Abstract:
:A 75-year-old female patient with agranulocytosis caused by ticlopidine is reported. She took the drug at 200 mg/day for 30 days to prevent recurrence of cerebral infarction. The leukocyte count at the nadir was 500/microliters on the 34th day since she started to take the drug. Complete recovery of her peripheral leukocytes came 12 days after its withdrawal. In this patient, mechanisms of ticlopidine-caused agranulocytosis were studied. The lymphocyte stimulation test using ticlopidine was negative. In the culture of marrow cells depleted of lymphocytes, ticlopidine directly inhibited the CFU-C in a dose-dependent manner. Neither the serum on the day of admission nor the T-lymphocytes pre-cultured with ticlopidine had any effect on the CFU-C. The lymphocyte stimulation test is useless in an attempt to find the causal drug in agranulocytosis if it is caused in a directly toxic manner. Agranulocytosis caused by ticlopidine is rare, but careful follow-up is necessary in the case of patients on the drug because there are some whose marrow cells are very sensitive to it.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Ono K,Kurohara K,Yoshihara M,Shimamoto Y,Yamaguchi Mdoi
10.1002/ajh.2830370405subject
Has Abstractpub_date
1991-08-01 00:00:00pages
239-42issue
4eissn
0361-8609issn
1096-8652journal_volume
37pub_type
杂志文章abstract::Glomerular hyperfiltration and microalbuminuria/proteinuria are early manifestations of sickle nephropathy. The effects of hydroxyurea therapy on these renal manifestations of sickle cell anemia (SCA) are not well defined. Our objective was to investigate the effects of hydroxyurea on glomerular filtration rate (GFR) ...
journal_title:American journal of hematology
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abstract::Fifteen recently diagnosed patients with acute leukemias admitted for induction chemotherapy were selected for study. When thrombocytopenic (venous platelet count less than 20 X 10(9)/l) these patients received prophylactic platelet transfusions. A total of 67 platelet transfusion therapies were administered and evalu...
journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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abstract::Duvelisib (IPI-145), an oral, dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ, was evaluated in a Phase 1 study in advanced hematologic malignancies, which included expansion cohorts in relapsed/refractory (RR) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and treatment-naïve (TN) CLL...
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journal_title:American journal of hematology
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更新日期:1988-07-01 00:00:00
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章,多中心研究
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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pub_type: 杂志文章,评审
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journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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abstract::Serum lactic dehydrogenase (LDH) levels are mildly elevated in beta-thalassemia major due to ineffective erythropoiesis. We reviewed the charts of 15 consecutive thalassemic children who underwent allogeneic, T-cell-depleted bone marrow transplantation (BMT) in our department during the last 3 years. Eleven patients h...
journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
abstract::By virtue of their religious principles, Jehovah's Witnesses (JWs) generally object to receiving blood products, raising numerous ethical, legal, and medical challenges for providers who care for these patients, especially in the emergent setting. In this review, we discuss several areas relevant to the care of JWs, i...
journal_title:American journal of hematology
pub_type: 杂志文章,评审
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journal_title:American journal of hematology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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