Immunological evaluation of harvested stem cells obtained by leukapheresis after chemotherapy.

abstract：:Coagulation factor VIII and von Willebrand factor (VWF) are key proteins in procoagulant activation. Higher FVIII coagulant activity (FVIII :C) and VWF antigen (VWF :Ag) are risk factors for cardiovascular disease and venous thromboembolism. Beyond associations with ABO blood group, genetic determinants of FVIII and V...

journal_title：American journal of hematology

authors： Tang W,Cushman M,Green D,Rich SS,Lange LA,Yang Q,Tracy RP,Tofler GH,Basu S,Wilson JG,Keating BJ,Weng LC,Taylor HA,Jacobs DR Jr,Delaney JA,Palmer CD,Young T,Pankow JS,O'Donnell CJ,Smith NL,Reiner AP,Folsom AR

更新日期：2015-06-01 00:00:00

abstract：:Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon but distinctive clinicoradiological entity comprising of headache, seizures, visual disturbance, and altered mental function, in association with posterior cerebral white matter edema. With appropriate management, RPLS is reversible in the majorit...

journal_title：American journal of hematology

authors： Tam CS,Galanos J,Seymour JF,Pitman AG,Stark RJ,Prince HM

更新日期：2004-09-01 00:00:00

abstract：:HIV infection has been associated with an increased risk of developing several types of malignancies, including aggressive peripheral T-cell lymphomas (PTCL). However, this is a rare occurrence with no more than a hundred cases reported in the literature. The purpose of this multicenter study is to describe the charac...

journal_title：American journal of hematology

authors： Castillo JJ,Beltran BE,Bibas M,Bower M,Collins JA,Cwynarski K,Diez-Martin JL,Hernandez-Ilizaliturri F,Horwitz SM,Montoto S,Pantanowitz L,Ribera JM,Vose JM

更新日期：2011-03-01 00:00:00

abstract：:We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of ...

journal_title：American journal of hematology

authors： Sinisalo M,Hietaharju A,Sauranen J,Wirta O

更新日期：2004-05-01 00:00:00

abstract：:The objective of this study is to establish a method to identify patients with primary immune thrombocytopenia (ITP) utilizing administrative data from diverse data sources that would be appropriate for epidemiologic studies of ITP, regardless of patients' age and source of health care. Medical records of the Oklahoma...

journal_title：American journal of hematology

authors： Terrell DR,Beebe LA,Vesely SK,Neas BR,Segal JB,George JN

更新日期：2012-09-01 00:00:00

abstract：:High-density lipoprotein (HDL) of 100-400 micrograms/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1-5 microM). Highly concentrated HDL (1,200 micrograms/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist-induced p...

journal_title：American journal of hematology

authors： Pfennig O,Zhao B,Frye S,Dierichs R

更新日期：1995-12-01 00:00:00

abstract：DISEASE OVERVIEW:Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, h...

journal_title：American journal of hematology

authors： Gertz MA

更新日期：2020-07-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a microangiopathy syndrome caused by a congenital or acquired deficiency of ADAMTS13, a plasma metalloprotease that cleaves von Willebrand factor (VWF) and thus prevents the formation of platelet-rich thrombi in the microcirculation. TTP can be fatal if not appropriately an...

journal_title：American journal of hematology

authors： Peyvandi F,Mannucci PM,Valsecchi C,Pontiggia S,Farina C,Retzios AD

更新日期：2013-10-01 00:00:00

abstract：:Children with sickle cell anemia (SCA) and a primary overt stroke are at high risk of recurrent (secondary) stroke. Chronic transfusion therapy dramatically reduces but does not eliminate this high risk, and inevitably results in transfusion-related hemosiderosis. We previously reported the use of hydroxyurea/phleboto...

journal_title：American journal of hematology

authors： Greenway A,Ware RE,Thornburg CD

更新日期：2011-04-01 00:00:00

abstract：:Plasma cell dyscrasias are a group of clinically and biochemically diverse disorders of unknown etiology, characterized by the disproportionate proliferation of one or more clones of B cells, and the presence of a structurally and electrophoretically homogeneous (monoclonal) immunoglobulin or polypeptide subunit in se...

journal_title：American journal of hematology

authors： Kapoor P,Singh E,Radhakrishnan P,Mehta P

更新日期：2006-12-01 00:00:00

abstract：:Despite the common practice of combining dexamethasone (Dex) with bortezomib (Bz) in patients with multiple myeloma (MM), until now there has been few prospective trials undertaken. We undertook a trial that recapitulated the original APEX study except that dexamethasone was incorporated from cycle 1. We also incorpor...

journal_title：American journal of hematology

authors： Harrison SJ,Quach H,Link E,Feng H,Dean J,Copeman M,Van De Velde H,Schwarer A,Baker B,Spencer A,Catalano J,Campbell P,Augustson B,Romeril K,Prince HM

更新日期：2015-05-01 00:00:00

abstract：:The activation pathways for the generation of enzymes involved in blood clotting, clot lysis, complement activation, and kinin generation are briefly reviewed. The interrelationship of the four systems is illustrated by the multiple functions of four key enzymes: Factor XIIa, kallikrein, plasmin, and C1 esterase. The ...

journal_title：American journal of hematology

authors： Murano G

更新日期：1978-01-01 00:00:00

abstract：:Comparison of the chromosome findings obtained on routine examination (10-50 cells) of the marrows from patients with Ph1-positive CML with those based on a large number (110-500 cells) of metaphases in six of these patients, in whom appropriate material was available, revealed the presence of small percentages of ane...

journal_title：American journal of hematology

authors： Sonta SI,Sandberg AA

更新日期：1977-01-01 00:00:00

abstract：:We report a 45-year-old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, elect...

journal_title：American journal of hematology

authors： Leebeek FW,Knot EA,Ten Cate JW,Traas DW

更新日期：1989-01-01 00:00:00

abstract：:In light of the relationship between immune system dysregulation and multiple myeloma (MM) risk, we investigated whether genetic variation in 92 immune function genes among 77 gene regions are associated with MM susceptibility in a population-based case-control study (108 cases and 482 controls) conducted among Caucas...

journal_title：American journal of hematology

authors： Lee KM,Baris D,Zhang Y,Hosgood HD 3rd,Menashe I,Yeager M,Zahm SH,Wang SS,Purdue MP,Chanock S,Zheng T,Rothman N,Lan Q

更新日期：2010-08-01 00:00:00

abstract：:Selective labeling of phagocytes in human blood can be achieved by incubation of unseparated, heparinized blood with 99mTc-sulfur colloid. We have developed a method for quantitation of granulocyte chemotaxis using granulocytes labeled by this technique. The method was found to be more accurate and less tedious to per...

journal_title：American journal of hematology

authors： English D,McPherson TA

更新日期：1977-01-01 00:00:00

abstract：:In HIV-positive patients with non-Hodgkin lymphoma (NHL), no benefit of adding rituximab to chemotherapy was seen in a randomized controlled trial (RCT). We performed a meta-analysis of prospective studies to ascertain outcomes in HIV-positive NHL patients treated with chemotherapy (chemo) versus rituximab and chemo (...

journal_title：American journal of hematology

authors： Castillo JJ,Echenique IA

更新日期：2012-03-01 00:00:00

abstract：DISEASE OVERVIEW:Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional disease features include bone marrow stromal reaction including reticulin fibrosis, abnorm...

journal_title：American journal of hematology

authors： Tefferi A

更新日期：2018-12-01 00:00:00

abstract：:A variability in DNA content detected was found with image cytometry, in immature bone marrow cells from 13 healthy donors (median age 31 yr). The mean coefficient of variation (C.V.) of the DNA content was found to be significantly (P = 0.0002) higher in immature blasts and promyelocytes than in mature granulocytes, ...

journal_title：American journal of hematology

authors： Widell S,Auer G,Hast R,Reizenstein P

更新日期：1993-08-01 00:00:00

abstract：:We studied levels of plasma endothelin-1 (ET-1) in 25 beta-thalassemia/Hb E patients before and after blood transfusion. Baseline ET-1 levels in these patients were significantly higher than in normal controls (10.17 +/- 2.1 pg/mL vs. 8.9 +/- 2.0 pg/mL, P < 0.05). After blood transfusion, levels of plasma ET-1 tend to...

journal_title：American journal of hematology

authors： Viprakasit V,Kankirawatana S,Akarasereenont P,Durongpisitkul K,Chotewuttakorn S,Tanphaichitr VS

更新日期：2002-07-01 00:00:00

abstract：:Phosphatidylinositol-3-kinase (PI3K) signaling plays a crucial role in oncogene-mediated tumor growth and proliferation. Buparlisib (BKM120) is an oral pan-class I PI3K inhibitor. This phase I study was conducted to determine the dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of BKM120 in patients (pts)...

journal_title：American journal of hematology

authors： Ragon BK,Kantarjian H,Jabbour E,Ravandi F,Cortes J,Borthakur G,DeBose L,Zeng Z,Schneider H,Pemmaraju N,Garcia-Manero G,Kornblau S,Wierda W,Burger J,DiNardo CD,Andreeff M,Konopleva M,Daver N

更新日期：2017-01-01 00:00:00

abstract：:A 71-year-old woman and her elder sister developed ligneous conjunctivitis after ocular surgery. Laboratory tests demonstrated that the proband and her sister had 6.6% and 8.1% of plasminogen activity, and 1.2 and 1.4 mg/dl of antigen, respectively. Thus, they were diagnosed as having severe type I plasminogen deficie...

journal_title：American journal of hematology

authors： Suzuki T,Ikewaki J,Iwata H,Ohashi Y,Ichinose A

更新日期：2009-06-01 00:00:00

abstract：:While surgery is commonly required for complications related to hemoglobin SC (HbSC) disease, little is known about the perioperative complications or the indications for preoperative transfusion in this group. We describe the patient characteristics, preoperative transfusion regimens, and outcome in 92 patients with ...

journal_title：American journal of hematology

authors： Neumayr L,Koshy M,Haberkern C,Earles AN,Bellevue R,Hassell K,Miller S,Black D,Vichinsky E

更新日期：1998-02-01 00:00:00

abstract：:Anemia is a major cause of morbidity and mortality among patients with sickle cell anemia. In this study, 108 episodes of severe anemia were prospectively evaluated in 108 patients with hemoglobin SS disease attending the pediatric sickle cell clinic of the University of Nigeria Teaching Hospital, Enugu, Nigeria. Youn...

journal_title：American journal of hematology

authors： Juwah AI,Nlemadim A,Kaine W

更新日期：2003-03-01 00:00:00

abstract：:Older patients with acute myeloid leukemia (AML) have poor outcomes, with median durations of complete remission lasting less than 1 year. Increased toxicity in older patients limits the delivery of standard consolidation therapies, such as allogeneic stem cell transplant or high-dose cytarabine. Azacitidine, a nucleo...

journal_title：American journal of hematology

authors： Griffin PT,Komrokji RS,De Castro CM,Rizzieri DA,Melchert M,List AF,Lancet JE

更新日期：2015-09-01 00:00:00

abstract：:A case of idiopathic immune-mediated von Willebrand's disease (AvWD) associated angiodysplasia and recurrent lower gastrointestinal bleeding is reported. Coagulation parameters at presentation were activated partial thromboplastin time of 41 sec, bleeding time >15 min, factor VIII procoagulant activity, 5%; von Willeb...

journal_title：American journal of hematology

authors： Alhumood SA,Devine DV,Lawson L,Nantel SH,Carter CJ

更新日期：1999-02-01 00:00:00

abstract：:Genetic modifiers contribute to phenotypic variability in patients with sickle cell anemia (SCA). The influence of the bilirubin UDP-glucuronosyltransferase (UGT) 1A1 (TA)(n)TAA promoter polymorphism on bilirubin levels and gallbladder disease in SCA was examined using prospectively collected data from the Cooperative...

journal_title：American journal of hematology

authors： Carpenter SL,Lieff S,Howard TA,Eggleston B,Ware RE

更新日期：2008-10-01 00:00:00

abstract：:Morbid obesity is a health problem that has been shown to be refractory to diet, exercise, and medical treatment. Surgeries designed to promote weight loss, termed bariatric surgery and typically involving a gastric bypass procedure, have recently been implemented to treat obesity with high success rates. However, lon...

journal_title：American journal of hematology

authors： Love AL,Billett HH

更新日期：2008-05-01 00:00:00

abstract：:Although treatment with plasma exchange increased the survival of patients with thrombotic thrombocytopenia purpura to 80% in the 1980s, no further increase of survival occurred over the next 20 years. However, more consistent use of adjuvant treatment with corticosteroids and rituximab in recent years has begun to fu...

journal_title：American journal of hematology

authors： George JN

更新日期：2012-05-01 00:00:00

abstract：:The case of a 21 year-old female with echinocytosis and a littoral cell hemangioma is reported. The patient had no significant past medical history and presented with abdominal pain and splenomegaly. A large percentage of echinocytes were noted on her peripheral smear in the absence of any known causes. A CT-recognize...

journal_title：American journal of hematology

authors： Altomare I,Desman G,Aledort LM

更新日期：2006-07-01 00:00:00