Abstract:
:The binding of anti-human platelet glycoprotein (GP) IIbIIIa monoclonal antibodies to human umbilical vein endothelial cells (HUVE) was studied. Scatchard analysis using 125I-anti-platelet GPIIb-IIIa monoclonal antibody showed that the maximum binding capacity (B max) was 8 X 10(4)/cell and Kd was 40.2 nM. The binding rate of 125I-anti-platelet GPIIbIIIa monoclonal antibodies to HUVE treated with TTP sera was 11.6 +/- 2.8%, compared with the 24.0 +/- 7.5% observed for HUVE treated with normal sera. These findings showed that there are GPIIb-IIIa on HUVE and that TTP sera may contain anti-platelet GPIIbIIIa antibodies.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Nakajima T,Koyama T,Kakishita E,Nagai Kdoi
10.1002/ajh.2830250113subject
Has Abstractpub_date
1987-05-01 00:00:00pages
115-8issue
1eissn
0361-8609issn
1096-8652journal_volume
25pub_type
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