Abstract:
:We report here a patient with de novo acute myelocytic leukemia with trilineage myelodysplasia (AML/TMDS) in whom cytogenetic analysis was normal at diagnosis and in whom Philadelphia chromosome (Ph1) with monosomy 7 emerged at the terminal stage of the disease. Reverse transcription polymerse chain reaction (RT-PCTR) on the Ph1 positive specimen detected the mRNA encoding p190bcr/abl but did not detect mRNA encoding p210bcr/abl. However, mRNA encoding p190bcr/abl was not detected at diagnosis and or at relapse. These observations support the hypothesis that late-appearing Ph1 and monosomy 7 might be the result of clonal evolution during the course of leukemia, and p190bcr/abl might play a role in the terminal transformation or progression of leukemia.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Matsue K,Miyamoto T,Ito M,Tsukuda Kdoi
10.1002/ajh.2830490413subject
Has Abstractpub_date
1995-08-01 00:00:00pages
341-6issue
4eissn
0361-8609issn
1096-8652journal_volume
49pub_type
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:2014-06-01 00:00:00
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journal_title:American journal of hematology
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更新日期:2015-06-01 00:00:00
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journal_title:American journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:American journal of hematology
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更新日期:2018-12-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章,评审
doi:10.1002/ajh.23459
更新日期:2013-07-01 00:00:00
abstract::The Mo2 antibody recognizes a monocyte-specific cell surface antigen of unknown function. Upward modulation of Mo2 surface epitope density was demonstrated in response to 72-hr culture of monocytes with respiratory syncytial virus (RSV), but this was not seen after culture with phytohemagglutinin or other respiratory ...
journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.2830250314
更新日期:1987-07-01 00:00:00
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:1991-09-01 00:00:00
abstract::Thalassemia is an inherited blood disorder that requires lifelong adherence to a complicated and burdensome medical regimen which could potentially impact emotional functioning of patients. The importance of understanding and promoting healthy emotional functioning is crucial not only to psychological well-being, but ...
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pub_type: 信件,多中心研究
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abstract::Several studies reported improved outcomes of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated with pediatric-based ALL regimens. This prompted the prospective investigation of a pediatric Augmented Berlin-Frankfurt-Münster (ABFM) regimen, and its comparison with hyper-fractionated cy...
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pub_type: 杂志文章
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abstract::Heparin-induced thrombocytopenia is a rare but severe complication of heparin therapy that can result in severe venous or arterial thromboembolic events and whose treatment remains partially unanswered. Recombinant hirudin is potentially effective as an antithrombotic treatment in the management of heparin-induced thr...
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pub_type: 临床试验,杂志文章,多中心研究
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