Abstract:
:Aplastic anemia is a disorder characterized by pancytopenia and bone marrow hypocellularity. There is some evidence that aplastic anemia may be due to suppression of hematopoiesis by activated T-suppressor cells. Thus, immunosuppressive agents have been used as an alternative to bone marrow transplantation for treatment. We report on a unique case of a patient with aplastic anemia who was treated with a course of immunosuppression including cyclosporine (CSA), anti-thymocyte globulin (ATG), and prednisone. Five months after this treatment, the patient developed a B cell lymphoproliferative disorder which was successfully treated with radiation therapy. Prior reports of CSA-associated lymphoproliferative disorders have appeared in the literature as potential side effects of immunosuppression following transplantation. This is the first report of a lymphoproliferative disorder associated with immunosuppressive treatment of aplastic anemia in a nontransplant setting. Thus, when presenting options for treatment of aplastic anemia, lymphoproliferative disorders should be included as a rare complication of immunosuppressive therapy.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Dorr V,Doolittle G,Woodroof Jdoi
10.1002/(SICI)1096-8652(199606)52:2<108::AID-AJH7>subject
Has Abstractpub_date
1996-06-01 00:00:00pages
108-13issue
2eissn
0361-8609issn
1096-8652pii
10.1002/(SICI)1096-8652(199606)52:2<108::AID-AJH7>journal_volume
52pub_type
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