UGT1A1 promoter polymorphisms and the development of hyperbilirubinemia and gallbladder disease in children with sickle cell anemia.

abstract：:We recently defined event-free survival at 24 months (EFS24) as a clinically relevant outcome for patients with DLBCL. Patients who fail EFS24 have very poor overall survival, while those who achieve EFS24 have a subsequent overall survival equivalent to that of the age- and sex-matched general population. Here, we de...

journal_title：American journal of hematology

authors： Maurer MJ,Jais JP,Ghesquières H,Witzig TE,Hong F,Haioun C,Thompson CA,Thieblemont C,Micallef IN,Porrata LF,Ribrag V,Nowakowski GS,Casasnovas O,Bologna S,Morschhauser F,Morrison VA,Peterson BA,Macon WR,Copie-Bergman C

更新日期：2016-02-01 00:00:00

abstract：:Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement. The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia. Hematopoietic growth factors serum levels were measured by ELISA technique in forty-eight...

journal_title：American journal of hematology

authors： Marta RF,Enria D,Molinas FC

更新日期：2000-05-01 00:00:00

abstract：:The human spleen normally retains about one-third of the body's platelets in an exchangeable pool which can be released into the circulation by alpha-adrenergic stimulation. Some previous investigators concluded that the splenic platelet population was enriched in a subpopulation of large, young, dense platelets (mega...

journal_title：American journal of hematology

authors： Chamberlain KG,Tong M,Penington DG

更新日期：1990-07-01 00:00:00

abstract：:Post-transfusion purpura (PTP) with severe thrombocytopenia occurred eight days after transfusion in a 28-year-old woman and responded to treatment with prednisone and plasma exchange. In contrast to nearly all previously studied cases of PTP, the patient's platelets were PlA1-positive and anti-PlA1 antibody could not...

journal_title：American journal of hematology

authors： Keimowitz RM,Collins J,Davis K,Aster RH

更新日期：1986-01-01 00:00:00

abstract：:Sickle cell (SS) disease is a complex of various genetic conditions. In some, homozygosity for the beta S gene may be present alone or in combination with the heterozygous or homozygous alpha-thalassemia-2 condition. Such combinations might ameliorate the clinical and hematological condition of the patient. The same m...

journal_title：American journal of hematology

authors： Huisman TH

更新日期：1979-01-01 00:00:00

abstract：:A common side effect of opioids is nausea and vomiting; however, the incidence in hospitalized patients receiving opioids for acute pain is unknown. We performed a retrospective study in adult patients with sickle cell disease admitted for an acute pain crisis during a six-month period to evaluate the incidence of nau...

journal_title：American journal of hematology

authors： Shord SS,Chew L,Villano J

更新日期：2008-03-01 00:00:00

abstract：:To clarify the presentation and course of patients with chronic lymphocytic leukemia (CLL) and amyloidosis. Mayo databases were interrogated for patients who carried a diagnosis of amyloidosis and CLL evaluated at Mayo Clinic, Rochester from January 1974 to October 2012. Charts were abstracted and data analyzed. Of th...

journal_title：American journal of hematology

authors： Kourelis TV,Gertz M,Zent C,Lacy M,Kyle R,Kapoor P,Zeldenrust S,Buadi F,Witzig T,Hayman S,Lust J,Russell S,Lin Y,Rajkumar VS,Kumar S,Leung N,Dingli D,Dispenzieri A

更新日期：2013-05-01 00:00:00

abstract：:The aim of the study was to assess the efficacy and safety of rituximab (RTX) for treating systemic lupus erythematosus (SLE)-associated immune cytopenias. This multicenter retrospective cohort study of adults from French referral centers and networks for adult immune cytopenias and SLE involved patients ≥18 years old...

journal_title：American journal of hematology

authors： Serris A,Amoura Z,Canouï-Poitrine F,Terrier B,Hachulla E,Costedoat-Chalumeau N,Papo T,Lambotte O,Saadoun D,Hié M,Blanche P,Lioger B,Gottenberg JE,Godeau B,Michel M

更新日期：2018-03-01 00:00:00

abstract：:Several studies provided evidence of a consistent antileukemic effect induced by cytomegalovirus (CMV) replication in acute myeloid leukemia (AML) patients receiving allogeneic hematopoietic stem cell transplantation (HSCT), however the use of antithymocyte globulin (ATG) as graft-versus-host disease prophylaxis, may ...

journal_title：American journal of hematology

authors： Busca A,Passera R,Pini M,Zallio F,Dellacasa C,Audisio E,Giaccone L,Maffini E,Costa C,Cavallo R,Bruno B

更新日期：2015-06-01 00:00:00

abstract：:Twenty-seven lymphomas of mucosa-associated lymphoid tissue (MALT) derived from distinct anatomical sites were tested for the presence of genetic lesions commonly involved in B-cell lymphomagenesis, including activation of proto-oncogenes (BCL-1, BCL-2, BCL-6, and c-MYC), disruption of tumor suppressor loci (p53, 6q),...

journal_title：American journal of hematology

authors： Gaidano G,Volpe G,Pastore C,Chiarle R,Capello D,Gloghini A,Perissinotto E,Savinelli F,Bosco M,Mazza U,Pileri S,Palestro G,Carbone A,Saglio G

更新日期：1997-12-01 00:00:00

abstract：:Thalassemia is one of the most prevalent monogenic diseases usually caused by quantitative defects in the production of β-globin leading to severe anemia. Technological advances in genome sequencing, stem cell selection, viral vector development, transduction and gene editing strategies now allow for efficient exvivo ...

journal_title：American journal of hematology

authors： Soni S

更新日期：2020-09-01 00:00:00

abstract：:Over 300,000 infants are born annually with sickle cell anemia (SCA) in sub-Saharan Africa, and >50% die young from infection or anemia, usually without diagnosis of SCA. Early identification by newborn screening (NBS), followed by simple interventions dramatically reduced the mortality of SCA in the United States, bu...

journal_title：American journal of hematology

authors： McGann PT,Ferris MG,Ramamurthy U,Santos B,de Oliveira V,Bernardino L,Ware RE

更新日期：2013-12-01 00:00:00

abstract：:Granulocyte macrophage-colony-stimulating factor (GM-CSF) has shown promise as a means of alleviating leukopenia associated with a wide variety of disorders. It is currently undergoing evaluation as an adjunct to bone marrow transplantation but its use in patients with metabolic disorders, such as Hurler's syndrome (H...

journal_title：American journal of hematology

authors： Lang E,Cibull ML,Gallicchio VS,Henslee-Downey PJ,Davey DD,Messino MJ,Harder EJ

更新日期：1992-12-01 00:00:00

abstract：:Children with sickle cell anemia (SCA) and a primary overt stroke are at high risk of recurrent (secondary) stroke. Chronic transfusion therapy dramatically reduces but does not eliminate this high risk, and inevitably results in transfusion-related hemosiderosis. We previously reported the use of hydroxyurea/phleboto...

journal_title：American journal of hematology

authors： Greenway A,Ware RE,Thornburg CD

更新日期：2011-04-01 00:00:00

abstract：:A 74-year old woman with Ph1-negative chronic myelogenous leukemia (CML) and heterozygous for glucose-6-phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that P...

journal_title：American journal of hematology

authors： Kaye FJ,Najfeld V,Singer J,Cuttner J,Fialkow PJ

更新日期：1984-07-01 00:00:00

abstract：:Patients initially diagnosed with type 1 von Willebrand disease (VWD) have been reclassified as type 2 after a more exhaustive analysis in several studies. Our study's objectives were (1) to reanalyze patients that were previously diagnosed as type 1 to achieve a more accurate diagnosis and (2) to compare the von Will...

journal_title：American journal of hematology

authors： Penas N,Pérez-Rodríguez A,Torea JH,Lourés E,Noya MS,López-Fernández MF,Batlle J

更新日期：2005-11-01 00:00:00

abstract：:Four factor XI (F XI)-deficient patients are described, all of whom formed circulating anticoagulants against F X1. In the three most severely affected patients (F XI 0%-6% activity), the anticoagulant appeared to have been stimulated by plasma infusion. However, in the milder case (25% F XI activity), no infusion had...

journal_title：American journal of hematology

authors： Schnall SF,Duffy TP,Clyne LP

更新日期：1987-12-01 00:00:00

abstract：:Increasing dose intensity (DI) of chemotherapy for patients with aggressive non-Hodgkin lymphoma (NHL) may improve outcomes at the cost of increased toxicity. This issue was addressed in a randomized trial aiming to double the DI of myelosuppressive drugs. Between 1994 and 1999, 250 patients with previously untreated ...

journal_title：American journal of hematology

authors： Hertzberg M,Matthews JP,Stone JM,Dubosq MC,Grigg A,Ellis D,Benson W,Browett P,Horvath N,Januszewicz H,Abdi E,Green M,Bonaventura A,Marlton P,Cannell P,Wolf M,ALLG.

更新日期：2014-05-01 00:00:00

abstract：:Platelet antibodies are detectable in only about 50% of patients with chronic autoimmune thrombocytopenia (AITP). We determined platelet antibodies against GPIa/IIa, GPIb/IX, GPIIb/IIIa, and GPV and reticulated platelets in three female patients with AITP, before and after immunoadsorption treatment. None of the three...

journal_title：American journal of hematology

authors： Leitner GC,Stiegler G,Horvath M,Hoecker P,Sagaster P,Panzer S

更新日期：2003-05-01 00:00:00

abstract：:Various in vitro studies and clinical observations suggest that Fanconi's anemia (FA) patients are unable to detoxify adequately superoxide anions (O2-) released by activated phagocytes. Recent studies have shown that certain lymphokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) ...

journal_title：American journal of hematology

authors： Schultz JC,Shahidi NT

更新日期：1993-02-01 00:00:00

abstract：:A small number of thromboembolic events, including deep venous thrombosis and myocardial infarction, have been reported in patients receiving IVIG. These events have primarily occurred in patients receiving high-dose IVIG and have been attributed to an increase in blood viscosity. To test the hypothesis that a procoag...

journal_title：American journal of hematology

authors： Wolberg AS,Kon RH,Monroe DM,Hoffman M

更新日期：2000-09-01 00:00:00

abstract：:A case of leukemia cutis (LC) of monocytic lineage in a patient with myelodysplastic syndrome (MDS) is presented. Cutaneous infiltrates were recognized concurrent with diagnosis of refractory anemia (RA) with monocytosis. Skin infiltrates subsequently spontaneously regressed although MDS progressed with increasing mon...

journal_title：American journal of hematology

authors： Yavorkovsky LL,Zain J,Wu CD,Trivelli L,Cook P

更新日期：2001-02-01 00:00:00

abstract：:Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete p...

journal_title：American journal of hematology

authors： Rosner F,Hirshaut Y,Grünwald HW,Deutsch S

更新日期：1978-01-01 00:00:00

abstract：:We prospectively treated 46 patients with favorable myelodysplastic syndrome classified as refractory anemia (RA), refractory cytopenia (RC), or refractory anemia with ringed sideroblasts (RARS). These patients received one of two schedules of 13-Cis-Retinoic Acid (low dose 80 mg daily for 6 months vs. high dose 200 m...

journal_title：American journal of hematology

authors： Letendre L,Levitt R,Pierre RV,Schroeder G,Krook JA,Mailliard JE,Morton RF,Tschetter LK

更新日期：1995-04-01 00:00:00

abstract：:This report reviews the diagnostic significance of immune markers, their relationship to patient outcome, and the therapeutic uses of monoclonal antibodies (MoAbs) in acute leukemia. Immunophenotyping allows for rapid and reproducible diagnosis in the majority of cases of acute leukemia. It is of particular importance...

journal_title：American journal of hematology

authors： Wang JC,Beauregard P,Soamboonsrup P,Neame PB

更新日期：1995-11-01 00:00:00

abstract：:Selective labeling of phagocytes in human blood can be achieved by incubation of unseparated, heparinized blood with 99mTc-sulfur colloid. We have developed a method for quantitation of granulocyte chemotaxis using granulocytes labeled by this technique. The method was found to be more accurate and less tedious to per...

journal_title：American journal of hematology

authors： English D,McPherson TA

更新日期：1977-01-01 00:00:00

abstract：:Clopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel-induced platelet inhibition and published literature correlates suboptimal clopidogrel response to ad...

journal_title：American journal of hematology

authors： Smock KJ,Saunders PJ,Rodgers GM,Johari V

更新日期：2011-12-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)-ALL 2008 was a prospective clinical trial designed to improve treatment outcome of childhood ALL through the first nation-wide collaborative study in China. Totally 2231 patients were recru...

journal_title：American journal of hematology

authors： Cui L,Li ZG,Chai YH,Yu J,Gao J,Zhu XF,Jin RM,Shi XD,Zhang LP,Gao YJ,Zhang RD,Zheng HY,Hu SY,Cui YH,Zhu YP,Zou Y,Ng MHL,Xiao Y,Li JH,Zhang YH,He HL,Xian Y,Wang TY,Li CK,Wu MY,Chinese Children Leukemia Gro

更新日期：2018-07-01 00:00:00

abstract：:ABO incompatibility is commonly observed in stem cell transplantation and its impact in this setting has been extensively investigated. HLA-mismatched unrelated donors (MMURD) are often used as an alternative stem cell source but are associated with increased transplant related complications. Whether ABO incompatibili...

journal_title：American journal of hematology

authors： Canaani J,Savani BN,Labopin M,Michallet M,Craddock C,Socié G,Volin L,Maertens JA,Crawley C,Blaise D,Ljungman PT,Cornelissen J,Russell N,Baron F,Gorin N,Esteve J,Ciceri F,Schmid C,Giebel S,Mohty M,Nagler A

更新日期：2017-08-01 00:00:00

abstract：:Therapy-related acute myeloid leukemia (t-AML) arises as a late complication following antecedent solid tumors or hematologic diseases and their associated treatments. There are limited data regarding risk factors and outcomes following allogeneic hematopoietic cell transplantation (HCT) for t-AML following a prior so...

journal_title：American journal of hematology

authors： Lee CJ,Labopin M,Beelen D,Finke J,Blaise D,Ganser A,Itälä-Remes M,Chevallier P,Labussière-Wallet H,Maertens J,Yakoub-Agha I,Bourhis JH,Mailhol A,Mohty M,Savani BN,Nagler A

更新日期：2019-04-01 00:00:00