Artificial neural network cascade identifies multi-P450 inhibitors in natural compounds.

abstract：:C-type cytoplasmic male sterility (CMS-C) is widely utilized for hybrid maize seed production. However, genetic mechanisms underlying the fertility restoration are very complicated. At present, there is a divergence on the number of fertility restorer genes in maize inbred line A619 for CMS-C. To further elucidate the...

journal_title：PeerJ

authors： Yongming L,Zhuofan Z,Yanli L,Chuan L,Jing W,Boxiao D,Bing L,Tao Q,Wenbing Z,Moju C

更新日期：2016-11-22 00:00:00

abstract：:Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoof-horn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship with pro-inflammatory cytokine (IL-1β) and virulent Dichelobacter nod...

journal_title：PeerJ

authors： Agbaje M,Rutland CS,Maboni G,Blanchard A,Bexon M,Stewart C,Jones MA,Totemeyer S

更新日期：2018-07-02 00:00:00

abstract：:The new leafhopper genus Vittalianareticulata gen. nov., sp. nov., is described from India, and placed in the tribe Opsiini based on ocelli close to eyes, without carina on anterior margin of the face and bifurcate aedeagus with two gonopores. Phylogenetic analysis with maximum likelihood (ML) using IQtree v1.4.1 of c...

journal_title：PeerJ

authors： Sunil,Meshram NM,Hashmi TR,Shashank PR

更新日期：2020-08-27 00:00:00

abstract：:In the Balearic Islands, different trammel net designs have been adopted to promote fisheries sustainability and reduce discards. Here, we compare the catch performance of three trammel net designs targeting the spiny lobster Palinurus elephas in terms of biomass, species composition and revenue from commercial catche...

journal_title：PeerJ

authors： Catanese G,Hinz H,Gil MDM,Palmer M,Breen M,Mira A,Pastor E,Grau A,Campos-Candela A,Koleva E,Grau AM,Morales-Nin B

更新日期：2018-05-17 00:00:00

abstract：:Elucidating the molecular mechanism of helix-coil transitions of short peptides is a long-standing conundrum in physical chemistry. Although the helix-coil transitions of poly-glutamic acid (PGA) have been extensively studied, the molecular details of its unfolding process still remain unclear. We performed all-atom c...

journal_title：PeerJ

authors： Ogasawara N,Kasahara K,Iwai R,Takahashi T

更新日期：2018-05-15 00:00:00

abstract：Background:Herpesviral hematopoietic necrosis disease, caused by cyprinid herpesvirus-2 (CyHV-2), is responsible for massive mortalities in the aquaculture of goldfish, Carassius auratus. Permissive cell lines for the isolation and propagation of CyHV-2 have been established from various goldfish tissues by sacrificing...

journal_title：PeerJ

authors： Dharmaratnam A,Kumar R,Valaparambil BS,Sood N,Pradhan PK,Das S,Swaminathan TR

更新日期：2020-07-14 00:00:00

abstract：Background:DegS is a periplasmic serine protease that is considered to be the initiator of the σE stress response pathway, and this protein plays an important role in the regulation of the stress response in E. coli. However, knowledge of the biological function and global regulatory network of DegS in Vibrio cholerae ...

journal_title：PeerJ

authors： Huang J,Chen Y,Chen J,Liu C,Zhang T,Luo S,Huang M,Min X

更新日期：2019-10-23 00:00:00

abstract：:Due to its remote and isolated location, Antarctica is home to a unique diversity of species. The harsh conditions have shaped a primarily highly adapted endemic fauna. This includes the notothenioid family Channichthyidae. Their exceptional physiological adaptations have made this family of icefish the focus of many ...

journal_title：PeerJ

authors： Kuhn T,Zizka VMA,Münster J,Klapper R,Mattiucci S,Kochmann J,Klimpel S

更新日期：2018-05-11 00:00:00

abstract：Background:In idiopathic sudden sensorineural hearing loss (ISSNHL), the relationship between the administration duration of vitamin B12 (vit B12) with adenosine triphosphate (ATP) and their therapeutic effect is not fully understood. Objective:To investigate the therapeutic effect of long-term 16 (≥weeks) administrat...

journal_title：PeerJ

authors： Kurioka T,Sano H,Furuki S,Yamashita T

更新日期：2020-12-16 00:00:00

abstract：:Vitiligo is a chronic asymptomatic disorder affecting melanocytes from the basal layer of the epidermis which leads to a patchy loss of skin color. Even though it is one of the neglected disease conditions, people suffering from vitiligo are more prone to psychological disorders. As of now, various studies have been d...

journal_title：PeerJ

authors： Srivastava P,Choudhury A,Talwar M,Mohanty S,Narad P,Sengupta A

更新日期：2020-05-21 00:00:00

abstract：:Palythoa caribaeorum is a zoanthid often dominant in shallow rocky environments along the west coast of the Atlantic Ocean, from the tropics to the subtropics. This species has high environmental tolerance and is a good space competitor in reef environments. Considering current and future scenarios in the global clima...

journal_title：PeerJ

authors： Durante LM,Cruz ICS,Lotufo TMC

更新日期：2018-05-17 00:00:00

abstract：:Reliable abundance estimates for species are fundamental in ecology, fisheries, and conservation. Consequently, predictive models able to provide reliable estimates for un- or poorly-surveyed locations would prove a valuable tool for management. Based on commonly used environmental and physical predictors, we develope...

journal_title：PeerJ

authors： Sequeira AMM,Mellin C,Lozano-Montes HM,Meeuwig JJ,Vanderklift MA,Haywood MDE,Babcock RC,Caley MJ

更新日期：2018-04-17 00:00:00

abstract：:While there have been increasing numbers of reports of human-wolf conflict in China during recent years, little is known about the nature of this conflict. In this study, we used questionnaires and semi-structured interviews to investigate local villagers' perceptions of wolves in Jiuzhaigou County, western China. We ...

journal_title：PeerJ

authors： Xu Y,Yang B,Dou L

更新日期：2015-06-09 00:00:00

abstract：BACKGROUND:The purpose of this study is to provide a report on scientific production during the period 2010-2014 in order to identify the major topics as well as the predominant actors (journals, countries, continents) involved in the field of eye disease. METHODS:A PubMed search was carried out to extract articles re...

journal_title：PeerJ

authors： Boudry C,Denion E,Mortemousque B,Mouriaux F

更新日期：2016-01-07 00:00:00

abstract：:A new species of the genus Mesacanthion Filipjev, 1927 was discovered during a survey of natural beaches of Jeju Island in South Korea. The new species Mesacanthion jejuensissp. nov. shares general morphology of the genus such as the outer labial and cephalic setae being situated at the middle of cephalic capsule, wel...

journal_title：PeerJ

authors： Jeong R,Tchesunov AV,Lee W

更新日期：2019-11-18 00:00:00

abstract：:We examined whether chemically mediated risk perception by prey and the effects of changes in prey behavior on basal resources vary as a function of the amount of prey biomass consumed by the predator. We studied these issues using a tritrophic system composed of blue crabs, Callinectes sapidus (top predator), mud cra...

journal_title：PeerJ

authors： Weissburg M,Beauvais J

更新日期：2015-11-19 00:00:00

abstract：:Quantitative morphometric analyses, particularly ontogenetic allometry, are common methods used in quantifying shape, and changes therein, in both extinct and extant organisms. Due to incompleteness and the potential for restricted sample sizes in the fossil record, palaeobiological analyses of allometry may encounter...

journal_title：PeerJ

authors： Brown CM,Vavrek MJ

更新日期：2015-03-10 00:00:00

abstract：:Mollusc shells are an abundant resource that have been long used to predict the structures of ancient ecological communities, examine evolutionary processes, reconstruct paleoenvironmental conditions, track and predict responses to climatic change, and explore the movement of hominids across the globe. Despite the ubi...

journal_title：PeerJ

authors： Ferreira S,Ashby R,Jeunen GJ,Rutherford K,Collins C,Todd EV,Gemmell NJ

更新日期：2020-07-30 00:00:00

abstract：:The incidence of pediatric cancer is lower than that of adult cancer worldwide. However, the former has detrimental side effects on the health of individuals, even after the cancer is cured, due to the impact of treatment on development. Recently, correlations have been made between the gut microbiome and cancer in se...

journal_title：PeerJ

authors： Sahly N,Moustafa A,Zaghloul M,Salem TZ

更新日期：2019-09-23 00:00:00

abstract：:Apis cerana cerana relies on its sensitive olfactory system to perform foraging activities in the surrounding environment. Olfactory receptors (ORs) are a primary requirement for odorant recognition and coding. However, the molecular recognition of volatile compounds with ORs in A. cerana cerana is still not clear. He...

journal_title：PeerJ

authors： Guo L,Zhao H,Jiang Y

更新日期：2018-06-11 00:00:00

abstract：:Histone lysine modifications are important epigenetic modifications in early embryonic development. JARID2, which is a member of the jumonji demethylase protein family, is a regulator of early embryonic development and can regulate mouse development and embryonic stem cell (ESC) differentiation by modifying histone ly...

journal_title：PeerJ

authors： Fu Y,Xu JJ,Sun XL,Jiang H,Han DX,Liu C,Gao Y,Yuan B,Zhang JB

更新日期：2017-12-21 00:00:00

abstract：:The etiology of cancer includes aberrant cellular homeostasis where a compromised RNA regulatory network is a prominent contributing factor. In particular, noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were recently shown to play important roles in the initiation, progression, and metas...

journal_title：PeerJ

authors： Ning P,Wu Z,Hu A,Li X,He J,Gong X,Xia Y,Shang Y,Bian H

更新日期：2018-01-12 00:00:00

abstract：:Cytokines are fundamental for a functioning immune system, and thus potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique. It is particularly suitable for detecting the expr...

journal_title：PeerJ

authors： Tsai MA,Chen IH,Wang JH,Chou SJ,Li TH,Leu MY,Ho HK,Yang WC

更新日期：2017-09-27 00:00:00

abstract：BACKGROUND:The practice of feeding of diets containing raw animal products (RAP) to pets (dogs and cats) is discouraged by veterinary organizations and governmental public health organizations. Nevertheless, the practice of feeding RAP to pets is increasing in popularity. Pet owner motivations for feeding RAP diets to ...

journal_title：PeerJ

authors： Morgan SK,Willis S,Shepherd ML

更新日期：2017-03-02 00:00:00

abstract：BACKGROUND:The human microbiota plays a key role in health and disease, and bacteriocins, which are small, bacterially produced, antimicrobial peptides, are likely to have an important function in the stability and dynamics of this community. Here we examined the density and distribution of the subclass I lantibiotic m...

journal_title：PeerJ

authors： Walsh CJ,Guinane CM,O' Toole PW,Cotter PD

更新日期：2017-04-27 00:00:00

abstract：:Using hypothetical scenarios, we provided participants with potential opening statements to a conflict discussion that varied on I/you language and communicated perspective. Participants rated the likelihood that the recipient of the statement would react in a defensive manner. Using I-language and communicating persp...

journal_title：PeerJ

authors： Rogers SL,Howieson J,Neame C

更新日期：2018-05-18 00:00:00

abstract：:Cedecea neteri is a very rare human pathogen. We have isolated a strain of C. neteri SSMD04 from pickled mackerel sashimi identified using molecular and phenotypics approaches. Using the biosensor Chromobacterium violaceum CV026, we have demonstrated the presence of short chain N-acyl-homoserine lactone (AHL) type quo...

journal_title：PeerJ

authors： Tan KH,Tan JY,Yin WF,Chan KG

更新日期：2015-09-01 00:00:00

abstract：:Flies use specialized photoreceptors R7 and R8 in the dorsal rim area (DRA) to detect skylight polarization. R7 and R8 form a tiered waveguide (central rhabdomere pair, CRP) with R7 on top, filtering light delivered to R8. We examine how the division of a given resource, CRP length, between R7 and R8 affects their abi...

journal_title：PeerJ

authors： Heras FJ,Laughlin SB

更新日期：2017-01-12 00:00:00

abstract：Background:The influenza virus can cause seasonal infections with mild to severe symptoms, circulating worldwide, and it can affect people in any age group. Therefore, this infection is a serious public health problem that causes severe illness and death in high-risk populations. Every year, 0.5% of the world's populat...

journal_title：PeerJ

authors： Silva T,S Salomon P,Hamerski L,Walter J,B Menezes R,Siqueira JE,Santos A,Santos JAM,Ferme N,Guimarães T,O Fistarol G,I Hargreaves P,Thompson C,Thompson F,Souza TM,Siqueira M,Miranda M

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:VSEARCH is an open source and free of charge multithreaded 64-bit tool for processing and preparing metagenomics, genomics and population genomics nucleotide sequence data. It is designed as an alternative to the widely used USEARCH tool (Edgar, 2010) for which the source code is not publicly available, algo...

journal_title：PeerJ

authors： Rognes T,Flouri T,Nichols B,Quince C,Mahé F

更新日期：2016-10-18 00:00:00