Autoimmune disease and cochlear pathology in the C3H/lpr strain mouse.

abstract：:Nitric oxide (NO) hyperpolarizes vascular smooth muscle cells and dilates blood vessels of various beds, but little is known on cochlear vasculatures. Using in vitro preparations of the spiral modiolar artery (SMA), intracellular electrical recording and labeling techniques, we found that the NO donor DPTA-NONOate (10...

journal_title：Hearing research

authors： Si JQ,Zhao H,Yang Y,Jiang ZG,Nuttall AL

更新日期：2002-09-01 00:00:00

abstract：:Low-frequency temporal information present in speech is critical for normal perception, however the neural mechanism underlying the differentiation of slow rates in acoustic signals is not known. Data from the rat trigeminal system suggest that the paralemniscal pathway may be specifically tuned to code low-frequency ...

journal_title：Hearing research

authors： Abrams DA,Nicol T,Zecker S,Kraus N

更新日期：2011-02-01 00:00:00

abstract：:Difference limens for the fundamental frequency (F0) of complex tones (DLCs) were measured for four normally hearing subjects and three subjects with cochlear hearing loss. The nominal F0 was 100, 200 or 400 Hz. The two tones to be compared contained either low resolved harmonics (RES), harmonics with intermediate res...

journal_title：Hearing research

authors： Moore BC,Moore GA

更新日期：2003-08-01 00:00:00

abstract：:This report describes a study that took advantage of the unique reactivity of the patas monkey (Erythrocebus patas) to dihydrostreptomycin-sulfate (DHSM) to investigate the effects of selective outer hair cell (OHC) lesions on psychophysical tuning curves (PTC). Four patas monkeys were trained using operant reinforcem...

journal_title：Hearing research

authors： Smith DW,Moody DB,Stebbins WC,Norat MA

更新日期：1987-01-01 00:00:00

abstract：:Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with ...

journal_title：Hearing research

authors： Smalt CJ,Lacirignola J,Davis SK,Calamia PT,Collins PP

更新日期：2017-06-01 00:00:00

abstract：:The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...

journal_title：Hearing research

authors： Naidu RC,Mountain DC

更新日期：1998-10-01 00:00:00

abstract：:Doppler vibrometers are used by many research groups to monitor the motion of the tympanic membrane (TM) and of middle ear ossicles for in vivo and in vitro studies. Power densities in these applications reach 80 W/cm(2). To determine the safe limit of exposure, a cw dye laser at a wavelength of 633 nm was used to inv...

journal_title：Hearing research

authors： Foth H,Färber S,Gauer A,Wagner R

更新日期：2000-04-01 00:00:00

abstract：:In recent years, new designs of cochlear implant electrodes have been introduced in an attempt to improve efficiency and performance by locating stimulation sites closer to spiral ganglion neurons and deeper into the scala tympani. The goal of this study was to document insertion depth, intracochlear position and inse...

journal_title：Hearing research

authors： Wardrop P,Whinney D,Rebscher SJ,Roland JT Jr,Luxford W,Leake PA

更新日期：2005-05-01 00:00:00

abstract：:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...

journal_title：Hearing research

authors： Henzl MT,Shibasaki O,Comegys TH,Thalmann I,Thalmann R

更新日期：1997-04-01 00:00:00

abstract：:Eye color may be an indicator of inner ear melanin content and has been associated with hearing loss. There is controversy as to whether eye color has an effect on acquired causes of sensorineural hearing loss. This review was conducted to analyze the literature evaluating the relationship between eye color and causes...

journal_title：Hearing research

authors： Mujica-Mota MA,Schermbrucker J,Daniel SJ

更新日期：2015-02-01 00:00:00

abstract：:Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...

journal_title：Hearing research

authors： Whittemore KR Jr,Merchant SN,Poon BB,Rosowski JJ

更新日期：2004-01-01 00:00:00

abstract：:The acoustic distortion product 2f1-f2 was measured in the ear canal of the gray short-tailed opossum. Monodelphis domestica, during stimulation with two pure tone stimuli of the frequencies f1 and f2 (f1 < f2). From 2f1-2f growth functions for different primary frequencies from 4 to 85 kHz, a distortion threshold cur...

journal_title：Hearing research

authors： Faulstich M,Kössl M,Reimer K

更新日期：1996-05-01 00:00:00

abstract：:High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, ...

journal_title：Hearing research

authors： Jiang C,Luo B,Manohar S,Chen GD,Salvi R

更新日期：2017-04-01 00:00:00

abstract：:In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms. We argue that this classification is only vaguely and variously defined in the literature, and that these terms often have unclear and different meaning to different i...

journal_title：Hearing research

authors： Popper AN,Fay RR

更新日期：2011-03-01 00:00:00

abstract：:The suppression tuning properties of the oto-acoustic distortion product emission, 2f1-f2 have been measured in the ear canal of gerbil and man. The results show the acoustic response to be suppressible in a similar, frequency-dependent manner in both species. Frequencies near to those of the stimulating tones are mos...

journal_title：Hearing research

authors： Brown AM,Kemp DT

更新日期：1984-01-01 00:00:00

abstract：:Subjective tinnitus may be defined as the perceptual correlate of altered spontaneous neural activity occurring in the absence of an externally evoking auditory stimulus. Tinnitus can be caused or exacerbated by one or more of five forms of stress. We propose and provide evidence supporting a model that explains, but ...

journal_title：Hearing research

authors： Sahley TL,Nodar RH

更新日期：2001-02-01 00:00:00

abstract：:Membrane-bound guanylyl cyclases (GCs) are peptide hormone receptors whereas the cytosolic isoforms are receptors for nitric oxide. In the inner ear, the membrane-bound GCs may be involved in the regulation of fluid homeostasis and the cytosolic forms possibly play a role in signal processing and regulation of local b...

journal_title：Hearing research

authors： Seebacher T,Beitz E,Kumagami H,Wild K,Ruppersberg JP,Schultz JE

更新日期：1999-01-01 00:00:00

abstract：:Progress in drug delivery to the ear has been achieved over the last few years. This review illustrates the main mechanisms of controlled drug release and the resulting geometry- and size-dependent release kinetics. The potency, physicochemical properties, and stability of the drug molecules are key parameters for des...

journal_title：Hearing research

authors： Mäder K,Lehner E,Liebau A,Plontke SK

更新日期：2018-10-01 00:00:00

abstract：:The marsupials, the large group of mammals which develop during fetal life in an externalized pouch, have been given little attention by auditory neurobiologists. In this review the structure of the auditory systems of the handful of marsupials which have been studied is described, the course of auditory development m...

journal_title：Hearing research

authors： Aitkin L

更新日期：1995-02-01 00:00:00

abstract：:The etiology of an incidentally discovered temporary threshold shift observed in an experimental animal (Harley guinea pig) is discussed with its potential implications for auditory research. ...

journal_title：Hearing research

authors： Rizer FM,Don M,Sininger Y

更新日期：1987-01-01 00:00:00

abstract：:In this study 9 human temporal bones from 8 individuals were fixed with Karnovsky solution by perilymphatic perfusion within 1-3 h after death and examined using the "block-surface method' (Spoendlin and Brun, 1974; Spoendlin and Schrott, 1987) and the "micro-dissection method' (Johnsson and Hawkins, 1967). The audiog...

journal_title：Hearing research

authors： Felder E,Schrott-Fischer A

更新日期：1995-11-01 00:00:00

abstract：:Structural relationships between intermediate cells and capillaries in the stria vascularis of gerbils were examined by confocal laser microscopy and electron microscopy. Immunostaining for an inward rectifier K(+) channel (Kir4.1), which was localized to intermediate cells, was used to determine the three-dimensional...

journal_title：Hearing research

authors： Takeuchi S,Ando M,Sato T,Kakigi A

更新日期：2001-05-01 00:00:00

abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...

journal_title：Hearing research

authors： Su YY,Luo B,Wang HT,Chen L

更新日期：2009-07-01 00:00:00

abstract：:The ubiquity of social vocalizations among animals provides the opportunity to identify conserved mechanisms of auditory processing that subserve communication. Identifying auditory coding properties that are shared across vocal communicators will provide insight into how human auditory processing leads to speech perc...

journal_title：Hearing research

authors： Woolley SM,Portfors CV

更新日期：2013-11-01 00:00:00

abstract：:The middle ear is a sophisticated and complex structure with a variety of functions, yet a delicate organ prone to injuries due to various reasons. Both, understanding and reconstructing its functions has always been an important topic for researchers from medical and technical background. Currently, human temporal bo...

journal_title：Hearing research

authors： Kuru I,Maier H,Müller M,Lenarz T,Lueth TC

更新日期：2016-10-01 00:00:00

abstract：:Wavelength-swept optical coherence tomography (OCT) was used to scan the structure of cadaveric chinchilla ears in three dimensions with high spatial resolution and measure the sound-induced displacements of the entire OCT-visible lateral surfaces of the ossicles in the lateral-to-medial direction. The simultaneous me...

journal_title：Hearing research

authors： Rosowski JJ,Ramier A,Cheng JT,Yun SH

更新日期：2020-10-01 00:00:00

abstract：:The dose-response ototoxic effects of cisplatin were studied in guinea pigs. Loss of Preyer reflex and suppression of the N1 amplitude occurred in cisplatin-treated animals and was described as dose-related. Drug-induced hair cell damage, as observed with scanning electron microscopy, occurred sporadically throughout ...

journal_title：Hearing research

authors： Barron SE,Daigneault EA

更新日期：1987-01-01 00:00:00

abstract：:Unlike the organ of Corti in mammals, the avian basilar papilla has no distinct populations of hair cells. Instead, there is a continuous change between the extreme forms (tall hair cells = THC, and short hair cells = SHC). The hair-cell innervation pattern is complicated, there being no simple gradient between THC (m...

journal_title：Hearing research

authors： Fischer FP

更新日期：1992-08-01 00:00:00

abstract：:A single-channel hydromechanical model of the human cochlea with nonlinear feedback on the membrane is introduced. The piezoelectric transducers for displacement measurement and force exertion on the membrane are constructed of PVF2 in the bimorph bending type. The passive response shows high-frequency slopes of about...

journal_title：Hearing research

authors： Lechner TP

更新日期：1993-04-01 00:00:00

abstract：:Kanamycin (KM)-induced changes in expression of the gene for glutamate-aspartate transporter (GLAST) in the rat cochlea were analyzed by Northern blotting. With the administration of KM (600 mg/kg/day) once daily for 20 days, the expression of GLAST mRNA gradually increased and reached a peak on day 20. Although the e...

journal_title：Hearing research

authors： Matsuda K,Ueda Y,Doi T,Tono T,Haruta A,Toyama K,Komune S

更新日期：1999-07-01 00:00:00