A minimal conformational switching-dependent model for amyloid self-assembly.

abstract：:The analysis of DNA methylation at CpG dinucleotides has become a major research focus due to its regulatory role in numerous biological processes, but the requisite need for assays which amplify bisulfite-converted DNA represents a major bottleneck due to the unique design constraints imposed on bisulfite-PCR primers...

journal_title：Scientific reports

authors： Lu J,Johnston A,Berichon P,Ru KL,Korbie D,Trau M

更新日期：2017-01-24 00:00:00

abstract：:Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 gen...

journal_title：Scientific reports

authors： Törmänen S,Korppi M,Teräsjärvi J,Vuononvirta J,Koponen P,Helminen M,He Q,Nuolivirta K

更新日期：2017-06-07 00:00:00

abstract：:Asymmetric cell divisions are of fundamental importance for the development of multicellular organisms, e.g. for the generation of founder cells. Prime examples are asymmetric cell divisions in germline precursors during the early embryogenesis of the transparent roundworm Caenorhabditis elegans, one of the major deve...

journal_title：Scientific reports

authors： Fickentscher R,Weiss M

更新日期：2017-08-24 00:00:00

abstract：:Optical projection tomography (OPT) is a tool used for three-dimensional imaging of millimeter-scale biological samples, with the advantage of exhibiting isotropic resolution typically in the micron range. OPT can be divided into two types: transmission OPT (tOPT) and emission OPT (eOPT). Compared with eOPT, tOPT disc...

journal_title：Scientific reports

authors： Fang M,Dong D,Zeng C,Liang X,Yang X,Arranz A,Ripoll J,Hui H,Tian J

更新日期：2016-01-11 00:00:00

abstract：:Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this s...

journal_title：Scientific reports

authors： Zhang W,Liu LF,Xiong YJ,Liu YF,Yu SB,Wu CW,Guo W

更新日期：2018-01-19 00:00:00

abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...

journal_title：Scientific reports

authors： Ren JK,Zhu XB,Yu HF,Tian Y,Yang HF,Gu CZ,Wang NL,Ren YF,Zhao SP

更新日期：2012-01-01 00:00:00

abstract：:Differential vulnerability among motor neuron (MN) subtypes is a fundamental feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) MNs are more vulnerable than fast fatigue-resistant (FR) or slow (S) MNs. The reason for this selective vulnerability remains enigmatic. We report here that the extracellular...

journal_title：Scientific reports

authors： Morisaki Y,Niikura M,Watanabe M,Onishi K,Tanabe S,Moriwaki Y,Okuda T,Ohara S,Murayama S,Takao M,Uchida S,Yamanaka K,Misawa H

更新日期：2016-06-06 00:00:00

abstract：:Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses...

journal_title：Scientific reports

authors： Tokarz R,Mishra N,Tagliafierro T,Sameroff S,Caciula A,Chauhan L,Patel J,Sullivan E,Gucwa A,Fallon B,Golightly M,Molins C,Schriefer M,Marques A,Briese T,Lipkin WI

更新日期：2018-02-16 00:00:00

abstract：:Focal adhesion kinase (FAK) is a 125 kDa protein recruited as a participant in focal adhesion dynamics and serves as a signaling scaffold for the assembly and subsequent maturation of focal contact. Identification of new FAK binding proteins could reveal potential signaling targets and contribute to further developmen...

journal_title：Scientific reports

authors： Nguyen BT,Pyun JC,Lee SG,Kang MJ

更新日期：2019-09-09 00:00:00

abstract：:Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent intermediate to bridge th...

journal_title：Scientific reports

authors： Avery KN,Zer C,Bzymek KP,Williams JC

更新日期：2015-01-15 00:00:00

abstract：:Despite the importance of urban trees, their growth reaction to climate change and to the urban heat island effect has not yet been investigated with an international scope. While we are well informed about forest growth under recent conditions, it is unclear if this knowledge can be simply transferred to urban enviro...

journal_title：Scientific reports

authors： Pretzsch H,Biber P,Uhl E,Dahlhausen J,Schütze G,Perkins D,Rötzer T,Caldentey J,Koike T,Con TV,Chavanne A,Toit BD,Foster K,Lefer B

更新日期：2017-11-13 00:00:00

abstract：:Lightweight, simple and flexible self-powered photodetectors are urgently required for the development and application of advanced optical systems for the future of wearable electronic technology. Here, using a low-temperature reduction process, we report a chemical approach for producing freestanding monolithic reduc...

journal_title：Scientific reports

authors： Moon IK,Ki B,Yoon S,Choi J,Oh J

更新日期：2016-09-16 00:00:00

abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...

journal_title：Scientific reports

authors： Coni S,Mancuso AB,Di Magno L,Sdruscia G,Manni S,Serrao SM,Rotili D,Spiombi E,Bufalieri F,Petroni M,Kusio-Kobialka M,De Smaele E,Ferretti E,Capalbo C,Mai A,Niewiadomski P,Screpanti I,Di Marcotullio L,Canettieri G

更新日期：2017-03-09 00:00:00

abstract：:The quantities and proportions of protein fractions have notable effects on the nutritional and technological value of milk. Although much is known about the effects of genetic variants on milk proteins, the complex relationships among the set of genes and pathways regulating the different protein fractions synthesis ...

journal_title：Scientific reports

authors： Pegolo S,Mach N,Ramayo-Caldas Y,Schiavon S,Bittante G,Cecchinato A

更新日期：2018-01-12 00:00:00

abstract：:The aims of this study were, firstly, to assess the effect of concurrent peripheral artery disease (PAD) on the health-related quality of life (QOL) of people diagnosed with a small abdominal aortic aneurysm (AAA); and secondly, to test whether the peroxisome proliferator-activated receptor α agonist fenofibrate impro...

journal_title：Scientific reports

authors： Golledge J,Pinchbeck J,Rowbotham SE,Yip L,Jenkins JS,Quigley F,Moxon JV

更新日期：2020-09-03 00:00:00

abstract：:A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...

journal_title：Scientific reports

authors： Zhang HL,Zang Y,Xie J,Li J,Chen GR,He XP,Tian H

更新日期：2014-07-01 00:00:00

abstract：:We compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae for subsequent Miseq sequencing. Purification of DNA was based on matrix binding (silica or anion exchange resin) or differential precipitation (salting out), respectively. The choice of extraction kit had ...

journal_title：Scientific reports

authors： Becker L,Steglich M,Fuchs S,Werner G,Nübel U

更新日期：2016-06-17 00:00:00

abstract：:Multiple sclerosis is a chronic, autoimmune and neurodegenerative disease affecting multiple functional systems and resulting in motor impairments associated with muscle weakness and lack of movement coordination. We quantified upper limb motor deficits with a robot-based assessment including behavioral and muscle syn...

journal_title：Scientific reports

authors： Pellegrino L,Coscia M,Muller M,Solaro C,Casadio M

更新日期：2018-02-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) expand during inflammation and exhibit immunomodulatory functions on innate and adaptive immunity. However, their impact on trauma-induced immune responses, characterized by an early pro-inflammatory phase and dysregulated adaptive immunity involving lymphocyte apoptosis, exhau...

journal_title：Scientific reports

authors： Kustermann M,Klingspor M,Huber-Lang M,Debatin KM,Strauss G

更新日期：2019-05-29 00:00:00

abstract：:NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...

journal_title：Scientific reports

authors： Kobayashi M,Usui F,Karasawa T,Kawashima A,Kimura H,Mizushina Y,Shirasuna K,Mizukami H,Kasahara T,Hasebe N,Takahashi M

更新日期：2016-05-26 00:00:00

abstract：:We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. A prospective cohort study was conducted to recruit 46,285 participants...

journal_title：Scientific reports

authors： Yin L,Deng G,Mente A,Sun Y,Liu X,Zhang X,Wang X,Wang Y,Bo J,Chen H,Liu X,Gao N,Bai X,Rangarajan S,Li W

更新日期：2018-04-30 00:00:00

abstract：:Evidence on the association between dietary fiber intake and pancreatic cancer risk has been controversial. Therefore, we carried out this meta-analysis to summarize available evidence from epidemiologic studies on this point. Relevant studies were identified by searching PubMed, Embase and Web of Science databases as...

journal_title：Scientific reports

authors： Wang CH,Qiao C,Wang RC,Zhou WP

更新日期：2015-06-02 00:00:00

abstract：:A long-lived reservoir of latently infected T cells prevents antiretroviral therapy from eliminating HIV-1 infection. Furthering our understanding of the dynamics of latency generation and maintenance is therefore vital to improve treatment outcome. Using mathematical models and experiments, we suggest that the death ...

journal_title：Scientific reports

authors： Wodarz D,Levy DN

更新日期：2017-06-19 00:00:00

abstract：:Chlorophyll derivatives are known to enhance vision in vertebrates. They are thought to bind visual pigments (i.e., opsins apoproteins bound to retinal chromophores) directly within the retina. Consistent with previous findings in vertebrates, here we show that chlorin e6 - a chlorophyll derivative - enhances photopho...

journal_title：Scientific reports

authors： Degl'Innocenti A,Rossi L,Salvetti A,Marino A,Meloni G,Mazzolai B,Ciofani G

更新日期：2017-06-13 00:00:00

abstract：:GPS-derived Total Electron Content (TEC) is an integrated quantity; hence it is difficult to relate the detection of ionospheric perturbations in TEC to a precise altitude. As TEC is weighted by the maximum ionospheric density, the corresponding altitude (hmF2) is, generally, assumed as the perturbation detection alti...

journal_title：Scientific reports

authors： Thomas D,Bagiya MS,Sunil PS,Rolland L,Sunil AS,Mikesell TD,Nayak S,Mangalampalli S,Ramesh DS

更新日期：2018-08-14 00:00:00

abstract：:X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool...

journal_title：Scientific reports

authors： Sung Y,Segars WP,Pan A,Ando M,Sheppard CJ,Gupta R

更新日期：2015-07-14 00:00:00

abstract：:Hot-iron disbudding, a routine procedure that prevents horn bud growth through cauterization, is painful for calves. The resulting burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non-evoked pain. We evaluated conditioned place preference for analgesia in 44 calves disbud...

journal_title：Scientific reports

authors： Adcock SJJ,Tucker CB

更新日期：2020-03-02 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson's disease (PD) patients significantly improved their moto...

journal_title：Scientific reports

authors： Li H,Lei X,Yan T,Li H,Huang B,Li L,Xu L,Liu L,Chen N,Lü L,Ma Y,Xu L,Li J,Wang Z,Zhang B,Hu X

更新日期：2015-07-29 00:00:00

abstract：:By growing monolayer FeSe on SrTiO3(001) surface, researchers obtain the highest superconducting transition-temperature for iron-based superconductor. Here, we study the antiferromagnetic (AFM) checkerboard monolayer FeSe adsorbed on SrTiO3(001) surface. We show that the system has a considerable charge transfer from ...

journal_title：Scientific reports

authors： Zheng F,Wang Z,Kang W,Zhang P

更新日期：2013-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a severe neurodegenerative disorder for which identification of differentially expressed genes is one way to find new therapeutic targets. Here, we conducted analysis to identify age-independent, AD-specific genes. We found that the MET, WIF1, and NPTX2 genes are downregulated in AD. WIF1 a...

journal_title：Scientific reports

authors： Liu H,Luo K,Luo D

更新日期：2018-02-09 00:00:00