prophylactic-dose anticoagulation, and separately with in-hospital aspirin compared to no a...

journal_title：American journal of hematology

authors： Meizlish ML,Goshua G,Liu Y,Fine R,Amin K,Chang E,DeFilippo N,Keating C,Liu Y,Mankbadi M,McManus D,Wang SY,Price C,Bona RD,Ochoa Chaar CI,Chun HJ,Pine AB,Rinder HM,Siner JM,Neuberg DS,Owusu KA,Lee AI

更新日期：2021-01-21 00:00:00

abstract：OVERVIEW:Evidence suggests that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment r...

journal_title：American journal of hematology

authors： Estey EH

更新日期：2014-11-01 00:00:00

abstract：:A single-tube osmotic fragility test has been proposed for thalassemia screening with a range of different concentrations of saline having been employed. We have compared the sensitivity and specificity of 0.32%, 0.34%, and 0.36% buffered saline, and on the basis of our findings, recommend the use of 0.36% saline. Thi...

journal_title：American journal of hematology

authors： Chow J,Phelan L,Bain BJ

更新日期：2005-07-01 00:00:00

abstract：:Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expa...

journal_title：American journal of hematology

authors： Furutani E,Newburger PE,Shimamura A

更新日期：2019-03-01 00:00:00

abstract：:Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their beta S chromosomes. One subject had an alpha-thalassemia (-alpha/-alpha). The haplotypes were the common type #19, associated with severe disease, and type #31, n...

journal_title：American journal of hematology

authors： Bakioglu I,Hattori Y,Kutlar A,Mathew C,Huisman TH

更新日期：1985-11-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is feasible and effective in selected older patients with Multiple Myeloma, but specific criteria for evaluating ASCT eligibility in elderly patients are lacking. We evaluated 131 patients aged 65-75 considered for ASCT at our center: The Charlson Comorbidity Index (CCI), He...

journal_title：American journal of hematology

authors： Belotti A,Ribolla R,Cancelli V,Crippa C,Bianchetti N,Ferrari S,Bottelli C,Cattaneo C,Tucci A,De La Fuente Barrigon C,Rossi G

更新日期：2020-07-01 00:00:00

abstract：:A 17-year-old male with bilineal hybrid acute leukemia is described. Two-color flow cytometric analysis of blast surface phenotype revealed that there were two groups of blasts which showed either CD 10+ CD 19+ CD 13- CD 33- or CD 10- CD 19- CD 13+ CD 33+, but not both. He developed a complete remission by treatment w...

journal_title：American journal of hematology

authors： Jinnai I,Kusumoto S,Shiomi Z,Bessho M,Saitoh M,Hirashima K,Minamihisamatsu M,Kamiyama T,Takase K

更新日期：1990-10-01 00:00:00

abstract：:Granulysin is a newly identified CTL/NK cell-related cytotoxic protein, which is secreted in both constitutive and Ca-dependent manner. To evaluate its significance in stem-cell transplantation (SCT), serum granulysin was measured by newly established ELISA method in 26 patients undergoing SCT (21 allogeneic and 5 aut...

journal_title：American journal of hematology

authors： Nagasawa M,Isoda T,Itoh S,Kajiwara M,Morio T,Shimizu N,Ogawa K,Nagata K,Nakamura M,Mizutani S

更新日期：2006-05-01 00:00:00

abstract：:Leg ulcers are a well recognized complication of sickle cell disease that has been attributed to venous insufficiency. We studied 16 patients with sickle cell disease and active ulcers using venous pulse volume recordings and photoplethysmography (Doppler studies). Based on hemodynamic monitoring, all 16 patients exhi...

journal_title：American journal of hematology

authors： Billett HH,Patel Y,Rivers SP

更新日期：1991-06-01 00:00:00

abstract：:We measured the plasma level of fibrinogen in 560 patients with disseminated intravascular coagulation (DIC) and evaluated its relationship with outcome and with other hemostatic markers. Forty-seven percent of patients had >200 mg/dL of plasma fibrinogen and 24% had <100 mg/dl of plasma fibrinogen, suggesting that pl...

journal_title：American journal of hematology

authors： Wada H,Mori Y,Okabayashi K,Gabazza EC,Kushiya F,Watanabe M,Nishikawa M,Shiku H,Nobori T

更新日期：2003-01-01 00:00:00

abstract：:Infantile malignant osteopetrosis (IMO) includes various genetic disorders that affect osteoclast development and/or function. Genotype-phenotype correlation studies in IMO have been hampered by the rarity and heterogeneity of the disease and by the severity of the clinical course, which often leads to death early in ...

journal_title：American journal of hematology

authors： Mazzolari E,Forino C,Razza A,Porta F,Villa A,Notarangelo LD

更新日期：2009-08-01 00:00:00

abstract：:Acute leukemias of ambiguous lineage (ALAL) comprise acute undifferentiated leukemias (AUL) and mixed-phenotype acute leukemias (MPAL). In the revised fourth edition of the World Health Organization (WHO) classification provided further refinements to the diagnostic criteria for ALAL. Molecular characterization of MPA...

journal_title：American journal of hematology

authors： Patel SS,Weinberg OK

更新日期：2020-06-01 00:00:00

abstract：:Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIF...

journal_title：American journal of hematology

authors： Andersen CL,Siersma VD,Hasselbalch HC,Lindegaard H,Vestergaard H,Felding P,de Fine Olivarius N,Bjerrum OW

更新日期：2013-10-01 00:00:00

abstract：:In May 2005 at the 8th International Symposium on Myelodysplastic Syndromes (MDS), a consensus meeting was held on iron overload in MDS (Seymour, Hematol Oncol Clin 2005; Suppl 1:18-25). The recommendations of the 2005 consensus meeting were discussed in the context of currently available evidence at the 9th Internati...

journal_title：American journal of hematology

authors： Bennett JM,MDS Foundation's Working Group on Transfusional Iron Overload.

更新日期：2008-11-01 00:00:00

abstract：:In this study we describe the time-dependent effects of a high dose (750 micrograms/ml/24 hr) continuous infusion of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on monocyte number, cytokine release, and superoxide anion production. Blood was taken from patients prior to rhGM-CSF infus...

journal_title：American journal of hematology

authors： Perkins RC,Vadhan-Raj S,Scheule RK,Hamilton R,Holian A

更新日期：1993-08-01 00:00:00

abstract：:Patients with indolent non-Hodgkin lymphoma (NHL) have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy, and safety of adding lenalidomid...

journal_title：American journal of hematology

authors： Rosenthal A,Dueck AC,Ansell S,Gano K,Conley C,Nowakowski GS,Camoriano J,Leis JF,Mikhael JR,Keith Stewart A,Inwards D,Dingli D,Kumar S,Noel P,Gertz M,Porrata L,Russell S,Colgan J,Fonseca R,Habermann TM,Kapoor P,B

更新日期：2017-05-01 00:00:00

abstract：:Although infectious complications represent a relevant cause of morbidity and mortality in patients with myelofibrosis (MF), little is known about their incidence, outcome and risk factors. We retrospectively evaluated a cohort of 507 MF patients, diagnosed between 1980 and 2014 in five Italian hematology centers, to ...

journal_title：American journal of hematology

authors： Polverelli N,Breccia M,Benevolo G,Martino B,Tieghi A,Latagliata R,Sabattini E,Riminucci M,Godio L,Catani L,Nicolosi M,Perricone M,Sollazzo D,Colafigli G,Campana A,Merli F,Vitolo U,Alimena G,Martinelli G,Lewis RE,V

更新日期：2017-01-01 00:00:00

abstract：:Erythrocytes from ten patients with severe liver disease displayed low methylene blue-stimulated hexose monophosphate (HMP) shunt activity and glucose recycling despite elevated total glucose consumption when compared to controls. Heinz body formation was increased and reduced glutathione concentration significantly d...

journal_title：American journal of hematology

authors： Smith JR,Kay NE,Gottlieb AJ,Oski FA

更新日期：1979-01-01 00:00:00

abstract：:A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37-year-old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of heredita...

journal_title：American journal of hematology

authors： Hanano M,Takahashi H,Itoh M,Shibata A

更新日期：1992-09-01 00:00:00

abstract：:Lysosomes (granules) of rabbit PMN leukocytes were extracted with either HCl or H2SO4, and the extracts were chromatographed over Sephadex to separate protein constituents. Some of the low molecular weight cationic proteins homogeneous on SDS PAGE (8% and 12.5% gels) were characterized by electrophoretic mobility in a...

journal_title：American journal of hematology

authors： Herion JC,Bucher JR,Penniall R,Walker RI,Baker M,Roberts HR

更新日期：1979-01-01 00:00:00

abstract：:The incidence of multiple myeloma (MM) is known to be variable according to ethnicity. However, the differences in clinical characteristics between ethnic groups are not well-defined. In Asian countries, although the incidence of MM has been lower than that of Western countries, there is growing evidence that MM is in...

journal_title：American journal of hematology

authors： Kim K,Lee JH,Kim JS,Min CK,Yoon SS,Shimizu K,Chou T,Kosugi H,Suzuki K,Chen W,Hou J,Lu J,Huang XJ,Huang SY,Chng WJ,Tan D,Teoh G,Chim CS,Nawarawong W,Siritanaratkul N,Durie BG

更新日期：2014-07-01 00:00:00

abstract：:Intravenous (IV) granulocyte colony stimulating factor (G-CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato-oncological patients receiving chemotherapy. To compare IV vs. SC G-CSF administration, we conducted a randomized, open-label trial. We included inpatients rece...

journal_title：American journal of hematology

authors： Paul M,Ram R,Kugler E,Farbman L,Peck A,Leibovici L,Lahav M,Yeshurun M,Shpilberg O,Herscovici C,Wolach O,Itchaki G,Bar-Natan M,Vidal L,Gafter-Gvili A,Raanani P

更新日期：2014-03-01 00:00:00