Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients.

abstract：:Fifteen recently diagnosed patients with acute leukemias admitted for induction chemotherapy were selected for study. When thrombocytopenic (venous platelet count less than 20 X 10(9)/l) these patients received prophylactic platelet transfusions. A total of 67 platelet transfusion therapies were administered and evalu...

journal_title：American journal of hematology

authors： Kutti J,Zaroulis CG,Safai-Kutti S,Dinsmore RE,Day NK,Good RA

更新日期：1981-11-01 00:00:00

abstract：:Clopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel-induced platelet inhibition and published literature correlates suboptimal clopidogrel response to ad...

journal_title：American journal of hematology

authors： Smock KJ,Saunders PJ,Rodgers GM,Johari V

更新日期：2011-12-01 00:00:00

abstract：:Some patients suffering from malignancies may benefit of myeloablative chemotherapy followed by hematological reconstitution with autologous peripheral blood reinfusion. A quick evaluation of the number of hematopoietic progenitors present in leukapheresis blood samples is necessary to ensure the collection of a suffi...

journal_title：American journal of hematology

authors： Teixeira G,Lenormand B,Jean P,Fardoun D,Sumereau-Dassin E,Bastit D,Tilly H,Piguet H,Monconduit M,Vannier JP

更新日期：1992-03-01 00:00:00

abstract：:We present a female patient with T-gamma LGL leukemia, who was followed for the last 20 years. Over these years she developed several autoimmune disorders, including Sjögren's syndrome, Hashimoto's thyroiditis, premature ovarian failure (compatible with type II autoimmune polyglandular syndrome), amegakaryocytic throm...

journal_title：American journal of hematology

authors： Ergas D,Tsimanis A,Shtalrid M,Duskin C,Berrebi A

更新日期：2002-02-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is a rare inherited telomeropathy most frequently caused by mutations in a number of genes all thought to be involved in telomere maintenance. The main causes of mortality in DC are bone marrow failure as well as malignancies including leukemias and solid tumors. The clinical picture includ...

journal_title：American journal of hematology

authors： Perdigones N,Perin JC,Schiano I,Nicholas P,Biegel JA,Mason PJ,Babushok DV,Bessler M

更新日期：2016-12-01 00:00:00

abstract：:Positron emission tomography-computed tomography (PET-CT) can identify bony lesions, assess disease burden, and detect extramedullary disease (EMD) in patients with multiple myeloma. We retrospectively reviewed records of patients who underwent PET-CT within 60 days of a new diagnosis (before therapy commenced) to ide...

journal_title：American journal of hematology

authors： Aljama MA,Sidiqi MH,Buadi FK,Lacy MQ,Gertz MA,Dispenzieri A,Dingli D,Muchtar E,Fonder AL,Hayman SR,Hobbs MA,Gonsalves WI,Warsame RM,Kourelis T,Hwa YL,Kapoor P,Kyle RA,Leung N,Go RS,Rajkumar SV,Kumar SK

更新日期：2018-12-01 00:00:00

abstract：:Familial Pseudohyperkalemia (FP) is a dominant red cell trait characterized by increased serum [K(+)] in whole blood stored at or below room temperature, without additional hematological abnormalities. Functional gene mapping and sequencing analysis of the candidate genes within the 2q35-q36 critical interval identifi...

journal_title：American journal of hematology

authors： Andolfo I,Alper SL,Delaunay J,Auriemma C,Russo R,Asci R,Esposito MR,Sharma AK,Shmukler BE,Brugnara C,De Franceschi L,Iolascon A

更新日期：2013-01-01 00:00:00

abstract：:The investigation of kindreds with recurrent thrombotic disease has advanced the understanding of the mechanisms of coagulation and fibrinolysis. In those cases where an etiology has been established, congenital thrombotic disorders are associated either with deficiencies or qualitative abnormalities in inhibitors of ...

journal_title：American journal of hematology

authors： Rodgers GM,Shuman MA

更新日期：1986-04-01 00:00:00

abstract：:In this study, we further established the role of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-alpha (IFN-alpha) as regulators of proliferation of acute myeloid leukemia (AML) cells. AML cells from 8 of 15 patients incorporated high levels of 3H-thymidin...

journal_title：American journal of hematology

authors： Carter A,Silvian-Draxler I,Tatarsky I

更新日期：1992-08-01 00:00:00

abstract：:Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than 0.5 x 10(9)/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are principal categories of SCN. Since 1994, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data to monitor th...

journal_title：American journal of hematology

authors： Dale DC,Cottle TE,Fier CJ,Bolyard AA,Bonilla MA,Boxer LA,Cham B,Freedman MH,Kannourakis G,Kinsey SE,Davis R,Scarlata D,Schwinzer B,Zeidler C,Welte K

更新日期：2003-02-01 00:00:00

abstract：:Several studies reported improved outcomes of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated with pediatric-based ALL regimens. This prompted the prospective investigation of a pediatric Augmented Berlin-Frankfurt-Münster (ABFM) regimen, and its comparison with hyper-fractionated cy...

journal_title：American journal of hematology

authors： Rytting ME,Jabbour EJ,Jorgensen JL,Ravandi F,Franklin AR,Kadia TM,Pemmaraju N,Daver NG,Ferrajoli A,Garcia-Manero G,Konopleva MY,Borthakur G,Garris R,Wang S,Pierce S,Schroeder K,Kornblau SM,Thomas DA,Cortes JE,O'Brie

更新日期：2016-08-01 00:00:00

abstract：:A preclinical study demonstrated anti-proliferative and apoptotic effect of propranolol on multiple myeloma (MM) cell. Clinical studies suggested that beta-blocker (BB) might impact the prognosis of breast, prostate, colorectal, ovarian, lung, and skin cancer. This retrospective study evaluated the effect of BB in MM ...

journal_title：American journal of hematology

authors： Hwa YL,Shi Q,Kumar SK,Lacy MQ,Gertz MA,Kapoor P,Buadi FK,Leung N,Dingli D,Go RS,Hayman SR,Gonsalves WI,Russell S,Lust JA,Lin Y,Rajkumar SV,Dispenzieri A

更新日期：2017-01-01 00:00:00

abstract：:Studies of in vitro chemotaxis and spontaneous migration of human leukocytes using the accepted method with the Boyden-chamber-filter are troublesome, because of the need for specially constructed vessels as well as the difficulties caused by the use of membrane filters. We describe a new and simplified method for mea...

journal_title：American journal of hematology

authors： Barak Y,Karov Y,Levin S

更新日期：1983-05-01 00:00:00

abstract：:Hemoglobin Lyon-Bron was found in two members of a family of German ascent presenting with a moderate normocytic anemia. In this alpha 2 globin variant, the N-terminal valine of the chain was replaced by an alanine. Electrospray mass spectrometry of the alpha chain showed that, as normally, the initiator methionine wa...

journal_title：American journal of hematology

authors： Lacan P,Souillet G,Aubry M,Promé D,Richelme-David S,Kister J,Wajcman H,Francina A

更新日期：2002-03-01 00:00:00

abstract：:Immunologic studies were performed on mononuclear cells from ten chronically transfused children with sickle cell disease, and the results were compared with those from five other groups: 21 sickle cell patients who were not receiving regular transfusions, 6 chronically transfused children with other forms of refracto...

journal_title：American journal of hematology

authors： Wang W,Herrod H,Presbury G,Wilimas J

更新日期：1985-09-01 00:00:00

abstract：:Since multiple myeloma (MM) is still not-curable, the management of relapse remains challenging. Given the known efficacy of alkylating agents in MM, we conducted a phase I/II study to test a new three drug combination in which Fotemustine (Muphoran), an alkylating agent of nitrosurea family, was added to bortezomib +...

journal_title：American journal of hematology

authors： Mangiacavalli S,Pochintesta L,Pascutto C,Cocito F,Pompa A,Cazzola M,Corso A

更新日期：2013-02-01 00:00:00

abstract：:Mutations at positions beta IVS1-6, beta IVS1-110, and beta 39 of the beta globin gene are responsible for the three most common thalassemic genes in the Mediterranean population. The polymerase chain reaction (PCR) was employed to amplify a 536 base pair segment surrounding this region. Nonradioactive labelling of an...

journal_title：American journal of hematology

authors： Hendy JG,Cauchi MN

更新日期：1990-06-01 00:00:00

abstract：:This paper describes, for the first time, the utilization of nebulized morphine in the management of severe chest pain in two young adult African-American patients who suffered from generalized acute sickle cell painful episodes. While hospitalized, both patients developed new sharp chest wall pain, and were treated w...

journal_title：American journal of hematology

authors： Ballas SK,Viscusi ER,Epstein KR

更新日期：2004-06-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of therapy. For patien...

journal_title：American journal of hematology

authors： Harrington WJ Sr,Kolodny L,Horstman LL,Jy W,Ahn YS

更新日期：1997-02-01 00:00:00

abstract：:A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37-year-old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of heredita...

journal_title：American journal of hematology

authors： Hanano M,Takahashi H,Itoh M,Shibata A

更新日期：1992-09-01 00:00:00

abstract：:The binding of anti-human platelet glycoprotein (GP) IIbIIIa monoclonal antibodies to human umbilical vein endothelial cells (HUVE) was studied. Scatchard analysis using 125I-anti-platelet GPIIb-IIIa monoclonal antibody showed that the maximum binding capacity (B max) was 8 X 10(4)/cell and Kd was 40.2 nM. The binding...

journal_title：American journal of hematology

authors： Nakajima T,Koyama T,Kakishita E,Nagai K

更新日期：1987-05-01 00:00:00

abstract：:Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIF...

journal_title：American journal of hematology

authors： Andersen CL,Siersma VD,Hasselbalch HC,Lindegaard H,Vestergaard H,Felding P,de Fine Olivarius N,Bjerrum OW

更新日期：2013-10-01 00:00:00

abstract：:The optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients-46 adults, 25 children-affected by Burkitt lymphoma/leukemia were tr...

journal_title：American journal of hematology

authors： Todeschini G,Bonifacio M,Tecchio C,Balter R,Carli G,Stefani PM,Adami F,Zamò A,Dei Tos AP,Marino F,Gherlinzoni F,Marradi P,Semenzato G,Pizzolo G

更新日期：2012-01-01 00:00:00

abstract：:An infectious episode is the presenting manifestation of hairy cell leukemia (HCL) in approximately 30% of cases. Most often this is bacterial and only rare cases of opportunistic fungal infection are described. We report a patient who presented with sporotrichal involvement of multiple cutaneous sites and lymph nodes...

journal_title：American journal of hematology

authors： Kumar S,Kumar D,Gourley WK,Alperin JB

更新日期：1994-06-01 00:00:00

abstract：:Hydroxyurea is a drug that is used to treat some patients with sickle cell disease. We have measured the deformability of sickle erythrocytes incubated in hydroxyurea in vitro and found that hydroxyurea acts to decrease the deformability of these cells. The deformability of normal erythrocytes was not significantly af...

journal_title：American journal of hematology

authors： Huang Z,Louderback JG,King SB,Ballas SK,Kim-Shapiro DB

更新日期：2001-07-01 00:00:00

abstract：:While systemic plasma endothelin-1 (ET-1) levels are increased during acute crisis in sickle cell disease, the relative levels of potent vasoactive factors that contribute to the regulation of vascular function, such as ET-1, NO, and cell-free hemoglobin, during the course of periodic vaso-occlusive episodes remain un...

journal_title：American journal of hematology

authors： Ergul S,Brunson CY,Hutchinson J,Tawfik A,Kutlar A,Webb RC,Ergul A

更新日期：2004-07-01 00:00:00

abstract：:Nucleotide sequence analysis of the 5' beta-globin gene flanking region has been carried out for numerous homozygous beta-thalassemia patients with different mutations and of various ethnic backgrounds. Four different rearrangements were found associated with numerous beta-thalassemia mutations. The (AT)X(T)Y repeat m...

journal_title：American journal of hematology

authors： Dimovski AJ,Adekile AD,Divoky V,Baysal E,Huisman TH

更新日期：1994-01-01 00:00:00

abstract：:Zoledronic acid (ZOL), an intravenous bisphosphonate, has been shown to reduce and delay the incidence of skeletal-related events (SREs) in multiple myeloma (MM) patients with bone disease. A retrospective claims-based analysis was conducted that used two distinct US managed care databases to examine the relationship ...

journal_title：American journal of hematology

authors： Henk HJ,Teitelbaum A,Perez JR,Kaura S

更新日期：2012-05-01 00:00:00

abstract：:An adolescent male patient developed functional asplenia in the course of graft versus host disease (GVHD) after successful allogeneic bone marrow transplantation (BMT) for aplastic anemia. Coincident with the onset of the asplenia, amelioration of the ongoing GVHD was observed. Unexpectedly, after 34 months of functi...

journal_title：American journal of hematology

authors： Demetrakopoulos GE,Tsokos GC,Levine AS

更新日期：1982-02-01 00:00:00

abstract：:Since platelets express both platelet-specific and class I HLA antigens, serum antiplatelet reactivity assessed by most platelet antibody techniques could be due to antibodies with either or both specificities. Flow cytometric analysis of sera for detection of antiplatelet antibody commonly employs a purified platelet...

journal_title：American journal of hematology

authors： Freedman J,Hornstein A

更新日期：1991-12-01 00:00:00