Prenatal diagnosis of thalassemia in the Chinese.

abstract：:Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recru...

journal_title：American journal of hematology

authors： Cui L,Li ZG,Chai YH,Yu J,Gao J,Zhu XF,Jin RM,Shi XD,Zhang LP,Gao YJ,Zhang RD,Zheng HY,Hu SY,Cui YH,Zhu YP,Zou Y,Ng MHL,Xiao Y,Li JH,Zhang YH,He HL,Xian Y,Wang TY,Li CK,Wu MY,Chinese Children Leukemia Gro

更新日期：2018-07-01 00:00:00

abstract：:Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9-71 years) clinically stable on ERT with imiglucerase, safely switched to a compa...

journal_title：American journal of hematology

authors： Elstein D,Mehta A,Hughes DA,Giraldo P,Charrow J,Smith L,Shankar SP,Hangartner TN,Kunes Y,Wang N,Crombez E,Zimran A

更新日期：2015-07-01 00:00:00

abstract：:The Sickle Cell Disease Clinical Research Network (SCDCRN) designed the PROACTIVE Feasibility Study (ClinicalTrials.gov NCT00951808) to determine whether elevated serum levels of secretory phospholipase A2 (sPLA2) during hospitalization for pain would permit preemptive therapy of sickle cell acute chest syndrome (ACS)...

journal_title：American journal of hematology

authors： Miller ST,Kim HY,Weiner D,Wager CG,Gallagher D,Styles L,Dampier CD,Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN).

更新日期：2012-03-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) may convert to a diffuse large cell lymphoma (Richter's syndrome) over time. In occasional cases of Richter's transformation, Epstein-Barr virus (EBV) has been identified in the lymphoma cells. To evaluate the association of EBV infection with Richter's syndrome, the biopsy specimens...

journal_title：American journal of hematology

authors： Ansell SM,Li CY,Lloyd RV,Phyliky RL

更新日期：1999-02-01 00:00:00

abstract：:Most cases of immune hemolytic anemia are associated with a positive direct antiglobulin test. However, in some cases, the antiglobulin test is not sensitive enough to detect low levels of red-cell bound antibodies. This report describes a method using radiolabelled purified staphylococcal protein A which is capable o...

journal_title：American journal of hematology

authors： Yam P,Petz LD,Spath P

更新日期：1982-06-01 00:00:00

abstract：:Matching for HLA-A, -B, -C, and -DRB1 loci (8/8 match) is currently the gold standard for unrelated donor hematopoietic cell transplantation (HCT). In Europe, patients are also matched at the HLA-DQB1 loci (10/10 match). However, there is increasing evidence that matching at HLA-DRB3/4/5 loci may help to lower transpl...

journal_title：American journal of hematology

authors： Ducreux S,Dubois V,Amokrane K,Yakoub-Agha I,Labalette M,Michallet M,Rubio MT,Kennel A,Forcade E,Lafarge X,Bulabois CE,Masson D,Daguindau E,Devys A,Moalic V,Quelvennec E,Boudifa A,Picard C,Van Endert P,de Matteis M,

更新日期：2018-05-04 00:00:00

abstract：:Several parameters may predict disease severity and overall survival in chronic lymphocytic leukemia (CLL). The purpose of our study of 190 CLL patients was to compare immunoglobulin heavy chain variable region (IgV(H)) mutation status, cytogenetic abnormalities, and leukemia cell CD38 and Zap-70 to older, traditional...

journal_title：American journal of hematology

authors： Weinberg JB,Volkheimer AD,Chen Y,Beasley BE,Jiang N,Lanasa MC,Friedman D,Vaccaro G,Rehder CW,Decastro CM,Rizzieri DA,Diehl LF,Gockerman JP,Moore JO,Goodman BK,Levesque MC

更新日期：2007-12-01 00:00:00

abstract：:Multiple myeloma (MM) and primary systemic light chain amyloidosis (AL) are both chronic plasma cell dyscrasias with different clinical expression but limited treatment options for relapsed refractory disease. We report the effect of the addition of clarithromycin on 31 MM and 17 AL with relapsed or refractory disease...

journal_title：American journal of hematology

authors： Shaulov A,Ganzel C,Benyamini N,Barshay Y,Goldschmidt N,Lavie D,Libster D,Gural A,Avni B,Gatt ME

更新日期：2017-02-01 00:00:00

abstract：:Plerixafor, a recently approved peripheral blood progenitor cell mobilizing agent, is often added to granulocyte-colony stimulating factor (G-CSF) to mobilize peripheral blood progenitor cells in patients with lymphoma or myeloma who cannot mobilize enough CD34+ cells with G-CSF alone to undergo autologous stem cell t...

journal_title：American journal of hematology

authors： Smith VR,Popat U,Ciurea S,Nieto Y,Anderlini P,Rondon G,Alousi A,Qazilbash M,Kebriaei P,Khouri I,de Lima M,Champlin R,Hosing C

更新日期：2013-09-01 00:00:00

abstract：:The aim of our study was to assess the cytokine profile of sickle cell disease (SCD) patients in steady state and in vaso-occlusive crisis (VOC). VOC has a complex nature, involving interactions between sickle red blood cells (RBC), the endothelium, and leucocytes. Endothelial damage due to recurrent adhesion of sickl...

journal_title：American journal of hematology

authors： Pathare A,Al Kindi S,Alnaqdy AA,Daar S,Knox-Macaulay H,Dennison D

更新日期：2004-12-01 00:00:00

abstract：:The biosynthesis of the minor hemoglobin FIc, which contains acetylated gamma chains, and the major hemoglobin Fo was studied during erythroid cell differentiation and maturation in cultures of erythroid precursors isolated from five human umbilical cord blood samples. A gradual decrease in the synthesis of Hb FIc was...

journal_title：American journal of hematology

authors： Abraham EC,Reese AL,Stallings M,Abraham A,Garbutt GJ,Huisman TH

更新日期：1982-05-01 00:00:00

abstract：:The incidence of drug-induced neutropenia has not changed in the western hemisphere over the last 30 years. Yet, the drug panorama has changed considerably. This implies that host factors may play an intriguing role for this idiosyncratic reaction. The knowledge as to mechanisms for the reaction has advanced with emer...

journal_title：American journal of hematology

authors： Tesfa D,Keisu M,Palmblad J

更新日期：2009-07-01 00:00:00

abstract：:The objective of the study was to explore the risks and benefits of splenectomy in advanced agnogenic myeloid metaplasia (AMM). We searched the literature (Medline, 1970-1987) for studies of postoperative survival, operative mortality and effects of splenectomy on painful splenomegaly, and portal hypertension or trans...

journal_title：American journal of hematology

authors： Benbassat J,Gilon D,Penchas S

更新日期：1990-02-01 00:00:00

abstract：:To elucidate the precise mechanisms of molecular and cellular regulation of hemopoiesis, it is necessary to develop a chemically defined culture assay for purified hemopoietic progenitors. To approach this long-term goal, we attempted to develop a serum-free culture system for enriched human progenitors that permits e...

journal_title：American journal of hematology

authors： Sonoda Y,Ogawa M

更新日期：1988-08-01 00:00:00

abstract：:Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and V...

journal_title：American journal of hematology

authors： Tang W,Cushman M,Green D,Rich SS,Lange LA,Yang Q,Tracy RP,Tofler GH,Basu S,Wilson JG,Keating BJ,Weng LC,Taylor HA,Jacobs DR Jr,Delaney JA,Palmer CD,Young T,Pankow JS,O'Donnell CJ,Smith NL,Reiner AP,Folsom AR

更新日期：2015-06-01 00:00:00

abstract：DISEASE OVERVIEW:Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, h...

journal_title：American journal of hematology

authors： Gertz MA

更新日期：2020-07-01 00:00:00

abstract：:Intravenous (IV) granulocyte colony stimulating factor (G-CSF) might be safer and more convenient than subcutaneous (SC) administration to hospitalized hemato-oncological patients receiving chemotherapy. To compare IV vs. SC G-CSF administration, we conducted a randomized, open-label trial. We included inpatients rece...

journal_title：American journal of hematology

authors： Paul M,Ram R,Kugler E,Farbman L,Peck A,Leibovici L,Lahav M,Yeshurun M,Shpilberg O,Herscovici C,Wolach O,Itchaki G,Bar-Natan M,Vidal L,Gafter-Gvili A,Raanani P

更新日期：2014-03-01 00:00:00

abstract：:Substantial evidence exists indicating T cell abnormalities in chronic lymphocytic leukemia (CLL). There is also evidence that the T cell is an important source of burst promoting activity (BPA) for the peripheral blood (PB) erythroid burst forming unit (BFU-e). We studied the BPA of T cells and response of BFU-e in n...

journal_title：American journal of hematology

authors： Socinski MA,Ershler WB

更新日期：1984-02-01 00:00:00

abstract：:Thalassemia is an inherited blood disorder that requires lifelong adherence to a complicated and burdensome medical regimen which could potentially impact emotional functioning of patients. The importance of understanding and promoting healthy emotional functioning is crucial not only to psychological well-being, but ...

journal_title：American journal of hematology

authors： Mednick L,Yu S,Trachtenberg F,Xu Y,Kleinert DA,Giardina PJ,Kwiatkowski JL,Foote D,Thayalasuthan V,Porter JB,Thompson AA,Schilling L,Quinn CT,Neufeld EJ,Yamashita R,Thalassemia Clinical Research Network.

更新日期：2010-10-01 00:00:00

abstract：:Human T-cell leukemia virus (HTLV-I) is known to be associated with certain hematologic malignancies, and a related virus, HTLV-III/LAV, might be the cause of AIDS. Some persons with AIDS have had evidence of HTLV-I infection. Unrelated to these findings, it has been suggested that HTLV-I is transmitted via blood prod...

journal_title：American journal of hematology

authors： Jason JM,McDougal JS,Cabradilla C,Kalyanaraman VS,Evatt BL

更新日期：1985-10-01 00:00:00

abstract：:The purpose of the study was to determine if UDP-glucuronosyltransferase (UGT) 2B7 allelic variants encoding for UGT2B7, primary enzyme responsible for morphine glucuronidation contribute to the variability in the hepatic clearance of morphine in sickle cell disease (SCD). Twenty-four hour PK study of morphine and UGT...

journal_title：American journal of hematology

authors： Darbari DS,van Schaik RH,Capparelli EV,Rana S,McCarter R,van den Anker J

更新日期：2008-03-01 00:00:00

abstract：:A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported. It is proposed that ectopic production of the active vitamin D metabolite related to ongoing clonal expansion in the bone marrow accounts for the hypercalcemic state. Consistently low levels of circulating type ...

journal_title：American journal of hematology

authors： Voss A,Schmidt K,Hasselbalch H,Junker P

更新日期：1992-03-01 00:00:00

abstract：:Protein S (ProS) is a physiological inhibitor of coagulation with an important function in the down-regulation of thrombin generation. ProS deficiency is a major risk factor for venous thrombosis. This study enrolled 40 ProS-deficient probands to investigate the molecular basis of hereditary ProS deficiency in Chinese...

journal_title：American journal of hematology

authors： Tang L,Jian XR,Hamasaki N,Guo T,Wang HF,Lu X,Wang QY,Hu Y

更新日期：2013-10-01 00:00:00

abstract：:Fetal calf serum (FCS) is used as a component of the media for cells grown in culture. However, the high cost of FCS has stimulated a search for a possible alternative. Approximately 10% of human platelet concentrates prepared for clinical transfusions are outdated. Sera prepared from platelet concentrates were compar...

journal_title：American journal of hematology

authors： Schwartz KA,Lu G,Trosko JE,Chang CC

更新日期：1984-07-01 00:00:00

abstract：:Although large vessel thrombi are occasionally reported in patients with homozygous sickle cell disease, the role of intravascular coagulation in typical pain crises is controversial. Therefore, we studied 24 sickle cell patients during and between episodes of pain crisis, using several sensitive tests of hemostasis. ...

journal_title：American journal of hematology

authors： Green D,Scott JP

更新日期：1986-12-01 00:00:00

abstract：:A new density system for the separation of human red blood cells by density-gradient centrifugation is described. The gradient medium is made with colloidal silica particles coated with polyvinylpyrrolidone suspended in aqueous solution of meglamine diatrizoate. By this method, more than 10 red-cell fractions can be s...

journal_title：American journal of hematology

authors： Vettore L,De Matteis MC,Zampini P

更新日期：1980-01-01 00:00:00

abstract：:The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and labor...

journal_title：American journal of hematology

authors： Edlund M,Blombäck M,von Schoultz B,Andersson O

更新日期：1996-12-01 00:00:00

abstract：:Intravenous morphine is the treatment of choice for severe pain during vaso- occlusive crisis in sickle cell disease (SCD). However, side effects of morphine may hamper effective treatment, and high plasma levels of morphine are associated with severe complications such as acute chest syndrome. Furthermore, adequate d...

journal_title：American journal of hematology

authors： van Beers EJ,van Tuijn CF,Nieuwkerk PT,Friederich PW,Vranken JH,Biemond BJ

更新日期：2007-11-01 00:00:00

abstract：:We have generated a murine hybridoma that secretes a monoclonal antibody (mAb) that is highly specific for hemoglobin C (HbC) [alpha 2 beta 2 6(A3)Glu----Lys] and shows no cross reactivity with HbA, HbA2, HbF, HbS, HbE, or Hb O-Arab. Using this antibody, we developed a simple and rapid enzyme linked immunosorbent assa...

journal_title：American journal of hematology

authors： Shyamala M,Kiefer CR,Moscoso H,Garver FA

更新日期：1990-03-01 00:00:00

abstract：:Most previous studies on telomere length (TL) in chronic lymphocytic leukemia (CLL) are based on referral cohorts including a high proportion of aggressive cases. Here, the impact of TL was analyzed in a population-based cohort of newly diagnosed CLL (n = 265) and in relation to other prognostic markers. Short telomer...

journal_title：American journal of hematology

authors： Mansouri L,Grabowski P,Degerman S,Svenson U,Gunnarsson R,Cahill N,Smedby KE,Geisler C,Juliusson G,Roos G,Rosenquist R

更新日期：2013-08-01 00:00:00