Final results of a single institution experience with a pediatric-based regimen, the augmented Berlin-Frankfurt-Münster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper-CVAD regimen.

abstract：:Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by isolated overproduction of platelets, thrombohemorrhagic complications, and a median age of 50-60. When it occurs in younger patients, the incidence of complications has been reported to be quite low, with a good long-term prognosis. We r...

journal_title：American journal of hematology

authors： Millard FE,Hunter CS,Anderson M,Edelman MJ,Kosty MP,Luiken GA,Marino GG

更新日期：1990-01-01 00:00:00

abstract：:Skin fibroblasts from patients with a variety of hematologic disorders were infected with SV40 virus in vitro in attempts to discover the reason for increased susceptibility of Fanconi anemia cells to this transforming virus. The proportion of skin fibroblasts expressing SV40 T-antigen by immunofluorescent methods was...

journal_title：American journal of hematology

authors： Lubiniecki AS,Blattner WA,Dosik H,McIntosh S,Wertelecki W

更新日期：1980-01-01 00:00:00

abstract：DISEASE OVERVIEW:Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). DIAGNOSIS:The diagnosis of MF or SS requires the integration of clinical and histopathologic data. ...

journal_title：American journal of hematology

authors： Wilcox RA

更新日期：2014-08-01 00:00:00

abstract：:Acetylsalicylic acid (ASA) is currently recommended as an antithrombotic for patients with essential thrombocythemia (ET) who are at an increased risk of thrombotic events. However, ASA is also associated with an increased risk of bleeding in these patients as compared to the risk of bleeding in other patients treated...

journal_title：American journal of hematology

authors： Cortelazzo S,Marchetti M,Orlando E,Falanga A,Barbui T,Buchanan MR

更新日期：1998-04-01 00:00:00

abstract：:Secondary acute myeloid leukemia (sAML) traditionally has inferior outcomes compared to de novo AML. Allogeneic hematopoietic cell transplantation (HCT) is the sole potentially curative therapy. This study analyzes the outcomes for unmanipulated haploidentical HCT (haploHCT) for sAML using the Acute Leukemia Working P...

journal_title：American journal of hematology

authors： Li Z,Labopin M,Ciceri F,Blaise D,Tischer J,Ehninger G,Van Lint MT,Koc Y,Santarone S,Forcade E,Castagna L,Polge E,Mailhol A,Ruggeri A,Mohty M,Savani BN,Nagler A

更新日期：2018-06-01 00:00:00

abstract：:We report a family with a dominantly transmitted syndrome resembling Fanconi's anemia and spanning two generations. This syndrome was characterized by an ill-defined hematologic stem cell disorder, immune dysfunction, poor dentition, hyperpigmented skin, warts, and multiple second trimester spontaneous abortions and i...

journal_title：American journal of hematology

authors： Alter CL,Levine PH,Bennett J,Kessler C,Rick M,Washburn RG,Gallin JI,Miller RW,Auerbach AD

更新日期：1989-12-01 00:00:00

abstract：:Lymphomatoid granulomatosis (LG) is an uncommon but potentially fatal disease. The disease primarily involves the lungs; however, skin, renal, and central nervous system (CNS) are seen in varying proportions. Neurological involvement occurs in one third of the patients, and confers a worse prognosis. The use of radiot...

journal_title：American journal of hematology

authors： Petrella TM,Walker IR,Jones GW,Leber B

更新日期：1999-12-01 00:00:00

abstract：:Patients with indolent non-Hodgkin lymphoma (NHL) have multiple treatment options yet there is no consensus as to the best initial therapy. Lenalidomide, an immunomodulatory agent, has single agent activity in relapsed lymphoma. This trial was conducted to assess feasibility, efficacy, and safety of adding lenalidomid...

journal_title：American journal of hematology

authors： Rosenthal A,Dueck AC,Ansell S,Gano K,Conley C,Nowakowski GS,Camoriano J,Leis JF,Mikhael JR,Keith Stewart A,Inwards D,Dingli D,Kumar S,Noel P,Gertz M,Porrata L,Russell S,Colgan J,Fonseca R,Habermann TM,Kapoor P,B

更新日期：2017-05-01 00:00:00

abstract：:A 71-year-old woman and her elder sister developed ligneous conjunctivitis after ocular surgery. Laboratory tests demonstrated that the proband and her sister had 6.6% and 8.1% of plasminogen activity, and 1.2 and 1.4 mg/dl of antigen, respectively. Thus, they were diagnosed as having severe type I plasminogen deficie...

journal_title：American journal of hematology

authors： Suzuki T,Ikewaki J,Iwata H,Ohashi Y,Ichinose A

更新日期：2009-06-01 00:00:00

abstract：:A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37-year-old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of heredita...

journal_title：American journal of hematology

authors： Hanano M,Takahashi H,Itoh M,Shibata A

更新日期：1992-09-01 00:00:00

abstract：:A 25-year-old African-American man with sickle cell-beta(+)-thalassemia presented with acute asthma of 2 days' duration. The asthma was well controlled by 48 hr, and parenteral medications were changed to oral bronchodilators and steroids. Sixty hours after presentation, he developed pain similar to that of sickle cel...

journal_title：American journal of hematology

authors： Johnson K,Stastny JF,Rucknagel DL

更新日期：1994-08-01 00:00:00

abstract：:Fetal calf serum (FCS) is used as a component of the media for cells grown in culture. However, the high cost of FCS has stimulated a search for a possible alternative. Approximately 10% of human platelet concentrates prepared for clinical transfusions are outdated. Sera prepared from platelet concentrates were compar...

journal_title：American journal of hematology

authors： Schwartz KA,Lu G,Trosko JE,Chang CC

更新日期：1984-07-01 00:00:00

abstract：:In a phase II trial, we evaluated chlorambucil and rituximab (CLB-R) as first-line induction treatment with or without R as maintenance for elderly chronic lymphocytic leukemia (CLL) patients. Treatment consisted of eight 28-day cycles of CLB (8 mg/m(2) /day, days 1-7) and R (day 1 of cycle 3, 375 mg/m(2) ; cycles 4-8...

journal_title：American journal of hematology

authors： Foà R,Del Giudice I,Cuneo A,Del Poeta G,Ciolli S,Di Raimondo F,Lauria F,Cencini E,Rigolin GM,Cortelezzi A,Nobile F,Callea V,Brugiatelli M,Massaia M,Molica S,Trentin L,Rizzi R,Specchia G,Di Serio F,Orsucci L,Ambros

更新日期：2014-05-01 00:00:00

abstract：:Intensive induction chemotherapy using anthracycline and cytarabine backbone is considered the most effective upfront therapy in physically fit older patients with acute myeloid leukemia (AML). However, outcomes of the standard induction in elderly AML are inferior to those observed in younger patients, and they are s...

journal_title：American journal of hematology

authors： Pluta A,Robak T,Wrzesien-Kus A,Katarzyna Budziszewska B,Sulek K,Wawrzyniak E,Czemerska M,Zwolinska M,Golos A,Holowiecka-Goral A,Kyrcz-Krzemien S,Piszcz J,Kloczko J,Mordak-Domagala M,Lange A,Razny M,Madry K,Wiktor-Jedrze

更新日期：2017-04-01 00:00:00

abstract：:Binding of chemoattractant to polymorphonuclear leukocytes (PMNL) triggers a series of events like polymerization of actin and tubulin, orientation of cells, chemotaxis, increase in fluid pinocytosis and phagocytosis, and stimulation of microbicidal pathways which includes lysosomal degranulation and generation of rea...

journal_title：American journal of hematology

authors： Radhika V,Thennarasu S,Naik NR,Kumar A,Advani SH,Bhisey AN

更新日期：1996-07-01 00:00:00

abstract：:Autologous 51Cr-platelet kinetic studies were performed in splenectomized mongrel dogs. Mean survival time of PRP-platelets was 5.4 +/- 1.5 (SD) days (n = 6). The curves, though slightly curvilinear, showed mostly a linear type of decay, denoting that platelet removal from the circulation is mainly determined by aging...

journal_title：American journal of hematology

authors： Mezzano D,Aranda E,Foradori A,Rodríguez S,Lira P

更新日期：1984-01-01 00:00:00

abstract：:Among 47 patients with thrombotic thrombocytopenic purpura (TTP), 8 patients were diagnosed to have postoperative-TTP. Two patients underwent vascular surgery, 5 patients coronary artery bypass grafts, and 1 patient resection of myocardial sarcoma. Prior to surgery, all patients except one had normal hemograms and pla...

journal_title：American journal of hematology

authors： Chang JC,Shipstone A,Llenado-Lee MA

更新日期：1996-09-01 00:00:00

abstract：:We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and imm...

journal_title：American journal of hematology

authors： Lust JA,Banks PM,Hooper WC,Paya CV,Kueck BD,Hanson GA,Ritch PS,Woloschak GE

更新日期：1989-07-01 00:00:00

abstract：:The arachidonic acid metabolites produced by human peripheral blood monocytes were studied to determine which metabolites could have a role in thrombogenesis. Monocytes were found to be free of platelets by scanning electron microscopy and by measurement of 12-HETE. Human peripheral blood monocytes produce thromboxane...

journal_title：American journal of hematology

authors： Jones CM,Hall ER,Hester JP,Wu KK

更新日期：1989-07-01 00:00:00

abstract：:Forty-one patients with polycythemia vera (PV) according to the PVSG criteria were analysed retrospectively from January 1960 to March 1996. There were 23 male and 18 female patients with a median follow-up of 66.5 months (3-431 months). Median age was 62 (range: 37-85). The median hemoglobin level at diagnosis was 18...

journal_title：American journal of hematology

authors： Chim CS,Kwong YL,Chan PT,Liang R

更新日期：1997-09-01 00:00:00

abstract：:Familial Pseudohyperkalemia (FP) is a dominant red cell trait characterized by increased serum [K(+)] in whole blood stored at or below room temperature, without additional hematological abnormalities. Functional gene mapping and sequencing analysis of the candidate genes within the 2q35-q36 critical interval identifi...

journal_title：American journal of hematology

authors： Andolfo I,Alper SL,Delaunay J,Auriemma C,Russo R,Asci R,Esposito MR,Sharma AK,Shmukler BE,Brugnara C,De Franceschi L,Iolascon A

更新日期：2013-01-01 00:00:00

abstract：:Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIF...

journal_title：American journal of hematology

authors： Andersen CL,Siersma VD,Hasselbalch HC,Lindegaard H,Vestergaard H,Felding P,de Fine Olivarius N,Bjerrum OW

更新日期：2013-10-01 00:00:00

abstract：:Variation in bleeding in the perioperative period is a complex and multifactorial event associated with immediate and delayed consequences for the patient and health care resources. Little is known about the complex genetic influences on perioperative bleeding. With the discovery of multiple variations in the human ge...

journal_title：American journal of hematology

authors： Muehlschlegel JD,Body SC

更新日期：2008-09-01 00:00:00

abstract：:The "platelet function analyzer" (PFA)-100 was first introduced to us in 1995. Since then, the instrument has appeared in over 50 reviews and almost 1000 publications. Recently, the PFA-100 has been "upgraded" to the PFA-200, which has transformed the user interface and electronic management, but retained the fundamen...

journal_title：American journal of hematology

authors： Favaloro EJ

更新日期：2017-04-01 00:00:00

abstract：:We studied the growth of erythroid burst-forming units (BFU-E) and erythroid colony forming units (CFU-E) from bone marrow and blood in six patients with erythroleukemia. Five patients grew CFU-E, while BFU-E were found in the marrow of two and in the peripheral blood of only one patient. In all cases with colony grow...

journal_title：American journal of hematology

authors： Newcomb MM,Balducci L,Coleman MB,Steinberg MH

更新日期：1978-01-01 00:00:00

abstract：DISEASE OVERVIEW:Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, h...

journal_title：American journal of hematology

authors： Gertz MA

更新日期：2020-07-01 00:00:00

abstract：:Acute leukemias of ambiguous lineage (ALAL) comprise acute undifferentiated leukemias (AUL) and mixed-phenotype acute leukemias (MPAL). In the revised fourth edition of the World Health Organization (WHO) classification provided further refinements to the diagnostic criteria for ALAL. Molecular characterization of MPA...

journal_title：American journal of hematology

authors： Patel SS,Weinberg OK

更新日期：2020-06-01 00:00:00

abstract：:Drug metabolizing genes are involved in the detoxification of chemical carcinogens. Polymorphisms in drug-metabolizing genes affect the risk of some forms of cancer. We analyzed six polymorphisms to evaluate their association with risk for non-Hodgkin lymphoma (NHL), and to examine whether smoking modifies these assoc...

journal_title：American journal of hematology

authors： Kim HN,Kim NY,Yu L,Kim YK,Lee IK,Yang DH,Lee JJ,Shin MH,Park KS,Choi JS,Kim HJ

更新日期：2009-12-01 00:00:00

abstract：:Venous thromboembolism (VTE) is common but often unrecognized in medically ill patients. Over the past 5 years, three large-scale placebo-controlled trials enrolling a total of 5500 medically ill patients have highlighted the risk of VTE in this group. These trials have helped to define a specific at-risk patient prof...

journal_title：American journal of hematology

authors： Stinnett JM,Pendleton R,Skordos L,Wheeler M,Rodgers GM

更新日期：2005-03-01 00:00:00

abstract：:Granulocyte macrophage-colony-stimulating factor (GM-CSF) has shown promise as a means of alleviating leukopenia associated with a wide variety of disorders. It is currently undergoing evaluation as an adjunct to bone marrow transplantation but its use in patients with metabolic disorders, such as Hurler's syndrome (H...

journal_title：American journal of hematology

authors： Lang E,Cibull ML,Gallicchio VS,Henslee-Downey PJ,Davey DD,Messino MJ,Harder EJ

更新日期：1992-12-01 00:00:00