Abstract:
:Evaluation of pharmacologic agents that stimulate fetal hemoglobin production has been done mainly in baboons and macaques. We investigated whether results in transgenic mice can predict the stimulation of fetal hemoglobin in primates, by testing gamma globin induction in response to a new ribonucleotide reductase inhibitor, Didox. A transgenic mouse line carrying the human A gamma gene linked to a locus control region cassette was used. Treatment of transgenic mice with Didox resulted in induction of gamma gene expression as documented by an increase in F reticulocytes and F cells and an elevation of gamma/gamma + beta biosynthetic ratio. Similarly, administration of Didox to a baboon in the nonanemic and chronically anemic state resulted in induction of gamma gene expression as shown by increases in F reticulocytes, F cells, and Hb F. These results suggest that the muLCR-A gamma transgenic mice can be used to screen new pharmacologic compounds for gamma globin inducibility.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Pace BS,Elford HL,Stamatoyannopoulos Gdoi
10.1002/ajh.2830450208subject
Has Abstractpub_date
1994-02-01 00:00:00pages
136-41issue
2eissn
0361-8609issn
1096-8652journal_volume
45pub_type
杂志文章abstract::By virtue of their religious principles, Jehovah's Witnesses (JWs) generally object to receiving blood products, raising numerous ethical, legal, and medical challenges for providers who care for these patients, especially in the emergent setting. In this review, we discuss several areas relevant to the care of JWs, i...
journal_title:American journal of hematology
pub_type: 杂志文章,评审
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abstract::Trimethoprim and sulfamethoxazole (Bactrim r) is a widely used antibiotic combination effective against a broad spectrum of microbial organisms. There are reports of neutropenia developing during even brief periods of oral therapy, particularly in individuals with either folate deficiency or increased folate requireme...
journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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doi:10.1002/ajh.21327
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abstract::Although standard clinical prognostic factors predict outcome in diffuse large B-cell lymphoma (DLBCL), predicting the outcome of patients might be further refined using biological factors. We tested whether serum cytokines could provide prognostic information in DLBCL patients. Thirty cytokines were measured in pretr...
journal_title:American journal of hematology
pub_type: 杂志文章,随机对照试验
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abstract::Botrocetin, a protein isolated from the venom of the snake Bothrops jararaca, induces platelet aggregation/agglutination by von Willebrand factor (vWF) binding to the membrane glycoprotein (GP) Ib, an action resembling that of ristocetin. However, some differences in the interaction between vWF and platelet GPIb induc...
journal_title:American journal of hematology
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abstract::A 6-year-old child of northern European ancestry was found to have microcytic, hypochromic anemia with an elevated level of hemoglobin A2 and an unbalanced pattern of globin chain synthesis characteristic of beta-thalassemia trait. Hematologic and globin synthesis studies of both parents yielded entirely normal result...
journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:1998-08-01 00:00:00
abstract::Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their beta S chromosomes. One subject had an alpha-thalassemia (-alpha/-alpha). The haplotypes were the common type #19, associated with severe disease, and type #31, n...
journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.2830170113
更新日期:1984-07-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
doi:10.1002/ajh.21569
更新日期:2010-01-01 00:00:00
abstract::A 28-year-old asymptomatic male of Iranian Jewish (Meshadi) heritage was found on routine exam to have an erythrocytosis (RBC = 6.22 x 10(12)/l, Hgb = 19.2 g/dl, Hct = 58.9%). Splenomegaly was absent on physical exam. There was no family history of erythrocytosis. His oxygen dissociation curve was left-shifted with a ...
journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
abstract::An HTLV-I-seronegative case of adult T-cell leukemia (ATL) carrying the HTLV-I genome is reported. Screening serological tests were negative and Western blot analysis revealed only a faint band for HTLV-I p24. Polymerase chain reaction (PCR) disclosed the presence of HTLV-I gag, pol, env, pX, and LTR sequences in the ...
journal_title:American journal of hematology
pub_type: 杂志文章
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journal_title:American journal of hematology
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journal_title:American journal of hematology
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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journal_title:American journal of hematology
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abstract::A case of leukemia cutis (LC) of monocytic lineage in a patient with myelodysplastic syndrome (MDS) is presented. Cutaneous infiltrates were recognized concurrent with diagnosis of refractory anemia (RA) with monocytosis. Skin infiltrates subsequently spontaneously regressed although MDS progressed with increasing mon...
journal_title:American journal of hematology
pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:American journal of hematology
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journal_title:American journal of hematology
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更新日期:2012-01-01 00:00:00
abstract::Infantile malignant osteopetrosis (IMO) includes various genetic disorders that affect osteoclast development and/or function. Genotype-phenotype correlation studies in IMO have been hampered by the rarity and heterogeneity of the disease and by the severity of the clinical course, which often leads to death early in ...
journal_title:American journal of hematology
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更新日期:2009-08-01 00:00:00
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