Abstract:
Background:In idiopathic sudden sensorineural hearing loss (ISSNHL), the relationship between the administration duration of vitamin B12 (vit B12) with adenosine triphosphate (ATP) and their therapeutic effect is not fully understood. Objective:To investigate the therapeutic effect of long-term 16 (≥weeks) administration of vit B12 with ATP on the prognosis of ISSNHL patients and compare it with those of short-term (<8 weeks) and middle-term (≥8 weeks, <16 weeks) administration. Methods:We retrospectively reviewed the medical records of 117 patients with ISSNHL treated between 2015 and 2018. Results:The overall recovery rate was 32.5%. Initial higher hearing threshold and initial higher grade of hearing loss (HL) were associated with a poor prognosis. However, the administration duration of vit B12 and ATP did not influence the overall hearing improvement. With regard to the time course of hearing recovery, there was no significant difference in hearing recovery among the long-, middle-, and short-term administration groups until 16 weeks after treatment. However, at 16-24 weeks after initial treatment, the short-term administration group exhibited significantly lower hearing recovery than did the long-term administration groups. Conclusions:The administration duration of vit B12 and ATP did not influence the overall hearing prognosis in ISSNHL, but long-term administration of vit B12 and ATP helped prevent the progression of HL after ISSNHL. Our results suggest that long-term administration of vit B12 and ATP is not necessarily required to treat ISSNHL patients, except for slowly progressing HL in the affected ears.
journal_name
PeerJjournal_title
PeerJauthors
Kurioka T,Sano H,Furuki S,Yamashita Tdoi
10.7717/peerj.10406subject
Has Abstractpub_date
2020-12-16 00:00:00pages
e10406issn
2167-8359pii
10406journal_volume
8pub_type
杂志文章相关文献
PeerJ文献大全abstract::Ethylene response factors (ERFs) are plant-specific transcription factors (TFs) that play important roles in plant growth and stress defense and have received a great amount of attention in recent years. In this study, seven ERF genes related to abiotic stress tolerance and response were identified in plants of the Po...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10206
更新日期:2020-10-20 00:00:00
abstract::Herein, we identified the tomato SlMYB102 gene as a MYB family transcription factor of the R2R3-MYB subfamily. We additionally determined that the SlMYB102 promoter region contains photoresponsive, abiotic stress-responsive, and hormone-responsive regulatory elements, and we detected higher SlMYB102 expression in the ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10059
更新日期:2020-10-07 00:00:00
abstract::Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on previous work showing that mitochondrial respiratory parameters are impaired in whole cells from CFS...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6500
更新日期:2019-03-01 00:00:00
abstract::Percent of body fat and physiological stress are important correlates to wildlife demographics. We studied winter percent of body fat and physiological stress levels for a declining elk (Cervus canadensis nelsoni) population in South Dakota, 2011-2013. We obtained percent of winter body fat, pregnancy status, lactatio...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7185
更新日期:2019-06-27 00:00:00
abstract::Grouping large genomic fragments assembled from shotgun metagenomic sequences to deconvolute complex microbial communities, or metagenome binning, enables the study of individual organisms and their interactions. Because of the complex nature of these communities, existing metagenome binning methods often miss a large...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1165
更新日期:2015-08-27 00:00:00
abstract::Allium tenuissimum L. is a widely distributed perennial herbaceous species in temperate and desert steppes. Relative to other wild Allium species, it produces unique sweet flavors, more biomass in arid and cold environments, and has generated greater interest for crop production. Successful crop establishment, however...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8866
更新日期:2020-04-07 00:00:00
abstract::Cordycepin is a component of the extract obtained from Cordyceps militaris and has many biological activities, including anti-cancer, anti-metastatic and anti-inflammatory effects. Intervertebral disc degeneration (IDD) is a degenerative disease that is closely related to the inflammation of nucleus pulposus (NP) cell...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1992
更新日期:2016-05-10 00:00:00
abstract::Finite Element Analysis (FEA) is a useful method for understanding form and function. However, modelling of fossil taxa invariably involves assumptions as a result of preservation-induced loss of information in the fossil record. To test the validity of predictions from FEA, given such assumptions, these results could...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4426
更新日期:2018-02-26 00:00:00
abstract:Background:The gray snapper (Lutjanus griseus) has a tropical and subtropical distribution. In much of its range this species represents one of the most important fishery resources because of its high quality meat and market value. Due to this, this species is vulnerable to overfishing, and population declines have bee...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8485
更新日期:2020-02-10 00:00:00
abstract:Aim:Historically, the distribution of Sandhill Cranes included much of North America and extending in summer into northeast Russia. In recent years, observations of sandhill cranes in Asia during the non-breeding period have been frequently reported. However, the distribution and abundance of sandhill cranes during the...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7545
更新日期:2019-08-30 00:00:00
abstract:Background:Acute respiratory distress syndrome (ARDS) is associated with significantly increased risk of death, and early risk stratification may help to choose the appropriate treatment. The study aimed to develop a neural network model by using a genetic algorithm (GA) for the prediction of mortality in patients with...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7719
更新日期:2019-09-16 00:00:00
abstract::Ocean acidification (OA) is not an isolated threat, but acts in concert with other impacts on ecosystems and species. Coastal marine invertebrates will have to face the synergistic interactions of OA with other global and local stressors. One local factor, common in coastal environments, is trace element contamination...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.538
更新日期:2014-09-09 00:00:00
abstract:Background:Geographic variation in body size and condition can reveal differential local adaptation to resource availability or climatic factors. Body size and condition are related to fitness in garter snakes (Thamnophis), thus good body condition may increase survival, fecundity in females, and mating success in male...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.6601
更新日期:2019-03-13 00:00:00
abstract::The increase in bioinformatics resources such as tools/scripts and databases poses a great challenge for users seeking to construct interactive and reproducible biological data analysis applications. Here, we propose an open-source, comprehensive, flexible R package named BioInstaller that consists of the R functions,...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5853
更新日期:2018-10-31 00:00:00
abstract::In this paper, we propose a method for automatically detecting the times during which game players exhibit specific behavior, such as when players commonly show excitement, concentration, immersion, and surprise. The proposed method detects such outlying behavior based on the game players' characteristics. These chara...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1502
更新日期:2015-12-10 00:00:00
abstract::Resistance strategies of clonal organs, and parent and offspring shoots of Phragmites australis (common reed) to heavy metal pollution in soils are not well known. To clarify the tolerance or resistance strategies in reeds, we conducted a pot experiment with five levels of Pb concentration (0∼4,500 mg kg-1) in flood a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4188
更新日期:2018-01-03 00:00:00
abstract:Background:High throughput DNA sequencing of bulk invertebrate samples or metabarcoding is becoming increasingly used to provide profiles of biological communities for environmental monitoring. As metabarcoding becomes more widely applied, new reference DNA barcodes linked to individual specimens identified by taxonomi...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4980
更新日期:2018-06-13 00:00:00
abstract:Background:The association between asthma (AS), allergic rhinitis (AR) and oral diseases remains inconclusive in adults. AS and AR often coexist. However, studies that investigate AS, AR together and their association with oral diseases are scarce. Methods:Data from 22,898 men and 28,541 women, aged 21 to 25 years, we...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7643
更新日期:2019-09-10 00:00:00
abstract:Background:Trace elements are essential for the growth and survival of plants, and their concentrations and distributions in plants are effective reflections of ecological adaptation strategies. However, this aspect has seldom been addressed. Method:Changes in the leaf and branch trace elements of Pinus massoniana Lam...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9935
更新日期:2020-09-16 00:00:00
abstract::Almost all extant testudinids are highly associated with terrestrial habitats and the few tortoises with high affinity to aquatic environments are found within the genus Manouria. Manouria belongs to a clade which forms a sister taxon to all remaining tortoises and is suitable as a model for studying evolutionary tran...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1172
更新日期:2015-08-11 00:00:00
abstract:Background:The distribution and use of camphor (Cinnamomum camphora L.) trees are constrained by increasing soil salinity in south-eastern China along the Yangtze River. However, the response mechanism of this species to salinity, especially in team of photosynthesis, are unknown. Methods:Here, we analysed themorpholo...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9443
更新日期:2020-08-07 00:00:00
abstract::Soil sickness is the progressive loss of soil quality due to continuous monocropping. The bacterial populations are critical to sustaining agroecosystems, but their responses to long-term peanut monocropping have not been determined. In this study, based on a previously constructed gradient of continuous monocropped p...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9024
更新日期:2020-04-28 00:00:00
abstract::The p53 activation is induced by stressors, such as DNA damage, oxidative stress, and activated oncogenes, and can promote cell cycle arrest, cellular senescence, and apoptosis. The large yellow croaker (Larimichthys crocea) is an important warm temperate marine fish in the Chinese aquiculture industry. However, few s...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10532
更新日期:2020-12-18 00:00:00
abstract:Background:Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed class of drugs in the practice of psychiatry. Cytochrome P450 (CYP) 2C19 and CYP2D6 are established as clinically relevant drug metabolizing enzymes (DMEs) that influence the pharmacokinetics of SSRIs and may either be group...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7860
更新日期:2019-10-09 00:00:00
abstract:Background:Patellofemoral pain (PFP) is often reported as a diffuse pain at the front of the knee during knee-loading activities. A patient's description of pain location and distribution is commonly drawn on paper by clinicians, which is difficult to quantify, report and compare within and between patients. One way of...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4406
更新日期:2018-03-08 00:00:00
abstract::In this paper, we map the distribution of scale-rayed wrasse Acantholabrus palloni in eastern Skagerrak based on a combination of verified and personally communicated angling records. Long thought to be occasional vagrants outside its known range in the eastern Atlantic Ocean and Mediterranean Sea, we ask if this rare...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5900
更新日期:2018-11-06 00:00:00
abstract:Background:Oral cancer progresses from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. The critical needs in oral cancer treatment are expanding our knowledge of malignant tumour progression and the development of useful approaches to prevent dysplastic lesions. This study was designed to gain ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10619
更新日期:2021-01-04 00:00:00
abstract::Background. Just as for most other tortoise species, the once common Chaco tortoise, Chelonoidis chilensis (Testudinidae), is under constant threat across it distribution in Argentina, Bolivia and Paraguay. Despite initial qualitative description of the species distribution and further individual reports of new locati...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1298
更新日期:2015-10-01 00:00:00
abstract:Background:Extensive genome rearrangements, known as chromothripsis, have been recently identified in several cancer types. Chromothripsis leads to complex structural variants (cSVs) causing aberrant gene expression and the formation of de novo fusion genes, which can trigger cancer development, or worsen its clinical ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7071
更新日期:2019-06-12 00:00:00
abstract::In the Western honey bee, Apis mellifera, queens and workers have different longevity although they share the same genome. Queens consume royal jelly (RJ) as the main food throughout their life, including as adults, but workers only eat worker jelly when they are larvae less than 3 days old. In order to explore the ef...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3118
更新日期:2017-03-28 00:00:00