Sporotrichosis as a presenting manifestation of hairy cell leukemia.

Abstract:

:An infectious episode is the presenting manifestation of hairy cell leukemia (HCL) in approximately 30% of cases. Most often this is bacterial and only rare cases of opportunistic fungal infection are described. We report a patient who presented with sporotrichal involvement of multiple cutaneous sites and lymph nodes. The lesions resolved following antifungal therapy, but persisting pancytopenia and splenomegaly necessitated further hematological evaluation. A diagnosis of HCL was suspected based on morphologically characteristic hairy cells in the peripheral blood that contained tartrate resistant acid phosphatase. A bone marrow biopsy specimen had a normocellular marrow with an increase in interstitial lymphoid cells that stained with L26, MB2, and LN2 antibodies. On flow cytometry these cells were positive for the leukocyte common antigen, B cell markers, and the CD11c antigen confirming the diagnosis of HCL. We believe that this is the first report of sporotrichosis infection as a presenting manifestation of HCL.

journal_name

Am J Hematol

authors

Kumar S,Kumar D,Gourley WK,Alperin JB

doi

10.1002/ajh.2830460214

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

134-7

issue

2

eissn

0361-8609

issn

1096-8652

journal_volume

46

pub_type

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