Final results of a single institution experience with a pediatric-based regimen, the augmented Berlin-Frankfurt-Münster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper-CVAD regimen.


:Several studies reported improved outcomes of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated with pediatric-based ALL regimens. This prompted the prospective investigation of a pediatric Augmented Berlin-Frankfurt-Münster (ABFM) regimen, and its comparison with hyper-fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone (hyper-CVAD) in AYA patients. One hundred and six AYA patients (median age 22 years) with Philadelphia chromosome- (Ph) negative ALL received ABFM from October 2006 through March 2014. Their outcome was compared to 102 AYA patients (median age 27 years), treated with hyper-CVAD at our institution. The complete remission (CR) rate was 93% with ABFM and 98% with hyper-CVAD. The 5-year complete remission duration (CRD) were 53 and 55%, respectively (P = 0.98). The 5-year overall survival (OS) rates were 60 and 60%, respectively. The MRD status on Day 29 and Day 84 of therapy was predictive of long-term outcomes on both ABFM and hyper-CVAD. Severe regimen toxicities with ABFM included hepatotoxicity in 41%, pancreatitis in 11%, osteonecrosis in 9%, and thrombosis in 19%. Myelosuppression-associated complications were most significant with hyper-CVAD. In summary, ABFM and hyper-CVAD resulted in similar efficacy outcomes, but were associated with different toxicity profiles, asparaginase-related with ABFM and myelosuppression-related with hyper-CVAD. Am. J. Hematol. 91:819-823, 2016. © 2016 Wiley Periodicals, Inc.


Am J Hematol


Rytting ME,Jabbour EJ,Jorgensen JL,Ravandi F,Franklin AR,Kadia TM,Pemmaraju N,Daver NG,Ferrajoli A,Garcia-Manero G,Konopleva MY,Borthakur G,Garris R,Wang S,Pierce S,Schroeder K,Kornblau SM,Thomas DA,Cortes JE,O'Brie




Has Abstract


2016-08-01 00:00:00












  • Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers.

    abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 14. At day 5 marrow ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Dale DC,Liles WC,Llewellyn C,Price TH

    更新日期:1998-01-01 00:00:00

  • A novel alpha-thalassemia-2 (-2.7-kb) observed in a Chinese patient with Hb H disease.

    abstract::We describe a newly detected alpha-thalassemia-2 (alpha-thal-2) deletion characterized by a small -2.7-kb deletion involving the alpha 1 globin gene. This deletion has thus far been observed in only one Chinese subject with Hb H disease. ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Zhao JB,Zhao L,Fei YJ,Liu JC,Huisman TH

    更新日期:1991-11-01 00:00:00

  • Epstein-Barr virus infection in Richter's transformation.

    abstract::Chronic lymphocytic leukemia (CLL) may convert to a diffuse large cell lymphoma (Richter's syndrome) over time. In occasional cases of Richter's transformation, Epstein-Barr virus (EBV) has been identified in the lymphoma cells. To evaluate the association of EBV infection with Richter's syndrome, the biopsy specimens...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Ansell SM,Li CY,Lloyd RV,Phyliky RL

    更新日期:1999-02-01 00:00:00

  • HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype.

    abstract::We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reactio...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Nakase K,Hasegawa M,Tsuji K,Ikeda T,Tamaki S,Tanigawa M,Miyanishi E,Shiku H

    更新日期:2000-05-01 00:00:00

  • Platelet glycoprotein Ia 807C/T (Phe224) and 873G/A (Thr246) dimorphisms in Turkey.

    abstract::At sites of vascular injury, the platelet collagen receptor Glycoprotein Ia/IIa (GPIa/IIa) acts as an important mediator of platelet adhesion to fibrillar collagens. Two silent polymorphisms (807C/T and 873G/A) within the glycoprotein Ia gene have been implicated in increased risk of developing thrombosis and myocardi...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Komurcu E,Erginel-Unaltuna N

    更新日期:2002-01-01 00:00:00

  • Pure red cell aplasia with thymona: evidence of T-cell clonal disorder.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Masuda M,Arai Y,Okamura T,Mizoguchi H

    更新日期:1997-04-01 00:00:00

  • Primary prevention of sickle cell disease using preimplantation genetic testing and in vitro fertilization is cost-effective.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Cordeiro Mitchell CN,Pradhan A,Singh B,Naik RP,Baker VL,Lanzkron SM,Christianson MS,Pecker LH

    更新日期:2020-08-20 00:00:00

  • Immunoglobulin light chain amyloidosis: 2011 update on diagnosis, risk-stratification, and management.

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    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Gertz MA

    更新日期:2011-02-01 00:00:00

  • Hyperferritinemia as indicator for intravenous immunoglobulin treatment in reactive macrophage activation syndromes.

    abstract::The underlying mechanisms of reactive macrophage activation syndromes (rMAS) are not understood in detail, and there is no specific treatment. This observational study was prompted by intravenous immunoglobulin (IVIG), dramatically halting two distinct rMAS episodes in the same patient. We evaluated the potential bene...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Emmenegger U,Frey U,Reimers A,Fux C,Semela D,Cottagnoud P,Spaeth PJ,Neftel KA

    更新日期:2001-09-01 00:00:00

  • Immunological abnormalities in splenic marginal zone cell lymphoma.

    abstract::The clinical features of patients with splenic marginal zone cell lymphoma (SMZCL) have rarely been reported. In the present study, immunological abnormalities, particularly hematological abnormalities, observed in SMZCL were described. Autoimmune hemolytic anemia, immune thrombocytopenia, and appearance of lupus anti...

    journal_title:American journal of hematology

    pub_type: 杂志文章,评审


    authors: Murakami H,Irisawa H,Saitoh T,Matsushima T,Tamura J,Sawamura M,Karasawa M,Hosomura Y,Kojima M

    更新日期:1997-11-01 00:00:00

  • Prevalence of factor V G1691A (factor V-Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population.

    abstract::Factor V G1691A (FV-Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of venous and placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies di...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Finan RR,Tamim H,Ameen G,Sharida HE,Rashid M,Almawi WY

    更新日期:2002-12-01 00:00:00

  • A single-center experience in 20 patients with infantile malignant osteopetrosis.

    abstract::Infantile malignant osteopetrosis (IMO) includes various genetic disorders that affect osteoclast development and/or function. Genotype-phenotype correlation studies in IMO have been hampered by the rarity and heterogeneity of the disease and by the severity of the clinical course, which often leads to death early in ...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Mazzolari E,Forino C,Razza A,Porta F,Villa A,Notarangelo LD

    更新日期:2009-08-01 00:00:00

  • First-line treatment of 102 chronic myeloid leukemia patients with imatinib: a long-term single institution analysis.

    abstract::Imatinib mesylate radically changed the natural history of chronic myeloid leukemia (CML). The recent availability of alternative tyrosine kinase inhibitors (TKIs) renders the clinical management of CML more complex. In this article, we summarize our long-term single institution experience. From 2003 to 2012, 102 pati...

    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Viganò I,Di Giacomo N,Bozzani S,Antolini L,Piazza R,Gambacorti Passerini C

    更新日期:2014-10-01 00:00:00

  • The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Suzuki T,Ikewaki J,Iwata H,Ohashi Y,Ichinose A

    更新日期:2009-06-01 00:00:00

  • Normalization of serum lactic dehydrogenase in beta-thalassemia patients following bone marrow transplantation.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Toren A,Or R,Kapelushnik J,Chividalli G,Aku M,Slavin S,Nagler A

    更新日期:1996-02-01 00:00:00

  • Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial.

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    journal_title:American journal of hematology

    pub_type: 临床试验,信件


    authors: Wood JC,Glynos T,Thompson A,Giardina P,Harmatz P,Kang BP,Paley C,Coates TD

    更新日期:2010-10-01 00:00:00

  • Study of fibrinolytic parameters in different types of polycythemia.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Lugassy G,Filin I

    更新日期:1999-03-01 00:00:00

  • Occult hemorrhage in children with severe ITP.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Flores A,Buchanan GR

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  • Cytokine profile of sickle cell disease in Oman.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Pathare A,Al Kindi S,Alnaqdy AA,Daar S,Knox-Macaulay H,Dennison D

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  • Hemostatic effects of low-dose protamine following cardiopulmonary bypass.

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    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miyashita T,Nakajima T,Hayashi Y,Kuro M

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  • Prevalence of pulmonary hypertension in hereditary spherocytosis.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Crary SE,Ramaciotti C,Buchanan GR

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  • Comparative study of micro-transplantation from HLA fully mismatched unrelated and partly matched related donors in acute myeloid leukemia.

    abstract::Micro-transplantation (MST) by chemotherapy, combined with granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (GPBSC) infusion, from an HLA partial matched related donor has shown some encouraging effective therapy for acute myeloid leukemia (AML). However, the outcome of human leukocyte antige...

    journal_title:American journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Hu KX,Du X,Guo M,Yu CL,Qiao JH,Sun QY,Zuo HL,Cai B,Huang YJ,Ai HS,Dong Z,Wang Y

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  • Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

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    journal_title:American journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Gordeuk VR,Reboussin DM,McLaren CE,Barton JC,Acton RT,McLaren GD,Harris EL,Reiss JA,Adams PC,Speechley M,Phatak PD,Sholinsky P,Eckfeldt JH,Chen WP,Passmore L,Dawkins FW

    更新日期:2008-08-01 00:00:00

  • Successful engraftment and stable full donor chimerism after myeloablation with thiotepa, fludarabine, and melphalan and CD34-selected peripheral allogeneic stem cell transplantation in hemophagocytic lymphohistiocytosis.

    abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative option for primary hemophagocytic lymphohistiocytosis (HLH), a rare disease of infants and young children, characterized by recurrent fever, hepatosplenomegaly, and cytopenia. We report a case of successful engraftment and stable fu...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Cesaro S,Gazzola MV,Marson P,Calore E,Caenazzo L,Destro R,De Silvestro G,Varotto S,Pillon M,Zanesco L,Messina C

    更新日期:2003-02-01 00:00:00

  • Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent.

    abstract::Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. F...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Berger-Achituv S,Ellis MH,Curtis BR,Wolach B

    更新日期:2008-08-01 00:00:00

  • NK-cell repertoire is feasible for diagnosing Epstein-Barr virus-infected NK-cell lymphoproliferative disease and evaluating the treatment effect.

    abstract::Epstein-Barr virus (EBV) occasionally infects T and NK cells and causes EBV-infected T/NK-cell lymphoproliferative disease (LPD), which comprises chronic active EBV infection, EBV-associated hemophagocytic syndrome, mosquito allergy, hydroa vacciniforme, aggressive NK-cell leukemia, and NK/T-cell lymphoma. The diagnos...

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Sawada A,Sato E,Koyama M,Higuchi B,Kusuki S,Kim JY,Takeshita Y,Sakata A,Sakata N,Okamura T,Yasui M,Inoue M,Kawa K

    更新日期:2006-08-01 00:00:00

  • Effects of hydroxyurea in a population of Brazilian patients with sickle cell anemia.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Vicari P,Barretto de Mello A,Figueiredo MS

    更新日期:2005-03-01 00:00:00

  • Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease.

    abstract::Sickle cell disease (SCD) nephropathy and lower estimated glomerular filtration rate (eGFR) are risk factors for early mortality. Furthermore, rate of eGFR decline predicts progression to end-stage renal disease in many clinical settings. However, factors predicting renal function decline in SCD are poorly documented....

    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Xu JZ,Garrett ME,Soldano KL,Chen ST,Clish CB,Ashley-Koch AE,Telen MJ

    更新日期:2018-12-01 00:00:00

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Keefer MJ,Weber MJ,Bottomley SS,Solanki DL,Hosty TA

    更新日期:1987-07-01 00:00:00

  • Arachidonic acid metabolites produced by platelet-depleted human blood monocytes: a possible role in thrombogenesis.

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    journal_title:American journal of hematology

    pub_type: 杂志文章


    authors: Jones CM,Hall ER,Hester JP,Wu KK

    更新日期:1989-07-01 00:00:00