Function of JARID2 in bovines during early embryonic development.

Abstract:

:Histone lysine modifications are important epigenetic modifications in early embryonic development. JARID2, which is a member of the jumonji demethylase protein family, is a regulator of early embryonic development and can regulate mouse development and embryonic stem cell (ESC) differentiation by modifying histone lysines. JARID2 can affect early embryonic development by regulating the methylation level of H3K27me3, which is closely related to normal early embryonic development. To investigate the expression pattern of JARID2 and the effect of JARID2-induced H3K27 methylation in bovine oocytes and early embryonic stages, JARID2 mRNA expression and localization were detected in bovine oocytes and early embryos via qRT-PCR and immunofluorescence in the present study. The results showed that JARID2 is highly expressed in the germinal vesicle (GV), MII, 2-cell, 4-cell, 8-cell, 16-cell and blastocyst stages, but the relative expression level of JARID2 in bovine GV oocytes is significantly lower than that at other oocyte/embryonic stages (p < 0.05), and JARID2 is expressed primarily in the nucleus. We next detected the mRNA expression levels of embryonic development-related genes (OCT4, SOX2 and c-myc) after JARID2 knockdown through JARID2-2830-siRNA microinjection to investigate the molecularpathwayunderlying the regulation of H3K27me3 by JARID2 during early embryonic development. The results showed that the relative expression levels of these genes in 2-cell embryos weresignificantly higher than those in the blastocyst stage, and expression levels were significantly increased after JARID2 knockdown. In summary, the present study identified the expression pattern of JARID2 in bovine oocytes and at each early embryonic stage, and the results suggest that JARID2 plays a key role in early embryonic development by regulating the expression of OCT4, SOX2 and c-myc via modification of H3K27me3 expression. This work provides new data for improvements in the efficiency of in vitro embryo culture as well as a theoretical basis for further studying the regulatory mechanisms involved in early embryonic development.

journal_name

PeerJ

journal_title

PeerJ

authors

Fu Y,Xu JJ,Sun XL,Jiang H,Han DX,Liu C,Gao Y,Yuan B,Zhang JB

doi

10.7717/peerj.4189

subject

Has Abstract

pub_date

2017-12-21 00:00:00

pages

e4189

issn

2167-8359

pii

4189

journal_volume

5

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Parents know best: transgenerational predator recognition through parental effects.

    abstract::In highly biodiverse systems, such as coral reefs, prey species are faced with predatory threats from numerous species. Recognition of predators can be innate, or learned, and can help increase the chance of survival. Research suggests that parental exposure to increased predatory threats can affect the development, b...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9340

    authors: Atherton JA,McCormick MI

    更新日期:2020-06-18 00:00:00

  • Efficacy and safety of low molecular weight heparin compared to unfractionated heparin for chronic outpatient hemodialysis in end stage renal disease: systematic review and meta-analysis.

    abstract::Background. Low molecular weight heparin (LMWH) is an effective anti-coagulant for thrombotic events. However, due to its predominant renal clearance, there are concerns that it might be associated with increased bleeding in patients with renal disease. Objectives. We systematically evaluated the efficacy and safety o...

    journal_title:PeerJ

    pub_type: 杂志文章,评审

    doi:10.7717/peerj.835

    authors: Palamaner Subash Shantha G,Kumar AA,Sethi M,Khanna RC,Pancholy SB

    更新日期:2015-03-10 00:00:00

  • A large cockroach from the mesosaur-bearing Konservat-Lagerstätte (Mangrullo Formation), Late Paleozoic of Uruguay.

    abstract::Barona arcuata, n.gen et n.sp., a left forewing of a relatively large cockroach of the Order Blattaria, is described from mesosaur-bearing lagoonal shales of the Mangrullo Formation (north-eastern Uruguay). While most of the insect remains recovered from the Mangrullo Formation come from sandy limestones, associated t...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6289

    authors: Calisto V,Piñeiro G

    更新日期:2019-01-18 00:00:00

  • Microbial communities mediating algal detritus turnover under anaerobic conditions.

    abstract:BACKGROUND:Algae encompass a wide array of photosynthetic organisms that are ubiquitously distributed in aquatic and terrestrial habitats. Algal species often bloom in aquatic ecosystems, providing a significant autochthonous carbon input to the deeper anoxic layers in stratified water bodies. In addition, various alga...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2803

    authors: Morrison JM,Murphy CL,Baker K,Zamor RM,Nikolai SJ,Wilder S,Elshahed MS,Youssef NH

    更新日期:2017-01-10 00:00:00

  • Factors affecting sustainable adoption of e-health technology in developing countries: an exploratory survey of Nigerian hospitals from the perspective of healthcare professionals.

    abstract:Background:E-health technology applications are essential tools of modern information technology that improve quality of healthcare delivery in hospitals of both developed and developing countries. However, despite its positive benefits, studies indicate that the rate of the e-health adoption in some developing countri...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4436

    authors: Zayyad MA,Toycan M

    更新日期:2018-03-01 00:00:00

  • Integrated genomic analyses of lung squamous cell carcinoma for identification of a possible competitive endogenous RNA network by means of TCGA datasets.

    abstract::The etiology of cancer includes aberrant cellular homeostasis where a compromised RNA regulatory network is a prominent contributing factor. In particular, noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were recently shown to play important roles in the initiation, progression, and metas...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4254

    authors: Ning P,Wu Z,Hu A,Li X,He J,Gong X,Xia Y,Shang Y,Bian H

    更新日期:2018-01-12 00:00:00

  • Sound production in the Meagre, Argyrosomus regius (Asso, 1801): intraspecific variability associated with size, sex and context.

    abstract:Background:Many fish taxa produce sound in voluntary and in disturbance contexts but information on the full acoustic repertoire is lacking for most species. Yet, this knowledge is critical to enable monitoring fish populations in nature through acoustic monitoring. Methods:In this study we characterized the sounds em...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8559

    authors: Pereira BP,Vieira M,Pousão-Ferreira P,Candeias-Mendes A,Barata M,Fonseca PJ,Amorim MCP

    更新日期:2020-02-24 00:00:00

  • Distribution patterns of dinoflagellate communities along the Songhua River.

    abstract:Background:Dinoflagellates have the potential to pose severe ecological and economic damages to aquatic ecosystems. It is therefore largely needed to understand the causes and consequences of distribution patterns of dinoflagellate communities in order to manage potential environmental problems. However, a majority of ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6733

    authors: Gao Y,Chen Y,Xiong W,Li S,Zhan A

    更新日期:2019-04-09 00:00:00

  • CD36 identified by weighted gene co-expression network analysis as a hub candidate gene in lupus nephritis.

    abstract::Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), which often progresses to end-stage renal disease (ESRD) and ultimately leads to death. At present, there are no definitive therapies towards LN, so that illuminating the molecular mechanism behind the disease has become an urgent ta...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.7722

    authors: Yang H,Li H

    更新日期:2019-10-01 00:00:00

  • Coronatine inhibits stomatal closure and delays hypersensitive response cell death induced by nonhost bacterial pathogens.

    abstract::Pseudomonas syringae is the most widespread bacterial pathogen in plants. Several strains of P. syringae produce a phytotoxin, coronatine (COR), which acts as a jasmonic acid mimic and inhibits plant defense responses and contributes to disease symptom development. In this study, we found that COR inhibits early defen...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.34

    authors: Lee S,Ishiga Y,Clermont K,Mysore KS

    更新日期:2013-02-12 00:00:00

  • Viromes of one year old infants reveal the impact of birth mode on microbiome diversity.

    abstract::Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageome during this developmental period. We p...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4694

    authors: McCann A,Ryan FJ,Stockdale SR,Dalmasso M,Blake T,Ryan CA,Stanton C,Mills S,Ross PR,Hill C

    更新日期:2018-05-07 00:00:00

  • Utilizing mutual information for detecting rare and common variants associated with a categorical trait.

    abstract::Background. Genome-wide association studies have succeeded in detecting novel common variants which associate with complex diseases. As a result of the fast changes in next generation sequencing technology, a large number of sequencing data are generated, which offers great opportunities to identify rare variants that...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2139

    authors: Sun L,Wang C,Hu YQ

    更新日期:2016-06-16 00:00:00

  • Metabolomics window into the role of acute kidney injury after coronary artery bypass grafting in diabetic nephropathy progression.

    abstract:Introduction:Metabolomics has emerged as a valuable tool to discover novel biomarkers and study the pathophysiology of diabetic nephropathy (DN). However, the effect of postoperative acute kidney injury (AKI) on diabetes mellitus (DM) to chronic DN progression has not been evaluated from the perspective of metabolomics...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9111

    authors: Wang J,Yan W,Zhou X,Liu Y,Tang C,Peng Y,Liu H,Sun L,Xiao L,He L

    更新日期:2020-05-14 00:00:00

  • Exoskeletons of Bougainvilliidae and other Hydroidolina (Cnidaria, Hydrozoa): structure and composition.

    abstract::The exoskeleton is an important source of characters for the taxonomy of Hydroidolina. It originates as epidermal secretions and, among other functions, protects the coenosarc of the polypoid stage. However, comparative studies on the exoskeletal tissue origin, development, chemical, and structural characteristics, as...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2964

    authors: Mendoza-Becerril MA,Marian JE,Migotto AE,Marques AC

    更新日期:2017-02-16 00:00:00

  • Crossmodal congruency effect scores decrease with repeat test exposure.

    abstract::The incorporation of feedback into a person's body schema is well established. The crossmodal congruency task (CCT) is used to objectively quantify incorporation without being susceptible to experimenter biases. This visual-tactile interference task is used to calculate the crossmodal congruency effect (CCE) score as ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6976

    authors: Blustein D,Gill S,Wilson A,Sensinger J

    更新日期:2019-05-22 00:00:00

  • Estimating the incidence and diagnosed proportion of HIV infections in Japan: a statistical modeling study.

    abstract:Background:Epidemiological surveillance of HIV infection in Japan involves two technical problems for directly applying a classical backcalculation method, i.e., (i) all AIDS cases are not counted over time and (ii) people diagnosed with HIV have received antiretroviral therapy, extending the incubation period. The pre...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6275

    authors: Nishiura H

    更新日期:2019-01-15 00:00:00

  • A systematic review of the direct and indirect effects of herbivory on plant reproduction mediated by pollination.

    abstract:Background:Plant reproduction is influenced by the net outcome of plant-herbivore and plant-pollinator interactions. While both herbivore impacts and pollinator impacts on plant reproduction have been widely studied, few studies examine them in concert. Methodology:Here, we review the contemporary literature that exam...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.9049

    authors: Haas SM,Lortie CJ

    更新日期:2020-06-08 00:00:00

  • Tandem-repeat protein domains across the tree of life.

    abstract::Tandem-repeat protein domains, composed of repeated units of conserved stretches of 20-40 amino acids, are required for a wide array of biological functions. Despite their diverse and fundamental functions, there has been no comprehensive assessment of their taxonomic distribution, incidence, and associations with org...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.732

    authors: Jernigan KK,Bordenstein SR

    更新日期:2015-01-13 00:00:00

  • Sarc-F and muscle function in community dwelling adults with aged care service needs: baseline and post-training relationship.

    abstract:Background:This study sought to better understand the psychometric properties of the SARC-F, by examining the baseline and training-related relationships between the five SARC-F items and objective measures of muscle function. Each of the five items of the SARC-F are scored from 0 to 2, with total score of four or more...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8140

    authors: Keogh JWL,Henwood T,Gardiner PA,Tuckett AG,Hetherington S,Rouse K,Swinton P

    更新日期:2019-11-27 00:00:00

  • Genetic diversity of Simao pine in China revealed by SRAP markers.

    abstract:Background:Simao pine (Pinus kesiya Royle ex Gordon var. langbianensis (A. Chev.) Gaussen) is one of the most important tree species in the production of timber and resin in China. However, the genetic diversity of the natural populations has not been assessed to date. In this study, sequence related amplified polymorp...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6529

    authors: Wang D,Shen B,Gong H

    更新日期:2019-02-26 00:00:00

  • Aridity and land use negatively influence a dominant species' upper critical thermal limits.

    abstract::Understanding the physiological tolerances of ectotherms, such as thermal limits, is important in predicting biotic responses to climate change. However, it is even more important to examine these impacts alongside those from other landscape changes: such as the reduction of native vegetation cover, landscape fragment...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6252

    authors: Andrew NR,Miller C,Hall G,Hemmings Z,Oliver I

    更新日期:2019-01-10 00:00:00

  • The adaptive value of habitat preferences from a multi-scale spatial perspective: insights from marsh-nesting avian species.

    abstract:BACKGROUND:Habitat selection and its adaptive outcomes are crucial features for animal life-history strategies. Nevertheless, congruence between habitat preferences and breeding success has been rarely demonstrated, which may result from the single-scale evaluation of animal choices. As habitat selection is a complex m...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3164

    authors: Jedlikowski J,Brambilla M

    更新日期:2017-03-28 00:00:00

  • Obesity, but not hypohydration, mediates changes in mental task load during passive heating in females.

    abstract:Background:The independent effects of hypohydration and hyperthermia on cognition and mood is unclear since the two stresses often confound each other. Further, it is unknown if obese individuals have the same impairments during hyperthermia and hypohydration that is often observed in non-obese individuals. Methods:Th...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5394

    authors: Caldwell AR,Burchfield J,Moyen NE,Tucker MA,Butts CL,Elbin RJ,Ganio MS

    更新日期:2018-08-16 00:00:00

  • Evolution of the scholarly mega-journal, 2006-2017.

    abstract::Mega-journals are a new kind of scholarly journal made possible by electronic publishing. They are open access (OA) and funded by charges, which authors pay for the publishing services. What distinguishes mega-journals from other OA journals is, in particular, a peer review focusing only on scientific trustworthiness....

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4357

    authors: Björk BC

    更新日期:2018-02-09 00:00:00

  • Developmental effects of environmental light on male nuptial coloration in Lake Victoria cichlid fish.

    abstract:Background:Efficient communication requires that signals are well transmitted and perceived in a given environment. Natural selection therefore drives the evolution of different signals in different environments. In addition, environmental heterogeneity at small spatial or temporal scales may favour phenotypic plastici...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4209

    authors: Wright DS,Rietveld E,Maan ME

    更新日期:2018-01-03 00:00:00

  • The first reported ceratopsid dinosaur from eastern North America (Owl Creek Formation, Upper Cretaceous, Mississippi, USA).

    abstract::Ceratopsids ("horned dinosaurs") are known from western North America and Asia, a distribution reflecting an inferred subaerial link between the two landmasses during the Late Cretaceous. However, this clade was previously unknown from eastern North America, presumably due to limited outcrop of the appropriate age and...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3342

    authors: Farke AA,Phillips GE

    更新日期:2017-05-23 00:00:00

  • Assessing the disturbance potential of small unoccupied aircraft systems (UAS) on gray seals (Halichoerus grypus) at breeding colonies in Nova Scotia, Canada.

    abstract::The use of small unoccupied aircraft systems (UAS) for ecological studies and wildlife population assessments is increasing. These methods can provide significant benefits in terms of costs and reductions in human risk, but little is known if UAS-based approaches cause disturbance of animals during operations. To addr...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.4467

    authors: Arona L,Dale J,Heaslip SG,Hammill MO,Johnston DW

    更新日期:2018-03-19 00:00:00

  • DeepSNVMiner: a sequence analysis tool to detect emergent, rare mutations in subsets of cell populations.

    abstract::Background. Massively parallel sequencing technology is being used to sequence highly diverse populations of DNA such as that derived from heterogeneous cell mixtures containing both wild-type and disease-related states. At the core of such molecule tagging techniques is the tagging and identification of sequence read...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2074

    authors: Andrews TD,Jeelall Y,Talaulikar D,Goodnow CC,Field MA

    更新日期:2016-05-24 00:00:00

  • Metacarpal torsion in apes, humans, and early Australopithecus: implications for manipulatory abilities.

    abstract::Human hands, when compared to that of apes, have a series of adaptations to facilitate manipulation. Numerous studies have shown that Australopithecus afarensis and Au. africanus display some of these adaptations, such as a longer thumb relative to the other fingers, asymmetric heads on the second and fifth metacarpal...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1311

    authors: Drapeau MS

    更新日期:2015-10-06 00:00:00

  • Importance of biotic predictors in estimation of potential invasive areas: the example of the tortoise beetle Eurypedus nigrosignatus, in Hispaniola.

    abstract::Climatic variables have been the main predictors employed in ecological niche modeling and species distribution modeling, although biotic interactions are known to affect species' spatial distributions via mechanisms such as predation, competition, and mutualism. Biotic interactions can affect species' responses to ab...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6052

    authors: Simões MVP,Peterson AT

    更新日期:2018-12-05 00:00:00