Five adults with mild sickle cell anemia share a beta S chromosome with the same haplotype.

abstract：:Immune thrombocytopenia is frequently encountered in medical practice and is generally accepted as being caused by an IgG antibody. The capability of detecting platelet-bound IgG as a diagnostic and therapeutic modality is critical for appropriate care and management of patients with idiopathic thrombocytopenic purpur...

journal_title：American journal of hematology

authors： Tate DY,Carlton GT,Nesbit ME,White JG,Krivit W,Sorenson RL

更新日期：1980-01-01 00:00:00

abstract：:Thalassemia is an inherited blood disorder that requires lifelong adherence to a complicated and burdensome medical regimen which could potentially impact emotional functioning of patients. The importance of understanding and promoting healthy emotional functioning is crucial not only to psychological well-being, but ...

journal_title：American journal of hematology

authors： Mednick L,Yu S,Trachtenberg F,Xu Y,Kleinert DA,Giardina PJ,Kwiatkowski JL,Foote D,Thayalasuthan V,Porter JB,Thompson AA,Schilling L,Quinn CT,Neufeld EJ,Yamashita R,Thalassemia Clinical Research Network.

更新日期：2010-10-01 00:00:00

abstract：:Granulocyte macrophage-colony-stimulating factor (GM-CSF) has shown promise as a means of alleviating leukopenia associated with a wide variety of disorders. It is currently undergoing evaluation as an adjunct to bone marrow transplantation but its use in patients with metabolic disorders, such as Hurler's syndrome (H...

journal_title：American journal of hematology

authors： Lang E,Cibull ML,Gallicchio VS,Henslee-Downey PJ,Davey DD,Messino MJ,Harder EJ

更新日期：1992-12-01 00:00:00

abstract：:Philadelphia chromosome (Ph1) positive, or "adult-type," chronic granulocytic leukemia (CGL) differs in many clinical and laboratory aspects from PH1-negative, or "juvenile," CGL. Because of these differences, the disorders have been considered two distinct disease entities. We present a child with Ph1-positive CGL wh...

journal_title：American journal of hematology

authors： Gay JC,Dessypris EN,Roloff JS,Lukens JN

更新日期：1984-01-01 00:00:00

abstract：:The arachidonic acid metabolites produced by human peripheral blood monocytes were studied to determine which metabolites could have a role in thrombogenesis. Monocytes were found to be free of platelets by scanning electron microscopy and by measurement of 12-HETE. Human peripheral blood monocytes produce thromboxane...

journal_title：American journal of hematology

authors： Jones CM,Hall ER,Hester JP,Wu KK

更新日期：1989-07-01 00:00:00

abstract：:We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, elect...

journal_title：American journal of hematology

authors： Leebeek FW,Knot EA,Ten Cate JW,Traas DW

更新日期：1989-01-01 00:00:00

abstract：:The above abstract from the THSNA 2016 Summit Abstract Proceedings, first published online in the American Journal of Hematology on 20 July 2016 in Wiley OnlineLibrary (www.onlinelibrary.wiley.com), and in Volume 91, Issue 9, p. E427, has been retracted by agreement between the authors, the journal Editor-in-Chief, Ca...

journal_title：American journal of hematology

authors：

更新日期：2017-04-01 00:00:00

abstract：:Acetylsalicylic acid (ASA) is currently recommended as an antithrombotic for patients with essential thrombocythemia (ET) who are at an increased risk of thrombotic events. However, ASA is also associated with an increased risk of bleeding in these patients as compared to the risk of bleeding in other patients treated...

journal_title：American journal of hematology

authors： Cortelazzo S,Marchetti M,Orlando E,Falanga A,Barbui T,Buchanan MR

更新日期：1998-04-01 00:00:00

abstract：:Heparin-associated thrombocytopenia with thrombosis (HATT) is fatal in 29% and leads to limb amputation in another 21% of patients. Patients with arterial thrombosis do worse than do those with venous thrombosis alone. Heparin-associated thrombocytopenia is mediated through IgG or IgM immunoglobulin fractions and is b...

journal_title：American journal of hematology

authors： Nand S,Robinson JA

更新日期：1988-07-01 00:00:00

abstract：:We report here a patient with de novo acute myelocytic leukemia with trilineage myelodysplasia (AML/TMDS) in whom cytogenetic analysis was normal at diagnosis and in whom Philadelphia chromosome (Ph1) with monosomy 7 emerged at the terminal stage of the disease. Reverse transcription polymerse chain reaction (RT-PCTR)...

journal_title：American journal of hematology

authors： Matsue K,Miyamoto T,Ito M,Tsukuda K

更新日期：1995-08-01 00:00:00

abstract：:Fetal hemoglobin (HbF) inhibits the polymerization of sickle hemoglobin, modulating the clinical features of sickle cell anemia (SCA). Hydroxyurea (HU) therapy can increase the HbF level, although its production can be influenced by genetic determinants. Twenty-two Brazilian SCA patients were evaluated over 5 years be...

journal_title：American journal of hematology

authors： Vicari P,Barretto de Mello A,Figueiredo MS

更新日期：2005-03-01 00:00:00

abstract：:A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

journal_title：American journal of hematology

authors： Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

更新日期：1999-02-01 00:00:00

abstract：:The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and labor...

journal_title：American journal of hematology

authors： Edlund M,Blombäck M,von Schoultz B,Andersson O

更新日期：1996-12-01 00:00:00

abstract：:Secondary leukaemia following treatment of M3 acute promyelocytic leukaemia (APL) is a rare event. We describe a patient in remission following chemotherapy for APL who relapsed with M2 acute non-lymphoblastic leukaemia (ANLL). The original t(15;17) (q22;q21) chromosome translocation was lost and replaced by a clone c...

journal_title：American journal of hematology

authors： Hatzis T,Standen GR,Howell RT,Savill C,Wagstaff M,Scott GL

更新日期：1995-01-01 00:00:00

abstract：:We evaluated possible prognostic factors just before salvage therapy with vincristine, doxorubicin, and dexamethasone (VAD) for 36 patients with refractory multiple myeloma. The median duration from diagnosis to the first VAD salvage was 14 months (range 2-76 months). Among parameters that have been shown to be associ...

journal_title：American journal of hematology

authors： Suguro M,Kanda Y,Yamamoto R,Chizuka A,Hamaki T,Matsuyama T,Takezako N,Miwa A,Togawa A

更新日期：2000-10-01 00:00:00

abstract：:An adolescent male patient developed functional asplenia in the course of graft versus host disease (GVHD) after successful allogeneic bone marrow transplantation (BMT) for aplastic anemia. Coincident with the onset of the asplenia, amelioration of the ongoing GVHD was observed. Unexpectedly, after 34 months of functi...

journal_title：American journal of hematology

authors： Demetrakopoulos GE,Tsokos GC,Levine AS

更新日期：1982-02-01 00:00:00

abstract：:Three Indonesian patients with identical genotypes, each compound heterozygotes for Filipino beta(o)-thalassemia/HbE, expressed different clinical severities. One patient has mild disease and is transfusion independent, while the other two are severely affected and transfusion dependent. The size of the Filipino beta(...

journal_title：American journal of hematology

authors： Setianingsih I,Williamson R,Daud D,Harahap A,Marzuki S,Forrest S

更新日期：1999-09-01 00:00:00

abstract：:Levels of many coagulation factors are low in the healthy infant and even lower in the asphyxiated premature infant. We investigated whether a brief exposure to asphyxia at the time of birth causes the activation and consumption of coagulation factors. Following delivery by caesarean section, premature lambs were asph...

journal_title：American journal of hematology

authors： Andrew M,O'Brodovich H,Mitchell L

更新日期：1988-07-01 00:00:00

abstract：:Celecoxib, a specific cyclooxygenase-2 (Cox-2) inhibitor, has been shown to possess antitumor activity in a variety of cancer cells. However, the antitumor activity of celecoxib in hematopoietic tumors, especially in chronic myeloid leukemia (CML), has not been well established. This study was designed to investigate ...

journal_title：American journal of hematology

authors： Zhang GS,Liu DS,Dai CW,Li RJ

更新日期：2006-04-01 00:00:00

abstract：:Central nervous system (CNS) thrombotic events are a well-known complication of acute lymphoblastic leukemia (ALL) induction therapy, especially with treatments including l-asparaginase (l-ASP). Data on risk factors and clinical evolution is still lacking in adult patients. We report on the clinical evolution of 22 CN...

journal_title：American journal of hematology

authors： Couturier MA,Huguet F,Chevallier P,Suarez F,Thomas X,Escoffre-Barbe M,Cacheux V,Pignon JM,Bonmati C,Sanhes L,Bories P,Daguindau E,Dorvaux V,Reman O,Frayfer J,Orvain C,Lhéritier V,Ifrah N,Dombret H,Hunault-Berger M,

更新日期：2015-11-01 00:00:00

abstract：:A small number of thromboembolic events, including deep venous thrombosis and myocardial infarction, have been reported in patients receiving IVIG. These events have primarily occurred in patients receiving high-dose IVIG and have been attributed to an increase in blood viscosity. To test the hypothesis that a procoag...

journal_title：American journal of hematology

authors： Wolberg AS,Kon RH,Monroe DM,Hoffman M

更新日期：2000-09-01 00:00:00

abstract：:The "platelet function analyzer" (PFA)-100 was first introduced to us in 1995. Since then, the instrument has appeared in over 50 reviews and almost 1000 publications. Recently, the PFA-100 has been "upgraded" to the PFA-200, which has transformed the user interface and electronic management, but retained the fundamen...

journal_title：American journal of hematology

authors： Favaloro EJ

更新日期：2017-04-01 00:00:00

abstract：:Withdrawal: Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective. The above article, published online on 20 August 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, t...

journal_title：American journal of hematology

authors： Cordeiro Mitchell CN,Pradhan A,Singh B,Naik RP,Baker VL,Lanzkron SM,Christianson MS,Pecker LH

更新日期：2020-08-20 00:00:00

abstract：:Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expa...

journal_title：American journal of hematology

authors： Furutani E,Newburger PE,Shimamura A

更新日期：2019-03-01 00:00:00

abstract：:The introduction of Imatinib (IM) has significantly altered the treatment for CML, although only limited follow-up results are available. As failure of Interferon-alpha had been associated with poor prognosis and results of IM-treatment in this patient group may allow earlier estimation of long-term benefits for early...

journal_title：American journal of hematology

authors： Hess G,Meyer RG,Schuch B,Bechthold K,El-Kholy I,Huber C

更新日期：2008-03-01 00:00:00

abstract：:We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

journal_title：American journal of hematology

authors： Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

更新日期：2002-02-01 00:00:00

abstract：:We report a family with a dominantly transmitted syndrome resembling Fanconi's anemia and spanning two generations. This syndrome was characterized by an ill-defined hematologic stem cell disorder, immune dysfunction, poor dentition, hyperpigmented skin, warts, and multiple second trimester spontaneous abortions and i...

journal_title：American journal of hematology

authors： Alter CL,Levine PH,Bennett J,Kessler C,Rick M,Washburn RG,Gallin JI,Miller RW,Auerbach AD

更新日期：1989-12-01 00:00:00

abstract：:With the emerging success of treating CD19 expressing B cell malignancies with ex vivo modified, autologous T cells that express CD19-directed chimeric antigen receptors (CAR), there is intense interest in expanding this evolving technology to develop effective modalities to treat other malignancies including solid tu...

journal_title：American journal of hematology

authors： Perera LP,Zhang M,Nakagawa M,Petrus MN,Maeda M,Kadin ME,Waldmann TA,Perera PY

更新日期：2017-09-01 00:00:00

abstract：:Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM2 has been mapped to this chromosome, we examined the possible association of MDM2 in the pathogenesis of CLL. A rearrangement of the MDM2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Sout...

journal_title：American journal of hematology

authors： Huang YQ,Raphael B,Buchbinder A,Li JJ,Zhang WG,Friedman-Kien AE

更新日期：1994-10-01 00:00:00

abstract：:Extensive extralymphatic Hodgkin disease developed in a young man with common variable immunodeficiency manifested by hypogammaglobulinemia, recurrent sinopulmonary infections, and multiple autoimmune phenomena. Both humoral and cell-mediated immune dysfunction were present prior to treatment. After two cycles of chem...

journal_title：American journal of hematology

authors： Fesus SM,Hagemeister FB,Manning J

更新日期：1989-10-01 00:00:00